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公开(公告)号：US20110207944A1
公开(公告)日：2011-08-25
申请号：US13126128
申请日：2009-11-02
申请人： Yuko Nakamura , Hiroshi Saito , Kazuo Nagasawa , Atsushi Kittaka
发明人： Yuko Nakamura , Hiroshi Saito , Kazuo Nagasawa , Atsushi Kittaka
IPC分类号： C07D207/26
CPC分类号： C07D207/273
摘要： Compound represented by formula (1) or a pharmaceutically acceptable solvate thereof, useful for treating or preventing Paget's disease of bone, hypercalcaemia, osteoporosis or asthma. (1) R1 represents a C1-C6 alkyl group or C7-C15 aralkyl group (the aromatic ring of which can be substituted by a C1-C6 alkyl group, C1-C6 alkoxy group, a hydroxyl group, a halogenatom or a trifluoromethyl group), R2 represents a C1-C6 alkyl group, and R3 represents a C1-C6 alkyl or alkoxy group, which can be substituted with a hydroxyl group.
摘要翻译： 由式（1）表示的化合物或其药学上可接受的溶剂化物，可用于治疗或预防佩吉特氏骨，高钙血症，骨质疏松症或哮喘。 （1）R1表示C1-C6烷基或C7-C15芳烷基（其芳香环可被C1-C6烷基，C1-C6烷氧基，羟基，卤原子或三氟甲基取代） ），R2表示C1-C6烷基，R3表示可被羟基取代的C1-C6烷基或烷氧基。
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2.发明授权Glycosyltransferase, novel glycosyltransferase gene, and novel sugar donor compound 有权糖基转移酶，新型糖基转移酶基因和新型糖供体化合物公开(公告)号：US08722868B2
公开(公告)日：2014-05-13
申请号：US13389233
申请日：2010-01-21
申请人： Yoshihiro Ozeki , Nobuhiro Sasaki , Kazuo Nagasawa , Masayuki Tera , Yuki Matsuba , Haruka Nakamura , Yutaka Abe
发明人： Yoshihiro Ozeki , Nobuhiro Sasaki , Kazuo Nagasawa , Masayuki Tera , Yuki Matsuba , Haruka Nakamura , Yutaka Abe
CPC分类号： C12N9/1048 , C07H13/08 , C07H15/18 , C07H17/065 , C12P19/44 , C12P19/60
摘要： An object of the present invention is to provide a sugar donating reagent comprising a sugar donor compound other than a sugar nucleotide and an enzyme capable of catalyzing a glycosyl transfer reaction using a sugar donor compound other than a sugar nucleotide. The present invention provides the following: a sugar donating reagent containing a compound of formula (A): wherein R1 is independently selected from hydrogen, or C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl in which each of the groups is unsubstituted or substituted with one or more groups selected from OH, F, Cl, Br, I, CN, NO2, and SO2, n is 0, 1, 2, 3, 4 or 5, m is 0 or 1, and X represents a monosaccharide bound via a β bond on its anomeric carbon; a glycosyltransferase capable of catalyzing a glycosyl transfer reaction using the sugar donor; and a glycosyltransferase gene comprising DNA encoding the glycosyltransferase.
摘要翻译： 本发明的目的是提供一种含糖糖核苷酸以外的糖供体化合物和能够使用糖核苷酸以外的糖供体化合物催化糖基转移反应的酶的供糖试剂。 本发明提供以下：含有式（A）化合物的给糖试剂：其中R 1独立地选自氢或C 1-6烷基，C 2-6烯基和C 2-6炔基，其中每个基团 未取代或被一个或多个选自OH，F，Cl，Br，I，CN，NO2和SO2的基团取代，n为0,1,2,3,4或5，m为0或1，X 代表通过＆bgr结合的单糖; 其端基异碳碳键; 能够使用糖供体催化糖基转移反应的糖基转移酶; 和包含编码糖基转移酶的DNA的糖基转移酶基因。
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公开(公告)号：US06377899B1
公开(公告)日：2002-04-23
申请号：US09383886
申请日：1999-08-26
申请人： Masumi Sakai , Kazuo Nagasawa
发明人： Masumi Sakai , Kazuo Nagasawa
IPC分类号： G01C2500
摘要： For calibrating a spectrophotometer having a monochromator with a rotary mechanism to rotate a diffraction grating for producing a monochromatic beam of light of a specified target wavelength, transmission errors by the rotary mechanism are preliminarily measured to obtain an error curve having peaks corresponding to feed angles. A smallest angular interval, greater than an allowable limit, between a pair of feed angles corresponding to a mutually adjacent pair of peaks in the error curve is selected. One or more lamps emitting bright lines with wavelength interval which corresponds to motion of the rotary mechanism by less than one half of the selected smallest angular interval are used as a light source. Control values to be supplied to the rotary mechanism for obtaining monochromatic beams of light from the bright lines emitted from the selected lamps are determined by measurements. A calibration table, from which a required control value corresponding to a specified wavelength value can be retrieved, is produced from these control values and wavelength values of the bright lines and is stored in a memory device.
