-
公开(公告)号：US08747391B2
公开(公告)日：2014-06-10
申请号：US13706462
申请日：2012-12-06
IPC分类号： A61K9/22
CPC分类号： A61M5/1684 , A61M5/14276 , A61M2205/3317 , A61M2205/3389
摘要： An implantable pump includes a base plate and a can that are parts of the pump housing. The base plate bottom divides the housing into a first electronics chamber and a second chamber. A bellows mechanism is connected to the base plate and is disposed within the second chamber. The bellow mechanism has an expandable sidewall and a bottom plate. The bellow mechanism divides the second chamber into a medicament receiving portion and a non-medicament-receiving portion. The bellow mechanism has an intermediate plate disposed within the medicament-receiving portion. A coil is disposed in a recess on the lower surface of the base plate, and the coil is spaced from an internal wall of the recess. The amount of fluid remaining in the implantable pump can be monitored by energizing the coil. A primary magnetic field is generated by the energized coil. A secondary magnetic field, which is dependant on the position of the bottom and intermediate plate of the bellow mechanism, couples back to the primary field affecting the electrical characteristics of the coil. The amount of fluid remaining in the reservoir is determined based on the resulting changes in the electrical characteristics of the coil.
摘要翻译： 可植入泵包括作为泵壳体的部件的基板和罐。 基板底部将壳体分成第一电子室和第二室。 波纹管机构连接到基板并且设置在第二室内。 波纹管机构具有可膨胀的侧壁和底板。 波纹管机构将第二腔室分成药物接收部分和非药物接收部分。 波纹管机构具有设置在药物接收部分内的中间板。 线圈设置在基板的下表面上的凹部中，线圈与凹部的内壁间隔开。 可以通过对线圈通电来监测可植入泵中剩余的流体量。 由励磁线圈产生初级磁场。 取决于波纹管机构的底板和中间板的位置的次级磁场耦合回到影响线圈的电特性的初级场。 基于所得到的线圈的电特性的变化来确定储存器中剩余的流体的量。
-
公开(公告)号：US20120247227A1
公开(公告)日：2012-10-04
申请号：US13077091
申请日：2011-03-31
申请人： Rocco Crivelli
发明人： Rocco Crivelli
IPC分类号： G01L5/00
CPC分类号： G01L19/086 , A61B5/0031 , A61B5/6861 , A61B2562/0247 , G01L19/149
摘要： An implantable active pressure transducer including a pressure sensing element and associated sensor circuitry together enclosed within an innermost glass packaging. The pressure sensing element is anodically bonded to the innermost packaging substantially aligned with an opening defined therein. An outermost biocornpatible metal packaging forms a cavity divided into first and second chambers by an intermediate partition. The innermost packaging is disposed within the first chamber without physically directly contacting or being fixed to the outermost packaging. A barrier plate is hermetically sealed to the intermediate partition to hermetically isolate the battery and communication circuitry from a pressure transmitting fluid. Inductive coupling is used to communicate data detected by the pressure sensing element internally within the implant.
摘要翻译： 一种可植入主动压力传感器，包括压力感测元件和相关联的传感器电路，一起封闭在最内层的玻璃包装内。 压力感测元件阳极结合到基本上与其中限定的开口对齐的最内层的包装。 最外面的生物相容性金属包装通过中间隔板形成分为第一和第二腔室的空腔。 最内层的包装设置在第一室内，而不物理地直接接触或固定在最外层的包装上。 阻挡板气密地密封到中间隔板上，以将电池和通信电路与压力传递流体密封隔离。 感应耦合用于在植入物内部传送由压力感测元件检测到的数据。
-
公开(公告)号：US08231563B2
公开(公告)日：2012-07-31
申请号：US12655404
申请日：2009-12-30
CPC分类号： A61M27/006
摘要： An electrokinetic actuator for fluid flow titration including two chambers separated from one another by a porous dielectric disposed therebetween. A plurality of electrodes are disposed about a perimeter of the first and second chambers. Polar electrolyte disposed within the actuator is able to pass through the porous dielectric between the first and second chambers upon the application of an electric field or electric potential to the plural electrodes. A mechanical valve actuation mechanism connected to the second chamber allows for fine titration of fluid flow using electro-osmosis, including full-flow and/or complete cut-off. The polar electrolyte is isolated to prohibit intermixing with a fluid being titrated (such as cerebrospinal fluid).
