公开(公告)号：US20050038104A1

公开(公告)日：2005-02-17

申请号：US10902562

申请日：2004-07-29

申请人： Zhidong Chen ,  John Ginn ,  Eugene Hickey ,  Weimin Liu ,  Can Mao ,  Tina Morwick ,  Peter Nemoto ,  Denice Spero ,  Sanxing Sun

发明人： Zhidong Chen ,  John Ginn ,  Eugene Hickey ,  Weimin Liu ,  Can Mao ,  Tina Morwick ,  Peter Nemoto ,  Denice Spero ,  Sanxing Sun

IPC分类号： A61K31/38 ,  A61P29/00 ,  C07D333/70 ,  C07D409/04 ,  C07D409/14 ,  C07D409/02 ,  C07D333/72

CPC分类号： C07D409/04 ,  A61K31/38 ,  C07D333/70 ,  C07D409/14

摘要： Disclosed are compounds of the formula I shown below, wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds.

摘要翻译： 公开了下文所示的式I化合物，其中R1，R2，R3和R4如本文所述，其作为抗炎剂是有活性的。 还公开了使用和制备这些化合物的方法。

公开(公告)号：US06974870B2

公开(公告)日：2005-12-13

申请号：US10730172

申请日：2003-12-06

申请人： Charles L. Cywin ,  Can Mao ,  Jonathan Emeigh ,  Roman Wolfgang Fleck ,  Ming-Hong Hao ,  Eugene Hickey ,  Weimin Liu ,  Daniel Richard Marshall ,  Tina Morwick ,  Peter Nemoto ,  Ronald John Sorcek ,  Sanxing Sun ,  Jiang-Ping Wu ,  Erick Young ,  Darren DiSalvo ,  John Ginn ,  Pier Cirillo

发明人： Charles L. Cywin ,  Can Mao ,  Jonathan Emeigh ,  Roman Wolfgang Fleck ,  Ming-Hong Hao ,  Eugene Hickey ,  Weimin Liu ,  Daniel Richard Marshall ,  Tina Morwick ,  Peter Nemoto ,  Ronald John Sorcek ,  Sanxing Sun ,  Jiang-Ping Wu ,  Erick Young ,  Darren DiSalvo ,  John Ginn ,  Pier Cirillo

IPC分类号： A61K31/38 ,  A61K31/435 ,  C07D495/04 ,  A61K31/4365 ,  A61K31/497 ,  A61K31/5377

CPC分类号： A61K31/38 ,  A61K31/435 ,  C07D495/04

摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.

公开(公告)号：US07329764B2

公开(公告)日：2008-02-12

申请号：US10902562

申请日：2004-07-29

申请人： Zhidong Chen ,  John David Ginn ,  Eugene Richard Hickey ,  Weimin Liu ,  Can Mao ,  Tina Marie Morwick ,  Peter Allen Nemoto ,  Denice Spero ,  Sanxing Sun

发明人： Zhidong Chen ,  John David Ginn ,  Eugene Richard Hickey ,  Weimin Liu ,  Can Mao ,  Tina Marie Morwick ,  Peter Allen Nemoto ,  Denice Spero ,  Sanxing Sun

IPC分类号： C07D333/00 ,  A61K31/38

CPC分类号： C07D409/04 ,  A61K31/38 ,  C07D333/70 ,  C07D409/14

摘要： Disclosed are compounds of the formula I shown below, wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds

摘要翻译： 公开了下文所示的式I化合物，其中R1，R2，R3和R4如本文所述，其作为抗炎剂是有活性的。 还公开了使用和制备这些化合物的方法

公开(公告)号：US20110034512A1

公开(公告)日：2011-02-10

申请号：US12937378

申请日：2009-04-23

申请人： Darren Disalvo ,  Daniel Kuzmich ,  Can Mao ,  Hossein Razavi ,  Christopher Sarko ,  Alan David Swinamer ,  David Smith Thomson ,  Qiang Zhang

发明人： Darren Disalvo ,  Daniel Kuzmich ,  Can Mao ,  Hossein Razavi ,  Christopher Sarko ,  Alan David Swinamer ,  David Smith Thomson ,  Qiang Zhang