摘要翻译： 为了校准具有旋转机构的单色仪的分光光度计，以旋转用于产生指定目标波长的单色光束的衍射光栅，预先测量旋转机构的传输误差，以获得具有与进给角度对应的峰值的误差曲线。 选择对应于误差曲线中相互相邻的峰对的一对进给角之间的最大角度间隔（大于允许极限）。 一个或多个灯发出亮线，其波长间隔对应于旋转机构的运动小于所选择的最小角度间隔的一半，被用作光源。 通过测量确定要提供给旋转机构的控制值，用于从所选择的灯发出的亮线获得单色光束。 从这些控制值和亮线的波长值产生校准表，可从中检索与指定波长值相对应的所需控制值，并存储在存储器件中。
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公开(公告)号：US4095304A
公开(公告)日：1978-06-20
申请号：US766566
申请日：1977-02-07
IPC分类号： A47L11/33
CPC分类号： A47L11/4075 , A47L11/33 , A47L11/40 , A47L11/4013 , A47L11/4025 , A47L11/4041
摘要： A hand sweeper according to the present invention comprises a base in the form of a dust box having a rotary brush and driving wheels for transmitting their rotation to the rotary brush and a cover body for covering the dust box. The cover body has a handle pivotably attached thereto and is removably connected to the dust box.
摘要翻译： 根据本发明的手动清扫器包括具有旋转刷的集尘箱形式的基座和用于将其旋转传递到旋转刷的驱动轮和用于覆盖集尘盒的盖体。 盖体具有可枢转地附接到其上的手柄，并且可拆卸地连接到集尘盒。
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5.发明授权公开(公告)号：US07170596B2
公开(公告)日：2007-01-30
申请号：US10837781
申请日：2004-05-04
申请人： Masumi Sakai , Kazuo Nagasawa
发明人： Masumi Sakai , Kazuo Nagasawa
IPC分类号： G01J3/36
摘要： An atomic absorption spectrophotometer including a self reverse type hollow cathode lamp and a photomultiplier tube further includes a preliminary tester for measuring a strength of a signal L when a smaller current is supplied to the hollow cathode lamp and a strength of a signal H when a larger current is supplied while a voltage V applied between a cathode and an anode of the photomultiplier is changed. It also includes an optimal voltage detector for detecting a value V0 of the voltage V at which a super ratio U (which is defined as a ratio of a first ratio L0/H0 to a second ratio L1/H1) is closest to unity under a condition that two values V1 and V0 of the voltage V are arbitrarily chosen so that a ratio H1/H0 or a ratio L1/L0 is a predetermined value. The value V0 is used in the following proper measurement of a sample analysis to apply voltage V to the photomultiplier tube of the photometric detector, where a larger current and a smaller current are alternately supplied to the hollow cathode lamp to perform the background correction. This automatically improves the accuracy of the background correction.
