公开(公告)号：US5955109A

公开(公告)日：1999-09-21

申请号：US79220

申请日：1993-06-17

申请人： Richard Won ,  Martin A. Katz ,  Chung H. Cheng ,  Sergio Nacht

发明人： Richard Won ,  Martin A. Katz ,  Chung H. Cheng ,  Sergio Nacht

IPC分类号： A61K8/04 ,  A61K8/81 ,  A61K9/16 ,  A61Q7/00 ,  A61Q17/00

CPC分类号： A61K8/671 ,  A61K8/0279 ,  A61K8/8152 ,  A61K9/1635 ,  A61Q19/00 ,  A61K2800/56 ,  A61Q19/08 ,  Y10S514/859 ,  Y10S514/951

摘要： Retinoic acid compositions intended for topical application are incorporated in novel formulations in which they are retained as impregnants inside the pores of porous solid particles or microspheres. The pores form a continuous network open to the exterior of the particles, permitting outward diffusion of the retinoic acid impregnant at a controlled rate depending on the pore size. The impregnated particles are prepared by impregnation of preformed particles with the retinoic acid.

摘要翻译： 用于局部施用的视黄酸组合物掺入新的制剂中，其中它们作为浸渍剂保留在多孔固体颗粒或微球的孔内。 孔形成连续的网状物，通过颗粒的外部，允许维甲酸浸渍剂以受控的速度取决于孔径而向外扩散。 浸渍的颗粒通过用视黄酸浸渍预形成的颗粒来制备。

公开(公告)号：US5510116A

公开(公告)日：1996-04-23

申请号：US95611

申请日：1993-07-21

申请人： Michael Froix ,  Larry Shipley ,  Christine J. Y. Liau ,  Hien Nguyen ,  Sok L. Khor

发明人： Michael Froix ,  Larry Shipley ,  Christine J. Y. Liau ,  Hien Nguyen ,  Sok L. Khor

IPC分类号： A61L9/14 ,  B65D83/14 ,  F17C11/00 ,  A61L9/04

CPC分类号： B65D83/60 ,  A61L9/14 ,  F17C11/00

摘要： An apparatus for dispensing pressurized material is comprised of a container, a polymeric matrix having a network of macropores located within the container, and a propellant that may be reversibly sorbed with the network of macropores so as to desorb as the partial pressure of the propellant within the container decreases. The network of pores is substantially non-swellable upon sorption and desorption of the propellant during filling and use of the dispensing apparatus. The polymeric matrix may comprise aggregates of macroporous polymeric particles in which the particles define a substantially non-collapsible pore network and the aggregates define interstitial spaces between the particles, and the interstitial spaces are substantially larger than the pore network.

摘要翻译： 用于分配加压材料的装置包括容器，具有位于容器内的大孔网络的聚合物基质和可与大孔网络可逆地吸附的推进剂，以便随着推进剂的分压而解吸 容器减少。 在填充和使用分配装置期间，推进剂的吸附和解吸时孔的网络基本上不溶胀。 聚合物基质可以包括大孔聚合物颗粒的聚集体，其中颗粒限定基本上不可塌陷的孔网络，并且聚集体限定颗粒之间的间隙，并且间隙空间基本上大于孔网络。

公开(公告)号：US4690825A

公开(公告)日：1987-09-01

申请号：US784382

申请日：1985-10-04

申请人： Richard Won

发明人： Richard Won

IPC分类号： A61K9/58 ,  A01N25/10 ,  A61J20060101 ,  A61K20060101 ,  A61K8/00 ,  A61K8/11 ,  A61K9/16 ,  A61K47/00 ,  A61K47/32 ,  A61Q5/00 ,  B01J13/14 ,  C08J9/28

CPC分类号： A61K9/1635 ,  C08J9/28 ,  C08J9/286 ,  Y10S514/963 ,  Y10S514/965

摘要： Delivery vehicles comprised of a polymeric bead having a network of pores with an active ingredient held within the network are provided for use in a method to provide controlled release of the active ingredient. The network of pores is substantially non-collapsible upon removal of the active ingredient and the delivery vehicles are polymerized by a process in which the active ingredient also comprises the porogen during formation of the network of pores.

公开(公告)号：US5879716A

公开(公告)日：1999-03-09

申请号：US76824

申请日：1993-06-14

申请人： Martin A. Katz ,  Chung H. Cheng ,  Sergio Nacht

发明人： Martin A. Katz ,  Chung H. Cheng ,  Sergio Nacht

IPC分类号： A61K8/04 ,  A61K8/38 ,  A61K8/81 ,  A61Q7/00 ,  A61Q17/00 ,  A61K9/16

CPC分类号： A61Q19/00 ,  A61K8/0279 ,  A61K8/38 ,  A61K8/8152 ,  A61K2800/56 ,  A61Q17/005 ,  Y10S514/859 ,  Y10S514/951

摘要： Benzoyl peroxide intended for topical application is incorporated in novel formulations in which it is retained as impregnants inside the pores of porous solid particles or microspheres. The pores form a continuous network open to the exterior of the particles, permitting outward diffusion of the benzoyl peroxide impregnant at a controlled rate depending on the pore size. The impregnated particles are prepared by impregnation of preformed particles with the benzoyl peroxide.

