公开(公告)号：US20090011433A1

公开(公告)日：2009-01-08

申请号：US12178918

申请日：2008-07-24

Applicant: Tedd E. Elich ,  Sandra L. Volrath ,  Stephanie C. Weatherly

Inventor： Tedd E. Elich ,  Sandra L. Volrath ,  Stephanie C. Weatherly

IPC: G01N33/68

CPC classification number: C12N9/93

Abstract: A peptide comprising an Acetyl CoA carboxylase (ACCase) having a deleted biotin binding domain, having a deleted carboxy transferase domain, and having a functional biotin carboxylase (BC) domain is described. A nucleic acid that encodes the peptide described above and a recombinant host cell that contains the nucleic acid and expresses the encoded peptide is also described. A method of identifying Acetyl CoA carboxylase inhibitors, fungicides, herbicides and pharmaceuticals is also described herein.

Abstract translation: 描述了包含具有缺失的生物素结合结构域的乙酰辅酶A羧化酶（ACCase），具有缺失的羧基转移酶结构域并具有功能性生物素羧化酶（BC）结构域的肽。 还描述了编码上述肽的核酸和含有核酸并表达编码肽的重组宿主细胞。 本文还描述了鉴定乙酰CoA羧化酶抑制剂，杀真菌剂，除草剂和药物的方法。

公开(公告)号：US20100009982A1

公开(公告)日：2010-01-14

申请号：US12501717

申请日：2009-07-13

Applicant: Richard Anderson ,  Steven Breazeale ,  Tedd Elich ,  Shy-Fuh Lee

Inventor： Richard Anderson ,  Steven Breazeale ,  Tedd Elich ,  Shy-Fuh Lee

IPC: A61K31/5386 ,  C07D498/10 ,  A61P3/00 ,  A61P35/04 ,  A61P31/10 ,  A01N43/86 ,  A61P25/28

CPC classification number: C07D498/10 ,  C07D471/10 ,  C07D513/10

Abstract: The present invention provides compounds of formula I: along with methods of use of these compounds as pharmaceuticals, particularly in the treatment of obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, insulin resistance, diseases associated with reduced neuronal metabolism, and cancer as well as the use of these compounds for treatment of pathogens of humans and animals, and for the control of agricultural pests, particularly fungi, weeds and insects.

Abstract translation: 本发明提供式I化合物以及这些化合物作为药物的使用方法，特别是用于治疗肥胖，代谢综合征，动脉粥样硬化，心血管疾病，胰岛素抵抗，与神经元代谢减少有关的疾病以及癌症以及 使用这些化合物来治疗人类和动物的病原体，以及控制农业害虫，特别是真菌，杂草和昆虫。

公开(公告)号：US08110570B2

公开(公告)日：2012-02-07

申请号：US12501717

申请日：2009-07-13

Applicant: Richard Anderson ,  Steven Breazeale ,  Tedd Elich ,  Shy-Fuh Lee

Inventor： Richard Anderson ,  Steven Breazeale ,  Tedd Elich ,  Shy-Fuh Lee

IPC: C07D413/04 ,  A61K31/537

CPC classification number: C07D498/10 ,  C07D471/10 ,  C07D513/10

Abstract: The present invention provides compounds of formula I: along with methods of use of these compounds as pharmaceuticals, particularly in the treatment of obesity, metabolic syndrome, atherosclerosis, cardiovascular disease, insulin resistance, diseases associated with reduced neuronal metabolism, and cancer as well as the use of these compounds for treatment of pathogens of humans and animals, and for the control of agricultural pests, particularly fungi, weeds and insects.

Abstract translation: 本发明提供式I化合物以及这些化合物作为药物的使用方法，特别是用于治疗肥胖，代谢综合征，动脉粥样硬化，心血管疾病，胰岛素抵抗，与减少的神经元代谢相关的疾病以及癌症以及 使用这些化合物来治疗人类和动物的病原体，以及控制农业害虫，特别是真菌，杂草和昆虫。

公开(公告)号：US20080200461A1

公开(公告)日：2008-08-21

申请号：US12033925

申请日：2008-02-20

Applicant: Richard Anderson ,  Takeo Hokama ,  Shy-Fuh Lee ,  Rafael Oey ,  Tedd Elich ,  Steven Breazeale

Inventor： Richard Anderson ,  Takeo Hokama ,  Shy-Fuh Lee ,  Rafael Oey ,  Tedd Elich ,  Steven Breazeale