摘要翻译： 包括自反向型中空阴极灯和光电倍增管的原子吸收分光光度计还包括用于当向空心阴极灯供应较小电流时测量信号L的强度的预测试仪和当较大的电流时的信号H的强度 当施加在光电倍增管的阴极和阳极之间的电压V改变时，电流被提供。 它还包括一个最佳电压检测器，用于检测电压V的值V0，其中超级比率U（其被定义为第一比率L0 / H0与第二比率L1 / H1的比率）最接近于单位 条件是任意地选择电压V的两个值V1和V0，使得比率H1 / H0或比率L1 / L0是预定值。 值V0用于样本分析的以下适当测量，以将电压V施加到光度检测器的光电倍增管，其中较大的电流和较小的电流交替地供应到空心阴极灯以执行背景校正。 这自动提高了背景校正的准确性。
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公开(公告)号：US4099284A
公开(公告)日：1978-07-11
申请号：US770768
申请日：1977-02-22
IPC分类号： A47L11/33
CPC分类号： A47L11/4072 , A47L11/33 , A47L11/4013 , A47L11/4038 , A47L11/4041 , A47L11/4069
摘要： Driving wheels for auxiliary rotary wheels are provided at the forward corners of a sweeper in a spaced relationship from driving wheels for a main rotary brush to provide a long wheel base.
摘要翻译： 辅助旋转轮的驱动轮以与主旋转刷的驱动轮间隔的关系设置在清扫机的前角处以提供长轮距。
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7.发明申请NOVEL GLYCOSYLTRANSFERASE, NOVEL GLYCOSYLTRANSFERASE GENE, AND NOVEL SUGAR DONOR COMPOUND 有权新型糖蛋白酶，新型糖酵解酶基因和新型糖配合物公开(公告)号：US20120135469A1
公开(公告)日：2012-05-31
申请号：US13389233
申请日：2010-01-21
申请人： Yoshihiro Ozeki , Nobuhiro Sasaki , Kazuo Nagasawa , Masayuki Tera , Yuki Matsuba , Haruka Nakamura , Yutaka Abe
发明人： Yoshihiro Ozeki , Nobuhiro Sasaki , Kazuo Nagasawa , Masayuki Tera , Yuki Matsuba , Haruka Nakamura , Yutaka Abe
CPC分类号： C12N9/1048 , C07H13/08 , C07H15/18 , C07H17/065 , C12P19/44 , C12P19/60
摘要： An object of the present invention is to provide a sugar donating reagent comprising a sugar donor compound other than a sugar nucleotide and an enzyme capable of catalyzing a glycosyl transfer reaction using a sugar donor compound other than a sugar nucleotide. The present invention provides the following: a sugar donating reagent containing a compound of formula (A): wherein R1 is independently selected from hydrogen, or C1-6 alkyl, C2-6 alkenyl, and C2-6 alkynyl in which each of the groups is unsubstituted or substituted with one or more groups selected from OH, F, Cl, Br, I, CN, NO2, and SO2, n is 0, 1, 2, 3, 4 or 5, m is 0 or 1, and X represents a monosaccharide bound via a β bond on its anomeric carbon; a glycosyltransferase capable of catalyzing a glycosyl transfer reaction using the sugar donor; and a glycosyltransferase gene comprising DNA encoding the glycosyltransferase.
摘要翻译： 本发明的目的是提供一种含糖糖核苷酸以外的糖供体化合物和能够使用糖核苷酸以外的糖供体化合物催化糖基转移反应的酶的供糖试剂。 本发明提供以下：含有式（A）化合物的给糖试剂：其中R 1独立地选自氢或C 1-6烷基，C 2-6烯基和C 2-6炔基，其中每个基团 未取代或被一个或多个选自OH，F，Cl，Br，I，CN，NO2和SO2的基团取代，n为0,1,2,3,4或5，m为0或1，X 代表通过＆bgr结合的单糖; 其端基异碳碳键; 能够使用糖供体催化糖基转移反应的糖基转移酶; 和包含编码糖基转移酶的DNA的糖基转移酶基因。
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公开(公告)号：US07524980B2
公开(公告)日：2009-04-28
申请号：US10980253
申请日：2004-11-04
申请人： Kazuo Nagasawa , Yuichi Hashimoto , Yuko Kato
发明人： Kazuo Nagasawa , Yuichi Hashimoto , Yuko Kato
IPC分类号： C07C401/00 , C07C403/00 , C07D207/00 , A01N45/00 , A61K31/59
CPC分类号： C07D207/273 , C07D261/02
摘要： Compounds expressed by the following formula (1) or pharmaceutically permissible solvate thereof which is effective for treating Paget's disease of bone, hypercalcemia or osteoporosis. In the formula, R1 is a C2-C10 alkyl group, or a C7-C15 aralkyl group whose aromatic ring is optionally substituted with a C1-C6 alkyl group, a C1-C6 alkoxyl group, a hydroxyl group, a halogen atom or a trifluoromethyl group; and R2 is a C1-C10 alkyl group, or a C7-C15 aralkyl group whose aromatic ring is optionally substituted with a C1-C6 alkyl group, a C1-C6 alkoxyl group, a hydroxyl group, a halogen atom or a trifluoromethyl group.
