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公开(公告)号：US20240276957A1
公开(公告)日：2024-08-22
申请号：US17616790
申请日：2020-06-05
发明人： Giovanni Cianchetta , Peng Liu , Shengfang Jin , Brian Christopher Shook , Zhihua Sui , Kai Lu , Barden Chan , Gavin Whissell
IPC分类号： A01K67/0275 , C12N9/10 , C12N9/22 , C12N15/11 , C12N15/85
CPC分类号： A01K67/0275 , C12N9/1029 , C12N9/22 , C12N15/11 , C12N15/8509 , C12Y203/01037 , A01K2217/054 , A01K2217/075 , A01K2227/105 , A01K2267/0306 , C12N2015/8536 , C12N2310/20 , C12N2800/80
摘要： Described herein is a compound of Formula I or a pharmaceutically acceptable salt thereof: wherein Ring A R1, R2, a, b, and n are as defined herein. Also described is a method of treating a subject having a disorder in need of treatment, comprising inhibiting aminolevulinic acid synthase 2 (ALAS2) in the subject by administering a compound of Formula (I) or a pharmaceutically acceptable salt thereof. Disorders that are of particular interest are blood disorders, such as porphyria and anemia.
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公开(公告)号：US20200281501A1
公开(公告)日：2020-09-10
申请号：US16790860
申请日：2020-02-14
发明人： Lenny Dang , Valeria Fantin , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Francesco G. Salituro , Jeffrey O. Saunders , Shin-San Michael Su , Katharine Yen
IPC分类号： A61B5/055 , A61K31/41 , A61K31/426 , A61K45/06 , C12N15/113 , G01N33/574 , G16H40/63 , C12Q1/32 , C12Q1/6886
摘要： Methods of treating and evaluating subjects having neoactive mutants are described herein.
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公开(公告)号：US10711314B2
公开(公告)日：2020-07-14
申请号：US15963784
申请日：2018-04-26
发明人： Leonard Luan C. Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
IPC分类号： C12Q1/32 , C12Q1/6886 , A61K31/225 , A61K31/015 , A61K31/05 , A61K31/122 , A61K31/355 , A61K31/375 , A61K31/381 , A61K31/522 , A61K31/7004 , A61K31/713 , A61K38/06 , A61K38/44 , A61K31/194
摘要： Methods of diagnosing subjects having a cell proliferation-related disorder or suspected of having a cell proliferation-related disorder associated with mutant IDH enzymes with 2HG neoactivity.
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公开(公告)号：US09982309B2
公开(公告)日：2018-05-29
申请号：US15238161
申请日：2016-08-16
发明人： Leonard Luan C. Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
IPC分类号： A61K31/225 , C12Q1/68 , A61K31/015 , A61K31/05 , A61K31/122 , A61K31/355 , A61K31/375 , A61K31/381 , A61K31/522 , A61K31/7004 , A61K31/713 , A61K38/06 , A61K38/44 , C12Q1/32 , A61K31/194
CPC分类号： C12Q1/6886 , A61K31/015 , A61K31/05 , A61K31/122 , A61K31/194 , A61K31/225 , A61K31/355 , A61K31/375 , A61K31/381 , A61K31/522 , A61K31/7004 , A61K31/713 , A61K38/063 , A61K38/44 , C12Q1/32 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156
摘要： Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).
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公开(公告)号：US20170044620A1
公开(公告)日：2017-02-16
申请号：US15238161
申请日：2016-08-16
发明人： Leonard Luan C. Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
IPC分类号： C12Q1/68 , A61K31/194
CPC分类号： C12Q1/6886 , A61K31/015 , A61K31/05 , A61K31/122 , A61K31/194 , A61K31/225 , A61K31/355 , A61K31/375 , A61K31/381 , A61K31/522 , A61K31/7004 , A61K31/713 , A61K38/063 , A61K38/44 , C12Q1/32 , C12Q2600/106 , C12Q2600/112 , C12Q2600/118 , C12Q2600/136 , C12Q2600/156
摘要： Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).
摘要翻译： 治疗和评估具有IDH（例如，IDH1或IDH2）的新生突变体的受试者的方法。
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公开(公告)号：US20190276894A1
公开(公告)日：2019-09-12
申请号：US15963784
申请日：2018-04-26
发明人： Leonard Luan C. Dang , Stefan Gross , Hyun Gyung Jang , Shengfang Jin , Shin-San Michael Su , Craig Thompson
IPC分类号： C12Q1/6886 , A61K31/355 , A61K31/375 , A61K31/05 , A61K31/522 , A61K31/713 , A61K31/015 , A61K31/122 , A61K31/194 , A61K38/06 , A61K31/225 , A61K38/44 , C12Q1/32 , A61K31/7004 , A61K31/381
摘要： Methods of treating and evaluating subjects having neoactive mutants of IDH (e.g., IDH1 or IDH2).
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