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1.发明申请公开(公告)号：US20090275126A1
公开(公告)日：2009-11-05
申请号：US12504717
申请日：2009-07-17
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.
摘要翻译： 公开了针对胰岛素样生长因子I受体（IGF-1R）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。 这些抗体涉及抗肿瘤治疗。
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2.发明授权公开(公告)号：US07378503B2
公开(公告)日：2008-05-27
申请号：US10815449
申请日：2004-04-01
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565
摘要： Antibodies which bind to IGF-IR and inhibit the binding of IGF-I and IGF-II to IGF-IR are characterized. These antibodies are implicated in anti-tumor therapy.
摘要翻译： 表征与IGF-1R结合并抑制IGF-I和IGF-II与IGF-1R结合的抗体。 这些抗体涉及抗肿瘤治疗。
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3.发明授权公开(公告)号：US07572897B2
公开(公告)日：2009-08-11
申请号：US11869250
申请日：2007-10-09
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Antibodies against IGF-IR are implicated in antitumor therapy.
摘要翻译： 公开了针对胰岛素样生长因子I受体（IGF-1R）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。 抗IGF-1R的抗体涉及抗肿瘤治疗。
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4.发明申请公开(公告)号：US20080132686A1
公开(公告)日：2008-06-05
申请号：US11869250
申请日：2007-10-09
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.
摘要翻译： 公开了针对胰岛素样生长因子I受体（IGF-1R）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。 这些抗体涉及抗肿瘤治疗。
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公开(公告)号：US07579157B2
公开(公告)日：2009-08-25
申请号：US10886838
申请日：2004-07-08
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
IPC分类号： G01N33/577
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing the antibodies, and uses for the antibodies are disclosed. Antibodies against IGF-IR are implicated in antitumor therapy.
摘要翻译： 公开了针对胰岛素样生长因子I受体（IGF-1R）的抗体，其制备方法，含有抗体的药物组合物和抗体的用途。 抗IGF-1R的抗体涉及抗肿瘤治疗。
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6.发明申请公开(公告)号：US20050008642A1
公开(公告)日：2005-01-13
申请号：US10886838
申请日：2004-07-08
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vugt
IPC分类号： C07K16/28 , C12N15/13 , A61K39/395 , C07K16/22 , G01N33/53
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.
摘要翻译： 公开了针对胰岛素样生长因子I受体（IGF-1R）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。 这些抗体涉及抗肿瘤治疗。
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公开(公告)号：US20060263356A1
公开(公告)日：2006-11-23
申请号：US11325197
申请日：2006-01-03
申请人： Josef Endl , Maria Fuentes , Yvo Graus , Adelbert Grossmann , Sebastian Neumann , Paul Parren , Frank Rebers , Joerg Regula , Ralf Schumacher , Stefan Seeber , Jan stracke , Kay-Gunnar Stubenrauch , Jan Van De Winkel , Martine Van Vugt , Sandra Vereecken-Verploegen
发明人： Josef Endl , Maria Fuentes , Yvo Graus , Adelbert Grossmann , Sebastian Neumann , Paul Parren , Frank Rebers , Joerg Regula , Ralf Schumacher , Stefan Seeber , Jan stracke , Kay-Gunnar Stubenrauch , Jan Van De Winkel , Martine Van Vugt , Sandra Vereecken-Verploegen
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/06
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/76
摘要： An antibody binding to IL-13Rα1, inhibiting IL-13 bioactivity and comprising a variable heavy and a variable light chain, characterized in that the variable heavy chain amino acid sequence CDR3 of said antibody is selected from the group consisting of the heavy chain CDR3 sequences of SEQ ID NO: 1, 3, 5, 7 or 9 is useful in the treatment of asthma and allergic diseases.
