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公开(公告)号：US07989441B2
公开(公告)日：2011-08-02
申请号：US11916887
申请日：2006-06-06
申请人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
发明人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
IPC分类号： A61K31/44 , C07D223/12 , C07D211/76
CPC分类号： C07K5/0808 , C07D213/56 , C07D223/10 , C07D223/16 , C07D471/04 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0827 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula I.
摘要翻译： 本公开涉及式I的XIAP抑制剂化合物。
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公开(公告)号：US20090069294A1
公开(公告)日：2009-03-12
申请号：US11916887
申请日：2006-06-06
申请人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
发明人： Zhuoliang Chen , Mark G. Palermo , Sushil K. Sharma , Troy Smith , Christopher S. Straub , Run-Ming D. Wang , Yaping Wang , Leigh Zawel
IPC分类号： A61K31/55 , C07D243/02 , A61K31/551 , A61K31/407 , A61K31/435 , C07D221/04 , C07D487/04 , A61P35/00 , C07D495/04 , A61K31/4365 , A61K31/4412 , C07D211/76 , C07D223/14
CPC分类号： C07K5/0808 , C07D213/56 , C07D223/10 , C07D223/16 , C07D471/04 , C07D487/04 , C07D487/06 , C07D513/04 , C07K5/06026 , C07K5/06191 , C07K5/0806 , C07K5/0827 , C07K5/1008
摘要： The present disclosure relates to XIAP inhibitor compounds of the formula I.
摘要翻译： 本公开涉及式I的XIAP抑制剂化合物。
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公开(公告)号：US08338440B2
公开(公告)日：2012-12-25
申请号：US13456274
申请日：2012-04-26
申请人： Mark G. Palermo , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
发明人： Mark G. Palermo , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC分类号： A61K31/427 , A61K31/4245 , A61K31/422 , A61K31/435 , A61K31/40 , A61K31/506 , A61K31/41
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
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公开(公告)号：US08207183B2
公开(公告)日：2012-06-26
申请号：US13178946
申请日：2011-07-08
申请人： Mark G. Palermo , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming Wang , Leigh Zawel , Yanling Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
发明人： Mark G. Palermo , Sushil Kumar Sharma , Christopher Sean Straub , Run-Ming Wang , Leigh Zawel , Yanling Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC分类号： A61K31/427 , A61K31/4245 , A61K31/422 , A61K31/435 , A61K31/40 , A61K31/506 , A61K31/41 , C07D277/20 , C07D271/06 , C07D263/30 , C07D401/02 , C07D239/02 , C07D403/02
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula (I).
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公开(公告)号：US20080242658A1
公开(公告)日：2008-10-02
申请号：US10594413
申请日：2005-04-06
申请人： Mark G Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
发明人： Mark G Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC分类号： A61K31/407 , C07D471/04 , C07D207/08 , C07D487/04 , C07D207/32 , A61P35/00 , A61K31/4439 , A61K31/422 , A61K31/41 , A61K31/506 , C07D401/04 , C07D403/12 , A61K31/437 , A61K31/55 , A61K31/40
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
摘要翻译： 抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物
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公开(公告)号：US20050234042A1
公开(公告)日：2005-10-20
申请号：US11099941
申请日：2005-04-06
申请人： Mark Palermo , Sushil Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark Charest , Feng He
发明人： Mark Palermo , Sushil Sharma , Christopher Straub , Run-Ming Wang , Leigh Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark Charest , Feng He
IPC分类号： A61K31/40 , A61K31/4025 , A61K31/437 , A61K31/4745 , A61K31/55 , C07D207/06 , C07D207/08 , C07D207/09 , C07D207/16 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/02 , C07D471/04 , C07D487/04
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
摘要翻译： 抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物
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公开(公告)号：US07419975B2
公开(公告)日：2008-09-02
申请号：US11099941
申请日：2005-04-06
申请人： Mark Gabriel Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Scott Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
发明人： Mark Gabriel Palermo , Sushil Kumar Sharma , Christopher Straub , Run-Ming Wang , Leigh Scott Zawel , Yanlin Zhang , Zhuoliang Chen , Yaping Wang , Fan Yang , Wojciech Wrona , Gang Liu , Mark G. Charest , Feng He
IPC分类号： A61K31/407 , A61K31/437 , A61K31/55 , C07D487/04 , C07D471/04
CPC分类号： C07D207/16 , C07D207/06 , C07D207/08 , C07D207/09 , C07D401/04 , C07D401/12 , C07D403/04 , C07D403/06 , C07D403/12 , C07D405/10 , C07D405/12 , C07D409/12 , C07D413/04 , C07D413/14 , C07D417/04 , C07D471/04 , C07D487/04
摘要： Novel compounds that inhibit the binding of the Smac protein to Inhibitor of Apoptosis Proteins (IAPs) of the formula I
摘要翻译： 抑制Smac蛋白与抑制凋亡蛋白抑制剂（IAP）的新型化合物
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8.发明授权公开(公告)号：US09434719B2
公开(公告)日：2016-09-06
申请号：US14408418
申请日：2014-03-12
申请人： Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
发明人： Thomas Raymond Caferro , Zhuoliang Chen , Young Shin Cho , Abran Q. Costales , Julian Roy Levell , Gang Liu , James R. Manning , Martin Sendzik , Cynthia Shafer , Michael David Shultz , James Sutton , Yaping Wang , Qian Zhao
IPC分类号： C07D413/04 , A61K31/506 , C07D413/14 , C07D417/14 , A61K31/5377
CPC分类号： C07D413/14 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D413/04 , C07D417/14
摘要： The invention is directed to a formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2a, R2b and R3-R7 are herein. The invention is also directed to compositions containing a compound of formula (I) and to the use of such compounds in the inhibition of mutant IDH proteins having a neomorphic activity. The invention is further directed to the use of a compound of formula (I) in the treatment of diseases or disorders associated with such mutant IDH proteins including, but not limited to, cell-proliferation disorders, such as cancer.