摘要翻译： 用于局部施用的过氧化苯甲酰引入新的制剂中，其作为浸渍剂保留在多孔固体颗粒或微球的孔内。 孔形成连续的网状物，通过颗粒的外部，允许过氧化苯甲酰浸渍剂以受控的速率取决于孔径而向外扩散。 浸渍的颗粒通过用过氧化苯甲酰浸渍预制颗粒来制备。

公开(公告)号：US5256400A

公开(公告)日：1993-10-26

申请号：US803298

申请日：1991-12-04

申请人： Michael Froix ,  Larry Shipley ,  Christine J. Y. Liau ,  Hien Nguyen ,  Sok L. Khor

发明人： Michael Froix ,  Larry Shipley ,  Christine J. Y. Liau ,  Hien Nguyen ,  Sok L. Khor

IPC分类号： A61L9/14 ,  B65D83/14 ,  F17C11/00 ,  A61L9/04

CPC分类号： B65D83/60 ,  A61L9/14 ,  F17C11/00

摘要： An apparatus for dispensing pressurized material is comprised of a container, a polymeric matrix having a network of macropores located within the container, and a propellant that may be reversibly sorbed with the network of macropores so as to desorb as the partial pressure of the propellant within the container decreases. The network of pores is substantially non-swellable upon sorption and desorption of the propellant during filling and use of the dispensing apparatus. The polymeric matrix may comprise aggregates of macroporous polymeric particles in which the particles define a substantially non-collapsible pore network and the aggregates define interstitial spaces between the particles, and the interstitial spaces are substantially larger than the pore network.

摘要翻译： 用于分配加压材料的装置包括容器，具有位于容器内的大孔网络的聚合物基质和可与大孔网络可逆地吸附的推进剂，以便随着推进剂的分压而解吸 容器减少。 在填充和使用分配装置期间，推进剂的吸附和解吸时孔的网络基本上不溶胀。 聚合物基质可以包括大孔聚合物颗粒的聚集体，其中颗粒限定基本上不可塌陷的孔网络，并且聚集体限定颗粒之间的间隙，并且间隙空间基本上大于孔网络。

公开(公告)号：US5145675A

公开(公告)日：1992-09-08

申请号：US644869

申请日：1991-01-23

申请人： Richard Won

发明人： Richard Won

IPC分类号： A01N25/18 ,  A61K8/04 ,  A61K8/34 ,  A61K8/49 ,  A61K8/67 ,  A61K8/81 ,  A61K9/16 ,  A61Q7/00 ,  A61Q17/00 ,  A61Q17/02

CPC分类号： A61Q19/00 ,  A01N25/18 ,  A61K8/0279 ,  A61K8/347 ,  A61K8/4953 ,  A61K8/678 ,  A61K8/8152 ,  A61K9/16 ,  A61K9/1635 ,  A61Q17/00 ,  A61Q17/02 ,  A61Q7/00 ,  A61K2800/56

摘要： Active substances intended for topical application are incorporated in novel formulations in which they are retained as impregnants inside the pores of porous solid particles or microspheres. The pores form a continuous network open to the exterior of the particles, permitting outward diffusion of the impregnants at a controlled rate depending on the pore size. The impregnated particles are prepared by impregnation of preformed particles with the active substance.

摘要翻译： 用于局部施用的活性物质掺入新的制剂中，其中它们作为浸渍剂保留在多孔固体颗粒或微球的孔内。 孔形成连续的网状物，直到颗粒的外部，允许浸渍剂以受控的速率取决于孔径而向外扩散。 浸渍的颗粒通过用活性物质浸渍预制颗粒来制备。

公开(公告)号：US5028435A

公开(公告)日：1991-07-02

申请号：US355718

申请日：1989-05-22

申请人： Martin Katz ,  Sergio Nacht ,  Jorge Heller

发明人： Martin Katz ,  Sergio Nacht ,  Jorge Heller

IPC分类号： A61K9/70

CPC分类号： A61K9/7023

摘要： Transdermal drug delivery systems comprise a backing or enclosure having a matrix layer which incorporates a drug and a percutaneous enhancer for the drug. The percutaneous enhancer and/or drug will be contained within polymeric particles dispersed through the matrix layer, where the polymeric particles define pore networks which are sized to release the enhancer and/or drug into the matrix layer at rate(s) selected to provide for a desired rate of drug penetration. By isolating the enhancer within the polymeric particles, adverse interactions between the enhancer and the matrix layer and/or the drug can be minimized. Moreover, the release rate of the enhancer into the matrix layer can be carefully controlled, which in turn controls the penetration rate of the drug into the treated host.