摘要翻译： 由下式（1）表示的化合物或其药学上可允许的溶剂化物，其可有效治疗佩格特氏骨，高钙血症或骨质疏松症。 在该式中，R 1是C 2 -C 10烷基或其芳环任选被C 1 -C 6烷基，C 1 -C 6烷氧基，羟基，卤原子或卤素原子任意取代的C 7 -C 15芳烷基 三氟甲基 或者R 1为C 1 -C 10烷基，或者其芳环任选被C 1 -C 6烷基，C 1 -C 6烷氧基，羟基，卤素原子或三氟甲基取代的C 7 -C 15芳烷基。
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公开(公告)号：US20050182032A1
公开(公告)日：2005-08-18
申请号：US10980253
申请日：2004-11-04
申请人： Kazuo Nagasawa , Yuichi Hashimoto , Yuko Kato
发明人： Kazuo Nagasawa , Yuichi Hashimoto , Yuko Kato
IPC分类号： A61K31/4015 , A61K31/59 , C07D207/273 , C07D261/02
CPC分类号： C07D207/273 , C07D261/02
摘要： Compounds expressed by the following formula (1) or pharmaceutically permissible solvate thereof which is effective for treating Paget's disease of bone, hypercalcemia or osteoporosis. In the formula, R1 is a C2-C10 alkyl group, or a C7-Cl5 aralkyl group whose aromatic ring is optionally substituted with a C1-C6 alkyl group, a C1-C6 alkoxyl group, a hydroxyl group, a halogen atom or a trifluoromethyl group; and R2 is a C1-C10 alkyl group, or a C7-C15 aralkyl group whose aromatic ring is optionally substituted with a C1-C6 alkyl group, a C1-C6 alkoxyl group, a hydroxyl group, a halogen atom or a trifluoromethyl group.
摘要翻译： 由下式（1）表示的化合物或其药学上可允许的溶剂化物，其可有效治疗佩格特氏骨，高钙血症或骨质疏松症。 在该式中，R 1是C 2 -C 10烷基或C 7 -C 11烷基 芳香环任选被C 1 -C 6烷基取代的芳烷基，C 1〜 -C 6烷氧基，羟基，卤素原子或三氟甲基; R 2是C 1 -C 10烷基或C 7 -C 10烷基， 芳香环任选被C 1 -C 6烷基取代的C 15 -C 18芳烷基，C 1 -C 6烷基， 烷氧基，羟基，卤素原子或三氟甲基。
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公开(公告)号：US3958408A
公开(公告)日：1976-05-25
申请号：US523892
申请日：1974-11-14
申请人： Kazuo Nagasawa
发明人： Kazuo Nagasawa
CPC分类号： G04G17/04
摘要： A circuit block for an electronic watch comprises a time standard circuit, that is a timing module and a regulating element. The time standard circuit unit includes an oscillator, an oscillating circuit, a divider and a driving circuit all of which are collectively sealed in a vacuum or evacuated case. The regulating element serves to regulate the period of output signals from the time standard circuit unit at a value to be required. The time standard circuit unit and the regulating element are mounted on the same substrate.
摘要翻译： 电子手表的电路块包括时间标准电路，即时序模块和调节元件。 时间标准电路单元包括振荡器，振荡电路，分频器和驱动电路，所有这些都集中密封在真空或抽真空的壳体中。 调节元件用于将时间标准电路单元的输出信号的周期调整为需要的值。 时间标准电路单元和调节元件安装在相同的基板上。
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