专利检索 ap:("Zacharia Cheruvallath" OR "Colin Loweth" OR "Ruth Nutt" OR "Darryl Rideout" OR "Joseph Semple" OR "Jing Wang" OR "Feiyue Wu" OR "Shankari Mylvaganam" OR "Hengyi Zhu" OR "Jianzhong Sun") AND inv:"Feiyue Wu" 第 1 页

1.

发明申请
Thiazole and thiadiazole inhibitors of tyrosine phosphatases 失效
标题翻译：噻唑和噻二唑抑制剂酪氨酸磷酸酶

公开(公告)号：US20060194768A1

公开(公告)日：2006-08-31

申请号：US11219402

申请日：2005-09-02

申请人： Zacharia Cheruvallath , Colin Loweth , Ruth Nutt , Darryl Rideout , Joseph Semple , Jing Wang , Feiyue Wu , Shankari Mylvaganam , Hengyi Zhu , Jianzhong Sun

发明人： Zacharia Cheruvallath , Colin Loweth , Ruth Nutt , Darryl Rideout , Joseph Semple , Jing Wang , Feiyue Wu , Shankari Mylvaganam , Hengyi Zhu , Jianzhong Sun

IPC分类号： A61K31/426 , A61K31/427 , A61K31/675 , C07D277/38

CPC分类号： C07D277/38 , C07D277/42 , C07D285/135 , C07D417/12 , C07D417/14 , C07F9/6539 , C07F9/65395

摘要： Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.

摘要翻译： 提供化合物和组合物用于调节蛋白酪氨酸磷酸酶的活性。在一个实施方案中，化合物和组合物是抑制蛋白酪氨酸磷酸酶1B活性的噻唑和噻二唑。

2.

发明申请
Trisubstituted nitrogen modulators of tyrosine phosphatases 审中-公开
标题翻译：酪氨酸磷酸酶的三取代氮调节剂

公开(公告)号：US20060135773A1

公开(公告)日：2006-06-22

申请号：US11156230

申请日：2005-06-17

申请人： Joseph Semple , Darryl Rideout , Ruth Nutt , Mark Shenderovich , Jing Wang , Shankari Mylvaganam , Feiyue Wu , Chung Tsai , Venkatachalapathi Yalamoori , Colin Loweth

发明人： Joseph Semple , Darryl Rideout , Ruth Nutt , Mark Shenderovich , Jing Wang , Shankari Mylvaganam , Feiyue Wu , Chung Tsai , Venkatachalapathi Yalamoori , Colin Loweth

IPC分类号： C07F9/06 , C07D207/30 , C07D257/04

CPC分类号： A61K31/66 , C07C311/16 , C07C311/18 , C07C311/19 , C07C311/29 , C07C311/51 , C07C317/32 , C07C2601/04 , C07D207/337 , C07D257/04 , C07D295/26 , C07D333/34 , C07F9/3882 , C07F9/4056 , C07F9/4075 , C07F9/4426 , C07F9/4465 , C07F9/59 , C07F9/6524 , C07F9/65517

摘要： Compounds, compositions and methods are provided for modulating the activity of protein tyrosine phosphatases, including PTP-1B. In one embodiment, the compounds are N,N-dibenzylarylsulfonamides.

摘要翻译： 提供化合物，组合物和方法用于调节蛋白酪氨酸磷酸酶（包括PTP-1B）的活性。在一个实施方案中，化合物是N，N-二苄基芳基磺酰胺。

3.

发明申请
THIAZOLE AND THIADIAZOLE INHIBITORS OF TYROSINE PHOSPHATASES 审中-公开
标题翻译：酪氨酸磷酸酯的噻唑和噻唑唑抑制剂

公开(公告)号：US20080200371A1

公开(公告)日：2008-08-21

申请号：US12057609

申请日：2008-03-28

申请人： Zacharia S. CHERUVALLATH , Colin J. Loweth , Ruth F. Nutt , Darryl Rideout , Joseph E. Semple , Jing Wang , Feiyue Wu , Shankari Mylvaganam , Hengyi Zhu , Jianzhong Sun

发明人： Zacharia S. CHERUVALLATH , Colin J. Loweth , Ruth F. Nutt , Darryl Rideout , Joseph E. Semple , Jing Wang , Feiyue Wu , Shankari Mylvaganam , Hengyi Zhu , Jianzhong Sun

IPC分类号： A61K31/675 , A61K38/28 , A61P3/04 , A61K31/426 , C07D277/38 , A61K31/433 , C07D285/135 , C07F9/28 , A61P7/12 , A61P9/12

CPC分类号： C07D277/38 , C07D277/42 , C07D285/135 , C07D417/12 , C07D417/14 , C07F9/6539 , C07F9/65395

摘要： Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.

