-
![Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2005/12/13/US06974870B2/abs.jpg.150x150.jpg)
公开(公告)号：US06974870B2
公开(公告)日：2005-12-13
申请号：US10730172
申请日：2003-12-06
申请人： Charles L. Cywin , Can Mao , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Erick Young , Darren DiSalvo , John Ginn , Pier Cirillo
发明人： Charles L. Cywin , Can Mao , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Erick Young , Darren DiSalvo , John Ginn , Pier Cirillo
IPC分类号： A61K31/38 , A61K31/435 , C07D495/04 , A61K31/4365 , A61K31/497 , A61K31/5377
CPC分类号： A61K31/38 , A61K31/435 , C07D495/04
摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
-
![Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2008/07/29/US07405225B2/abs.jpg.150x150.jpg)
2.发明授权Substituted 3-amino-thieno[2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses 有权取代的3-氨基 - 噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法及其用途公开(公告)号：US07405225B2
公开(公告)日：2008-07-29
申请号：US11206707
申请日：2005-08-18
申请人： Charles L. Cywin , Zhidong Chen , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu
发明人： Charles L. Cywin , Zhidong Chen , Jonathan Emeigh , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Tina Morwick , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu
IPC分类号： A01N43/42 , A61K31/44 , C07D471/02 , C07D491/02 , C07D498/02 , C07D513/02 , C07D515/02
CPC分类号： C07D495/04 , A61K31/38 , A61K31/435 , C08G63/6956 , C08G63/916
摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 1和R 2 2在本文中定义，其可用作IkappaB激酶（IKK）复合物的激酶活性的抑制剂 。 因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫疾病炎性疾病和癌症。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
-
公开(公告)号：US07705151B2
公开(公告)日：2010-04-27
申请号：US12399292
申请日：2009-03-06
申请人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
发明人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
IPC分类号： C07D471/02 , C07D413/00
CPC分类号： C07D471/04
摘要： Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 3，R 5，R 7和R 8在本文中定义，其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
-
公开(公告)号：US07678911B2
公开(公告)日：2010-03-16
申请号：US12014190
申请日：2008-01-15
申请人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
发明人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
IPC分类号： C07D471/02 , C07D413/00
CPC分类号： C07D471/04
摘要： Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 3，R 5，R 7和R 8在本文中定义，其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
-
公开(公告)号：US07321041B2
公开(公告)日：2008-01-22
申请号：US10413980
申请日：2003-04-15
申请人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
发明人： Charles L. Cywin , Scott E. Jakes , Joachim Heider , Mark A. Bobko , Renee L. Des Jarlais , Mark Player , James Rinker , Michael Winters , Bao-ping Zhao
IPC分类号： C07D471/02
CPC分类号： C07D471/04
摘要： Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 3，R 5，R 7和R 8是 其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
-
![Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses](/abs-image/US/2005/11/15/US06964956B2/abs.jpg.150x150.jpg)
6.发明授权Substituted 3-amino-thieno [2,3-b]pyridine-2-carboxylic acid amide compounds and processes for preparing and their uses 有权取代的3-氨基 - 噻吩并[2,3-b]吡啶-2-羧酸酰胺化合物及其制备方法及其用途公开(公告)号：US06964956B2
公开(公告)日：2005-11-15
申请号：US10453175
申请日：2003-06-03
申请人： Charles L. Cywin , Zhidong Chen , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Tina Morwick , Jonathan Emeigh
发明人： Charles L. Cywin , Zhidong Chen , Roman Wolfgang Fleck , Ming-Hong Hao , Eugene Hickey , Weimin Liu , Daniel Richard Marshall , Peter Nemoto , Ronald John Sorcek , Sanxing Sun , Jiang-Ping Wu , Tina Morwick , Jonathan Emeigh
IPC分类号： A61K31/38 , A61K31/435 , A61K31/4365 , A61K31/438 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K31/541 , A61P1/04 , A61P3/10 , A61P9/00 , A61P9/10 , A61P11/00 , A61P11/06 , A61P11/08 , A61P13/12 , A61P17/00 , A61P17/02 , A61P17/06 , A61P19/02 , A61P21/04 , A61P25/00 , A61P25/04 , A61P25/28 , A61P29/00 , A61P35/00 , A61P35/02 , A61P37/00 , A61P37/06 , A61P39/00 , A61P43/00 , C07B61/00 , C07D495/04 , C07D519/00 , A61K31/551
CPC分类号： C07D495/04 , A61K31/38 , A61K31/435 , C08G63/6956 , C08G63/916
摘要： Disclosed are compounds of formula (I): wherein R1 and R2 are defined herein, which are useful as inhibitors of the kinase activity of the IκB kinase (IKK) complex. The compounds are therefore useful in the treatment of IKK mediated diseases including autoimmune diseases inflammatory diseases and cancer. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 1和R 2 2在本文中定义，其可用作IkappaB激酶（IKK）复合物的激酶活性的抑制剂 。 因此，这些化合物可用于治疗IKK介导的疾病，包括自身免疫疾病炎性疾病和癌症。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
-
7.发明授权Substituted 1-(4-aminophenyl)pyrazoles and their use as anti-inflammatory agents 有权取代的1-（4-氨基苯基）吡唑及其作为抗炎剂的用途公开(公告)号：US06506747B1
公开(公告)日：2003-01-14
申请号：US09324933
申请日：1999-06-03
申请人： Rajashekhar Betageri , Charles L. Cywin , Karl Hargrave , Mary Ann Hoermann , Thomas M. Kirrane , Thomas M. Parks , Usha R. Patel , John R. Proudfoot , Rajiv Sharma , Sanxing Sun , Xiao-Jun Wang
发明人： Rajashekhar Betageri , Charles L. Cywin , Karl Hargrave , Mary Ann Hoermann , Thomas M. Kirrane , Thomas M. Parks , Usha R. Patel , John R. Proudfoot , Rajiv Sharma , Sanxing Sun , Xiao-Jun Wang
IPC分类号： A61K31535
CPC分类号： C07D401/04 , C07D231/14 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/04 , C07D413/12 , C07D495/04
摘要： 1-(4-aminophenyl)pyrazoles optionally substituted on the 3- and 5-positions of the pyrazole ring and on the amino group at the 4-position of the phenyl ring are disclosed and described, which pyrazoles inhibit IL-2 production in T-lymphocytes.
