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公开(公告)号：US06461867B1
公开(公告)日：2002-10-08
申请号：US08913612
申请日：1997-09-08
申请人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per A. Peterson , Alain Luxembourg , Didier J. Leturcq , Ann M. Moriarty
发明人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per A. Peterson , Alain Luxembourg , Didier J. Leturcq , Ann M. Moriarty
IPC分类号： C12N506
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： Materials and methods of activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a synthetic antigen presenting matrix for activating T lymphocytes to a specific peptide is described.
摘要翻译： 描述了对特定抗原肽具有特异性活化T淋巴细胞的材料和方法，以及活体T淋巴细胞在体外用于治疗各种疾病状况的用途。 特别地，描述了用于将T淋巴细胞活化到特定肽的合成抗原呈递基质。
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公开(公告)号：US06255073B1
公开(公告)日：2001-07-03
申请号：US09039762
申请日：1998-03-16
IPC分类号： C12P2100
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： Materials and methods of activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, fragments of cells for activating T lymphocytes to a specific peptide are described.
摘要翻译： 描述了对特定抗原肽具有特异性活化T淋巴细胞的材料和方法，以及活体T淋巴细胞在体外用于治疗各种疾病状况的用途。 特别地，描述了用于将T淋巴细胞激活到特定肽的细胞片段。
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公开(公告)号：US06251627B1
公开(公告)日：2001-06-26
申请号：US09039641
申请日：1998-03-16
IPC分类号： C12P2100
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： The present invention relates to methods for producing synthetic matrix for activating T lymphocytes.
摘要翻译： 本发明涉及生产用于激活T淋巴细胞的合成基质的方法。
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公开(公告)号：US06225042B1
公开(公告)日：2001-05-01
申请号：US09039982
申请日：1998-03-16
IPC分类号： A01N102
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： The present invention relates to methods for activating T lymphocytes using a synthetic matrix, and for specifically activating T lymphocytes reactive to a specific peptide.
摘要翻译： 本发明涉及使用合成基质激活T淋巴细胞的方法，并且用于特异性激活对特定肽具有反应性的T淋巴细胞。
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公开(公告)号：US06828150B2
公开(公告)日：2004-12-07
申请号：US10266463
申请日：2002-10-08
申请人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per A. Peterson , Alain Luxembourg , Didier J. Leturcq , Ann M. Moriarty
发明人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per A. Peterson , Alain Luxembourg , Didier J. Leturcq , Ann M. Moriarty
IPC分类号： C12N500
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8+ T-cells to produce cytokines and become cytotoxic.
摘要翻译： 本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。 一种这样的基质是已被转染以产生MHC抗原呈递分子并辅助分子如共刺激分子的细胞。 该基质可用于激活CD8 + T细胞以产生细胞因子并变成细胞毒性。
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6.发明授权公开(公告)号：US06362001B1
公开(公告)日：2002-03-26
申请号：US09042492
申请日：1998-03-16
IPC分类号： C12N1563
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： Materials and methods of activating T lymphocytes with specificity for particular antigenic peptides are described, as well as the use of activated T lymphocytes in vitro for the treatment of a variety of disease conditions. In particular, a method for producing a synthetic antigen presenting drosophila cell line for activating T lymphocytes to a specific peptide is described.
摘要翻译： 描述了对特定抗原肽具有特异性活化T淋巴细胞的材料和方法，以及活体T淋巴细胞在体外用于治疗各种疾病状况的用途。 特别地，描述了一种用于产生用于将T淋巴细胞活化到特定肽的呈现果蝇细胞系的合成抗原的方法。
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公开(公告)号：US20050152916A1
公开(公告)日：2005-07-14
申请号：US11005750
申请日：2004-12-07
申请人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per Peterson , Alain Luxembourg , Didier Leturcq , Ann Moriarty
发明人： Zeling Cai , Jonathan Sprent , Anders Brunmark , Michael Jackson , Per Peterson , Alain Luxembourg , Didier Leturcq , Ann Moriarty
IPC分类号： C12N15/09 , A61K35/14 , A61K38/00 , A61K39/00 , A61K48/00 , A61P35/00 , C07K14/025 , C07K14/145 , C07K14/705 , C07K14/74 , C12N5/07 , C12N5/0783 , C12N5/10 , C12N15/12 , C12N15/85 , C12P21/02
CPC分类号： C12N5/0601 , A61K38/00 , A61K2039/5158 , C07K14/005 , C07K14/70503 , C07K14/70539 , C12N5/0636 , C12N15/85 , C12N2501/50 , C12N2501/51 , C12N2502/50 , C12N2502/99 , C12N2760/16122 , C12N2760/18822 , C12N2760/20222 , C12N2830/002 , C12N2830/75 , C12N2830/80 , Y10S530/812 , Y10S530/827
摘要： The present invention relates to synthetic antigen-presenting matrices, their methods of making and their methods of use. One such matrix is cells that have been transfected to produce MHC antigen-presenting molecules and assisting molecules such as co-stimulatory molecules. The matrices can be used to activate CD8+ T-cells to produce cytokines and become cytotoxic.
