公开(公告)号：US20220151920A1

公开(公告)日：2022-05-19

申请号：US17529155

申请日：2021-11-17

申请人： Bend Research, Inc.

发明人： Kimberly Shepard ,  Michael Banks ,  David Vodak

IPC分类号： A61K9/00 ,  A61K31/337 ,  A61K31/4745 ,  A61K31/555 ,  A61K31/517 ,  C07K16/22 ,  A61K33/243 ,  A61K9/16 ,  A61K45/06

摘要： The present disclosure relates to inhalable dry powder formulations comprising one or more antibodies or one or more angiogenesis inhibiting active pharmaceutical ingredients, methods of manufacture of such compositions, e.g., via spray drying, as well as their local administration to the lung for use in the treatment, prevention and/or delay of progression of asthma, COPD, lung infections, cystic fibrosis, or lung cancer.

公开(公告)号：US11116728B2

公开(公告)日：2021-09-14

申请号：US16440907

申请日：2019-06-13

申请人： Bend Research, Inc.

发明人： Dwayne Thomas Friesen ,  Leah E. Appel ,  Joshua Richard Shockey ,  Sanjay Konagurthu ,  Edward Dennis LaChapelle

IPC分类号： A61K9/50

摘要： A pharmaceutical composition comprises multiparticulates comprising a melt-congeal core and a solid amorphous dispersion layer of a poorly water soluble drug and polymer. The multiparticulates are suitable for improving bioavailability of poorly water soluble drugs. The melt-congeal cores facilitate application of the solid amorphous dispersion layer, and allow incorporation of additional optional components to the core so as to adjust the release of drug from the multiparticulate.

公开(公告)号：US09757464B2

公开(公告)日：2017-09-12

申请号：US14179480

申请日：2014-02-12

申请人： Bend Research, Inc.

发明人： Warren K. Miller ,  David T. Vodak ,  Daniel E. Dobry ,  David K. Lyon ,  Dwayne T. Friesen ,  Michael M. Morgen ,  Corey J. Bloom ,  Daniel T. Smithey

IPC分类号： A61K47/36 ,  A61K9/00 ,  A61K9/10 ,  A61K9/16 ,  A61K9/19 ,  A61K9/51 ,  A61K31/57

CPC分类号： A61K47/36 ,  A61K9/0019 ,  A61K9/0048 ,  A61K9/0075 ,  A61K9/0095 ,  A61K9/10 ,  A61K9/1652 ,  A61K9/19 ,  A61K9/5161 ,  A61K31/57

摘要： Pharmaceutical compositions are provided comprising an active agent and a dextran polymer derivative. The compositions include from 0.01 to 99 wt % of an active agent and from 1 to 99.99 wt % of a dextran polymer derivative. The dextran polymer derivative is selected from dextran acetate, dextran propionate, dextran succinate, dextran acetate propionate, dextran acetate succinate, dextran propionate succinate, dextran acetate propionate succinate, and mixtures thereof.

公开(公告)号：US09713594B2

公开(公告)日：2017-07-25

申请号：US14426647

申请日：2013-09-05

申请人： Bend Research, Inc.

发明人： Jason A. Everett ,  Randy J. Wald ,  Sanjay Konagurthu

IPC分类号： A61K9/10 ,  A61K9/50 ,  A61K9/16 ,  A61K9/20 ,  A61K31/4166

CPC分类号： A61K9/5089 ,  A61K9/10 ,  A61K9/1611 ,  A61K9/1652 ,  A61K9/1694 ,  A61K9/2009 ,  A61K9/2054 ,  A61K9/2077 ,  A61K9/2095 ,  A61K31/4166

摘要： An exemplary method comprises providing a spray-dried dispersion comprising particles, the particles comprising an active agent and a polymer, the dispersion particles having an average particle diameter of less than 50 μm. An ordered mixture is formed by high-shear mixing the dispersion with a powdered glidant, wherein the average particle diameter of the glidant is less than or equal to one fifth the average particle diameter of the dispersion after high-shear mixing. The dosage forms are formed by at least one of directly compressing the ordered mixture to form a tablet and encapsulating the ordered mixture to form a capsule.

公开(公告)号：US09545384B2

公开(公告)日：2017-01-17

申请号：US12451814

申请日：2008-05-26

申请人： Warren Kenyon Miller

发明人： Warren Kenyon Miller

IPC分类号： A61K9/51 ,  A61K31/355 ,  A61K47/22 ,  A61K47/38

CPC分类号： A61K9/5123 ,  A61K9/5161 ,  A61K31/355 ,  A61K47/22 ,  A61K47/38

摘要： A pharmaceutical composition comprises nanoparticles comprising a poorly water soluble drug, a non-ionizable cellulosic polymer, and TPGS.