摘要翻译： 与IL-13Rα1结合的抗体，抑制IL-13生物活性并包含可变重链和可变轻链，其特征在于所述抗体的可变重链氨基酸序列CDR3选自重链CDR3序列 的SEQ ID NO：1,3,5,7或9可用于治疗哮喘和过敏性疾病。
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公开(公告)号：US20110070239A1
公开(公告)日：2011-03-24
申请号：US12958278
申请日：2010-12-01
申请人： Joseph Endl , Elsie M. Eugui , Maria Elena Fuentes , Yvo Graus , Aran Frank Labrijn , Martin Lanzendoerfer , Paul Parren , Frank Rebers , Ralf Schumacher , Stefan Seeber , Jan Van De Winkel , Martine Van Vugt
发明人： Joseph Endl , Elsie M. Eugui , Maria Elena Fuentes , Yvo Graus , Aran Frank Labrijn , Martin Lanzendoerfer , Paul Parren , Frank Rebers , Ralf Schumacher , Stefan Seeber , Jan Van De Winkel , Martine Van Vugt
IPC分类号： A61K39/395 , C07H21/04 , C12P21/06 , C12N5/074
CPC分类号： C07K16/2875 , C07K2317/21 , C07K2317/52 , C07K2317/56
摘要： This invention relates to anti-OX40L antibodies and, in particular, to anti-OX40L antibodies and variants thereof that contain a Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from inflammatory diseases.
摘要翻译： 本发明涉及抗OX40L抗体，特别涉及抗OX40L抗体及其变体，其含有源自人源的Fc部分，并且不结合补体因子C1q。 这些抗体具有新的和本发明的性质，为患有炎性疾病的患者带来益处。
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公开(公告)号：US07807158B2
公开(公告)日：2010-10-05
申请号：US11325197
申请日：2006-01-03
申请人： Josef Endl , Maria Elena Fuentes , Yvo Graus , Adelbert Grossmann , Sebastian Neumann , Paul Parren , Frank Rebers , Joerg Thomas Regula , Ralf Schumacher , Stefan Seeber , Jan Olaf Stracke , Kay-Gunnar Stubenrauch , Jan Van De Winkel , Martine Van Vugt , Sandra Vereecken-Verploegen
发明人： Josef Endl , Maria Elena Fuentes , Yvo Graus , Adelbert Grossmann , Sebastian Neumann , Paul Parren , Frank Rebers , Joerg Thomas Regula , Ralf Schumacher , Stefan Seeber , Jan Olaf Stracke , Kay-Gunnar Stubenrauch , Jan Van De Winkel , Martine Van Vugt , Sandra Vereecken-Verploegen
IPC分类号： A61K39/395
CPC分类号： C07K16/2866 , C07K2317/21 , C07K2317/56 , C07K2317/76
摘要： The instant specification discloses an antibody binding to IL-13Rα1, inhibiting IL-13 bioactivity and comprising a variable heavy and a variable light chain, characterized in that the variable heavy chain amino acid sequence CDR3 of this antibody is selected from the group consisting of the heavy chain CDR3 sequences of SEQ ID NO: 1, 3, 5, 7 or 9, and this antibody is useful in the treatment of asthma and allergic diseases.
摘要翻译： 本说明书公开了结合IL-13Rα1的抗体，抑制IL-13生物活性并包含可变重链和可变轻链，其特征在于该抗体的可变重链氨基酸序列CDR3选自 SEQ ID NO：1,3,5,7或9的重链CDR3序列，该抗体可用于治疗哮喘和过敏性疾病。
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公开(公告)号：US07501496B1
公开(公告)日：2009-03-10
申请号：US11229162
申请日：2005-09-16
申请人： Joseph Endl , Elsie M. Eugui , Maria Elena Fuentes , Yvo Graus , Aran Frank Labrijn , Martin Lanzendoerfer , Paul Parren , Frank Rebers , Ralf Schumacher , Stefan Seeber , Jan Van De Winkel , Martine Van Vugt
发明人： Joseph Endl , Elsie M. Eugui , Maria Elena Fuentes , Yvo Graus , Aran Frank Labrijn , Martin Lanzendoerfer , Paul Parren , Frank Rebers , Ralf Schumacher , Stefan Seeber , Jan Van De Winkel , Martine Van Vugt
IPC分类号： C07K16/00 , C07K16/28 , A61K39/395
CPC分类号： C07K16/2875 , C07K2317/21 , C07K2317/52 , C07K2317/56
摘要： This invention relates to anti-OX40L antibodies and, in particular, to anti-OX40L antibodies and variants thereof that contain a Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from inflammatory diseases.
摘要翻译： 本发明涉及抗OX40L抗体，特别涉及抗OX40L抗体及其变体，其含有源自人源的Fc部分，并且不结合补体因子C1q。 这些抗体具有新的和本发明的性质，为患有炎性疾病的患者带来益处。
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