IPC分类号： A61K31/416 ,  C07D231/56 ,  A61K31/4439 ,  C07D401/02 ,  A61K31/454 ,  A61P1/00 ,  A61P19/02 ,  A61P11/06 ,  A61P13/12 ,  A61P25/28 ,  A61P3/10 ,  A61P37/00

CPC分类号： C07D231/56 ,  C07D401/12

摘要： Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

公开(公告)号：US08546442B2

公开(公告)日：2013-10-01

申请号：US13328199

申请日：2011-12-16

申请人： Rajashekhar Betageri ,  Brian Nicholas Cook ,  Darren DiSalvo ,  Christian Harcken ,  Daniel Kuzmich ,  Pingrong Liu ,  John Lord ,  Can Mao ,  Hossein Razavi

发明人： Rajashekhar Betageri ,  Brian Nicholas Cook ,  Darren DiSalvo ,  Christian Harcken ,  Daniel Kuzmich ,  Pingrong Liu ,  John Lord ,  Can Mao ,  Hossein Razavi

IPC分类号： A01N43/56 ,  A01N43/42 ,  A61K31/415 ,  A61K31/44 ,  C07D231/54 ,  C07D487/02

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

摘要翻译： 公开了式（I）化合物，其可用于治疗通过包括自身免疫疾病如类风湿性关节炎和多发性硬化的CCR1的活性介导或持续的多种疾病和病症。 还公开了制备方法和使用方法。

公开(公告)号：US08293917B2

公开(公告)日：2012-10-23

申请号：US12990248

申请日：2009-05-01

申请人： Brian Nicholas Cook ,  Christian Harcken ,  Thomas Wei-Ho Lee ,  Pingrong Liu ,  Jord Lord ,  Can Mao ,  Wang Mao ,  Brian Christopher Raudenbush ,  Hossein Razavi ,  Christopher Ronald Sarko ,  Alen David Swinamer

发明人： Brian Nicholas Cook ,  Christian Harcken ,  Thomas Wei-Ho Lee ,  Pingrong Liu ,  Jord Lord ,  Can Mao ,  Wang Mao ,  Brian Christopher Raudenbush ,  Hossein Razavi ,  Christopher Ronald Sarko ,  Alen David Swinamer

IPC分类号： C07D401/00 ,  A61K31/44

CPC分类号： C07D401/12 ,  C07D231/14 ,  C07D405/14 ,  C07D417/12

摘要： Disclosed are compounds of the formula (I) which block the interaction of CCR1 and its ligands and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 公开了式（I）的化合物，其阻断CCR1及其配体的相互作用，因此可用于治疗通过CCR1的活性介导或维持的多种疾病和病症，包括自身免疫疾病，例如类风湿性关节炎和多发性 硬化。 还公开了包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

公开(公告)号：US09056858B2

公开(公告)日：2015-06-16

申请号：US13499939

申请日：2010-10-19

申请人： Brian Nicholas Cook ,  Daniel Kuzmich ,  Can Mao ,  Hossein Razavi

发明人： Brian Nicholas Cook ,  Daniel Kuzmich ,  Can Mao ,  Hossein Razavi

IPC分类号： C07D401/12 ,  A61K31/5377 ,  A61K31/4439 ,  A61K31/437 ,  C07D213/62 ,  C07D471/04

CPC分类号： C07D401/12 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/5377 ,  C07D213/62 ,  C07D471/04

摘要： Disclosed are CCR1 receptor antagonists of the formula (I) wherein Ar1, Ar2, R1, X and G are disclosed herein. Also disclosed are compositions, methods of making and using compounds of the formula (I).

