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36 条记录 (耗时 0.028 秒)

    Thienodiazepine derivatives
    1.
    发明授权
    Thienodiazepine derivatives 失效
    噻吩并二氮杂衍生物

    公开(公告)号：US4017620A

    公开(公告)日：1977-04-12

    申请号：US575727

    申请日：1975-05-08

    申请人： Yutaka Kuwada ,  Kanji Meguro ,  Hiroyuki Tawada ,  Takashi Sohda ,  Hideaki Natsugari ,  Yoshiaki Sato

    发明人： Yutaka Kuwada ,  Kanji Meguro ,  Hiroyuki Tawada ,  Takashi Sohda ,  Hideaki Natsugari ,  Yoshiaki Sato

    IPC分类号： A61K31/55 ,  A61P25/00 ,  A61P25/20 ,  C07D495/14

    CPC分类号： C07D495/14

    摘要： There is disclosed new thienodiazepine derivatives of the general formula: ##STR1## wherein R.sup.1 represents a carboxyl group which may be esterified or amidated; each of R.sup.2 and R.sup.3 represents hydrogen atom or a lower alkyl group, or R.sup.2 and R.sup.3 may bond to each other to form an alkylene group; R.sup.4 represents a phenyl group which may have substituent; and R represents hydrogen atom, an acyl group or an alkyl group, or its pharmaceutically acceptable acid addition salts. The above compounds are useful as medicine in human and animal therapy, which act on the central nervous system, for example, as muscle relaxants, anticonvulsants, sedatives, minor tranquilizers, etc.

    摘要翻译： 公开了以下通式的新的噻吩并二氮杂衍生物：其中R 1表示可被酯化或酰胺化的羧基; R 2和R 3各自表示氢原子或低级烷基，或者R 2和R 3可以彼此键合形成亚烷基; R4表示可以具有取代基的苯基; R表示氢原子，酰基或烷基，或其药学上可接受的酸加成盐。 上述化合物可用作人和动物治疗中的药物，其作用于中枢神经系统，例如肌肉松弛剂，抗惊厥药，镇静剂，微量镇静剂等。

    4-Pyridine carbonyl phenyl 1,2,4 triazoles
    3.
    发明授权
    4-Pyridine carbonyl phenyl 1,2,4 triazoles 失效
    4-吡啶羰基苯基1,2,4-三唑

    公开(公告)号：US4044129A

    公开(公告)日：1977-08-23

    申请号：US592889

    申请日：1975-07-03

    申请人： Yutaka Kuwada ,  Kanji Meguro ,  Hideaki Natsugari ,  Yoshiaki Sato ,  Hiroyuki Tawada

    发明人： Yutaka Kuwada ,  Kanji Meguro ,  Hideaki Natsugari ,  Yoshiaki Sato ,  Hiroyuki Tawada

    IPC分类号： C07D401/04 ,  A61K31/44 ,  A61K31/4427 ,  A61K31/535 ,  A61P21/02 ,  A61P25/00 ,  A61P25/08 ,  A61P25/20 ,  C07D213/50 ,  C07D249/08 ,  C07D401/10 ,  C07D413/14

    CPC分类号： C07D249/08 ,  C07D213/50

    摘要： A novel triazole derivative of the general formula (I): ##STR1## wherein R.sup.1 and R.sup.2, which may be the same or different, represent alkyl group or aralkyl group and one of R.sup.1 and R.sup.2 may be hydrogen atom, or R.sup.1 and R.sup.2 form a heterocyclic ring together with the nitrogen atom adjacent thereto; R.sup.3 represents hydrogen atom or a hydrocarbon residue; R.sup.4 represents hydrogen atom or a lower alkyl group; Py represents a pyridyl group; and the ring A is either unsubstituted or substituted by halogen atom, nitro, alkyl, alkoxy or trifluoromethyl group, and pharmaceutically acceptable acid addition salts thereof are found to be useful as medicine in human and animal therapy, as these compounds act on the central nervous as for example, muscle relaxants, anticonvulsants, sedatives, minor tranquilizers, etc.

