公开(公告)号：US20100048610A1

公开(公告)日：2010-02-25

申请号：US12474799

申请日：2009-05-29

申请人： Yuki Yamaguchi ,  Minoru Koura ,  Sayaka Kurobuchi ,  Takayuki Matsuda ,  Ayumu Okuda ,  Hisashi Sumida ,  Yuuichirou Watanabe ,  Takashi Enomoto ,  Kimiyuki Shibuya

发明人： Yuki Yamaguchi ,  Minoru Koura ,  Sayaka Kurobuchi ,  Takayuki Matsuda ,  Ayumu Okuda ,  Hisashi Sumida ,  Yuuichirou Watanabe ,  Takashi Enomoto ,  Kimiyuki Shibuya

IPC分类号： A61K31/436 ,  C07D401/06 ,  A61K31/4439 ,  C07D491/056

CPC分类号： C07D233/72 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D491/048

摘要： [Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.

摘要翻译： [目的]提供一种新型的LXR＆bgr; 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式（I）表示的甲醇化合物或其盐或其溶剂化物。

公开(公告)号：US08008306B2

公开(公告)日：2011-08-30

申请号：US12430397

申请日：2009-04-27

申请人： Minoru Koura ,  Ayumu Okuda ,  Takayuki Matsuda ,  Yuki Yamaguchi ,  Hisashi Sumida ,  Sayaka Kurobuchi ,  Yuichiro Watanabe ,  Takashi Enomoto ,  Kimiyuki Shibuya

发明人： Minoru Koura ,  Ayumu Okuda ,  Takayuki Matsuda ,  Yuki Yamaguchi ,  Hisashi Sumida ,  Sayaka Kurobuchi ,  Yuichiro Watanabe ,  Takashi Enomoto ,  Kimiyuki Shibuya

IPC分类号： C07D215/12 ,  C07D215/233 ,  C07D241/40 ,  A61K31/4709 ,  A61K31/498

CPC分类号： C07D401/14 ,  C07D401/12 ,  C07D405/14

摘要： To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.A quinoline compound represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 提供一种新颖的LXR＆bgr 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 由以下通式（1）表示的喹啉化合物或其盐或其溶剂化物。

公开(公告)号：US08153634B2

公开(公告)日：2012-04-10

申请号：US12474799

申请日：2009-05-29

申请人： Yuki Yamaguchi ,  Minoru Koura ,  Sayaka Kurobuchi ,  Takayuki Matsuda ,  Ayumu Okuda ,  Hisashi Sumida ,  Yuichiro Watanabe ,  Takashi Enomoto ,  Kimiyuki Shibuya

发明人： Yuki Yamaguchi ,  Minoru Koura ,  Sayaka Kurobuchi ,  Takayuki Matsuda ,  Ayumu Okuda ,  Hisashi Sumida ,  Yuichiro Watanabe ,  Takashi Enomoto ,  Kimiyuki Shibuya

IPC分类号： A61K31/4166 ,  A61K31/4178 ,  A61K31/4355 ,  A61K31/4439 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  C07D401/02 ,  C07D401/06 ,  C07D405/14 ,  C07D405/02 ,  C07D491/048 ,  C07D233/72 ,  C07D403/02 ,  C07D403/06

CPC分类号： C07D233/72 ,  C07D401/04 ,  C07D401/06 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D405/04 ,  C07D405/14 ,  C07D491/048

摘要： [Object] To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A carbinol compound represented by the following general formula (I) or salt thereof, or their solvate.

