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1.发明申请公开(公告)号：US20050008642A1
公开(公告)日：2005-01-13
申请号：US10886838
申请日：2004-07-08
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vugt
IPC分类号： C07K16/28 , C12N15/13 , A61K39/395 , C07K16/22 , G01N33/53
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.
摘要翻译： 公开了针对胰岛素样生长因子I受体（IGF-1R）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。 这些抗体涉及抗肿瘤治疗。
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2.发明申请公开(公告)号：US20090275126A1
公开(公告)日：2009-11-05
申请号：US12504717
申请日：2009-07-17
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.
摘要翻译： 公开了针对胰岛素样生长因子I受体（IGF-1R）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。 这些抗体涉及抗肿瘤治疗。
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3.发明授权公开(公告)号：US07378503B2
公开(公告)日：2008-05-27
申请号：US10815449
申请日：2004-04-01
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
CPC分类号： C07K16/2863 , A61K2039/505 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565
摘要： Antibodies which bind to IGF-IR and inhibit the binding of IGF-I and IGF-II to IGF-IR are characterized. These antibodies are implicated in anti-tumor therapy.
摘要翻译： 表征与IGF-1R结合并抑制IGF-I和IGF-II与IGF-1R结合的抗体。 这些抗体涉及抗肿瘤治疗。
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4.发明授权公开(公告)号：US07572897B2
公开(公告)日：2009-08-11
申请号：US11869250
申请日：2007-10-09
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
IPC分类号： C07K16/28
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Antibodies against IGF-IR are implicated in antitumor therapy.
摘要翻译： 公开了针对胰岛素样生长因子I受体（IGF-1R）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。 抗IGF-1R的抗体涉及抗肿瘤治疗。
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5.发明申请公开(公告)号：US20080132686A1
公开(公告)日：2008-06-05
申请号：US11869250
申请日：2007-10-09
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing said antibodies, and uses for such antibodies are disclosed. Such antibodies are implicated in antitumor therapy.
摘要翻译： 公开了针对胰岛素样生长因子I受体（IGF-1R）的抗体，其制备方法，含有所述抗体的药物组合物及其用途。 这些抗体涉及抗肿瘤治疗。
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公开(公告)号：US07579157B2
公开(公告)日：2009-08-25
申请号：US10886838
申请日：2004-07-08
申请人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
发明人： Yvo Graus , Erhard Kopetzki , Klaus-Peter Kuenkele , Olaf Mundigl , Paul Parren , Frank Rebers , Ralf Schumacher , Jan van de Winkel , Martine Vriesema-van Vugt
IPC分类号： G01N33/577
CPC分类号： C07K16/2863 , A61K2039/505 , C07K16/2896 , C07K2317/73
摘要： Antibodies against insulin like growth factor I receptor (IGF-IR), methods for their production, pharmaceutical compositions containing the antibodies, and uses for the antibodies are disclosed. Antibodies against IGF-IR are implicated in antitumor therapy.
摘要翻译： 公开了针对胰岛素样生长因子I受体（IGF-1R）的抗体，其制备方法，含有抗体的药物组合物和抗体的用途。 抗IGF-1R的抗体涉及抗肿瘤治疗。
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公开(公告)号：US20050226876A1
公开(公告)日：2005-10-13
申请号：US11102403
申请日：2005-04-08
申请人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
发明人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
CPC分类号： C07K16/2854 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
摘要翻译： 本发明涉及抗P-选择素抗体，特别涉及含有源自人源的Fc部分并且不结合补体因子C1q的抗P-选择素抗体及其变体。 这些抗体具有新的和本发明的性质，为患有严重肢体缺血或外周动脉闭塞性疾病（CLI / PAOD）的患者带来益处。
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8.发明授权Methods of inhibiting the binding of P-selectin to PSGL-1 with anti-P-selectin antibodies 有权用抗P-选择蛋白抗体抑制P-选择素与PSGL-1结合的方法公开(公告)号：US07824684B2
公开(公告)日：2010-11-02
申请号：US12768150
申请日：2010-04-27
申请人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
发明人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
IPC分类号： A61K39/395 , C07K16/28
CPC分类号： C07K16/2854 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
摘要翻译： 本发明涉及抗P-选择素抗体，特别涉及含有源自人源的Fc部分并且不结合补体因子C1q的抗P-选择素抗体及其变体。 这些抗体具有新的和本发明的性质，为患有严重肢体缺血或外周动脉闭塞性疾病（CLI / PAOD）的患者带来益处。
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公开(公告)号：USRE44359E1
公开(公告)日：2013-07-09
申请号：US13471899
申请日：2012-05-15
申请人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Braemer , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
发明人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Braemer , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
CPC分类号： C07K16/2854 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
摘要翻译： 本发明涉及抗P-选凝素抗体，特别涉及含有源自人源的Fc部分并且不结合补体因子C1q的抗P-选择蛋白抗体及其变体。 这些抗体具有新的和本发明的性质，为患有严重肢体缺血或外周动脉闭塞性疾病（CLI / PAOD）的患者带来益处。
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公开(公告)号：US20090311779A1
公开(公告)日：2009-12-17
申请号：US12481623
申请日：2009-06-10
申请人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
发明人： Yvo Graus , Jacques Himber , Miranda Jansen-Molenaar , Dorothee Kling , Erhard Kopetzki , Paul Parren , Frank Rebers , Beat Steiner , Anne Stern , Pamela Strein , Kay-Gunnar Stubenrauch , Jan van de Winkel , Martine van Vugt
CPC分类号： C07K16/2854 , C07K2317/21 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92 , Y10S435/81
摘要： This invention relates to anti-P-selectin antibodies and, in particular, to anti-P-selectin antibodies and variants thereof that contain an Fc part derived from human origin and do not bind complement factor C1q. These antibodies have new and inventive properties causing a benefit for a patient suffering from critical limb ischemia or peripheral arterial occlusive disease (CLI/PAOD).
摘要翻译： 本发明涉及抗P-选择素抗体，特别涉及含有源自人源的Fc部分并且不结合补体因子C1q的抗P-选择素抗体及其变体。 这些抗体具有新的和本发明的性质，为患有严重肢体缺血或外周动脉闭塞性疾病（CLI / PAOD）的患者带来益处。
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