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公开(公告)号：US08298832B2
公开(公告)日：2012-10-30
申请号：US10593680
申请日：2005-03-17
申请人： Yuki Takii , Kunihisa Nagino , Fumio Nakamura , Hitoshi Nobumasa
发明人： Yuki Takii , Kunihisa Nagino , Fumio Nakamura , Hitoshi Nobumasa
CPC分类号： B01F13/0059 , B01F13/0052 , B01F13/0054 , B01F13/02 , G01N2035/00158 , G01N2035/00544 , Y10T436/25
摘要： The method of stirring a solution according to the present invention is a method of stirring a solution comprising contacting a selective binding substance immobilized on the surface of a carrier with a solution containing an analyte substance reactive with the selective binding substance, and mixing the fine particles or air bubbles into the solution containing an analyte substance, and moving the fine particles or air bubbles without allowing contact thereof with the selective binding substance-immobilized surface.The present invention provides a stirring method that accelerates the reaction of a carrier-immobilized selective binding substance with an analyte substance and detects a trace amount of analyte at high signal intensity and high S/N ratio.The present invention enables diagnosis and examination in the clinical setting by using a selective binding substance-immobilized carrier such as DNA chip.
摘要翻译： 根据本发明的搅拌溶液的方法是一种搅拌溶液的方法，其包括将固定在载体表面上的选择性结合物质与含有与选择性结合物质反应的分析物质的溶液接触，并将微粒子 或气泡进入含有分析物质的溶液中，并且移动细颗粒或气泡，而不允许其与选择性结合物质固定的表面接触。 本发明提供了一种加速载体固定的选择性结合物质与分析物质的反应并在高信号强度和高S / N比下检测微量分析物的搅拌方法。 本发明通过使用选择性结合物质固定载体如DNA芯片，能够在临床环境中进行诊断和检查。
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公开(公告)号：US20070178603A1
公开(公告)日：2007-08-02
申请号：US10593680
申请日：2005-03-17
申请人： Yuki Takii , Kunihisa Nagino , Fumio Nakamura , Hitoshi Nobumasa
发明人： Yuki Takii , Kunihisa Nagino , Fumio Nakamura , Hitoshi Nobumasa
IPC分类号： G01N1/00
CPC分类号： B01F13/0059 , B01F13/0052 , B01F13/0054 , B01F13/02 , G01N2035/00158 , G01N2035/00544 , Y10T436/25
摘要： The method of stirring a solution according to the present invention is a method of stirring a solution comprising contacting a selective binding substance immobilized on the surface of a carrier with a solution containing an analyte substance reactive with the selective binding substance, and mixing the fine particles or air bubbles into the solution containing an analyte substance, and moving the fine particles or air bubbles without allowing contact thereof with the selective binding substance-immobilized surface. The present invention provides a stirring method that accelerates the reaction of a carrier-immobilized selective binding substance with an analyte substance and detects a trace amount of analyte at high signal intensity and high S/N ratio. The present invention enables diagnosis and examination in the clinical setting by using a selective binding substance-immobilized carrier such as DNA chip.
摘要翻译： 根据本发明的搅拌溶液的方法是一种搅拌溶液的方法，其包括将固定在载体表面上的选择性结合物质与含有与选择性结合物质反应的分析物质的溶液接触，并将微粒子 或气泡进入含有分析物质的溶液中，并且移动细颗粒或气泡，而不允许其与选择性结合物质固定的表面接触。 本发明提供了一种加速载体固定的选择性结合物质与分析物质的反应并在高信号强度和高S / N比下检测微量分析物的搅拌方法。 本发明通过使用选择性结合物质固定载体如DNA芯片，能够在临床环境中进行诊断和检查。
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公开(公告)号：US20120046187A1
公开(公告)日：2012-02-23
申请号：US13254255
申请日：2010-03-15
申请人： Tomo Baba , Yuki Takii
发明人： Tomo Baba , Yuki Takii
CPC分类号： B01F13/0059 , B01F11/0022 , B01F13/0052 , B01L3/50273 , B01L3/502761 , B01L2200/0668 , B01L2300/0636 , B01L2300/0877 , B01L2400/0633
摘要： An analysis chip includes a carrier having a surface on which a selective binding substance(s) is(are) immobilized; a vessel holding a solution containing a test substance(s) which react(s) with the selective binding substance(s); and particles for stirring the solution, the particles being sealed within a space formed between the carrier and the vessel wherein a separator which allows passage therethrough of the solution containing the test substance(s), but does not allow passage therethrough of the particles is arranged in the space to separate the surface of the carrier on which the selective binding substance(s) is(are) immobilized and the particles.
摘要翻译： 分析芯片包括具有固定有选择性结合物质的表面的载体; 容纳含有与选择性结合物质反应的测试物质的溶液的容器; 和用于搅拌溶液的颗粒，颗粒被密封在载体和容器之间的空间内，其中允许允许通过其中含有测试物质但不允许颗粒通过其中的溶液的分离器 在分离其上固定有选择性结合物质的载体表面和颗粒的空间中。
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