摘要翻译： [目的]提供一种新型的LXR＆bgr; 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式（I）表示的甲醇化合物或其盐或其溶剂化物。

公开(公告)号：US20100063119A1

公开(公告)日：2010-03-11

申请号：US12516944

申请日：2007-11-29

申请人： Takayuki Matsuda ,  Ayumu Okuda ,  Minoru Koura ,  Yuki Yamaguchi ,  Sayaka Kurobuchi ,  Yuuichirou Watanabe ,  Kimiyuki Shibuya

发明人： Takayuki Matsuda ,  Ayumu Okuda ,  Minoru Koura ,  Yuki Yamaguchi ,  Sayaka Kurobuchi ,  Yuuichirou Watanabe ,  Kimiyuki Shibuya

IPC分类号： A61K31/4164 ,  C07D233/72 ,  C07D405/10 ,  C07D409/04 ,  A61K31/4178

CPC分类号： C07D233/72 ,  C07D233/76 ,  C07D233/78 ,  C07D235/02 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04

摘要： There is provided a novel LXRβ agonist useful as a preventative and/or therapeutic agent for arteriosclerosis; arteriosclerosis such as those resulting from diabetes; hyperlipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases caused by inflammatory cytokines, skin diseases such as allergic skin diseases, diabetes or Alzheimer's disease. The agonist is a carbinol derivative represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 提供了一个新颖的LXR＆bgr; 可用作动脉硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 高脂血症 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病，皮肤疾病如过敏性皮肤疾病，糖尿病或阿尔茨海默病。 激动剂是由以下通式（1）表示的甲醇衍生物或其盐或其溶剂合物。

公开(公告)号：US08168666B2

公开(公告)日：2012-05-01

申请号：US12516944

申请日：2007-11-29

申请人： Takayuki Matsuda ,  Ayumu Okuda ,  Minoru Koura ,  Yuki Yamaguchi ,  Sayaka Kurobuchi ,  Yuuichirou Watanabe ,  Kimiyuki Shibuya

发明人： Takayuki Matsuda ,  Ayumu Okuda ,  Minoru Koura ,  Yuki Yamaguchi ,  Sayaka Kurobuchi ,  Yuuichirou Watanabe ,  Kimiyuki Shibuya

IPC分类号： A61K31/4015 ,  C07D233/32

CPC分类号： C07D233/72 ,  C07D233/76 ,  C07D233/78 ,  C07D235/02 ,  C07D401/04 ,  C07D403/04 ,  C07D405/04 ,  C07D409/04

摘要： There is provided a novel LXRβ agonist useful as a preventative and/or therapeutic agent for arteriosclerosis; arteriosclerosis such as those resulting from diabetes; hyperlipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases caused by inflammatory cytokines, skin diseases such as allergic skin diseases, diabetes or Alzheimer's disease. The agonist is a carbinol derivative represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 提供了一个新颖的LXR＆bgr; 可用作动脉硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 高脂血症 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病，皮肤疾病如过敏性皮肤疾病，糖尿病或阿尔茨海默病。 激动剂是由以下通式（1）表示的甲醇衍生物或其盐或其溶剂合物。

公开(公告)号：US07951822B2

公开(公告)日：2011-05-31

申请号：US12413894

申请日：2009-03-30

申请人： Ayumu Okuda ,  Takayuki Matsuda ,  Toru Miura ,  Koichi Yamazaki ,  Yuki Yamaguchi ,  Minoru Koura ,  Sayaka Kurobuchi ,  Yuichiro Watanabe ,  Kimiyuki Shibuya

发明人： Ayumu Okuda ,  Takayuki Matsuda ,  Toru Miura ,  Koichi Yamazaki ,  Yuki Yamaguchi ,  Minoru Koura ,  Sayaka Kurobuchi ,  Yuichiro Watanabe ,  Kimiyuki Shibuya

IPC分类号： A61K31/4166 ,  A61K31/427 ,  A61K31/422 ,  A61K31/45 ,  A61K31/4525 ,  C07D405/12 ,  C07D417/12 ,  C07D413/12 ,  C07D407/12

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D417/12 ,  C07D417/14

摘要： The object is to provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease. The solving means is a 1,3-dihydroisobenzofuran derivative represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 目的是提供一种新颖的LXR＆bgr; 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 解决方法是由以下通式（1）表示的1,3-二氢异苯并呋喃衍生物或其盐或其溶剂合物。

