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公开(公告)号：US06461867B1
公开(公告)日：2002-10-08
申请号：US08913612
申请日：1997-09-08
申请人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per A. Peterson , Alain Luxembourg , Didier J. Leturcq , Ann M. Moriarty
发明人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per A. Peterson , Alain Luxembourg , Didier J. Leturcq , Ann M. Moriarty
IPC分类号： C12N506
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： Materials and methods of activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a synthetic antigen presenting matrix for activating T lymphocytes to a specific peptide is described.
摘要翻译： 描述了对特定抗原肽具有特异性活化T淋巴细胞的材料和方法，以及活体T淋巴细胞在体外用于治疗各种疾病状况的用途。 特别地，描述了用于将T淋巴细胞活化到特定肽的合成抗原呈递基质。
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公开(公告)号：US06255073B1
公开(公告)日：2001-07-03
申请号：US09039762
申请日：1998-03-16
IPC分类号： C12P2100
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： Materials and methods of activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, fragments of cells for activating T lymphocytes to a specific peptide are described.
摘要翻译： 描述了对特定抗原肽具有特异性活化T淋巴细胞的材料和方法，以及活体T淋巴细胞在体外用于治疗各种疾病状况的用途。 特别地，描述了用于将T淋巴细胞激活到特定肽的细胞片段。
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公开(公告)号：US06251627B1
公开(公告)日：2001-06-26
申请号：US09039641
申请日：1998-03-16
IPC分类号： C12P2100
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： The present invention relates to methods for producing synthetic matrix for activating T lymphocytes.
摘要翻译： 本发明涉及生产用于激活T淋巴细胞的合成基质的方法。
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公开(公告)号：US06225042B1
公开(公告)日：2001-05-01
申请号：US09039982
申请日：1998-03-16
IPC分类号： A01N102
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： The present invention relates to methods for activating T lymphocytes using a synthetic matrix, and for specifically activating T lymphocytes reactive to a specific peptide.
摘要翻译： 本发明涉及使用合成基质激活T淋巴细胞的方法，并且用于特异性激活对特定肽具有反应性的T淋巴细胞。
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公开(公告)号：US06828150B2
公开(公告)日：2004-12-07
申请号：US10266463
申请日：2002-10-08
申请人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per A. Peterson , Alain Luxembourg , Didier J. Leturcq , Ann M. Moriarty
发明人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per A. Peterson , Alain Luxembourg , Didier J. Leturcq , Ann M. Moriarty
IPC分类号： C12N500
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8+ T-cells to produce cytokines and become cytotoxic.
摘要翻译： 本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。 一种这样的基质是已被转染以产生MHC抗原呈递分子并辅助分子如共刺激分子的细胞。 该基质可用于激活CD8 + T细胞以产生细胞因子并变成细胞毒性。
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6.发明授权公开(公告)号：US06362001B1
公开(公告)日：2002-03-26
申请号：US09042492
申请日：1998-03-16
IPC分类号： C12N1563
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： Materials and methods of activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a method for producing a synthetic antigen presenting drosophila cell line for activating T lymphocytes to a specific peptide is described.
摘要翻译： 描述了对特定抗原肽具有特异性活化T淋巴细胞的材料和方法，以及活体T淋巴细胞在体外用于治疗各种疾病状况的用途。 特别地，描述了一种用于产生用于将T淋巴细胞活化到特定肽的呈现果蝇细胞系的合成抗原的方法。
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公开(公告)号：US20050152916A1
公开(公告)日：2005-07-14
申请号：US11005750
申请日：2004-12-07
申请人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per Peterson , Alain Luxembourg , Didier Leturcq , Ann Moriarty
发明人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per Peterson , Alain Luxembourg , Didier Leturcq , Ann Moriarty
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07K14/025 , C07K14/145 , C07K14/705 , C07K14/74 , C12N5/07 , C12N5/0783 , C12N5/10 , C12N15/12 , C12N15/85 , C12P21/02
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8+ T-cells to produce cytokines and become cytotoxic.
摘要翻译： 本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。 一种这样的基质是已被转染以产生MHC抗原呈递分子并辅助分子如共刺激分子的细胞。 该基质可用于激活CD8 + T细胞以产生细胞因子并变成细胞毒性。
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