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1.发明授权5-heterocyclyl pyrazolo[4,3-d]pyrimidin-7-ones for the treatment of male erectile dysfunction 有权5-杂环基吡唑并[4,3-d]嘧啶-7-酮用于治疗男性勃起功能障碍
公开(公告)号：US6077841A
公开(公告)日：2000-06-20
申请号：US388851
申请日：1999-09-02
申请人： Zhihua Sui , Jihua Guan , Mark J. Macielag
发明人： Zhihua Sui , Jihua Guan , Mark J. Macielag
IPC分类号： A61K31/519 , A61P9/04 , A61P9/10 , A61P9/12 , A61P15/10 , C07D487/04
CPC分类号： C07D487/04
摘要： The invention is directed to novel substituted 5-heterocyclyl pyrazolopyrimidinones and derivatives thereof, their synthesis and their use in treating sexual dysfunction in mammals, especially male erectile dysfunction. Pharmaceutical compositions containing the compounds and methods of using them to treat sexual dysfunction are also described.
摘要翻译： 本发明涉及新型取代的5-杂环基吡唑并嘧啶酮及其衍生物，其合成及其在治疗哺乳动物性功能障碍，特别是雄性勃起功能障碍中的用途。 还描述了含有化合物的药物组合物和使用它们治疗性功能障碍的方法。
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2.发明授权Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors 有权用作磷酸二酯酶抑制剂的取代的吡咯并吡喃酮衍生物公开(公告)号：US06818646B2
公开(公告)日：2004-11-16
申请号：US10638901
申请日：2003-08-11
申请人： Zhihua Sui , Mark J. Macielag , Jihua Guan , Weigin Jiang , James C. Lanter
发明人： Zhihua Sui , Mark J. Macielag , Jihua Guan , Weigin Jiang , James C. Lanter
IPC分类号： A61K314965
CPC分类号： C07D471/04
摘要： The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction.
摘要翻译： 本发明涉及式（I）或（II）的新型吡咯并吡喃酮衍生物：含有化合物的药物组合物及其用于治疗性功能障碍的用途。
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3.发明授权Substituted pyrrolopyridinone derivatives useful as phosphodiesterase inhibitors 有权用作磷酸二酯酶抑制剂的取代的吡咯并吡喃酮衍生物公开(公告)号：US06635638B2
公开(公告)日：2003-10-21
申请号：US09847749
申请日：2001-05-02
申请人： Zhihua Sui , Mark J. Macielag , Jihua Guan , Weiqin Jiang , James C. Lanter
发明人： Zhihua Sui , Mark J. Macielag , Jihua Guan , Weiqin Jiang , James C. Lanter
IPC分类号： C07D47104
CPC分类号： C07D471/04
摘要： The invention relates to novel pyrrolopyridinone derivatives of the formula (I) or (II): pharmaceutical compositions containing the compounds and their use for the treatment of sexual dysfunction.
摘要翻译： 本发明涉及式（I）或（II）的新型吡咯并吡喃酮衍生物：含有化合物的药物组合物及其用于治疗性功能障碍的用途。
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公开(公告)号：US07183445B2
公开(公告)日：2007-02-27
申请号：US10858435
申请日：2004-06-01
IPC分类号： C07C39/06 , C07C39/23 , C07D295/027 , C07D265/30
CPC分类号： C07D295/088 , C07C29/12 , C07C29/60 , C07C37/055 , C07C39/17 , C07C39/23 , C07C41/18 , C07C41/20 , C07C41/22 , C07C41/26 , C07C41/30 , C07C43/215 , C07C43/23 , C07C45/69 , C07C69/757 , C07C217/18 , C07C2601/14 , C07C2601/16 , C07C2602/08 , C07C2602/10 , C07D209/04 , C07C49/683 , C07C47/47 , C07C43/225 , C07C33/38
摘要： The present invention is directed to novel cyclohexyl derivatives, pharmaceutical compositions containing them and their use in the treatment of disorders and diseases mediated by an estrogen receptor.
摘要翻译： 本发明涉及新颖的环己基衍生物，含有它们的药物组合物及其在治疗由雌激素受体介导的病症和疾病中的用途。
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![Benzo[4,5]thieno[2,3-c]pyridine and Benzo[4,5]furo[2,3-c]pyridine Derivatives Useful as Inhibitors of Phosphodiesterase](/abs-image/US/2005/03/08/US06864253B2/abs.jpg.150x150.jpg)
5.发明授权Benzo[4,5]thieno[2,3-c]pyridine and Benzo[4,5]furo[2,3-c]pyridine Derivatives Useful as Inhibitors of Phosphodiesterase 有权苯并[4,5]噻吩并[2,3-c]吡啶和苯并[4,5]呋喃并[2,3-c]吡啶衍生物，可用作磷酸二酯酶抑制剂公开(公告)号：US06864253B2
公开(公告)日：2005-03-08
申请号：US10261861
申请日：2002-10-01
申请人： Zhihua Sui , Mark J. Macielag
发明人： Zhihua Sui , Mark J. Macielag
IPC分类号： A61K31/4365 , A61K31/437 , A61K31/444 , A61K31/506 , A61K31/5377 , A61P5/24 , A61P7/02 , A61P9/00 , A61P9/04 , A61P9/10 , A61P9/12 , A61P11/06 , A61P15/00 , A61P15/10 , A61P43/00 , C07D471/04 , C07D491/048 , C07D495/04 , C07D491/408 , A61K31/4355
CPC分类号： C07D471/04 , C07D495/04
摘要： The present invention relates to novel β-carboline derivatives of the general formula wherein all the variables are as described within the specification, useful as phosphodiesterase inhibitors. The present invention further relates to use of the described derivatives for the treatment of diseases and conditions related to PDE, for example male erectile dysfunction.
