利索-全球专利检索

  1. 登录
  2. 注册

搜索结果

6 条记录 (耗时 0.012 秒)

    Fidaxomicin purification method
    3.
    发明授权
    Fidaxomicin purification method 有权

    公开(公告)号：US10316052B2

    公开(公告)日：2019-06-11

    申请号：US15324555

    申请日：2015-07-07

    申请人： ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.

    发明人： Huijun Ren ,  Daochao Li ,  Xuexiao Ying ,  Feng Chen ,  Linghui Zheng ,  Lingping Wang ,  Hua Bai

    IPC分类号： C07H1/06 ,  C07H17/08 ,  C12P19/62

    摘要： A fidaxomicin purification method, comprising: fermenting Actinoplanes sp. HS-16-20 to generate fermented liquid; conducting solid/liquid separation on the fermented liquid, soaking mycelium in an organic solvent, and filtering to obtain a solution containing fidaxomicin; treating the solution with nanofiltration concentrate, and separating to obtain fidaxomicin crude product; conducting preparative column chromatography on the fidaxomicin crude product, eluting with an acid aqueous solution containing an organic solvent, and separating to obtain the refined fidaxomicin product.

    METHOD FOR PREPARING HIGHLY PURE DOXORUBICIN
    5.
    发明申请
    METHOD FOR PREPARING HIGHLY PURE DOXORUBICIN 审中-公开
    制备高纯度多摩霉素的方法

    公开(公告)号：US20150299241A1

    公开(公告)日：2015-10-22

    申请号：US14646202

    申请日：2013-10-25

    申请人： ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.

    发明人： Hua Chen ,  Zhiqiang Li ,  Linghui Zheng ,  Shuyi Lu ,  Wei Yan ,  Feng Chen ,  Lingping Wang ,  Hua Bai

    IPC分类号： C07H1/06 ,  C07H15/252

    CPC分类号： C07H1/06 ,  C07H15/252

    摘要： The present invention relates to a method for preparing highly pure doxorubicin. The method comprises the following steps: (1) chromatographing a prepurified doxorubicin solution by using macroporous resin, pre-washing the chromatographed system by using an acidic low concentration aqueous organic solvent, and performing elution by using an acidic high concentration aqueous organic solvent; (2) performing chromatographic separation on eluted components by using a preparative column, so that a highly pure doxorubicin component can be obtained, and the doxorubicin can, if needed, be separated from the aqueous solution by using conventional concentration and crystallization methods in the prior art. The present invention has the advantages such as simplicity, high yield, low cost, and less environmental pollution. The content of the prepared doxorubicin is greater than 99.5%, the content of each impurity is controlled to be lower than 0.10%, and the USP and EP standards are met.

    摘要翻译： 本发明涉及制备高纯度多柔比星的方法。 该方法包括以下步骤：（1）通过使用大孔树脂对预纯化的多柔比星溶液进行色谱分离，使用酸性低浓度有机有机溶剂对色谱系统进行预洗涤，并使用酸性高浓度有机有机溶剂进行洗脱; （2）使用制备柱对洗脱成分进行色谱分离，从而可以获得高纯度的多柔比星组分，如果需要，可以通过使用常规的浓缩和结晶方法将多柔比星与水溶液分离 艺术。 本发明具有简单，成品率高，成本低，环境污染少等优点。 制备的多柔比星的含量大于99.5％，每种杂质的含量控制在0.10％以下，符合USP和EP标准。