摘要翻译： 提供化合物和组合物用于调节蛋白酪氨酸磷酸酶的活性。在一个实施方案中，化合物和组合物是抑制蛋白酪氨酸磷酸酶1B活性的噻唑和噻二唑。

4.

发明授权
Thiazole and thiadiazole inhibitors of tyrosine phosphatases 失效
标题翻译：噻唑和噻二唑抑制剂酪氨酸磷酸酶

公开(公告)号：US07381736B2

公开(公告)日：2008-06-03

申请号：US11219402

申请日：2005-09-02

申请人： Zacharia S. Cheruvallath , Colin J. Loweth , Ruth F. Nutt , Darryl Rideout , Joseph E. Semple , Jing Wang , Feiyue Wu , Shankari Mylvaganam , Hengyi Zhu , Jianzhong Sun

发明人： Zacharia S. Cheruvallath , Colin J. Loweth , Ruth F. Nutt , Darryl Rideout , Joseph E. Semple , Jing Wang , Feiyue Wu , Shankari Mylvaganam , Hengyi Zhu , Jianzhong Sun

IPC分类号： A61K31/427 , C07D277/18

CPC分类号： C07D277/38 , C07D277/42 , C07D285/135 , C07D417/12 , C07D417/14 , C07F9/6539 , C07F9/65395

摘要： Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. In one embodiment, the compounds and compositions are thiazoles and thiadiazoles that inhibit the activity of protein tyrosine phosphatase 1B.

摘要翻译： 提供化合物和组合物用于调节蛋白酪氨酸磷酸酶的活性。在一个实施方案中，化合物和组合物是抑制蛋白酪氨酸磷酸酶1B活性的噻唑和噻二唑。

5.

发明申请
2-Imidazolone and 2-Imidazolidinone Heterocyclic Inhibitors of Tyrosine Phosphatases 审中-公开
标题翻译： 2-咪唑啉酮和2-咪唑啉酮杂环抑制剂酪氨酸磷酸酶

公开(公告)号：US20080070867A1

公开(公告)日：2008-03-20

申请号：US11814239

申请日：2006-01-17

申请人： Zacharia Cheruvallath , Joseph Semple , Vasanthakumar Rajappan , Darryl Rideout , Venkatachalapathi Yalamoori , Chung-Ying Tsai , Feiyue Wu , Lars Thoresen , Mark Shenderovich

发明人： Zacharia Cheruvallath , Joseph Semple , Vasanthakumar Rajappan , Darryl Rideout , Venkatachalapathi Yalamoori , Chung-Ying Tsai , Feiyue Wu , Lars Thoresen , Mark Shenderovich

IPC分类号： A61K31/675 , A61P3/10 , C07F9/02

CPC分类号： C07F9/65583 , C07F9/6506 , C07F9/65068 , C07F9/65586

摘要： Compounds and compositions are provided for modulating the activity of protein tyrosine phosphatases. The compounds for use in the compositions and methods provided herein have formulae (I) Protein tyrosine phosaphatase, including PTB-IB, mediated diseases and disorders include diabetes including Type 1 and Type 2 diabetes (and associated complications such as hypertension, ischemic diseases of the large and small blood vessels, blindness, circulatory problems, kidney failure and atherosclerosis), syndrome X, metabolic syndrome, glucose intolerance, insulin resistance, obesity, cancer, and neurodegenerative diseases.

摘要翻译： 提供化合物和组合物用于调节蛋白酪氨酸磷酸酶的活性。用于本文提供的组合物和方法的化合物具有式（I）蛋白酪氨酸磷酸酶，包括PTB-IB，介导的疾病和病症包括糖尿病，包括1型和2型糖尿病（以及相关并发症，例如高血压，缺血性疾病大，小血管，失明，循环问题，肾功能衰竭和动脉粥样硬化），综合征X，代谢综合征，葡萄糖不耐受，胰岛素抵抗，肥胖，癌症和神经变性疾病。