公开(公告)号：US20070037140A1

公开(公告)日：2007-02-15

申请号：US10556182

申请日：2003-05-09

申请人： Ze Li ,  Yiming Zhou ,  Shengce Tao ,  Jing Cheng ,  Jianwei Wang ,  Tao Hong ,  Yun Cheng ,  Quanzhong Shan

发明人： Ze Li ,  Yiming Zhou ,  Shengce Tao ,  Jing Cheng ,  Jianwei Wang ,  Tao Hong ,  Yun Cheng ,  Quanzhong Shan

IPC分类号： C12Q1/70 ,  C12Q1/68 ,  C12M1/34

CPC分类号： C07H21/00 ,  C12Q1/701

摘要： This invention relates generally to the field of virus detection. In particular, the invention provides chips, probes, primers, kits and methods for amplifying and detecting SARS-CoV nucleotide sequence. The clinical and other uses of the present chips, probes, primers, kits and methods are also contemplated.

摘要翻译： 本发明一般涉及病毒检测领域。 特别地，本发明提供用于扩增和检测SARS-CoV核​​苷酸序列的芯片，探针，引物，试剂盒和方法。 还考虑了本发明芯片，探针，引物，试剂盒和方法的临床和其它用途。

公开(公告)号：US08263562B2

公开(公告)日：2012-09-11

申请号：US13162981

申请日：2011-06-17

申请人： Yun Cheng ,  Ruihe Yu ,  Wanzhou Zhao ,  Jun Zhao ,  Jing Li

发明人： Yun Cheng ,  Ruihe Yu ,  Wanzhou Zhao ,  Jun Zhao ,  Jing Li

IPC分类号： A61K38/08

CPC分类号： A61K38/08

摘要： The application of a peptide having sequence of formula I or its derivant in preparing the medicine for preventing or treating liver damage, especially liver damage and hepatitis C is disclosed, Xaa1-Gln-Xaa2-Xaa3-Thr-Ser-Gly-Xaa4 (formula I) wherein, Xaa1 is deletion, Ala, Gly, Val, Leu or Ile, Xaa2 is Thr or Ser, Xaa3 is Tyr, Phe or Trp, and Xaa4 is deletion, Ala, Gly, Val, Leu, Ile or Pro. The composite medicine containing the said peptide, its preparation method, and the polynucleotide for coding the said peptide are also disclosed.

摘要翻译： Xaa1-Gln-Xaa2-Xaa3-Thr-Ser-Gly-Xaa4（式（I））表示具有式I或其衍生物的肽在制备用于预防或治疗肝损伤，特别是肝损伤和丙型肝炎的药物中的应用 I）其中Xaa1是缺失型，Ala，Gly，Val，Leu或Ile，Xaa2是Thr或Ser，Xaa3是Tyr，Phe或Trp，Xaa4是缺失，Ala，Gly，Val，Leu，Ile或Pro。 还公开了含有所述肽的复合药物及其制备方法和用于编码所述肽的多核苷酸。

公开(公告)号：US09605023B2

公开(公告)日：2017-03-28

申请号：US14742656

申请日：2015-06-17

申请人： Yun Cheng ,  Ruihe Yu

发明人： Yun Cheng ,  Ruihe Yu ,  Hong Li ,  Wanzhou Zhao

IPC分类号： C07K7/06 ,  A61K38/08 ,  A61K38/00

CPC分类号： C07K7/06 ,  A61K38/00 ,  A61K38/08

摘要： The present invention provides an application of an SP peptide or a derivative thereof in preparing medicines for preventing or treating asthma. The peptide or the derivative thereof is the SP peptide shown in Formula I or a pharmaceutically acceptable salt or ester thereof. The present invention also provides a method for treating asthma, the method comprises: administering to a patient with medicine containing the peptide or the derivative thereof with an effective therapeutic dosage. It proves through researches of the present invention that, the peptide or the derivative thereof can effectively alleviate pathological symptoms of asthma, especially pathological symptoms of allergic asthma. In the formula (I), Xaa1 is deletion, Ala, Gly, Val, Leu or Ile; Xaa2 is Thr or Ser; Xaa3 is Tyr, Phe or Trp; and Xaa4 is deletion, Ala, Gly, Val, Leu, Ile or Pro. Xaa1-Gln-Xaa2-Xaa3-Thr-Ser-Gly-Xaa4  (Formula I)