摘要翻译： 药物组合物包含包含难溶于水的药物，不可离子化的纤维素聚合物和TPGS的纳米颗粒。

公开(公告)号：US09457095B2

公开(公告)日：2016-10-04

申请号：US14659271

申请日：2015-03-16

申请人： Bend Research, Inc.

发明人： William J. Curatolo ,  Ravi M. Shanker ,  Walter C. Babcock ,  Dwayne T. Friesen ,  James A. S. Nightingale ,  Douglas A. Lorenz

IPC分类号： A61K47/38 ,  A61K9/14 ,  A61K9/16 ,  A61K31/135 ,  A61K31/4375 ,  A61K31/4178 ,  A61K31/496 ,  A61K31/517 ,  A61K31/404

CPC分类号： A61K47/38 ,  A61K9/146 ,  A61K9/1629 ,  A61K9/1652 ,  A61K31/135 ,  A61K31/404 ,  A61K31/4178 ,  A61K31/4375 ,  A61K31/496 ,  A61K31/517

摘要： A drug in a solubility-improved form is combined with a concentration-enhancing polymer in a sufficient amount so that the combination provides substantially enhanced drug concentration in a use environment relative to a control comprising the same amount of the same solubility-improved form of drug without the concentration-enhancing polymer.

公开(公告)号：US09358478B2

公开(公告)日：2016-06-07

申请号：US14738673

申请日：2015-06-12

申请人： Bend Research, Inc.

发明人： Daniel E. Dobry ,  James M. Mullin ,  Douglas L. Millard ,  Dwayne T. Friesen ,  David D. Newbold ,  John M. Baumann ,  Devon B. Dubose

IPC分类号： B01D1/18 ,  B01J2/04 ,  B01D1/20

CPC分类号： B01D1/18 ,  B01D1/20 ,  B01J2/04

摘要： A spray-drying apparatus includes a drying chamber that has a first end, a second end, and at least one side wall extending between the first and second ends to define an interior of the drying chamber having a center axis. A nozzle can be positioned at the first end of the drying chamber and be configured to atomize liquid and spray the atomized liquid into the interior of the drying chamber at a maximum spray pattern angle relative to the center axis. A heating device can be provided to heat the liquid prior to introduction into the drying chamber.

公开(公告)号：US09339467B2

公开(公告)日：2016-05-17

申请号：US14451879

申请日：2014-08-05

申请人： Bend Research, Inc.

发明人： Ronald A. Beyerinck ,  Heather L. M. Deibele ,  Dan E. Dobry ,  Roderick J. Ray ,  Dana M. Settell ,  Ken R. Spence

IPC分类号： A61K9/16 ,  B01J2/04 ,  A61K31/404 ,  A61K31/47 ,  A61J3/02 ,  A61K9/14

CPC分类号： A61K9/1682 ,  A61J3/02 ,  A61K9/146 ,  A61K9/1652 ,  A61K9/1694 ,  A61K31/404 ,  A61K31/47 ,  B01J2/04

摘要： Conventional spray-drying methods are improved by incorporation of a pressure nozzle and a diffuser plate to improve the flow of drying gas and a drying chamber extension to increase drying time, such improvements leading to the formation of homogeneous solid dispersions of drugs in concentration-enhancing polymers.

公开(公告)号：US09322749B2

公开(公告)日：2016-04-26

申请号：US14072263

申请日：2013-11-05

申请人： Bend Research, Inc.

发明人： David Dixon Newbold ,  Douglas Lee Millard ,  George Lewis Ellis, Jr.

IPC分类号： G01N1/14 ,  C12M1/26 ,  G01N1/10

CPC分类号： G01N1/14 ,  C12M33/04 ,  C12M37/00 ,  G01N2001/1037

摘要： A sample can be collected from an enclosed container by opening a sample collection valve and drawing the sample from the enclosed container. After delivery of the sample out of a fluid flow path, a sanitizing fluid can be directed along the fluid flow path to sanitize the fluid flow path.

摘要翻译： 通过打开样品收集阀并从封闭的容器中抽出样品，可以从封闭的容器收集样品。 在将样品从流体流路传送出去之后，可以沿流体流动路径引导消毒流体以消除流体流动路径。

公开(公告)号：US20150374827A1

公开(公告)日：2015-12-31

申请号：US14767264

申请日：2014-02-12

申请人： BEND RESEARCH, INC.

发明人： Warren K. Miller ,  Michael M. Morgen

IPC分类号： A61K47/20 ,  A61K31/517

CPC分类号： A61K31/517 ,  A61K9/146

摘要： Disclosed are compositions including a solid dispersion comprising a dispersion polymer, a basic low-water solubility active, and an anionic counterion, as well as methods of making and using the compositions.

摘要翻译： 公开了包括包含分散体聚合物，碱性低水溶性活性物质和阴离子抗衡离子的固体分散体的组合物，以及制备和使用该组合物的方法。