    摘要翻译： 通式（I）的新的三唑衍生物：（I）其中R 1和R 2可以相同或不同，表示烷基或芳烷基，R 1和R 2之一可以是氢原子或R 1 R2与邻近的氮原子一起形成杂环; R3表示氢原子或烃残基; R4代表氢原子或低级烷基; Py代表吡啶基; 发现环A是未取代的或被卤素原子取代的硝基，烷基，烷氧基或三氟甲基，其药学上可接受的酸加成盐可用作人和动物治疗中的药物，因为这些化合物作用于中枢神经 例如，肌肉松弛剂，抗惊厥药，镇静剂，小镇静剂等

    Benzazepine derivatives
    6.
    发明授权
    Benzazepine derivatives 失效
    苯扎西平衍生物

    公开(公告)号：US4002638A

    公开(公告)日：1977-01-11

    申请号：US505088

    申请日：1974-09-11

    申请人： Yutaka Kuwada ,  Hiroyuki Tawada ,  Kanji Meguro

    发明人： Yutaka Kuwada ,  Hiroyuki Tawada ,  Kanji Meguro

    IPC分类号： C07D487/04 ,  C07D249/12

    CPC分类号： C07D487/04 ,  Y10S514/906 ,  Y10S514/96

    摘要： Novel benzazepine derivatives of the formula ##STR1## wherein ring A is unsubstituted or substituted by halogen, nitro, alkyl, alkoxy or trifluoromethyl, R is hydrogen or alkyl which may be substituted, X is oxygen or sulfur and Y is -CH.sub.2 -CH.sub.2 - or -CH=CH-, and their pharmaceutically acceptable salts, exhibit excellent pharmacological activities such as analgetic and muscle relaxing activities.

    摘要翻译： 式A的新的苯并氮杂衍生物，其中环A未被取代或被卤素，硝基，烷基，烷氧基或三氟甲基取代，R是氢或可被取代的烷基，X是氧或硫，Y是-CH 2 -CH 2 - 或-CH = CH-及其药学上可接受的盐，表现出优异的药理活性，例如止痛和肌肉松弛活性。

    Benzodiazepine derivative and process for producing the same
    7.
    发明授权
    Benzodiazepine derivative and process for producing the same 失效
    苯并二氮杂衍生物及其制备方法

    公开(公告)号：US4046772A

    公开(公告)日：1977-09-06

    申请号：US566434

    申请日：1975-04-09

    申请人： Yutaka Kuwada ,  Hiroyuki Tawada ,  Kanji Meguro

    发明人： Yutaka Kuwada ,  Hiroyuki Tawada ,  Kanji Meguro

    IPC分类号： A61K31/55 ,  A61P21/02 ,  A61P25/08 ,  A61P25/20 ,  B23B33/00 ,  C07D487/04 ,  C07D487/14

    CPC分类号： C07D487/04 ,  B23B33/005 ,  Y10S514/906 ,  Y10S514/96

    摘要： A benzodiazepine derivative of the general formula: ##STR1## wherein R.sub.1 represents a hydrogen atom, an alkyl group or a carboxyl group which may be esterified or amidated; R represents a hydrogen atom, an acyl group or a lower alkyl group, and each of the rings A and B is unsubstituted or substituted by halogen atom, nitro, lower alkyl, trifluoromethyl or lower alkoxy group, or its pharmaceutically acceptable acid addition salt is found to be useful as medicine in human and animal therapy, which acts on the central nervous system, e.g. muscle relaxants, anticonvulsants, sedatives, tranquilizers etc.

    摘要翻译： 一种通式如下的苯并二氮杂衍生物：其中R 1表示氢原子，烷基或可被酯化或酰胺化的羧基; R表示氢原子，酰基或低级烷基，环A和B各自未被取代或被卤素原子，硝基，低级烷基，三氟甲基或低级烷氧基取代，或其药学上可接受的酸加成盐是 被发现在人和动物治疗中用作中枢神经系统的药物，例如 肌肉松弛剂，抗惊厥药，镇静剂，止痛药等。