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1.发明申请公开(公告)号：US20100047815A1
公开(公告)日：2010-02-25
申请号：US12441357
申请日：2007-08-07
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： G01N33/53
CPC分类号： G01N33/57492 , G01N33/54373
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different tumor markers in a protein sample extracted from tumor tissue, which can be used for the diagnosis of undifferentiated tumors. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of monoclonal antibodies used for detecting tumor markers in a tumor tissue sample and for the diagnosis of undifferentiated tumors.
摘要翻译： 本发明公开了使用SPR技术同时并定量测定从肿瘤组织提取的蛋白质样品中不同肿瘤标志物的浓度，可用于诊断未分化肿瘤。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于肿瘤标志物在肿瘤组织样品中检测的单克隆抗体和诊断 的未分化肿瘤。
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2.发明申请公开(公告)号：US20090239766A1
公开(公告)日：2009-09-24
申请号：US12441529
申请日：2007-08-27
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
CPC分类号： G01N33/56988 , G01N33/54353 , G01N33/54373 , G01N2333/16 , G01N2469/20 , Y10S436/805
摘要： This invention discloses using SPR technology to simultaneously and qualitatively measure the presence of HIV related antibodies in a serum sample for the diagnosis of HIV infection. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of HIV related antigens used for the diagnosis of HIV infection.
摘要翻译： 本发明公开了使用SPR技术同时且定性地测量血清样品中HIV相关抗体的存在，用于诊断HIV感染。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这对于用于诊断HIV感染的HIV相关抗原的固定是有利的。
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3.发明申请METHOD TO ASSESS CANCER SUSCEPTIBILITY AND DIFFERENTIAL DIAGNOSIS OF METASTASES OF UNKNOWN PRIMARY TUMORS 审中-公开评估癌症可疑性的方法和未知原发性肿瘤的病变的差异诊断公开(公告)号：US20100086920A1
公开(公告)日：2010-04-08
申请号：US12441344
申请日：2007-07-27
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
CPC分类号： G01N33/54373 , G01N33/544 , G01N33/553 , G01N33/57473
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different tumor markers in a serum sample, which can be used to screen for and determine susceptibility to cancer as well as for the differential diagnosis of metastases from an unknown primary tumor. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of monoclonal antibodies used for cancer susceptibility assessment and for differential diagnosis of metastases from an unknown primary tumor.
摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中不同肿瘤标志物的浓度，可用于筛选和确定对癌症的易感性以及来自未知原发肿瘤的转移的鉴别诊断。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这对于用于癌症易感性评估的单克隆抗体的固定以及来自未知的转移的鉴别诊断是有益的 原发性肿瘤。
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4.发明申请公开(公告)号：US20100009464A1
公开(公告)日：2010-01-14
申请号：US12442379
申请日：2007-09-17
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
CPC分类号： G01N33/54373 , G01N2800/36 , Y10S435/808 , Y10S436/805 , Y10S436/814 , Y10S436/817
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different sex hormones in a serum sample, which can be used to evaluate different clinical situations. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of representative sex hormones in a serum sample.
摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中不同性激素的浓度，可用于评估不同临床情况。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于检测血清样品中代表性性激素的相关抗体。
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公开(公告)号：US20100004872A1
公开(公告)日：2010-01-07
申请号：US12442378
申请日：2007-09-07
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
CPC分类号： G01N33/6893 , G01N2800/32 , G01N2800/325
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different cardiac biochemical markers in a serum sample, which can be used for the early diagnosis of cardiovascular diseases and myocardial infarction. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of representative cardiac biochemical markers in a serum sample.
摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中不同心脏生化标志物的浓度，可用于心血管疾病和心肌梗死的早期诊断。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于检测血清样品中代表性心脏生化标志物的相关抗体。
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6.发明申请公开(公告)号：US20090325190A1
公开(公告)日：2009-12-31
申请号：US12441530
申请日：2007-09-17
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： G01N33/53
CPC分类号： G01N33/553 , G01N33/54373 , G01N2800/042 , Y10S435/808 , Y10S436/805
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of diabetes related immunological makers in a serum sample, which can be used to diagnose and/or early diagnose diabetes as well as to predict the onset risk of diabetes in first-degree relatives. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antigens and antibodies used for the detection of respective diabetes related immunological makers in a serum sample.
摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中糖尿病相关免疫学家的浓度，可用于诊断和/或早期诊断糖尿病，并预测一级亲属糖尿病的发病风险 。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定相关抗原和抗体，用于检测相应的糖尿病相关免疫学家 血清样品。
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公开(公告)号：US08114682B2
公开(公告)日：2012-02-14
申请号：US12442379
申请日：2007-09-17
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： G01N33/553
CPC分类号： G01N33/54373 , G01N2800/36 , Y10S435/808 , Y10S436/805 , Y10S436/814 , Y10S436/817
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different sex hormones in a serum sample, which can be used to evaluate different clinical situations. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of representative sex hormones in a serum sample.
摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中不同性激素的浓度，可用于评估不同临床情况。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于检测血清样品中代表性性激素的相关抗体。
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8.发明授权公开(公告)号：US08110408B2
公开(公告)日：2012-02-07
申请号：US12441530
申请日：2007-09-17
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： G01N33/553
CPC分类号： G01N33/553 , G01N33/54373 , G01N2800/042 , Y10S435/808 , Y10S436/805
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of diabetes related immunological makers in a serum sample, which can be used to diagnose and/or early diagnose diabetes as well as to predict the onset risk of diabetes in first-degree relatives. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antigens and antibodies used for the detection of respective diabetes related immunological makers in a serum sample.
摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中糖尿病相关免疫学家的浓度，可用于诊断和/或早期诊断糖尿病，并预测一级亲属糖尿病的发病风险 。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定相关抗原和抗体，用于检测相应的糖尿病相关免疫学家 血清样品。
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9.发明申请METHOD TO DETECT VIRUS RELATED IMMUNOLOGICAL MARKERS FOR THE DIAGNOSIS OF RESPIRATORY TRACT INFECTIONS 失效检测病毒相关免疫标记物进行呼吸道感染诊断的方法公开(公告)号：US20100021882A1
公开(公告)日：2010-01-28
申请号：US12441792
申请日：2007-09-12
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： C12Q1/70
CPC分类号： B01J19/0046 , B01J2219/00527 , B01J2219/00605 , B01J2219/00659 , B01J2219/00702 , B01J2219/00722 , B01J2219/00725 , B01J2219/0074 , G01N33/54353 , G01N33/54373 , G01N33/56983 , G01N2800/12 , Y10S435/808 , Y10S436/805
摘要： This invention discloses using SPR technology to simultaneously and qualitatively detect the presence of respiratory tract viruses-related immunological markers in a serum sample, which can be used for the diagnosis of respiratory tract infections. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of representative antigens used to detect the respective respiratory tract viruses-related immunological markers (antibodies) in blood for the diagnosis of respiratory tract infections.
摘要翻译： 本发明公开了使用SPR技术同时定性检测血清样品中呼吸道病毒相关免疫学标志物的存在，可用于诊断呼吸道感染。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这对于固定用于检测各个呼吸道病毒相关免疫标记（抗体 ）用于诊断呼吸道感染。
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10.发明申请公开(公告)号：US20090275061A1
公开(公告)日：2009-11-05
申请号：US12441771
申请日：2007-09-12
申请人： Zhong Chen , Ning Liu , Yancun Li
发明人： Zhong Chen , Ning Liu , Yancun Li
IPC分类号： G01N33/566 , C12M1/34
CPC分类号： G01N33/6893 , G01N33/54353 , G01N33/54373 , G01N33/553 , G01N2800/085 , Y10S435/808 , Y10S436/805
摘要： This invention discloses using SPR technology to simultaneously and quantitatively measure the concentrations of different liver fibrosis-associated serum biomarkers in a serum sample, which can be used for the diagnosis of liver fibrosis. It also discloses an efficient formula to make a mixed SAM that can greatly enhance the immobilization ability of the metal surface in SPR based techniques, which is good for the immobilization of relevant antibodies used for the detection of liver fibrosis-associated serum biomarkers for the diagnosis of liver fibrosis.
摘要翻译： 本发明公开了使用SPR技术同时并定量测定血清样品中不同肝纤维化相关血清生物标志物的浓度，可用于诊断肝纤维化。 它还公开了一种制备混合SAM的有效配方，可以大大增强金属表面在基于SPR的技术中的固定能力，这有利于固定用于检测肝纤维化相关血清生物标志物的相关抗体用于诊断 的肝纤维化。
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