摘要翻译： 本发明涉及合成抗原呈递矩阵，其制备方法及其使用方法。 一种这样的基质是已被转染以产生MHC抗原呈递分子并辅助分子如共刺激分子的细胞。 该基质可用于激活CD8 + T细胞以产生细胞因子并变成细胞毒性。
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8.发明申请Methods for Improving Immune Function and Methods for Prevention or Treatment of Disease in a Mammalian Subject 审中-公开提高免疫功能的方法和哺乳动物疾病预防或治疗方法公开(公告)号：US20100310501A1
公开(公告)日：2010-12-09
申请号：US12279264
申请日：2007-02-16
申请人： Onur Boyman , Charles D. Surh , Jonathan Sprent , Mark Rubinstein , Marek Kovar
发明人： Onur Boyman , Charles D. Surh , Jonathan Sprent , Mark Rubinstein , Marek Kovar
IPC分类号： A61K38/20 , C07K16/24 , A61K38/19 , A61K38/21 , A61P17/06 , A61P19/02 , A61P3/10 , A61P29/00 , A61P11/06 , A61P37/08 , A61P37/00 , A61P35/02 , A61P35/00 , A61P37/04
CPC分类号： A61K39/3955 , A61K38/2013 , C07K16/244 , C07K16/246 , C07K2317/54 , C07K2317/74 , C07K2319/30 , C12N2760/10011
摘要： A method for increasing a biological activity of a cytokine or lymphokine and a method of treating a neoplastic disease, autoimmune disease, or infectious disease, and a method for expanding a hematopoietic cell population, is provided by administering an antibody capable of binding a cytokine or by administering a cytokine complexed with an antibody or by administering a cytokine complexed with a cytokine receptor to a mammalian subject in need thereof.
摘要翻译： 提供一种增加细胞因子或淋巴因子的生物学活性的方法和治疗肿瘤性疾病，自身免疫性疾病或感染性疾病的方法以及扩增造血细胞群体的方法，是通过施用能够结合细胞因子的抗体或 通过施用与抗体复合的细胞因子或通过向与需要的哺乳动物受试者施用与细胞因子受体复合的细胞因子。
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9.发明申请Methods for Improving Immune Function and Methods for Prevention or Treatment of Disease in a Mammalian Subject 审中-公开提高免疫功能的方法和哺乳动物疾病预防或治疗方法公开(公告)号：US20130142755A1
公开(公告)日：2013-06-06
申请号：US13533784
申请日：2012-06-26
申请人： Onur Boyman , Charles D. Surh , Jonathan Sprent , Mark Rubinstein , Marek Kovar
发明人： Onur Boyman , Charles D. Surh , Jonathan Sprent , Mark Rubinstein , Marek Kovar
IPC分类号： A61K39/395 , A61K38/20
CPC分类号： A61K39/3955 , A61K38/2013 , C07K16/244 , C07K16/246 , C07K2317/54 , C07K2317/74 , C07K2319/30 , C12N2760/10011
摘要： A method for increasing a biological activity of a cytokine or lymphokine and a method of treating a neoplastic disease, autoimmune disease, or infectious disease, and a method for expanding a hematopoietic cell population, is provided by administering an antibody capable of binding a cytokine or by administering a cytokine complexed with an antibody or by administering a cytokine complexed with a cytokine receptor to a mammalian subject in need thereof.
摘要翻译： 提供一种增加细胞因子或淋巴因子的生物学活性的方法和治疗肿瘤性疾病，自身免疫性疾病或感染性疾病的方法以及扩增造血细胞群体的方法，是通过施用能够结合细胞因子的抗体或 通过施用与抗体复合的细胞因子或通过向与需要的哺乳动物受试者施用与细胞因子受体复合的细胞因子。
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