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    ANTI-TUMOR AGENT
    7.
    发明申请
    ANTI-TUMOR AGENT 审中-公开
    抗肿瘤剂

    公开(公告)号：US20100216755A1

    公开(公告)日：2010-08-26

    申请号：US12774912

    申请日：2010-05-06

    申请人： Yukio NIHEI ,  Yoshihiro Morinaga ,  Manabu Suzuki ,  Yasuyo Suga

    发明人： Yukio NIHEI ,  Yoshihiro Morinaga ,  Manabu Suzuki ,  Yasuyo Suga

    IPC分类号： A61K31/567 ,  A61P35/00

    CPC分类号： A61K31/05 ,  A61K31/167 ,  A61K31/573 ,  A61K45/06 ,  A61K2300/00

    摘要： The present application provides a method for the treatment of tumors where the lethal dose of (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide is increased to twice or more, the toxicity at the pharmaceutically effective dosage of (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide is reduced, gastrointestinal toxicity at the pharmaceutically effective dosage of (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide is reduced, hepatic toxicity at the pharmaceutically effective dosage of (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide is reduced, and/or cardiovascular toxicity at the pharmaceutically effective dosage of (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide is reduced, by administering to a subject in need thereof a composition containing: (a) an effective amount of an anti-inflammatory active substance, wherein the anti-inflammatory active substance is a Dexamethasone selected from the group consisting Dexamethasone, an ester of Dexamethasone, and a salt of Dexamethasone; and (b) (Z)—N-[2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)vinyl]phenyl]-L-serinamide or a salt thereof.

    摘要翻译： 本申请提供了一种治疗肿瘤的方法，其中致死剂量的（Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺是 （Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺的药学有效剂量的毒性降低至两倍以上， 在（Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺的药学有效剂量下，胃肠道毒性降低，药物有效 （Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺的剂量和/或心血管毒性在药学有效剂量 Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺通过向有需要的受试者施用包含以下物质的组合物：（a） 有效量的抗炎活性物质，其中所述抗炎活性物质为 选自地塞米松，地塞米松的酯和地塞米松的盐的地塞米松; 和（b）（Z）-N- [2-甲氧基-5- [2-（3,4,5-三甲氧基苯基）乙烯基]苯基] -L-丝氨酰胺或其盐。