摘要翻译： 公开了式（I）的CCR1受体拮抗剂，其中本文公开了Ar1，Ar2，R1，X和G。 还公开了制备和使用式（I）化合物的组合物，方法。

公开(公告)号：US08263597B2

公开(公告)日：2012-09-11

申请号：US13184855

申请日：2011-07-18

申请人： Daniel Kuzmich ,  Can Mao ,  Alan David Swinamer ,  David Smith Thomson

发明人： Daniel Kuzmich ,  Can Mao ,  Alan David Swinamer ,  David Smith Thomson

IPC分类号： A61K31/416 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/5377 ,  C07D401/12 ,  C07D413/12 ,  C07D403/12 ,  C07D231/56 ,  A61P17/00 ,  A61P17/06 ,  A61P25/00 ,  A61P3/10 ,  A61P1/00 ,  A61P1/04 ,  A61P37/06 ,  A61P25/28 ,  A61P11/06 ,  A61P13/12 ,  A61P37/00 ,  A61P9/10 ,  A61P19/04

CPC分类号： C07D231/56 ,  C07D401/12

摘要： Disclosed indazoles compounds that are useful as antagonists of CCR1 activity and are thus useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are pharmaceutical compositions comprising these compounds, methods of using these compounds in the treatment of various diseases and disorders, processes for preparing these compounds and intermediates useful in these processes.

摘要翻译： 公开的吲唑化合物可用作CCR1活性的拮抗剂，因此可用于治疗通过CCR1的活性介导或维持的多种疾病和病症，包括自身免疫性疾病，例如类风湿性关节炎和多发性硬化症。 还公开了包含这些化合物的药物组合物，使用这些化合物治疗各种疾病和病症的方法，制备这些化合物的方法和可用于这些方法的中间体。

公开(公告)号：US07879873B2

公开(公告)日：2011-02-01

申请号：US12564129

申请日：2009-09-22

申请人： Brian Nicholas Cook ,  Darren DiSalvo ,  Daniel Robert Fandrick ,  Christian Harcken ,  Daniel Kuzmich ,  Thomas Wai-Ho Lee ,  Pingrong Liu ,  John Lord ,  Can Mao ,  Jochen Neu ,  Brian Christopher Raudenbush ,  Hossein Razavi ,  Jonathan Timothy Reeves ,  Jinhua J. Song ,  Alan David Swinamer ,  Zhulin Tan

发明人： Brian Nicholas Cook ,  Darren DiSalvo ,  Daniel Robert Fandrick ,  Christian Harcken ,  Daniel Kuzmich ,  Thomas Wai-Ho Lee ,  Pingrong Liu ,  John Lord ,  Can Mao ,  Jochen Neu ,  Brian Christopher Raudenbush ,  Hossein Razavi ,  Jonathan Timothy Reeves ,  Jinhua J. Song ,  Alan David Swinamer ,  Zhulin Tan

IPC分类号： A61K31/437 ,  C07D515/04

CPC分类号： C07D471/04

摘要： Disclosed are compounds of the formula (I), useful for treating a variety of diseases and disorders that are mediated or sustained through the activity of CCR1 including autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis. Also disclosed are methods of making and methods of using same.

公开(公告)号：US20120270870A1

公开(公告)日：2012-10-25

申请号：US13499939

申请日：2010-10-19

申请人： Brian Nicholas Cook ,  Daniel Kuzmich ,  Can Mao ,  Hossein Razavi

发明人： Brian Nicholas Cook ,  Daniel Kuzmich ,  Can Mao ,  Hossein Razavi

IPC分类号： C07D471/04 ,  C07D413/14 ,  A61K31/5377 ,  C07D213/62 ,  A61K31/4439 ,  A61P29/00 ,  A61P37/08 ,  A61P17/00 ,  A61P17/06 ,  A61P19/02 ,  A61P3/10 ,  A61P1/00 ,  A61P25/28 ,  A61P11/06 ,  A61P13/12 ,  A61P37/06 ,  A61K31/437

CPC分类号： C07D401/12 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/5377 ,  C07D213/62 ,  C07D471/04

摘要： Diclosed are CCR1 receptor antagonists of the formula (I) wherein Ar1, Ar2, R1, X and G are disclosed herein. Also disclosed are compositions, methods of making and using compounds of the formula (I).

摘要翻译： 被分类为式（I）的CCR1受体拮抗剂，其中本文公开了Ar1，Ar2，R1，X和G。 还公开了制备和使用式（I）化合物的组合物，方法。