公开(公告)号：US07919509B2

公开(公告)日：2011-04-05

申请号：US12394548

申请日：2009-02-27

申请人： Ayumu Okuda ,  Takayuki Matsuda ,  Toru Miura ,  Hidefumi Ozawa ,  Ayako Tosaka ,  Koichi Yamazaki ,  Yuki Yamaguchi ,  Sayaka Kurobuchi ,  Yuichiro Watanabe ,  Kimiyuki Shibuya

发明人： Ayumu Okuda ,  Takayuki Matsuda ,  Toru Miura ,  Hidefumi Ozawa ,  Ayako Tosaka ,  Koichi Yamazaki ,  Yuki Yamaguchi ,  Sayaka Kurobuchi ,  Yuichiro Watanabe ,  Kimiyuki Shibuya

IPC分类号： A61K31/4166 ,  A61K31/427 ,  A61K31/45 ,  A61K31/422 ,  A61K31/4525 ,  C07D405/12 ,  C07D417/12 ,  C07D413/12 ,  C07D407/12

CPC分类号： C07D405/12 ,  C07D405/14 ,  C07D409/14 ,  C07D413/12 ,  C07D417/12

摘要： To provide a novel LXRβ agonist that is useful as a preventative and/or therapeutic agent for atherosclerosis; arteriosclerosis such as those resulting from diabetes; dyslipidemia; hypercholesterolemia; lipid-related diseases; inflammatory diseases that are caused by inflammatory cytokines; skin diseases such as allergic skin diseases; diabetes; or Alzheimer's disease.[Solving Means] A 2-oxochromene derivative represented by the following general formula (1) or salt thereof, or their solvate.

摘要翻译： 提供一种新颖的LXR＆bgr 可用作动脉粥样硬化的预防和/或治疗剂的激动剂; 动脉硬化，如糖尿病引起的; 血脂异常 高胆固醇血症 脂质相关疾病; 由炎性细胞因子引起的炎性疾病; 皮肤病如过敏性皮肤病; 糖尿病; 或阿尔茨海默病。 [解决方案]由以下通式（1）表示的2-氧代色烯衍生物或其盐或其溶剂合物。

公开(公告)号：US20130157857A1

公开(公告)日：2013-06-20

申请号：US13819540

申请日：2011-07-26

申请人： Motoki Tanaka ,  Keijitsu Tanaka ,  Takeshi Shibuya ,  Eiji Ikuta ,  Kotaro Yoshinaga ,  Yuki Yamaguchi

发明人： Motoki Tanaka ,  Keijitsu Tanaka ,  Takeshi Shibuya ,  Eiji Ikuta ,  Kotaro Yoshinaga ,  Yuki Yamaguchi

IPC分类号： A01N43/713 ,  A01N43/20 ,  A01N37/22 ,  A01N43/653 ,  A01N43/10

CPC分类号： A01N43/713 ,  A01N31/02 ,  A01N37/10 ,  A01N37/22 ,  A01N37/26 ,  A01N43/10 ,  A01N43/20 ,  A01N43/653 ,  A01N47/38 ,  A01N49/00 ,  A01N2300/00

摘要： The present invention relates to an inhibitor for tobacco axillary bud growth, the inhibitor comprising, as an active ingredient, one or more kinds of very-long chain fatty acid synthesis inhibitors such as a chloroacetamide-based herbicide, fentrazamide, cafenstrole or indanofan; an inhibitor for tobacco axillary bud growth, the inhibitor comprising the aforesaid very-long chain fatty acid synthesis inhibitor together with clorthal-dimethyl or an aliphatic alcohol having 6 to 20 carbon atoms; and a method for inhibiting tobacco axillary bud growth which comprises applying the inhibitor for tobacco axillary bud growth. The inhibitor for tobacco axillary bud growth of the present invention shows sustained drug efficacy at a low concentration, induces neither chemical injury nor disease, and can contribute to the improvement in labor productivity.

