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![Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2005/12/13/US06974870B2/abs.jpg.150x150.jpg)
公开(公告)号：US06974870B2
公开(公告)日：2005-12-13
申请号：US10730172
申请日：2003-12-06
申请人： Charles L. Cywin , Can Mao , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Erick Young , Darren DiSalvo , John Ginn , Pier Cirillo
发明人： Charles L. Cywin , Can Mao , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Erick Young , Darren DiSalvo , John Ginn , Pier Cirillo
IPC分类号： A61K31/38 , A61K31/435 , C07D495/04 , A61K31/4365 , A61K31/497 , A61K31/5377
CPC分类号： A61K31/38 , A61K31/435 , C07D495/04
摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
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![Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2005/11/15/US06964956B2/abs.jpg.150x150.jpg)
2.发明授权Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses 有权取代的3-氨基 - 噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法及其用途公开(公告)号：US06964956B2
公开(公告)日：2005-11-15
申请号：US10453175
申请日：2003-06-03
申请人： Charles L. Cywin , Zhidong Chen , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Tina Morwick , Jonathan Emeigh
发明人： Charles L. Cywin , Zhidong Chen , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Tina Morwick , Jonathan Emeigh
IPC分类号： A61K31/38 , A61K31/435 , A61K31/4365 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P39/00 , A61P43/00 , C07B61/00 , C07D495/04 , C07D519/00 , A61K31/551
CPC分类号： C07D495/04 , A61K31/38 , A61K31/435 , C08G63/6956 , C08G63/916
摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 1和R 2 2在本文中定义，其可用作IkappaB激酶（IKK）复合物的激酶活性的抑制剂 。 因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫疾病炎性疾病和癌症。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
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![Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2008/07/29/US07405225B2/abs.jpg.150x150.jpg)
3.发明授权Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses 有权取代的3-氨基 - 噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法及其用途公开(公告)号：US07405225B2
公开(公告)日：2008-07-29
申请号：US11206707
申请日：2005-08-18
申请人： Charles L. Cywin , Zhidong Chen , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu
发明人： Charles L. Cywin , Zhidong Chen , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D495/04 , A61K31/38 , A61K31/435 , C08G63/6956 , C08G63/916
摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 1和R 2 2在本文中定义，其可用作IkappaB激酶（IKK）复合物的激酶活性的抑制剂 。 因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫疾病炎性疾病和癌症。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
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![Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2005/12/29/US20050288285A1/abs.jpg.150x150.jpg)
4.发明申请Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses 有权取代的3-氨基 - 噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法及其用途公开(公告)号：US20050288285A1
公开(公告)日：2005-12-29
申请号：US11206707
申请日：2005-08-18
申请人： Charles Cywin , Zhidong Chen , Roman Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Marshall , Peter Nemoto , Ronald Sorcek , Sanxing Sun , Jiang-Ping Wu , Tina Morwick , Jonathan Emeigh
发明人： Charles Cywin , Zhidong Chen , Roman Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Marshall , Peter Nemoto , Ronald Sorcek , Sanxing Sun , Jiang-Ping Wu , Tina Morwick , Jonathan Emeigh
IPC分类号： A61K31/38 , A61K31/435 , A61K31/4365 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P39/00 , A61P43/00 , C07B61/00 , C07D495/04 , C07D519/00 , C07D498/02 , A61K31/4743
CPC分类号： C07D495/04 , A61K31/38 , A61K31/435 , C08G63/6956 , C08G63/916
摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 1和R 2 2在本文中定义，其可用作IkappaB激酶（IKK）复合物的激酶活性的抑制剂 。 因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫疾病炎性疾病和癌症。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
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公开(公告)号：US20050038104A1
公开(公告)日：2005-02-17
申请号：US10902562
申请日：2004-07-29
申请人： Zhidong Chen , John Ginn , Eugene Hickey , Weimin Liu , Can Mao , Tina Morwick , Peter Nemoto , Denice Spero , Sanxing Sun
发明人： Zhidong Chen , John Ginn , Eugene Hickey , Weimin Liu , Can Mao , Tina Morwick , Peter Nemoto , Denice Spero , Sanxing Sun
IPC分类号： A61K31/38 , A61P29/00 , C07D333/70 , C07D409/04 , C07D409/14 , C07D409/02 , C07D333/72
CPC分类号： C07D409/04 , A61K31/38 , C07D333/70 , C07D409/14
摘要： Disclosed are compounds of the formula I shown below, wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds.
摘要翻译： 公开了下文所示的式I化合物，其中R1，R2，R3和R4如本文所述，其作为抗炎剂是有活性的。 还公开了使用和制备这些化合物的方法。
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公开(公告)号：US20050032772A1
公开(公告)日：2005-02-10
申请号：US10937636
申请日：2004-09-09
申请人： Michel Emmanuel , Leah Frye , Eugene Hickey , Weimin Liu , Tina Morwick , Denice Spero , Sanxing Sun , David Thomson , Yancey Ward , Erick Young
发明人： Michel Emmanuel , Leah Frye , Eugene Hickey , Weimin Liu , Tina Morwick , Denice Spero , Sanxing Sun , David Thomson , Yancey Ward , Erick Young
IPC分类号： A61K31/40 , A61K31/4468 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/5365 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/55 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/06 , A61P19/10 , A61P21/04 , A61P25/28 , A61P29/00 , A61P31/00 , A61P37/00 , A61P37/06 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/66 , C07D309/14 , C07D335/02 , C07D401/04 , C07D401/12 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D487/08 , A61K31/397 , A61K31/553 , A61K31/554
CPC分类号： C07D401/12 , C04B35/632 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/66 , C07D309/14 , C07D335/02 , C07D401/04 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D487/08
摘要： Disclosed are novel cathepsin S, K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.