摘要翻译： 一种用于流体流滴定的电动致动器，包括通过设置在它们之间的多孔电介质彼此隔开的两个室。 多个电极围绕第一和第二腔室的周边设置。 设置在致动器内的极性电解质能够在向多个电极施加电场或电位时通过第一和第二室之间的多孔电介质。 连接到第二室的机械阀致动机构允许使用电渗透（包括全流和/或完全截止）的精细滴定流体流动。 分离极性电解质以禁止与被滴定的流体混合（如脑脊液）。
-
公开(公告)号：US20110320049A1
公开(公告)日：2011-12-29
申请号：US12803574
申请日：2010-06-29
申请人： Olivier Chossat , Timothy Flynn
发明人： Olivier Chossat , Timothy Flynn
CPC分类号： G16H70/40 , A61M5/1407 , G06F19/00 , G06F19/326 , G06F19/3468 , G16H20/17
摘要： Minimizing improper dosage of a drug admixture (including a single primary drug component and at least one second drug component). For each drug component in the drug admixture, receiving a name of the drug component along with its dosage unit, a maximum dose warning level and a maximum concentration warning level. Receiving a concentration for each of the single primary drug component and the at least one secondary drug component; and a dose setting of only the primary drug component. Automatically calculating a dose of each of the at least one secondary drug component. Generating an alert when: (i) the received dose setting of the primary drug component or calculated dose setting of the at least one secondary drug component exceeds the dose warning level; or (ii) the received concentration of the primary drug component or the at least one secondary drug component exceeds the concentration warning level.
摘要翻译： 最小化药物混合物的不适当剂量（包括单一初级药物成分和至少一种第二药物成分）。 对于药物混合物中的每种药物成分，接受药物成分及其剂量单位的名称，最大剂量警告水平和最大浓度警戒水平。 接受每种单一原药成分和至少一种次级药物成分的浓度; 以及只有初级药物成分的剂量设定。 自动计算所述至少一种次要药物成分中的每一种的剂量。 在以下情况下产生警报：（i）所述主要药物成分的接收剂量设定或至少一种次要药物成分的计算剂量设定超过剂量警告水平; 或者（ii）主要药物成分或至少一种次要药物成分的接收浓度超过浓度警戒水平。
-
5.发明授权公开(公告)号：US07725272B2
公开(公告)日：2010-05-25
申请号：US11278048
申请日：2006-03-30
申请人： Alec Ginggen , Rocco Crivelli
发明人： Alec Ginggen , Rocco Crivelli
IPC分类号： G06F19/00
CPC分类号： A61M5/14276 , A61M5/14593 , A61M5/1723 , A61M2205/3372 , A61M2205/3389
摘要： Methods and devices are described for monitoring reservoir fluid in an implantable infusion pump. Such methods and devices can be used when the infusion pump has a temperature-dependent component. For example, a method of monitoring reservoir fluid can include obtaining measurements from the reservoir that include corresponding data related to the amount of fluid and temperature in the reservoir. A pair of measurements can be used to monitor the fluid level, or flow rate out of, the reservoir when the corresponding temperatures of the measurements are within a temperature tolerance value. In such an instance, a measured amount difference can be calculated based on the fluid amounts corresponding to the pair of measurements. Other variations of fluid monitoring methods, and implantable infusion pump systems that can perform fluid monitoring, are also described.
摘要翻译： 描述了用于监测可植入输液泵中的储层流体的方法和装置。 当输注泵具有温度依赖性组分时，可以使用这样的方法和装置。 例如，监测储层流体的方法可以包括从储层获得包括与储层中的流体量和温度有关的对应数据的测量。 当对应的测量温度在温度公差值内时，可以使用一对测量来监测储存器中的液位或流速。 在这种情况下，可以基于与该对测量对应的流体量来计算测量的量差。 还描述了可以执行流体监测的流体监测方法和可植入输注泵系统的其它变型。
-
公开(公告)号：US20070239231A1
公开(公告)日：2007-10-11
申请号：US11810996
申请日：2007-06-07
申请人： Alec Ginggen
发明人： Alec Ginggen
CPC分类号： A61M5/14276 , A61M2205/3317 , A61M2205/3523 , A61M2205/50 , A61M2205/52 , A61M2205/702 , A61N1/37 , A61N1/3718
摘要： A system for controlling an implantable medical device (e.g., a drug delivery device) susceptible to malfunctioning during exposure to a magnetic field and/or Radio Frequency field (e.g., during a magnetic resonance imaging procedure) and a method for operating the same. Exposure of the implantable device to the magnetic field and/or the Radio Frequency field is detected using the sensing device. When the detected magnetic field and/or Radio Frequency field exceeds a corresponding predetermined threshold level, an input signal is generated at the microcontroller. In response to the generated input signal, the microcontroller automatically triggers (i) a safety mode enabling a predetermined safety mode operation that alters some operation, without ceasing all operation, of the implantable medical device and/or (ii) after expiration of a predetermined safety mode time interval when the at least one field being detected falls below its corresponding predetermined threshold level or a predetermined period of time elapses, a self testing mode enabling a predetermined self testing operation to verify proper operation of the implantable medical device. Preferably, both the safety and self testing modes are automatically triggered.