IPC: A61K31/5377 ,  C07D239/72 ,  C07D413/06 ,  A61K31/5375 ,  C07D265/30 ,  A61K31/497

CPC classification number: C07D239/88 ,  C07D209/46 ,  C07D209/48 ,  C07D211/28 ,  C07D211/58 ,  C07D213/81 ,  C07D217/04 ,  C07D217/08 ,  C07D217/10 ,  C07D239/42 ,  C07D239/47 ,  C07D251/46 ,  C07D263/34 ,  C07D275/03 ,  C07D295/13 ,  C07D307/85 ,  C07D307/91 ,  C07D317/58 ,  C07D319/18 ,  C07D333/34 ,  C07D333/54 ,  C07D333/58 ,  C07D333/62 ,  C07D333/70 ,  C07D405/12 ,  C07D407/12 ,  C07D417/12 ,  C07D495/04 ,  C07D513/04

Abstract: The present invention provides compounds of formula I: along with methods of use thereof for the control of agricultural pests, particularly fungal pests, weedy pests and insect pests, as well as use as pharmaceuticals, particularly the treatment of obesity, metabolic syndrome, atherosclerosis, cardiovascular disease and insulin resistance, e.g., type II or adult-onset diabetes as well as fungal pathogens of humans and animals

Abstract translation: 本发明提供式I化合物及其用于控制​​农业害虫，特别是真菌害虫，杂草害虫和害虫的方法，以及用作药物，特别是用于治疗肥胖症，代谢综合征，动脉粥样硬化， 心血管疾病和胰岛素抵抗，例如II型或成人发病的糖尿病以及人和动物的真菌病原体

公开(公告)号：US07541472B2

公开(公告)日：2009-06-02

申请号：US11136185

申请日：2005-05-24

Applicant: Richard Anderson ,  Shy-Fuy Lee ,  Vivian Du ,  Takeo Hokama ,  Rafael Oey ,  Patricia Arakaki

Inventor： Richard Anderson ,  Shy-Fuy Lee ,  Vivian Du ,  Takeo Hokama ,  Rafael Oey ,  Patricia Arakaki

IPC: C07D213/55 ,  C07D409/00 ,  C07D411/00 ,  C07D277/30

CPC classification number: C07D213/643 ,  A01N43/40 ,  A01N43/76 ,  A01N43/78 ,  C07D213/55 ,  C07D213/68 ,  C07D263/32 ,  C07D263/34 ,  C07D277/30 ,  C07D285/06 ,  C07D405/12 ,  C07D409/06 ,  C07D417/12

Abstract: Compounds of formula I are described: along with compositions thereof, methods of use thereof (particularly as fungicides), and methods of making the same.

Abstract translation: 描述了式I化合物及其组合物，其使用方法（特别是作为杀真菌剂）及其制备方法。

公开(公告)号：US07432350B2

公开(公告)日：2008-10-07

申请号：US10633835

申请日：2003-08-04

Applicant: Tedd E. Elich ,  Sandra L. Volrath ,  Stephanie C. Weatherly

Inventor： Tedd E. Elich ,  Sandra L. Volrath ,  Stephanie C. Weatherly

IPC: C07K14/00 ,  A61K38/43 ,  C07H21/04 ,  C12N1/20 ,  C12N9/00

CPC classification number: C12N9/93

Abstract: A peptide comprising an Acetyl CoA carboxylase (ACCase) having a deleted biotin binding domain, having a deleted carboxy transferase domain, and having a functional biotin carboxylase (BC) domain is described. A nucleic acid that encodes the peptide described above and a recombinant host cell that contains the nucleic acid and expresses the encoded peptide is also described. A method of identifying Acetyl CoA carboxylase inhibitors, fungicides, and herbicides is also described herein.

Abstract translation: 描述了包含具有缺失的生物素结合结构域的乙酰辅酶A羧化酶（ACCase），具有缺失的羧基转移酶结构域并具有功能性生物素羧化酶（BC）结构域的肽。 还描述了编码上述肽的核酸和含有核酸并表达编码肽的重组宿主细胞。 本文还描述了鉴定乙酰CoA羧化酶抑制剂，杀真菌剂和除草剂的方法。

公开(公告)号：US07312181B2

公开(公告)日：2007-12-25

申请号：US11386499

申请日：2006-03-22

Applicant: Shy-Fuh Lee ,  Vivian Du ,  Richard Anderson

Inventor： Shy-Fuh Lee ,  Vivian Du ,  Richard Anderson

IPC: A01N43/40 ,  C07D213/46

CPC classification number: A01N47/34 ,  C07C337/06 ,  C07D213/56

Abstract: The present invention provides compounds of Formula I: wherein Ar1 is aryl or heteroaryl, Ar2 is aryl or heteroaryl, and R is a suitable organic group. Herbicidal composition comprising such active compounds, and methods for controlling undesirable plants by applying such compounds, are also described.

Abstract translation: 本发明提供式I化合物：其中Ar 1为芳基或杂芳基，Ar 2为芳基或杂芳基，R为合适的有机基团。 还描述了包含这种活性化合物的除草组合物，以及通过应用这些化合物来控制不期望的植物的方法。