摘要翻译： 公开和描述了在吡唑环的3位和5位和苯环4位的氨基上任意取代的1-（4-氨基苯基）吡唑，其中吡唑抑制T中的IL-2产生 淋巴细胞
-
公开(公告)号：US6080763A
公开(公告)日：2000-06-27
申请号：US181743
申请日：1998-10-29
申请人： John R. Regan , Pier F. Cirillo , Eugene R. Hickey , Neil Moss , Charles L. Cywin , Christopher Pargellis , Thomas A. Gilmore
发明人： John R. Regan , Pier F. Cirillo , Eugene R. Hickey , Neil Moss , Charles L. Cywin , Christopher Pargellis , Thomas A. Gilmore
IPC分类号： A61K31/381 , A61K31/415 , A61K31/4184 , A61K31/4427 , A61K31/443 , A61K31/4433 , A61K31/4436 , A61K31/4439 , A61K31/4725 , A61P29/00 , C07D231/40 , C07D235/30 , C07D333/36 , C07D401/04 , C07D401/12 , C07D405/12 , C07D409/04 , A61K31/44 , C07D231/38
CPC分类号： C07D235/30 , C07D231/40 , C07D333/36
摘要： Novel aromatic heterocyclic compounds inhibit cytokines production involved in immunoregulation and inflammation such as interleukin-1 and tumor necrosis factor production. The compounds are therefore useful in pharmaceutic compositions for treating diseases or pathological conditions involving inflammation such as chronic inflammatory diseases.
-
公开(公告)号：US20090171089A1
公开(公告)日：2009-07-02
申请号：US12399292
申请日：2009-03-06
申请人： Charles L. CYWIN , Scott E. JAKES , Joachim HEIDER , Mark A. BOBKO , Renee L. DES JARLAIS , Mark PLAYER , James RINKER , Michael WINTERS , Bao-ping ZHAO
发明人： Charles L. CYWIN , Scott E. JAKES , Joachim HEIDER , Mark A. BOBKO , Renee L. DES JARLAIS , Mark PLAYER , James RINKER , Michael WINTERS , Bao-ping ZHAO
IPC分类号： C07D471/04
CPC分类号： C07D471/04
摘要： Disclosed are compounds of formula (I): wherein R3, R5, R7 and R8 are defined herein, which are useful as inhibitors SYK kinase and are thus useful for treating diseases resulting from inappropriate mast cell activation, which include allergic and inflammatory diseases. Also disclosed are pharmaceutical compositions comprising these compounds and processes for preparing these compounds.
摘要翻译： 公开了式（I）的化合物：其中R 3，R 5，R 7和R 8在本文中定义，其可用作抑制剂SYK激酶，因此可用于治疗由不适当的肥大细胞活化引起的疾病，包括过敏性和炎性疾病。 还公开了包含这些化合物的药物组合物和制备这些化合物的方法。
-
公开(公告)号：US06608057B2
公开(公告)日：2003-08-19
申请号：US10082952
申请日：2001-10-24
申请人： Charles L. Cywin , Michel J. Emmanuel , Tina Morwick , Denice M. Spero , David S. Thomson , Yancey D. Ward
发明人： Charles L. Cywin , Michel J. Emmanuel , Tina Morwick , Denice M. Spero , David S. Thomson , Yancey D. Ward
IPC分类号： A61K31535
CPC分类号： C07D295/215 , C07C311/42 , C07D263/32 , C07D277/64 , C07D413/04
摘要： Disclosed are cathepsin S reversible inhibitory compounds of the formulas (I),(Ia) and (II),(IIa) as defined herein. The compounds are useful for treating autoimmune diseases. Also disclosed are processes for making such novel compounds
摘要翻译： 公开的是本文定义的式（I），（Ia）和（II），（IIa）的组织蛋白酶S可逆抑制化合物。 该化合物可用于治疗自身免疫性疾病。 还公开了制备这些新化合物的方法
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.025 秒)