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9.发明授权Compounds having activating effect on subtypes of peroxisome proliferator-activated receptors and its preparation method and uses 有权对过氧化物酶体增殖物激活受体亚型具有活化作用的化合物及其制备方法和用途公开(公告)号：US09346770B2
公开(公告)日：2016-05-24
申请号：US13704281
申请日：2011-06-18
申请人： Yaping Wang , Guojun Zheng , Peng Sun , Yi Li , Yingqiu Wu , Bin Liu , Xiaoyu Liu , Hua Bai , Hongyan Li , Xiaohe Zheng
发明人： Yaping Wang , Guojun Zheng , Peng Sun , Yi Li , Yingqiu Wu , Bin Liu , Xiaoyu Liu , Hua Bai , Hongyan Li , Xiaohe Zheng
IPC分类号： C07D263/32 , A61K31/421 , C07D413/10 , C07D277/24 , A61K31/439
CPC分类号： C07D263/32 , A61K31/439 , C07D277/24 , C07D413/10
摘要： Phenyl propanoic acid compounds having activating effect on peroxisome proliferator-activated receptors (PPARα,δ,γ) and a preparation method and uses thereof are provided in the present invention. The compounds can be used for treating or preventing diseases associated with peroxisome proliferator-activated receptors (PPARα,δ,γ).
摘要翻译： 在本发明中提供了对过氧化物酶体增殖物激活受体（PPARα，δ，γ）具有活化作用的苯基丙酸化合物及其制备方法和用途。 该化合物可用于治疗或预防与过氧化物酶体增殖物激活受体（PPARα，δ，γ）相关的疾病。
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公开(公告)号：US09309252B2
公开(公告)日：2016-04-12
申请号：US14568410
申请日：2014-12-12
申请人： Christopher Thomas Brain , Young Shin Cho , John William Giraldes , Bharat Lagu , Julian Roy Levell , Michael Joseph Luzzio , Lawrence Blas Perez , Yaping Wang , Fan Yang
发明人： Christopher Thomas Brain , Young Shin Cho , John William Giraldes , Bharat Lagu , Julian Roy Levell , Michael Joseph Luzzio , Lawrence Blas Perez , Yaping Wang , Fan Yang
IPC分类号： A01N43/90 , A61K31/519 , C07D487/04 , C07D519/00 , C07D471/08 , C07D471/10 , C07D487/08 , C07D498/08 , C07D498/20 , C07D487/10 , C07D498/10
CPC分类号： C07D487/04 , C07D471/08 , C07D471/10 , C07D487/08 , C07D487/10 , C07D498/08 , C07D498/10 , C07D498/20 , C07D519/00
摘要： The invention is directed to novel pyrrolopyrimidine compounds of formula (1) wherein R1, R2y, R4, R8-R11, A and L are defined herein and to salts, including pharmaceutically acceptable salts thereof. The compounds of the present invention are CDK4/6 inhibitors and could be useful in the treatment of diseases and disorders mediated by CDK4/6, such as cancer, including mantle cell lymphoma, liposarcoma, non small cell lung cancer, melanoma, squamous cell esophageal cancer and breast cancer. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CDK4/6 activity and to the treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.
摘要翻译： 本发明涉及式（1）的新颖的吡咯并嘧啶化合物，其中R 1，R 2y，R 4，R 8 -R 11，A和L在本文中定义，并且包括其药学上可接受的盐。 本发明的化合物是CDK4 / 6抑制剂，可用于治疗由CDK4 / 6介导的疾病和病症，如癌症，包括外套细胞淋巴瘤，脂肪肉瘤，非小细胞肺癌，黑素瘤，鳞状细胞食管癌 癌症和乳腺癌。 本发明还涉及包含本发明化合物的药物组合物。 本发明还涉及抑制CDK4 / 6活性的方法以及使用本发明化合物或包含本发明化合物的药物组合物治疗与之相关的病症。
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