公开(公告)号：US20110207944A1

公开(公告)日：2011-08-25

申请号：US13126128

申请日：2009-11-02

申请人： Yuko Nakamura ,  Hiroshi Saito ,  Kazuo Nagasawa ,  Atsushi Kittaka

发明人： Yuko Nakamura ,  Hiroshi Saito ,  Kazuo Nagasawa ,  Atsushi Kittaka

IPC分类号： C07D207/26

CPC分类号： C07D207/273

摘要： Compound represented by formula (1) or a pharmaceutically acceptable solvate thereof, useful for treating or preventing Paget's disease of bone, hypercalcaemia, osteoporosis or asthma. (1) R1 represents a C1-C6 alkyl group or C7-C15 aralkyl group (the aromatic ring of which can be substituted by a C1-C6 alkyl group, C1-C6 alkoxy group, a hydroxyl group, a halogenatom or a trifluoromethyl group), R2 represents a C1-C6 alkyl group, and R3 represents a C1-C6 alkyl or alkoxy group, which can be substituted with a hydroxyl group.

摘要翻译： 由式（1）表示的化合物或其药学上可接受的溶剂化物，可用于治疗或预防佩吉特氏骨，高钙血症，骨质疏松症或哮喘。 （1）R1表示C1-C6烷基或C7-C15芳烷基（其芳香环可被C1-C6烷基，C1-C6烷氧基，羟基，卤原子或三氟甲基取代） ），R2表示C1-C6烷基，R3表示可被羟基取代的C1-C6烷基或烷氧基。

公开(公告)号：US09073885B2

公开(公告)日：2015-07-07

申请号：US10543881

申请日：2004-01-29

申请人： Kazuya Takenouchi ,  Miyuki Anzai ,  Hiroshi Saito ,  Kazuhisa Okada ,  Seiichi Ishizuka ,  Daishiro Miura ,  Hiroaki Takayama ,  Atsushi Kittaka ,  Nozomi Saito ,  Toshie Fujishima

发明人： Kazuya Takenouchi ,  Miyuki Anzai ,  Hiroshi Saito ,  Kazuhisa Okada ,  Seiichi Ishizuka ,  Daishiro Miura ,  Hiroaki Takayama ,  Atsushi Kittaka ,  Nozomi Saito ,  Toshie Fujishima

IPC分类号： A61K31/593 ,  C07D307/58

CPC分类号： C07D307/58 ,  A61K31/593

摘要： A compound represented by the following Formula (1) that is effective for the treatment of Paget's disease of bone or hypercalcemia or a medically acceptable solvate thereof; [wherein R1 refers to hydrogen atom, C1-C6 alkyl group optionally substituted with hydrogen group or C1-C6 alkoxy group optionally substituted with hydroxyl group, R2a and R2b refer to hydrogen atom, C1-C10 alkyl group optionally substituted with hydroxyl group, C6-C10 aryl group optionally substituted with hydroxyl group or C7-C12 aralkyl group optionally substituted with a hydroxyl group, or are combined to represent ethylene group. However, a compound in which R1 is a hydrogen atom or a methyl group and R2a and R2b are hydrogen atoms is excluded].

摘要翻译： 由下式（1）表示的化合物可有效治疗佩吉特氏骨或高钙血症或其医学上可接受的溶剂合物; [其中，R1表示氢原子，可以被氢原子取代的C1-C6烷基或者被羟基取代的C1-C6烷氧基，R2a和R2b表示氢原子，可以被羟基取代的C1-C10烷基，C6 任选被羟基取代的-C 10芳基或任选被羟基取代的C 7 -C 12芳烷基，或被组合以代表亚乙基。 然而，除了R1是氢原子或甲基，R2a和R2b是氢原子的化合物]。

公开(公告)号：US20060148768A1

公开(公告)日：2006-07-06

申请号：US10543881

申请日：2004-01-29

申请人： Kazuya Takenouchi ,  Miyuki Anzai ,  Hiroshi Saito ,  Kazuhisa Okada ,  Seiichi Ishizuka ,  Daishiro Miura ,  Hiroaki Takayama ,  Atsushi Kittaka ,  Nozomi Saito ,  Toshie Fujishima

发明人： Kazuya Takenouchi ,  Miyuki Anzai ,  Hiroshi Saito ,  Kazuhisa Okada ,  Seiichi Ishizuka ,  Daishiro Miura ,  Hiroaki Takayama ,  Atsushi Kittaka ,  Nozomi Saito ,  Toshie Fujishima

IPC分类号： A61K31/59 ,  C07D307/02

CPC分类号： C07D307/58 ,  A61K31/593

摘要： A compound represented by the following Formula (1) that is effective for the treatment of Paget's disease of bone or hypercalcemia or a medically acceptable solvate thereof; [wherein R1 refers to hydrogen atom, C1-C6 alkyl group optionally substituted with hydrogen group or C1-C6 alkoxy group optionally substituted with hydroxyl group, R2a and R2b refer to hydrogen atom, C1-C10 alkyl group optionally substituted with hydroxyl group, C6-C10 aryl group optionally substituted with hydroxyl group or C7-C12 aralkyl group optionally substituted with a hydroxyl group, or are combined to represent ethylene group. However, a compound in which R1 is a hydrogen atom or a methyl group and R2a and R2b are hydrogen atoms is excluded].

摘要翻译： 由下式（1）表示的化合物可有效治疗佩吉特氏骨或高钙血症或其医学上可接受的溶剂合物; [其中R 1是氢原子，任选被氢或C 1 -C 6烷基取代的C 1 -C 6烷基， 任选被羟基取代的C 1 -C 6烷氧基，R 2a和R 2b是指氢原子，C 1〜 任选被羟基取代的C 1 -C 10烷基，任选被羟基取代的C 6 -C 10芳基或C 6 - 任选被羟基取代的或者被组合以代表亚乙基的C 1 -C 12芳烷基。 但是，不包括其中R 1是氢原子或甲基，R 2b和R 2b的氢原子的化合物。

公开(公告)号：US20050131242A1

公开(公告)日：2005-06-16

申请号：US10499962

申请日：2002-12-25

申请人： Hiroaki Takayama ,  Toshie Fujishima ,  Atsushi Kittaka

发明人： Hiroaki Takayama ,  Toshie Fujishima ,  Atsushi Kittaka

IPC分类号： A61K31/59 ,  A61P3/02 ,  C07C401/00

CPC分类号： A61K31/59 ,  C07C401/00

摘要： According to the present invention, there are provided vitamin D derivatives represented by the following general formula (1): wherein R1 and R2 may be the same or different, and each represents a straight chain or branched chain alkyl group optionally substituted by a hydroxyl group, and R3 represents a straight chain or branched chain alkyl group optionally substituted by a hydroxyl group.

摘要翻译： 根据本发明，提供由以下通式（1）表示的维生素D衍生物：其中R 1和R 2可以相同或不同，并且 各自表示任选被羟基取代的直链或支链烷基，R 3表示任选被羟基取代的直链或支链烷基。