公开(公告)号：US07985734B2

公开(公告)日：2011-07-26

申请号：US12066636

申请日：2006-06-01

申请人： Yun Cheng ,  Ruihe Yu ,  Wan Zhou Zhao ,  Jun Zhao ,  Jing Li

发明人： Yun Cheng ,  Ruihe Yu ,  Wan Zhou Zhao ,  Jun Zhao ,  Jing Li

IPC分类号： A61K38/08

CPC分类号： A61K38/08

摘要： The application of a peptide having sequence of formula I or its derivant in preparing the medicine for preventing or treating liver damage, especially liver damage and hepatitis C is disclosed, Xaa1-Gln-Xaa2-Xaa3-Thr-Ser-Gly-Xaa4 (formula I) wherein, Xaa1 is deletion, Ala, Gly, Val, Leu or Ile, Xaa2 is Thr or Ser, Xaa3 is Tyr, Phe or Trp, and Xaa4 is deletion, Ala, Gly, Val, Leu, Ile or Pro. The composite medicine containing the said peptide, its preparation method, and the polynucleotide for coding the said peptide are also disclosed.

摘要翻译： Xaa1-Gln-Xaa2-Xaa3-Thr-Ser-Gly-Xaa4（式（I））表示具有式I或其衍生物的肽在制备用于预防或治疗肝损伤，特别是肝损伤和丙型肝炎的药物中的应用 I）其中Xaa1是缺失型，Ala，Gly，Val，Leu或Ile，Xaa2是Thr或Ser，Xaa3是Tyr，Phe或Trp，Xaa4是缺失，Ala，Gly，Val，Leu，Ile或Pro。 还公开了含有所述肽的复合药物及其制备方法和用于编码所述肽的多核苷酸。

公开(公告)号：US20080227723A1

公开(公告)日：2008-09-18

申请号：US12066636

申请日：2006-06-01

申请人： Yun Cheng ,  Rui He Yu ,  Wan Zhou Zhao ,  Jun Zhao ,  Jing Li

发明人： Yun Cheng ,  Rui He Yu ,  Wan Zhou Zhao ,  Jun Zhao ,  Jing Li

IPC分类号： A61K38/08 ,  A61P1/16

CPC分类号： A61K38/08

摘要： The application of a peptide having sequence of formula I or its derivant in preparing the medicine for preventing or treating liver damage, especially liver damage and hepatitis C is disclosed, Xaa1-Gln-Xaa2-Xaa3-Thr-Ser-Gly-Xaa4 (formula I) wherein, Xaa1 is deletion, Ala,Gly,Val,Leu or Ile, Xaa2 is Thr or Ser, Xaa3 is Tyr, Phe or Trp, and Xaa4 is deletion, Ala, Gly, Val, Leu,Ile or Pro. The composite medicine containing the said peptide, its preparation method, and the polynucleotide for coding the said peptide are also disclosed.

摘要翻译： Xaa1-Gln-Xaa2-Xaa3-Thr-Ser-Gly-Xaa4（式（I））表示具有式I或其衍生物的肽在制备用于预防或治疗肝损伤，特别是肝损伤和丙型肝炎的药物中的应用 I）其中Xaa1是缺失型，Ala，Gly，Val，Leu或Ile，Xaa2是Thr或Ser，Xaa3是Tyr，Phe或Trp，Xaa4是缺失，Ala，Gly，Val，Leu，Ile或Pro。 还公开了含有所述肽的复合药物及其制备方法和用于编码所述肽的多核苷酸。