摘要翻译： 公开了本文进一步定义的新颖的组织蛋白酶S，K，F，L和B可逆抑制化合物（I），（II），（Ia）和（Ib）。 该化合物可用于治疗自身免疫性疾病。 还公开了制备这些新化合物的方法。
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公开(公告)号：US20050032792A1
公开(公告)日：2005-02-10
申请号：US10937533
申请日：2004-09-09
申请人： Michel Emmanuel , Leah Frye , Eugene Hickey , Weimin Liu , Tina Morwick , Denice Spero , David Thomson , Yancey Ward , Erick Young
发明人： Michel Emmanuel , Leah Frye , Eugene Hickey , Weimin Liu , Tina Morwick , Denice Spero , David Thomson , Yancey Ward , Erick Young
IPC分类号： A61K31/40 , A61K31/4468 , A61K31/454 , A61K31/496 , A61K31/506 , A61K31/517 , A61K31/5365 , A61K31/5377 , A61K31/538 , A61K31/541 , A61K31/55 , A61P1/04 , A61P3/10 , A61P9/10 , A61P11/06 , A61P19/10 , A61P21/04 , A61P25/28 , A61P29/00 , A61P31/00 , A61P37/00 , A61P37/06 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/66 , C07D309/14 , C07D335/02 , C07D401/04 , C07D401/12 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D487/08 , C07D417/02 , C07D413/02 , C07D43/02
CPC分类号： C07D401/12 , C04B35/632 , C07D205/04 , C07D207/14 , C07D207/16 , C07D211/58 , C07D211/60 , C07D211/66 , C07D309/14 , C07D335/02 , C07D401/04 , C07D403/06 , C07D405/12 , C07D413/12 , C07D413/14 , C07D417/12 , C07D455/02 , C07D487/08
摘要： Disclosed are cathepsin S ,K, F, L and B reversible inhibitory compounds of the formulas (I), (II), (Ia) and (Ib) further defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds.
摘要翻译： 公开了本文进一步定义的组合蛋白酶S，K，F，L和B可逆抑制化合物（I），（II），（Ia）和（Ib）。 该化合物可用于治疗自身免疫性疾病。 还公开了制备这些新化合物的方法。
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公开(公告)号：US20080008720A1
公开(公告)日：2008-01-10
申请号：US11836590
申请日：2007-08-09
申请人： Charles Cywin , Roman Fleck , Eugene Hickey , Weimin Liu , Tina Morwick , John Proudfoot , Denice Spero
发明人： Charles Cywin , Roman Fleck , Eugene Hickey , Weimin Liu , Tina Morwick , John Proudfoot , Denice Spero
IPC分类号： A61K31/551 , A61K31/4365 , A61K31/519 , A61P11/08 , A61P19/02 , A61P35/00 , A61P37/08 , C07D471/14 , C07D243/08 , A61P37/00 , A61P29/00 , A61P17/06 , A61K39/00 , A61K31/53
CPC分类号： C07D495/14
摘要： Disclosed are substituted tricyclic heterocycle compounds of the formulas (I), (II) and (III) shown below, wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds.
摘要翻译： 公开了以下所示的式（I），（II）和（III）的取代的三环杂环化合物，其中R 1，R 2，R 3， 本文描述了它们作为抗炎剂是有活性的。 还公开了使用和制备这些化合物的方法。
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公开(公告)号：US20050101601A1
公开(公告)日：2005-05-12
申请号：US10960550
申请日：2004-10-07
申请人： Charles Cywin , Roman Fleck , Eugene Hickey , Weimin Liu , Tina Morwick , John Proudfoot , Denice Spero
发明人： Charles Cywin , Roman Fleck , Eugene Hickey , Weimin Liu , Tina Morwick , John Proudfoot , Denice Spero
IPC分类号： A61K31/4365 , A61K31/4375 , A61K31/519 , A61K31/53 , C07D495/14 , A61K31/5377 , C07D498/14
CPC分类号： C07D495/14
摘要： Disclosed are substituted tricyclic heterocycle compounds of the formulas (I), (II) and (III) shown below, wherein R1, R2, R3 and R4 are described herein, which are active as anti-inflammatory agents. Also disclosed are methods of using and making such compounds.
摘要翻译： 公开了以下所示的式（I），（II）和（III）的取代的三环杂环化合物，其中R 1，R 2，R 3， 本文描述了它们作为抗炎剂是有活性的。 还公开了使用和制备这些化合物的方法。
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公开(公告)号：US06608057B2
公开(公告)日：2003-08-19
申请号：US10082952
申请日：2001-10-24
申请人： Charles L. Cywin , Michel J. Emmanuel , Tina Morwick , Denice M. Spero , David S. Thomson , Yancey D. Ward
发明人： Charles L. Cywin , Michel J. Emmanuel , Tina Morwick , Denice M. Spero , David S. Thomson , Yancey D. Ward
IPC分类号： A61K31535
CPC分类号： C07D295/215 , C07C311/42 , C07D263/32 , C07D277/64 , C07D413/04
摘要： Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds
摘要翻译： 公开的是本文定义的式（I），（Ia）和（II），（IIa）的组织蛋白酶S可逆抑制化合物。 该化合物可用于治疗自身免疫性疾病。 还公开了制备这些新化合物的方法
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