公开(公告)号：US09982314B2

公开(公告)日：2018-05-29

申请号：US15028577

申请日：2014-10-14

申请人： ZHEJIANG HISUN PHARMACEUTICAL CO., LTD.

发明人： Hao Xu ,  Fei Tang ,  Peijun Zhan ,  Jianhong Hu ,  Huijun Ren ,  Hongmei Fan ,  Linghui Zheng ,  Hua Bai

IPC分类号： C12N1/20 ,  C12P21/04 ,  C12R1/045 ,  C12P19/62

CPC分类号： C12R1/045 ,  C12N1/20 ,  C12P19/62

摘要： A bacterial strain of Actinoplanes sp. and and the use thereof. The bacterial strain is named Actinoplanes sp. HS-16-20, whose preservation number is CGMCC (China General Microbiological Culture Collection Center) No. 7294. The bacterial strain can be used to generate Fidaxomicin or analogs thereof or compositions containing Fidaxomicin, such as by aerobically fermenting the strain in nutrient medium containing assimilable carbon and/or nitrogen sources. Fidaxomicin has an inhibitory effect on various gram positive bacteria pathogens, and in particular, on Clostridium difficile.