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    ANTI-TUMOR AGENT
    4.
    发明申请
    ANTI-TUMOR AGENT 审中-公开
    抗肿瘤剂

    公开(公告)号：US20100216755A1

    公开(公告)日：2010-08-26

    申请号：US12774912

    申请日：2010-05-06

    申请人： Yukio NIHEI ,  Yoshihiro Morinaga ,  Manabu Suzuki ,  Yasuyo Suga

    发明人： Yukio NIHEI ,  Yoshihiro Morinaga ,  Manabu Suzuki ,  Yasuyo Suga

    IPC分类号： A61K31/567 ,  A61P35/00

    CPC分类号： A61K31/05 ,  A61K31/167 ,  A61K31/573 ,  A61K45/06 ,  A61K2300/00

    摘要： The present application provides a method for the treatment of tumors where the lethal dose of (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide is increased to twice or more, the toxicity at the pharmaceutically effective dosage of (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide is reduced, gastrointestinal toxicity at the pharmaceutically effective dosage of (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide is reduced, hepatic toxicity at the pharmaceutically effective dosage of (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide is reduced, and/or cardiovascular toxicity at the pharmaceutically effective dosage of (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide is reduced, by administering to a subject in need thereof a composition containing: (a) an effective amount of an anti-inflammatory active substance, wherein the anti-inflammatory active substance is a Dexamethasone selected from the group consisting Dexamethasone, an ester of Dexamethasone, and a salt of Dexamethasone; and (b) (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide or a salt thereof.

    摘要翻译： 本申请提供了一种治疗肿瘤的方法，其中致死剂量的（Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺是 （Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺的药学有效剂量的毒性降低至两倍以上， 在（Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺的药学有效剂量下，胃肠道毒性降低，药物有效 （Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺的剂量和/或心血管毒性在药学有效剂量 Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺通过向有需要的受试者施用包含以下物质的组合物：（a） 有效量的抗炎活性物质，其中所述抗炎活性物质为 选自地塞米松，地塞米松的酯和地塞米松的盐的地塞米松; 和（b）（Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺或其盐。

    KIT FOR DETERMINING POLYSACCHARIDE-BINDING ABILITY OF MONONUCLEAR CELLS PRESENT IN PERIPHERAL BLOOD
    9.
    发明申请
    KIT FOR DETERMINING POLYSACCHARIDE-BINDING ABILITY OF MONONUCLEAR CELLS PRESENT IN PERIPHERAL BLOOD 有权
    用于测定外周血中单核细胞多糖结合能力的试剂盒

    公开(公告)号：US20080220452A1

    公开(公告)日：2008-09-11

    申请号：US12117999

    申请日：2008-05-09

    申请人： Tetsuya Suga ,  Yasuyo Suga ,  Masahiro Murata

    发明人： Tetsuya Suga ,  Yasuyo Suga ,  Masahiro Murata

    IPC分类号： G01N33/53

    CPC分类号： G01N33/56972 ,  G01N2400/10 ,  Y10S435/975

    摘要： A kit for the determination of the ability of a peripheral blood mononuclear cell to bind to a polysaccharide herein provided comprises a detection reagent comprising a fluorescence-labeled immunostimulant polysaccharide; and a reference reagent comprising a fluorescence-labeled material of a polysaccharide different from that used in the fluorescence-labeled immunostimulant polysaccharide, and/or an immunostimulant polysaccharide which is not labeled with any fluorescent material and whose polysaccharide moiety is identical to that included in the fluorescence-labeled immunostimulant polysaccharide. The use of this kit would permit the estimation of the polysaccharide-binding ability of a peripheral blood mononuclear cell in a higher precision of estimation.

    摘要翻译： 用于测定外周血单核细胞与本文提供的多糖结合的能力的试剂盒包括含有荧光标记的免疫刺激多糖的检测试剂; 和包含不同于荧光标记的免疫刺激多糖中使用的多糖的荧光标记物质的参考试剂，和/或未用任何荧光材料标记的多糖部分与其中包含的多糖部分相同的免疫刺激多糖 荧光标记免疫刺激多糖。 该试剂盒的使用将允许以更高的估计精度估计外周血单核细胞的多糖结合能力。

    Kit for determining polysaccharide-binding activity of mononuclear cells present in peripheral blood
    10.
    发明授权
    Kit for determining polysaccharide-binding activity of mononuclear cells present in peripheral blood 有权
    用于测定外周血中存在的单核细胞的多糖结合活性的试剂盒

    公开(公告)号：US07553824B2

    公开(公告)日：2009-06-30

    申请号：US12117999

    申请日：2008-05-09

    申请人： Tetsuya Suga ,  Yasuyo Suga ,  Masahiro Murata

    发明人： Tetsuya Suga ,  Yasuyo Suga ,  Masahiro Murata

    IPC分类号： A01N43/04

    CPC分类号： G01N33/56972 ,  G01N2400/10 ,  Y10S435/975

    摘要： A kit for the determination of the ability of a peripheral blood mononuclear cell to bind to a polysaccharide herein provided comprises a detection reagent comprising a fluorescence-labeled immunostimulant polysaccharide; and a reference reagent comprising a fluorescence-labeled material of a polysaccharide different from that used in the fluorescence-labeled immunostimulant polysaccharide, and/or an immunostimulant polysaccharide which is not labeled with any fluorescent material and whose polysaccharide moiety is identical to that included in the fluorescence-labeled immunostimulant polysaccharide. The use of this kit would permit the estimation of the polysaccharide-binding ability of a peripheral blood mononuclear cell in a higher precision of estimation.

    摘要翻译： 用于测定外周血单核细胞与本文提供的多糖结合的能力的试剂盒包括含有荧光标记的免疫刺激多糖的检测试剂; 和包含不同于荧光标记的免疫刺激多糖中使用的多糖的荧光标记物质的参考试剂，和/或未用任何荧光材料标记的多糖部分与其中包含的多糖部分相同的免疫刺激多糖 荧光标记免疫刺激多糖。 该试剂盒的使用将允许以更高的估计精度估计外周血单核细胞的多糖结合能力。