公开(公告)号：US20120199497A1

公开(公告)日：2012-08-09

申请号：US13021956

申请日：2011-02-07

申请人： Zuifang Liu ,  Marco F. Cardosi ,  Christopher Philip Leach ,  Scott Sloss

发明人： Zuifang Liu ,  Marco F. Cardosi ,  Christopher Philip Leach ,  Scott Sloss

IPC分类号： G01N27/26

CPC分类号： G01N27/3272 ,  C12Q1/003 ,  C12Q1/006

摘要： An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (e.g., a whole blood sample) includes a substrate, at least one working electrode disposed on the substrate, a sample-soluble enzymatic reagent layer disposed above the working electrode, a diffusion-controlling layer (DCL) disposed between the at least one working electrode and the sample-soluble enzymatic reagent layer; and a sample-receiving chamber. In addition, the sample-soluble enzymatic reagent layer is configured and constituted for operable solubility in a bodily fluid sample applied to the electrochemical-based analytical test strip and received in the sample-receiving chamber and for electrochemical enzymatic reaction with an analyte in the bodily fluid sample. Moreover, the DCL is configured and constituted to provide a predetermined diffusion rate for a component (for example a mediator) of the electrochemical enzymatic reaction through the DCL that is less than the diffusion rate of the component through the bodily fluid sample and for operable hydration by the bodily fluid sample. A method for determining an analyte in a bodily fluid sample includes applying a bodily fluid sample to an electrochemical-based analytical test strip that includes a substrate, at least one working electrode disposed on the substrate, a sample-soluble enzymatic reagent layer disposed above the working electrode, a DCL disposed between the at least one working electrode and the sample-soluble enzymatic reagent layer; and a sample-receiving chamber defined in the electrochemical-based analytical test strip.

摘要翻译： 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）的基于电化学的分析测试条包括底物，设置在基底上的至少一个工作电极，样品可溶性酶 设置在所述工作电极上方的试剂层，设置在所述至少一个工作电极和所述样品可溶性酶试剂层之间的扩散控制层（DCL） 和样品接收室。 此外，样品可溶性酶试剂层被构造和构造成用于在施加到基于电化学的分析测试条上的体液样品中的可操作溶解度并且被接收在样品接收室中并且用于与身体中的分析物的电化学酶反应 流体样品。 此外，DCL被配置和构造成通过小于通过体液样品的组分的扩散速率的DCL为电化学酶反应的组分（例如介体）提供预定的扩散速率，并且为了可操作的水合 通过体液样品。 一种用于测定体液样品中的分析物的方法包括将体液样品施加到基于电化学的分析测试条，所述分析测试条包括基底，设置在基底上的至少一个工作电极，设置在基底上的样品可溶性酶试剂层 工作电极，设置在所述至少一个工作电极和所述样品可溶性酶试剂层之间的DCL; 以及在基于电化学的分析测试条中限定的样品接收室。

公开(公告)号：US09217723B2

公开(公告)日：2015-12-22

申请号：US13410609

申请日：2012-03-02

申请人： Scott Sloss ,  Russell Bain ,  Graeme Webster

发明人： Scott Sloss ,  Russell Bain ,  Graeme Webster

IPC分类号： G01N27/327

CPC分类号： G01N27/3272 ,  G01N33/66 ,  G01N2400/00

摘要： An analytical test strip (“ATT”) for use with a test meter includes a first insulating layer, with a first insulating layer upper surface, and a first electrically conductive layer (“ECL”) disposed thereon. The first ECL includes a first electrode portion (“EP”) and an electrical contact pad in electrical communication with the first EP. The ATT also includes a patterned spacer layer disposed above the first ECL that includes (i) a distal portion defining a bodily fluid sample-receiving chamber therein that overlies the first EP and (ii) an insulating proximal portion with an upper surface having a second ECL disposed thereon. The second ECL includes an interlayer contact portion and an electrical contact pad. A third ECL of the ATT includes a second EP and a proximal portion that overlies the interlayer contact portion. The second EP is disposed overlying and exposed to the sample-receiving chamber in an opposing relationship to the first EP.

