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1.发明申请METHOD OF SURFACE PLASMON RESONANCE (SPR) TECHNOLOGY TO DETECT GENOMIC DISORDERS FOR PRENATAL DIAGNOSIS 审中-公开表面等离子共振（SPR）技术检测基因治疗疾病进行临床诊断的方法公开(公告)号：US20100279422A1
公开(公告)日：2010-11-04
申请号：US12438333
申请日：2007-08-14
申请人： Zhong Chen , Ning Liu
发明人： Zhong Chen , Ning Liu
CPC分类号： G01N33/54373 , C12Q1/6883 , G01N21/553 , G01N33/553 , G01N2800/385 , Y10T436/143333
摘要： The present invention discloses using SPR technology to prenatally detect specific DNA loss or gain related to some genomic disorders. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of DNA markers used for the identification of chromosome numerical abnormalities (such as chromosomes 13, 18, 21, X and Y related anomalies) and chromosome microdeletion syndromes (such as DiGeorge syndrome, etc) is also disclosed.
摘要翻译： 本发明公开了使用SPR技术预先检测与某些基因组紊乱相关的特定DNA损失或增益。 制备混合SAM的有效配方可以大大增强金属表面在基于SPR的技术中的固定能力，这有助于固定用于鉴定染色体数值异常的DNA标记（如染色体13,18,21 ，X和Y相关异常）和染色体微缺失综合征（如DiGeorge综合征等）也被公开。
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2.发明申请公开(公告)号：US20100047815A1
公开(公告)日：2010-02-25
申请号：US12441357
申请日：2007-08-07
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： G01N33/53
CPC分类号： G01N33/57492 , G01N33/54373
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different tumor markers in a protein sample extracted from tumor tissue, which can be used for the diagnosis of undifferentiated tumors. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of monoclonal antibodies used for detecting tumor markers in a tumor tissue sample and for the diagnosis of undifferentiated tumors.
摘要翻译： 本发明公开了使用SPR技术同时并定量测定从肿瘤组织提取的蛋白质样品中不同肿瘤标志物的浓度，可用于诊断未分化肿瘤。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于肿瘤标志物在肿瘤组织样品中检测的单克隆抗体和诊断 的未分化肿瘤。
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3.发明申请METHOD OF SURFACE PLASMON RESONANCE (SPR) TO DETECT GENOMIC ABERRATIONS IN PATIENTS WITH CHRONIC LYMPHOCYTIC LEUKEMIA 审中-公开表面等离子体共振（SPR）检测慢性淋巴细胞白血病患者基因型异常的方法公开(公告)号：US20090311699A1
公开(公告)日：2009-12-17
申请号：US12441708
申请日：2007-08-22
申请人： Zhong Chen , Ning Liu
发明人： Zhong Chen , Ning Liu
CPC分类号： B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/00612 , B01J2219/00617 , B01J2219/00626 , B01J2219/00637 , B01J2219/00722
摘要： This invention discloses using SPR technology to detect CLL related genomic aberrations in peripheral blood samples. An efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of CLL related DNA markers used for the detection of genomic aberrations for patients with chronic lymphocytic leukemia (CLL) is also disclosed.
摘要翻译： 本发明公开了使用SPR技术检测外周血样品中的CLL相关基因组畸变。 制备混合SAM的有效配方可以大大增强金属表面在SPR技术中的固定能力，这对于用于检测慢性淋巴细胞性白血病（CLL）患者基因组畸变的CLL相关DNA标记物的固定是有益的 ）也被公开。
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4.发明申请公开(公告)号：US20090239766A1
公开(公告)日：2009-09-24
申请号：US12441529
申请日：2007-08-27
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
CPC分类号： G01N33/56988 , G01N33/54353 , G01N33/54373 , G01N2333/16 , G01N2469/20 , Y10S436/805
摘要： This invention discloses using SPR technology to simultaneously and qualitatively measure the presence of HIV related antibodies in a serum sample for the diagnosis of HIV infection. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of HIV related antigens used for the diagnosis of HIV infection.
摘要翻译： 本发明公开了使用SPR技术同时且定性地测量血清样品中HIV相关抗体的存在，用于诊断HIV感染。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这对于用于诊断HIV感染的HIV相关抗原的固定是有利的。
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5.发明授权Method for quantitative measurement of thyroid related antibodies or antigens in a serum sample 失效血清样品中甲状腺相关抗体或抗原的定量测定方法公开(公告)号：US08158440B2
公开(公告)日：2012-04-17
申请号：US12442381
申请日：2007-09-17
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： G01N33/53 , G01N33/553
CPC分类号： G01N33/54373 , G01N2800/046 , Y10S435/808 , Y10S436/805 , Y10S436/815
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of thyroid hormones and related antibodies in a serum sample, which can be used to evaluate thyroid functions and to diagnose thyroid diseases. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies and antigens used for the detection of respective thyroid hormones and related antibodies in a serum sample.
摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中甲状腺激素和相关抗体的浓度，可用于评估甲状腺功能和诊断甲状腺疾病。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于检测相应甲状腺激素和相关抗体的相关抗体和抗原 血清样品。
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6.发明授权Method for the identification of human immunodeficiency virus related antibodies in blood 失效血液中人体免疫缺陷病毒相关抗体鉴定方法公开(公告)号：US08158342B2
公开(公告)日：2012-04-17
申请号：US12441529
申请日：2007-08-27
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： G01N33/569 , G01N33/553
CPC分类号： G01N33/56988 , G01N33/54353 , G01N33/54373 , G01N2333/16 , G01N2469/20 , Y10S436/805
摘要： This invention discloses using SPR technology to simultaneously and qualitatively measure the presence of HIV related antibodies in a serum sample for the diagnosis of HIV infection. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of HIV related antigens used for the diagnosis of HIV infection.
摘要翻译： 本发明公开了使用SPR技术同时且定性地测量血清样品中HIV相关抗体的存在，用于诊断HIV感染。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这对于用于诊断HIV感染的HIV相关抗原的固定是有利的。
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公开(公告)号：US08153445B2
公开(公告)日：2012-04-10
申请号：US12441351
申请日：2007-07-31
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： G01N33/551 , G01N33/553
CPC分类号： G01N33/54373 , B01J19/0046 , B01J2219/00385 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00725 , B01J2219/0074 , G01N33/54353 , Y10S436/805
摘要： This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of infectious agent related antibodies and/or antigens in a serum sample, which can be used to screen for infectious agents in blood. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antigens and antibodies used for the screening of infectious agents in blood.
摘要翻译： 本发明公开了使用SPR技术同时且定性地检测血清样品中与感染因子相关的抗体和/或抗原的存在，其可用于筛选血液中的感染因子。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于筛选血液中感染因子的相关抗原和抗体。
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8.发明申请METHOD TO DETECT VIRUS RELATED IMMUNOLOGICAL MARKERS FOR THE DIAGNOSIS OF HEPATITIS B VIRUS INFECTION 审中-公开检测病毒相关免疫标记物用于诊断乙型肝炎病毒感染的方法公开(公告)号：US20100028856A1
公开(公告)日：2010-02-04
申请号：US12442375
申请日：2007-08-28
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
CPC分类号： C12Q1/706 , C12Q2565/628 , C12Q2563/131 , C12Q2537/143
摘要： This invention discloses using SPR technology to simultaneously and qualitatively measure the presence of HBV-associated immunological markers in a serum sample for the diagnosis of HBV infection. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of HBV related antigens or antibodies used for the diagnosis of HBV infection.
摘要翻译： 本发明公开了使用SPR技术同时定量测定血清样本中HBV相关免疫标志物的存在，用于诊断HBV感染。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定HBV相关抗原或用于诊断HBV感染的抗体。
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9.发明申请METHOD FOR QUANTITATIVE MEASUREMENT OF THYROID HORMONES AND RELATED ANTIBODIES IN A SERUM SAMPLE 失效血清样品中THYROID HORMONES和相关抗体的定量测量方法公开(公告)号：US20090280575A1
公开(公告)日：2009-11-12
申请号：US12442381
申请日：2007-09-17
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： G01N33/78
CPC分类号： G01N33/54373 , G01N2800/046 , Y10S435/808 , Y10S436/805 , Y10S436/815
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of thyroid hormones and related antibodies in a serum sample, which can be used to evaluate thyroid functions and to diagnose thyroid diseases. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies and antigens used for the detection of respective thyroid hormones and related antibodies in a serum sample.
摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中甲状腺激素和相关抗体的浓度，可用于评估甲状腺功能和诊断甲状腺疾病。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于检测相应甲状腺激素和相关抗体的相关抗体和抗原 血清样品。
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公开(公告)号：US20090263787A1
公开(公告)日：2009-10-22
申请号：US12441351
申请日：2007-07-31
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： C12Q1/70 , G01N33/553 , G01N33/552
CPC分类号： G01N33/54373 , B01J19/0046 , B01J2219/00385 , B01J2219/00626 , B01J2219/00637 , B01J2219/00659 , B01J2219/00725 , B01J2219/0074 , G01N33/54353 , Y10S436/805
摘要： This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of infectious agent related antibodies and/or antigens in a serum sample, which can be used to screen for infectious agents in blood. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antigens and antibodies used for the screening of infectious agents in blood.
摘要翻译： 本发明公开了使用SPR技术同时且定性地检测血清样品中与感染因子相关的抗体和/或抗原的存在，其可用于筛选血液中的感染因子。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于筛选血液中感染因子的相关抗原和抗体。
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