-
7.发明申请公开(公告)号：US20070027505A1
公开(公告)日：2007-02-01
申请号：US11193228
申请日：2005-07-29
申请人： Alec Ginggen
发明人： Alec Ginggen
IPC分类号： A61N1/00
CPC分类号： A61B5/06 , A61B5/0031 , A61B5/062 , A61M5/14276 , A61M39/0208 , A61M2205/3523 , A61M2209/045
摘要： A system and method for locating an internal device separated by a boundary from and in wireless communication with an external device. External device includes an active emitter mechanism wherein a carrier signal is modulated by a location interrogation signal thereby generating an external RF power signal during transmission to the internal device. A secondary antenna of the internal device receives the external RF power signal and induces an RF power signal therein that is converted to a DC induced voltage signal. An indication signal proportional to the intensity of the DC induced voltage signal induced in the secondary antenna is produced by the external device. The process is repeated each time the user moves the external device to a new location proximate the patient's body until a maximum DC induced voltage signal measurement is ascertained representative of a specific area in which the internal device is located.
摘要翻译： 一种用于定位由外部设备与无线通信中的边界隔开的内部设备的系统和方法。 外部设备包括有源发射机构，其中载波信号由位置询问信号调制，从而在传输到内部设备期间产生外部RF功率信号。 内部设备的辅助天线接收外部RF功率信号并且在其中引起RF功率信号，其被转换为DC感应电压信号。 与辅助天线中感应的直流感应电压信号的强度成比例的指示信号由外部设备产生。 每当用户将外部设备移动到靠近患者身体的新位置时重复该过程，直到确定表示内部设备所在的特定区域的最大DC感应电压信号测量值为止。
-
公开(公告)号：US20030120262A1
公开(公告)日：2003-06-26
申请号：US10356998
申请日：2003-02-03
发明人： Manfred Wieland , Volker Zacharias , Jan Wierzoch
IPC分类号： A61K009/22
CPC分类号： A61M5/14276 , A61M5/1684
摘要： The invention relates to an implantable infusion pump comprising a housing, a base plate, a propellant chamber, a bellows having an internal volume for receiving a medicament to be administered to a patient, a constriction segment leading to a catheter placed in the body of the patient and communicating with the bellows internal volume, a resonant circuit formed by a coil, and a capacitor detecting the distance between a bottom surface of the bellows and the base plate. The coil is mounted on or in a bottom surface of the base plate and pointing towards the bellows bottom surface such that an inductance of the coil and a resonant frequency of the resonant circuit is a function of the distance between the bellows bottom surface the base plate.
摘要翻译： 本发明涉及可植入输液泵，其包括壳体，底板，推进剂室，具有用于接纳要施用于患者的药物的内部容积的波纹管，通向放置在患者体内的导管的收缩部分 患者并与波纹管内部体积连通，由线圈形成的谐振电路以及检测波纹管底面与基板之间的距离的电容器。 线圈安装在基板的底表面上或指向波纹管底表面，使得线圈的电感和谐振电路的谐振频率是波纹管底表面与基板之间的距离的函数 。
-
公开(公告)号：US09953138B2
公开(公告)日：2018-04-24
申请号：US12803574
申请日：2010-06-29
申请人： Olivier Chossat , Timothy Flynn
发明人： Olivier Chossat , Timothy Flynn
CPC分类号： G16H70/40 , A61M5/1407 , G06F19/00 , G06F19/326 , G06F19/3468 , G16H20/17
摘要： Minimizing improper dosage of a drug admixture (including a single primary drug component and at least one second drug component). For each drug component in the drug admixture, receiving a name of the drug component along with its dosage unit, a maximum dose warning level and a maximum concentration warning level. Receiving a concentration for each of the single primary drug component and the at least one secondary drug component; and a dose setting of only the primary drug component. Automatically calculating a dose of each of the at least one secondary drug component. Generating an alert when: (i) the received dose setting of the primary drug component or calculated dose setting of the at least one secondary drug component exceeds the dose warning level; or (ii) the received concentration of the primary drug component or the at least one secondary drug component exceeds the concentration warning level.
-
公开(公告)号：US09318798B2
公开(公告)日：2016-04-19
申请号：US12254192
申请日：2008-10-20
申请人： Rocco Crivelli , Thierry Pipoz
发明人： Rocco Crivelli , Thierry Pipoz
CPC分类号： H01Q1/30 , A61N1/37229 , A61N1/3754 , H01Q1/273 , H01Q1/362 , H01Q1/40 , H01Q11/08
摘要： An implantable medical device includes a hermetically sealed housing that contains electronic circuitry. A feedthrough is disposed on an external surface of the housing. An antenna wire is disposed around the external surface of the housing. The antenna wire has one end connected to the feedthrough so that the antenna wire is in electric communication with at least a portion of the electronic circuitry. A heat shrink tube is sealingly disposed about substantially the entire external surface of the antenna wire to prevent fluids from contacting the antenna wire and thereby detuning the antenna wire. An antenna surround is disposed about the tube.
摘要翻译： 可植入医疗装置包括密封的壳体，其包含电子电路。 馈通设置在壳体的外表面上。 天线线设置在壳体的外表面周围。 天线线的一端连接到馈通，使得天线线与电子电路的至少一部分电连通。 密封地围绕天线线的整个外表面密封地设置热收缩管，以防止流体接触天线，从而使天线线失谐。 围绕管设置天线环绕。
-
-
-
-
-
-
-
-
-
搜索结果
51 条记录 (耗时 0.02 秒)