摘要翻译： 与测试仪一起使用的分析测试条（“ATT”）包括具有第一绝缘层上表面的第一绝缘层和设置在其上的第一导电层（“ECL”）。 第一ECL包括与第一EP电连接的第一电极部分（“EP”）和电接触焊盘。 ATT还包括设置在第一ECL上方的图案化间隔层，其包括（i）在其中限定其中覆盖第一EP的体液样品接收室的远端部分，以及（ii）绝缘近端部分，其上表面具有第二 ECL置于其上。 第二ECL包括层间接触部分和电接触焊盘。 ATT的第三ECL包括覆盖层间接触部分的第二EP和近端部分。 第二EP以与第一EP相对的关系设置为覆盖并暴露于样品接收室。

公开(公告)号：US20130341209A1

公开(公告)日：2013-12-26

申请号：US13529901

申请日：2012-06-21

申请人： Lynsey WHYTE ,  Scott Sloss ,  David Mccoll ,  Neil Whitehead ,  Antony Smith

发明人： Lynsey WHYTE ,  Scott Sloss ,  David Mccoll ,  Neil Whitehead ,  Antony Smith

IPC分类号： G01N27/26 ,  G01N33/66

CPC分类号： G01N27/3272 ,  B01L3/502 ,  B01L2300/0825 ,  G01N27/3274 ,  G01N33/492

摘要： An analytical test strip for the determination of an analyte (such as glucose and/or hematocrit) in a bodily fluid sample (such as a whole blood sample) includes a first capillary sample-receiving chamber, a second capillary sample-receiving chamber, and a physical barrier island disposed between the first and second capillary sample-receiving chambers. Moreover, the physical island barrier is disposed such that bodily fluid sample flow between the first capillary sample-receiving chamber and the second capillary sample-receiving chamber is prevented during use of the analytical test strip.

公开(公告)号：US09128038B2

公开(公告)日：2015-09-08

申请号：US13529901

申请日：2012-06-21

申请人： Lynsey Whyte ,  Scott Sloss ,  David Mccoll ,  Neil Whitehead ,  Antony Smith

发明人： Lynsey Whyte ,  Scott Sloss ,  David Mccoll ,  Neil Whitehead ,  Antony Smith

IPC分类号： G01N27/327 ,  G01N33/49 ,  B01L3/00

CPC分类号： G01N27/3272 ,  B01L3/502 ,  B01L2300/0825 ,  G01N27/3274 ,  G01N33/492

摘要： An analytical test strip for the determination of an analyte (such as glucose and/or hematocrit) in a bodily fluid sample (such as a whole blood sample) includes a first capillary sample-receiving chamber, a second capillary sample-receiving chamber, and a physical barrier island disposed between the first and second capillary sample-receiving chambers. Moreover, the physical island barrier is disposed such that bodily fluid sample flow between the first capillary sample-receiving chamber and the second capillary sample-receiving chamber is prevented during use of the analytical test strip.

摘要翻译： 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖和/或血细胞比容）的分析测试条包括第一毛细管样品接收室，第二毛细管样品接收室和 设置在第一和第二毛细管样品接收室之间的物理屏障岛。 此外，物理岛屏障设置成在分析测试条的使用期间防止了体液样品在第一毛细管样品接收室和第二毛细管样品接收室之间流动。

公开(公告)号：US08877023B2

公开(公告)日：2014-11-04

申请号：US13529890

申请日：2012-06-21

申请人： Lynsey Whyte ,  Scott Sloss ,  Neil Whitehead ,  David McColl ,  Antony Smith

发明人： Lynsey Whyte ,  Scott Sloss ,  Neil Whitehead ,  David McColl ,  Antony Smith

IPC分类号： G01N27/327 ,  C12Q1/54 ,  G01N33/66 ,  C12Q1/00

CPC分类号： G01N27/327 ,  C12Q1/004 ,  C12Q1/006

摘要： An electrochemical-based analytical test strip for the determination of an analyte (such as glucose) in a bodily fluid sample (for example, a whole blood sample) and/or a characteristic of the bodily fluid sample (for example, hematocrit) includes a first sample-receiving chamber with first and second sample-application openings, and first and second electrodes. The first and second electrodes are disposed in the first sample-receiving chamber between the first and second sample-application openings. The electrochemical-based analytical test strip also includes a second sample-receiving chamber and a plurality of electrodes disposed in the second sample-receiving chamber. In addition, the second sample-receiving chamber intersects the first sample-receiving chamber between the first and second electrodes, thereby defining a chamber intersection.

摘要翻译： 用于测定体液样品（例如全血样品）中的分析物（例如葡萄糖）和/或体液样品的特性（例如，血细胞比容）的基于电化学的分析测试条包括 第一样品接收室，其具有第一和第二样品施加开口，以及第一和第二电极。 第一和第二电极设置在第一和第二样品施加开口之间的第一样品接收室中。 基于电化学的分析测试条还包括第二样品接收室和设置在第二样品接收室中的多个电极。 此外，第二样本接收室在第一和第二电极之间与第一样本接收室相交，由此限定腔室交叉。