摘要翻译： 本发明涉及一种用于烟草腋芽生长的抑制剂，该抑制剂包含一种或多种非常长链脂肪酸合成抑制剂作为活性成分，例如基于氯乙酰胺的除草剂，芬太拉胺，咖啡豆或茚满那芬; 用于烟草腋芽生长的抑制剂，所述抑制剂包含上述非常长链脂肪酸合成抑制剂和氯代二甲基或具有6至20个碳原子的脂族醇; 以及抑制烟草腋芽生长的方法，其包括施用烟草腋芽生长抑制剂。 本发明的烟草腋芽生长抑制剂以低浓度显示持续的药物功效，既不引起化学损伤也不诱导疾病，并且可有助于提高劳动生产率。

公开(公告)号：US20140121112A1

公开(公告)日：2014-05-01

申请号：US14125681

申请日：2011-06-13

申请人： Motoki Tanaka ,  Keijitsu Tanaka ,  Takeshi Shibuya ,  Eiji Ikuta ,  Kotaro Yoshinaga ,  Yuki Yamaguchi

发明人： Motoki Tanaka ,  Keijitsu Tanaka ,  Takeshi Shibuya ,  Eiji Ikuta ,  Kotaro Yoshinaga ,  Yuki Yamaguchi

IPC分类号： A01N43/40 ,  A01N37/18

CPC分类号： A01N43/40 ,  A01N37/18 ,  A01N43/78 ,  A01N31/02 ,  A01N2300/00 ,  A01N49/00

摘要： The present invention relates to an inhibitor for tobacco axillary bud growth, the inhibitor comprising one or more cell division inhibitors selected from the group consisting of pyridine-based compounds and benzamide-based compounds. This inhibitor for tobacco axillary bud growth has excellent sustainability of effect at low concentration, does not cause chemical damage and disease, and can ensure an improvement in labor productivity. An aliphatic alcohol having 6 to 20 carbon atoms is furthermore combined with the cell division inhibitors selected from pyridine-based compounds and benzamide-based compounds to thereby synergistically enhance the effect of inhibiting the emergence and growth of tobacco axillary buds.

摘要翻译： 本发明涉及一种用于烟草腋芽生长的抑制剂，该抑制剂包含一种或多种选自吡啶类化合物和苯甲酰胺类化合物的细胞分裂抑制剂。 这种烟草腋芽生长抑制剂在低浓度下具有优异的作用效果，不会引起化学损伤和疾病，并且可以确保劳动生产率的提高。 此外，还可以将选自吡啶类化合物和苯甲酰胺类化合物的细胞分裂抑制剂与具有6〜20个碳原子的脂肪族醇组合，从而协同增强抑制烟草腋芽出芽和生长的效果。

公开(公告)号：US4505739A

公开(公告)日：1985-03-19

申请号：US368232

申请日：1982-01-13

申请人： Nansho Seki ,  Yuki Yamaguchi ,  Yukihiro Nakamura ,  Hiroshi Kubo ,  Tetsuo Tsuruya

发明人： Nansho Seki ,  Yuki Yamaguchi ,  Yukihiro Nakamura ,  Hiroshi Kubo ,  Tetsuo Tsuruya

IPC分类号： A01N43/56 ,  C07D231/40 ,  C22C38/00

CPC分类号： C07D231/40

摘要： A novel pyrazole derivative represented by the formula [I]: ##STR1## wherein X and Y are defined in the specification, which has a herbicidal activity, is disclosed. A process for preparing the pyrazole derivative of the formula [I] is also disclosed. A herbicide containing as an active ingredient the pyrazole derivative of the formula [I] is further disclosed.

摘要翻译： 公开了由式[I]代表的新颖的吡唑衍生物：其中X和Y在说明书中定义，其具有除草活性。 还公开了制备式[I]的吡唑衍生物的方法。 进一步公开含有作为活性成分的式[I]的吡唑衍生物的除草剂。