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公开(公告)号：US11464775B2
公开(公告)日：2022-10-11
申请号：US16639086
申请日：2018-08-15
发明人： Giovanni Cianchetta , Charles Kung , Tao Liu , Anil Kumar Padyana , Zhihua Sui , Zhenwei Cai , Dawei Cui , Jingjing Ji
IPC分类号： A61K31/5025 , A61K31/506 , A61K31/519 , C07D241/36 , C07D513/14 , A61K45/06
摘要： Described herein are methods of using compounds of Formula (I) to modulate PKM2 activity in a subject. These compounds are represented by Formula (I): wherein R1, R2, L1, and L2 are as defined herein.
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2.发明授权公开(公告)号：US11254652B2
公开(公告)日：2022-02-22
申请号：US16765456
申请日：2018-11-21
发明人： Jacob P. Sizemore , Liting Guo , Mahmoud Mirmehrabi , Yeqing Su
IPC分类号： C07D401/12
摘要： Provided herein are amorphous and crystalline hemisulfate salt forms of the formula (I). Also provided are pharmaceutical compositions comprising the amorphous and crystalline hemisulfate salt forms, methods for their manufacture, and uses thereof for treating conditions associated with pyruvate kinase such as e.g., pyruvate kinase deficiency.
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公开(公告)号：US20220005568A1
公开(公告)日：2022-01-06
申请号：US17477745
申请日：2021-09-17
IPC分类号： G16H15/00 , G16H70/40 , G16H10/20 , G06F16/00 , G06F40/247 , G06F40/279
摘要： Various embodiments include methods, computer program products and systems for analyzing reported adverse event (AE) data about a pharmaceutical, vaccine or medical device. In some cases, that reported AE data is unstructured. In these cases, a method can include: applying a natural language processing (NLP) filter to the unstructured reported AE data to generate an initial set of reporting codes for the unstructured reported AE data; providing the initial set of reporting codes for review by a healthcare professional, to either verify each of the reporting codes or modify at least one of the reporting codes, and generating a refined set of reporting codes based upon the review; and creating a safety case report linking the pharmaceutical, vaccine or medical device with the refined set of reporting codes. In additional embodiments, the safety report is provided to relevant authorities according to prescribed reporting criteria.
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公开(公告)号：US20210323944A1
公开(公告)日：2021-10-21
申请号：US17258102
申请日：2019-07-02
发明人： Chong-Hui GU , Jacob Paul SIZEMORE , Shijie ZHANG
IPC分类号： C07D401/14 , A61K9/20
摘要： Provided are formulations of ivosidenib including a number of polymorphs. Further provided are formulations of ivosidenib containing a number of known impurities. Still further provided are stable compositions of ivosidenib.
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公开(公告)号：US20210100805A1
公开(公告)日：2021-04-08
申请号：US16880871
申请日：2020-05-21
发明人： Vivek Saroj Kumar Chopra , Jorge DiMartino , Laurie A. Kenvin , Robert Douglas Knight , Kyle MacBerth , Krishnan Viswanadhan , Qiang Xu , Samuel V. Agresta
IPC分类号： A61K31/53 , A61K31/7068 , A61P35/02
摘要： Provided are methods and compositions for treating cancers in patients carrying an IDH2 mutation using a combination of an inhibitor of a mutant IDH2 enzyme and a DNA demethylating agent.
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公开(公告)号：US10711314B2
公开(公告)日：2020-07-14
申请号：US15963784
申请日：2018-04-26
发明人： Leonard Luan C. Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
IPC分类号： C12Q1/32 , C12Q1/6886 , A61K31/225 , A61K31/015 , A61K31/05 , A61K31/122 , A61K31/355 , A61K31/375 , A61K31/381 , A61K31/522 , A61K31/7004 , A61K31/713 , A61K38/06 , A61K38/44 , A61K31/194
摘要： Methods of diagnosing subjects having a cell proliferation-related disorder or suspected of having a cell proliferation-related disorder associated with mutant IDH enzymes with 2HG neoactivity.
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公开(公告)号：US10414740B2
公开(公告)日：2019-09-17
申请号：US15996723
申请日：2018-06-04
发明人： Rene M. Lemieux , Janeta Popovici-Muller , Francesco G. Salituro , Jeffrey O. Saunders , Jeremy Travins , Shunqi Yan
IPC分类号： C07D285/135 , C07D417/14 , C07D285/12 , C07D417/12 , C07D471/04
摘要： Compounds and compositions comprising compounds that inhibit glutaminase are described herein. Also described herein are methods of using the compounds that inhibit glutaminase in the treatment of cancer.
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公开(公告)号：US20180353491A1
公开(公告)日：2018-12-13
申请号：US16006234
申请日：2018-06-12
IPC分类号： A61K31/444 , A61P35/00
CPC分类号： A61K31/444 , A61K31/44 , A61K41/0038 , A61P35/00 , A61K2300/00
摘要： Provided are methods of treating a brain tumor in a patient in need thereof comprising administering to the patient a compound described herein and radiation therapy and/or one or more additional therapeutic agents.
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公开(公告)号：US10029987B2
公开(公告)日：2018-07-24
申请号：US15412976
申请日：2017-01-23
IPC分类号： A61K31/47 , A61K31/551 , C07D215/36 , C07D401/12 , C07D403/12 , C07D417/12
摘要： Compounds and compositions comprising compounds that modulate pyruvate kinase M2 (PKM2) are described herein. Also described herein are methods of using the compounds that modulate PKM2 in the treatment of cancer.
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公开(公告)号：US10028961B2
公开(公告)日：2018-07-24
申请号：US15093345
申请日：2016-04-07
发明人： Zenon D. Konteatis , Janeta Popovici-Muller , Jeremy M. Travins , Robert Zahler , Zhenwei Cai , Ding Zhou
IPC分类号： C07D401/04 , C07D403/04 , A61K31/506 , A61P35/00 , A61K31/53 , C07D417/04 , A61K45/06 , C07D251/18 , C07D401/14 , C07D405/14 , C07D405/12 , C07D413/04 , C07D417/14
CPC分类号： A61K31/53 , A61K31/506 , A61K31/5377 , A61K45/06 , C07D251/18 , C07D251/48 , C07D401/04 , C07D401/14 , C07D403/04 , C07D403/10 , C07D405/12 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/04 , C07D417/14
摘要： Provided are compounds useful for treating cancer and methods of treating cancer comprising administering to a subject in need thereof a compound described herein.
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