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公开(公告)号：US20120190674A1
公开(公告)日：2012-07-26
申请号：US13407251
申请日：2012-02-28
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/381 , A61K31/4436 , A61K31/4709 , A61K31/4725 , A61K31/5377 , A61P9/12 , A61P25/00 , A61P29/00 , A61P25/22 , A61P25/24 , A61P9/00 , C07D333/66 , A61K31/541
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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公开(公告)号：US20090264474A1
公开(公告)日：2009-10-22
申请号：US12175740
申请日：2008-07-18
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/4439 , C07D333/66 , A61K31/381 , C07D417/12 , C07D409/12 , A61K31/4196 , A61K31/427 , C07D401/14
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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公开(公告)号：US08809327B2
公开(公告)日：2014-08-19
申请号：US13407251
申请日：2012-02-28
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： A61K31/381 , A61K31/541 , A61K31/4709 , A61K31/5377 , A61P29/02
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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公开(公告)号：US08153682B2
公开(公告)日：2012-04-10
申请号：US12175740
申请日：2008-07-18
申请人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
发明人： Shawn T. Branum , Raymond W. Colburn , Scott L. Dax , Christopher M. Flores , Michele C. Jetter , Yi Liu , Donald Ludovici , Mark J. Macielag , Jay M. Matthews , James J. McNally , Laura M. Reaney , Ronald K. Russell , Ning Qin , Christopher Teleha , Kenneth M. Wells , Scott C. Youells , Mark A. Youngman
IPC分类号： C07D419/12 , C07D417/12 , C07D413/12 , C07D409/04 , C07D409/12 , C07D333/66 , A61K31/5377 , A61K31/496 , A61K31/4535 , A61K31/433 , A61K31/4245 , A61K31/422 , A61K31/4196 , A61K31/4192 , A61K31/4178 , A61K31/4025 , A61K31/381
CPC分类号： C07D333/66 , C07D333/36 , C07D409/12 , C07D409/14 , C07D417/12 , C07D495/04
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein A, B, G, Y, R1, R2, R3, and R4 are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中A，B，G，Y，R 1，R 2，R 3和R 4在本文中定义。
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![Imidazo[1,2-α]pyridine sulfonamides as TRPM8 modulators](/abs-image/US/2013/12/31/US08618150B2/abs.jpg.150x150.jpg)
公开(公告)号：US08618150B2
公开(公告)日：2013-12-31
申请号：US13316031
申请日：2011-12-09
IPC分类号： A61K31/415 , C07D235/02
CPC分类号： C07D471/04 , A61K31/415 , C07D235/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中Y，R 1，R 2，并且在本文中定义。
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![IMIDAZO[1,2-a]PYRIDINE SULFONAMIDES AS TRPM8 MODULATORS](/abs-image/US/2012/06/14/US20120149699A1/abs.jpg.150x150.jpg)
公开(公告)号：US20120149699A1
公开(公告)日：2012-06-14
申请号：US13316031
申请日：2011-12-09
IPC分类号： A61K31/5377 , A61P25/02 , A61P25/00 , A61P25/04 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , A61K31/415 , C07D235/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein Y, R1, R2, and are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中Y，R 1，R 2，并且在本文中定义。
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公开(公告)号：US08242157B2
公开(公告)日：2012-08-14
申请号：US12797743
申请日：2010-06-10
申请人： Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
发明人： Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
IPC分类号： C07D401/00 , C07D235/12 , C07D235/22 , A01N43/52 , A61K31/415
CPC分类号： C07D235/30 , C07D498/06
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R 0，R 1，R 2，R 3，R 4和a在本文中定义。
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公开(公告)号：US20110003801A1
公开(公告)日：2011-01-06
申请号：US12797743
申请日：2010-06-10
申请人： Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
发明人： Michele C. Jetter , Mark J. Macielag , Mingde Xia , Xiaoqing Xu
IPC分类号： A61K31/5383 , C07D235/30 , C07D498/06 , A61K31/4184 , A61P9/12 , A61P9/00 , A61P25/04 , A61P29/00
CPC分类号： C07D235/30 , C07D498/06
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R0, R1, R2, R3, R4 and a are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R 0，R 1，R 2，R 3，R 4和a在本文中定义。
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9.发明申请公开(公告)号：US20120302541A1
公开(公告)日：2012-11-29
申请号：US13503433
申请日：2010-10-28
申请人： Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
发明人： Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
IPC分类号： A61K31/40 , C07D211/26 , A61K31/445 , C07D401/12 , A61K31/4439 , C07D405/12 , A61K31/4025 , C07D409/12 , C07D403/12 , A61K31/506 , C07D295/096 , A61K31/495 , C07D413/12 , A61K31/4245 , C07D451/02 , A61K31/46 , C07C217/84 , A61K31/136 , C07D205/04 , A61K31/397 , C07D453/02 , A61K31/439 , A61P29/00 , A61P19/02 , A61P25/06 , A61P11/02 , A61P13/10 , A61P17/00 , A61P11/12 , A61P25/00 , A61P25/02 , A61P1/00 , A61P35/00 , A61P25/24 , A61P25/16 , A61P25/30 , A61P25/32 , A61P13/00 , A61P15/00 , A61P1/12 , A61P9/00 , A61P11/00 , C07D207/14
CPC分类号： C07D401/12 , C07C211/48 , C07C211/50 , C07C233/08 , C07C233/11 , C07C233/65 , C07C255/50 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/04 , C07D453/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，Ra和Y如本文所定义。
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10.发明授权公开(公告)号：US08846655B2
公开(公告)日：2014-09-30
申请号：US13503433
申请日：2010-10-28
申请人： Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
发明人： Steven J. Coats , Haiyan Bian , Chaozhong Cai , Bart L. DeCorte , Li Liu , Mark J. Macielag , Scott L. Dax , Philip M. Pitis , Peter J. Connolly , Wei He
IPC分类号： A61K31/40 , A61K31/445 , A61K31/4439 , A61K31/4025 , A61K31/506 , A61K31/495 , C07D211/56 , C07D405/12 , C07D207/09 , C07C255/50 , C07C211/48 , C07D413/12 , C07D401/12 , C07C211/50 , C07D205/04 , C07C233/08 , C07C233/11 , C07C233/65 , C07D451/04 , C07D453/02 , C07D409/12
CPC分类号： C07D401/12 , C07C211/48 , C07C211/50 , C07C233/08 , C07C233/11 , C07C233/65 , C07C255/50 , C07D205/04 , C07D207/09 , C07D211/56 , C07D405/12 , C07D409/12 , C07D413/12 , C07D451/04 , C07D453/02
摘要： Disclosed are compounds, compositions and methods for treating various diseases, syndromes, conditions and disorders, including pain. Such compounds are represented by Formula I as follows: wherein R1, R2, R3, Ra, and Y are defined herein.
摘要翻译： 公开了用于治疗各种疾病，综合征，病症和障碍（包括疼痛）的化合物，组合物和方法。 这样的化合物由式I表示如下：其中R1，R2，R3，Ra和Y如本文所定义。
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