公开(公告)号：US6096344A

公开(公告)日：2000-08-01

申请号：US806513

申请日：1997-02-24

申请人： Lin-Shu Liu ,  Michael Froix ,  Jorge Heller ,  Steven Y. Ng

发明人： Lin-Shu Liu ,  Michael Froix ,  Jorge Heller ,  Steven Y. Ng

IPC分类号： A61K9/00 ,  A61K9/16 ,  B01J13/02 ,  A61K9/50 ,  B32B5/16

CPC分类号： B01J13/02 ,  A61K9/1652 ,  Y10T428/2982

摘要： A composition for the sequestration and sustained delivery of an active ingredient in the form of porous particles, the composition comprising the product of the controlled dehydration of particles formed by the reaction of a polymeric anionic material with a polyvalent cation. The composition may be loaded with an active ingredient by soaking the particles in a solution of the active ingredient; and may then be dehydrated. They may then be soaked in a solution of a polymeric cationic material, to form particles providing the controlled release of the active ingredient.

摘要翻译： 用于多孔颗粒形式的活性成分的螯合和持续递送的组合物，该组合物包含通过聚合阴离子材料与多价阳离子的反应形成的颗粒受控脱水的产物。 组合物可以通过将颗粒浸泡在活性成分的溶液中来装载活性成分; 然后可以脱水。 然后将它们浸泡在聚合物阳离子材料的溶液中，以形成提供活性成分的受控释放的颗粒。

公开(公告)号：US5939453A

公开(公告)日：1999-08-17

申请号：US90648

申请日：1998-06-04

申请人： Jorge Heller ,  Steven Y. Ng

发明人： Jorge Heller ,  Steven Y. Ng

IPC分类号： C07D493/10 ,  A61K9/107 ,  A61K9/20 ,  A61K9/51 ,  A61K47/34 ,  C08G63/664 ,  C08G65/00 ,  C08G81/00 ,  C08L71/02 ,  C08L101/16 ,  A61K31/335 ,  C07D319/08

CPC分类号： A61K9/1075 ,  A61K9/204 ,  C08G63/664 ,  C08L71/02

摘要： PEG-POE, PEG-POE-PEG, and POE-PEG-POE block copolymers have both hydrophilic and hydrophobic blocks. They form micelles in aqueous solution, making them suitable for encapsulation or solubilization of hydrophobic or water-insoluble materials; and they also form bioerodible matrices for the sustained release of active agents, especially when the POE block(s) contain at least one unit containing an .alpha.-hydroxy acid.

摘要翻译： PEG-POE，PEG-POE-PEG和POE-PEG-POE嵌段共聚物具有亲水性和疏水性嵌段。 它们在水溶液中形成胶束，使其适合于疏水或水不溶性材料的包封或溶解; 并且它们还形成用于持续释放活性剂的生物可蚀解基质，特别是当POE嵌段含有至少一个含有α-羟基酸的单元时。

公开(公告)号：US5891470A

公开(公告)日：1999-04-06

申请号：US62138

申请日：1998-04-17

申请人： Marie A. Rinaldi ,  Subhash J. Saxena ,  Paul C. Tutschek

发明人： Marie A. Rinaldi ,  Subhash J. Saxena ,  Paul C. Tutschek

IPC分类号： A61K9/16 ,  A61K9/48 ,  A61K9/50 ,  A61K9/66 ,  A61K31/07 ,  A61K31/375 ,  A61K9/52 ,  A61K9/54 ,  A61K9/58

CPC分类号： A61K31/07 ,  A61K31/375 ,  A61K9/1635 ,  A61K9/4858 ,  A61K9/4866 ,  A61K9/5084 ,  Y10S514/963 ,  Y10S514/965

摘要： A softgel formulation containing retinol comprises a soft gelatin shell and a fill material within that shell containing retinol-impregnated microparticles. The fill material may be an optionally thickened silicone oil, or may be an emulsion comprising a silicone oil. Ascorbic acid may be present as ascorbic acid-impregnated microparticles and/or within the emulsion.

摘要翻译： 含有视黄醇的软胶囊制剂包含软明胶壳和在含有视黄醇浸渍微粒的外壳内的填充材料。 填充材料可以是任选增稠的硅油，或者可以是包含硅油的乳液。 抗坏血酸可以作为抗坏血酸浸渍的微粒和/或在乳液内存在。