摘要翻译： 本发明涉及一般制剂的新型β-咔啉衍生物，其全部变量如本说明书所述，可用作磷酸二酯酶抑制剂。 本发明还涉及所述衍生物用于治疗与PDE有关的疾病和病症（例如雄性勃起功能障碍）的用途。
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6.发明授权公开(公告)号：US06492358B2
公开(公告)日：2002-12-10
申请号：US09847767
申请日：2001-05-02
申请人： Zhihua Sui , Mark J. Macielag
发明人： Zhihua Sui , Mark J. Macielag
IPC分类号： C07D47104
CPC分类号： C07D471/04 , C07D495/04
摘要： The present invention relates to novel &bgr;-carboline derivatives of the general formula wherein all the variables are as described within the specification, useful as phosphodiesterase inhibitors. The present invention further relates to use of the described derivatives for the treatment of diseases and conditions related to PDE, for example male erectile dysfunction.
摘要翻译： 本发明涉及一般制剂的新型β-咔啉衍生物，其全部变量如本说明书所述，可用作磷酸二酯酶抑制剂。 本发明还涉及所述衍生物用于治疗与PDE有关的疾病和病症（例如雄性勃起功能障碍）的用途。
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公开(公告)号：US08809327B2
公开(公告)日：2014-08-19
申请号：US13407251
申请日：2012-02-28
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/381 , A61K31/541 , A61K31/4709 , A61K31/5377 , A61P29/02
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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8.发明授权Oxopiperazine-azetidine amides and oxodiazepine-azetidine amides as monoacylglycerol lipase inhibitors 失效氧基哌嗪 - 氮杂环丁烷酰胺和氧代二氮杂吖啶啶酰胺作为单酰基甘油脂肪酶抑制剂公开(公告)号：US08637498B2
公开(公告)日：2014-01-28
申请号：US13246232
申请日：2011-09-27
IPC分类号： A61K31/496 , A61K31/506 , A61K31/551 , C07D403/04 , C07D403/14 , C07D409/14 , C07D417/14
CPC分类号： C07D403/14 , C07D403/04 , C07D409/14 , C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (Ia) and Formula (Ib) as follows: wherein Y, Z, and n are defined herein; and wherein Yb and Zb are as defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物和对映体，非对映异构体及其药学上可接受的盐由式（Ia）和式（Ib）表示如下：其中Y，Z和n如本文所定义; 并且其中Yb和Zb如本文所定义。
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9.发明申请PIPERIDIN-4-YL-AZETIDINE DIAMIDES AS MONOACYLGLYCEROL LIPASE INHIBITORS 有权哌可啶-4-Y-AZETIDINE DIAMIDES作为单羟乙基脂肪酶抑制剂公开(公告)号：US20130102584A1
公开(公告)日：2013-04-25
申请号：US13277702
申请日：2011-10-20
申请人： Peter J. Connolly , Haiyan Bian , Xun Li , Li Liu , Mark J. Macielag , Mark E. McDonnell
发明人： Peter J. Connolly , Haiyan Bian , Xun Li , Li Liu , Mark J. Macielag , Mark E. McDonnell
IPC分类号： A61K31/454 , A61P25/00 , A61P25/06 , C07D417/14
CPC分类号： C07D417/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds, and enantiomers, diastereomers, and pharmaceutically acceptable salts thereof, are represented by Formula (I) as follows: wherein Y, Z, and R are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物和对映体，非对映异构体及其药学上可接受的盐由式（I）表示如下：其中Y，Z和R在本文中定义。
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10.发明申请公开(公告)号：US20110105527A1
公开(公告)日：2011-05-05
申请号：US12913917
申请日：2010-10-28
IPC分类号： A61K31/4965 , C07D401/14 , C07D401/02 , A61P19/02 , A61P25/06 , A61P25/00 , A61P29/00 , A61P17/02 , A61P17/00 , A61P3/10 , A61P1/00 , A61P15/00 , A61P35/00 , A61P25/16 , A61P25/28 , A61P25/24 , A61P25/30 , A61P13/02
CPC分类号： C07D401/14 , C07D403/14
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, L, X, and Y are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，L，X和Y如本文所定义。
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