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    SYSTEM FOR OPTICAL BASED DELIVERY OF EXOGENOUS MOLECULES TO CELLS
    5.
    发明申请
    SYSTEM FOR OPTICAL BASED DELIVERY OF EXOGENOUS MOLECULES TO CELLS 审中-公开
    用于基于光源分布的细胞外分泌的系统

    公开(公告)号：US20130052725A1

    公开(公告)日：2013-02-28

    申请号：US13285976

    申请日：2011-10-31

    申请人： Siavash Yazdanfar ,  Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

    发明人： Siavash Yazdanfar ,  Vasile Bogdan Neculaes ,  Kenneth Roger Conway ,  Allen Lawrence Garner ,  Evelina Roxana Loghin ,  Dmitry Vladimirovich Dylov ,  Brian Michael Davis ,  Chulmin Joo

    IPC分类号： C12M1/42

    CPC分类号： C12M35/02

    摘要： A system for delivering exogenous molecules comprises a support for containing cells and exogenous molecules; an infra-red (IR) light source that generates an IR optical beam with an average power density at least greater than 105 W/cm2; one or more optical elements; an imaging system to image the cells in a field of view; a processor that generates a signal for localization of cells in the field of view; a light pattern shaper for temporal focusing of optical beam to generate wide field illumination on the cells to permeabilise the cell membrane for delivering the exogenous molecules; and a controller that switches optical beam from wide field illumination to a focused illumination. The processor is operatively coupled to the imaging system and the light pattern shaper and transmits the signal for the localization of cells to ensure the temporal focusing of the optical beam on the cells.

    摘要翻译： 用于递送外源分子的系统包括用于含有细胞和外源分子的载体; 红外（IR）光源，其产生平均功率密度至少大于105W / cm2的IR光束; 一个或多个光学元件; 成像系统，用于在视场中对细胞进行成像; 处理器，其在视野中产生用于细胞定位的信号; 用于光束的时间聚焦的光图案整形器以在细胞上产生宽场照明以透过细胞膜以传递外源分子; 以及将光束从宽场照明切换到聚焦照明的控制器。 处理器可操作地耦合到成像系统和光图案整形器，并且传输信号用于细胞的定位，以确保光束在细胞上的时间聚焦。

    Nano-calorimeter device and associated methods of fabrication and use
    6.
    发明授权
    Nano-calorimeter device and associated methods of fabrication and use 失效
    纳米量热仪装置及相关的制造和使用方法

    公开(公告)号：US06988826B2

    公开(公告)日：2006-01-24

    申请号：US10847180

    申请日：2004-05-17

    申请人： Anis Zribi ,  Azar Alizadeh ,  Suryaprakash Ganti ,  Juan Antonio Sabate ,  Loucas Tsakalakos ,  Kenneth Roger Conway

    发明人： Anis Zribi ,  Azar Alizadeh ,  Suryaprakash Ganti ,  Juan Antonio Sabate ,  Loucas Tsakalakos ,  Kenneth Roger Conway

    IPC分类号： G01K17/00 ,  G01N25/00

    CPC分类号： B82Y15/00 ,  G01K17/006 ,  G01N25/4866

    摘要： The present invention provides a nano-calorimeter device operable for measuring and characterizing the thermodynamic and other physical properties of materials that are confined to essentially nano-scale dimensions. The nano-calorimeter device including a thin film membrane having a first surface and a second surface. The nano-calorimeter device also including a frame structure disposed adjacent to and in thermal contact with the first surface of the thin film membrane, the frame structure defining a plurality of hollow cells adjacent to and in thermal contact with the first surface of the thin film membrane. The nano-calorimeter device further including one or more micro-heating elements disposed adjacent to and in thermal contact with the second surface of the thin film membrane, the location of the one or more micro-heating elements disposed adjacent to the second surface of the thin film membrane substantially corresponding to the location of the plurality of hollow cells defined adjacent to the first surface of the thin film membrane.

    摘要翻译： 本发明提供一种可用于测量和表征被限制在基本上纳米级尺寸的材料的热力学和其它物理性能的纳米量热器装置。 纳米量热器装置包括具有第一表面和第二表面的薄膜膜。 所述纳米量热器装置还包括邻近所述薄膜膜的所述第一表面设置并与所述薄膜膜的第一表面热接触的框架结构，所述框架结构限定与所述薄膜的所述第一表面相邻并且与所述薄膜的第一表面热接触的多个中空细胞 膜。 所述纳米量热器装置还包括一个或多个设置在所述薄膜膜的第二表面附近并与之相接触的微加热元件，所述一个或多个微加热元件邻近所述薄膜膜的第二表面设置的位置 薄膜膜基本上对应于与薄膜膜的第一表面相邻限定的多个中空细胞的位置。

    Method and apparatus for determining if brush seals are defective
    7.
    发明授权
    Method and apparatus for determining if brush seals are defective 失效
    用于确定刷密封件是否有缺陷的方法和装置

    公开(公告)号：US06435011B1

    公开(公告)日：2002-08-20

    申请号：US09252386

    申请日：1999-02-18

    申请人： Osman Saim Dinc ,  James Louis Lawen, Jr. ,  Kenneth Roger Conway ,  Onika Misasha Kerber

    发明人： Osman Saim Dinc ,  James Louis Lawen, Jr. ,  Kenneth Roger Conway ,  Onika Misasha Kerber

    IPC分类号： G01M332

    CPC分类号： F16J15/3296 ,  F16J15/3288

    摘要： One method empirically determines a stiffness value for each of two or more different subsets of the bristles of a brush seal, then calculates a variation in stiffness, and then identifies the brush seal as defective if the calculated variation in stiffness exceeds a predetermined stiffness variation criteria. One apparatus includes a load transducer having a contact head sized to contact less than twenty percent of the bristles, a displacement transducer which measures the displacement of the free ends of the contacted bristles, and a clamp for securing the brush seal and presenting the bristles for contact.

    摘要翻译： 一种方法经验地确定刷毛密封件的刷毛的两个或更多个不同子集中的每一个的刚度值，然后计算刚度的变化，然后如果所计算的刚度变化超过预定刚度变化标准则将刷密封识别为有缺陷 。 一种装置包括具有接触头的负载传感器，接触头的尺寸设置为接触小于百分之二十的刷毛;位移传感器，其测量接触到的刷毛的自由端的位移;以及夹具，用于固定刷密封件并呈现刷毛 联系。