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公开(公告)号：US20220347204A1
公开(公告)日：2022-11-03
申请号：US17775707
申请日：2020-11-11
发明人： Lior ZANGI , Ajit MAGADUM
IPC分类号： A61K31/7105 , A61P9/04 , A61P9/10 , A61K45/06 , C12N9/12
摘要： The present disclosure generally relates to compositions and methods of use thereof for treating heart failure encompassing administering a composition of modified mRNA (modRNA) encoding for type 2 phosphatidylinositol-5-phosphate 4-kinase gamma (pip4k2c) to heart tissue of a subject in need thereof.
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公开(公告)号：US20240335561A1
公开(公告)日：2024-10-10
申请号：US18578960
申请日：2022-07-22
CPC分类号： A61K48/005 , A61K31/395 , A61K38/193 , A61K38/42 , A61K48/0075 , A61P7/06 , C12N9/22 , C12N15/111 , C12N2310/20
摘要： Disclosures herein are directed to compositions and methods for increasing gamma globinexpression in a cell or subject by suppressing expression of Klf1. Also described are methods of treating or ameliorating-hemoglobinopathies. The compositions are administered to a subject as a therapeutic amount of a gene editing composition, including an RNA-guided endonuclease and one or more gRNA or sgRNA, or one or more transcription activator-like effector nucleases (TALENs), that targets an intron of a Klf1 gene locus in at least one cell in the subject to effect a deletion in intron, thereby reducing expression of Klf1.
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公开(公告)号：US12110295B2
公开(公告)日：2024-10-08
申请号：US17254345
申请日：2019-06-21
IPC分类号： C07D487/04 , C07D401/14 , C07D417/14
CPC分类号： C07D487/04 , C07D401/14 , C07D417/14
摘要： Disclosed herein are WD40 repeat domain protein 5 (WDR5) degradation/disruption compounds including a WDR5 ligand, a degradation/disruption tag, and a linker, and methods of using such compounds in the treatment of WDR5-mediated diseases.
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公开(公告)号：US12103924B2
公开(公告)日：2024-10-01
申请号：US17336059
申请日：2021-06-01
发明人： Jian Jin , Jing Liu , Jianping Hu , Jieli Wei , Hyerin Yim , Md Kabir
IPC分类号： C07D417/12 , A61K9/00 , A61P35/00
CPC分类号： C07D417/12 , A61K9/0019 , A61P35/00
摘要： This disclosure relates to heterobifunctional compounds (e.g., bi-functional small molecule compounds), compositions comprising one or more of the heterobifunctional compounds, and to methods of use the heterobifunctional compounds for the treatment of certain disease in a subject in need thereof. The disclosure also relates to methods for identifying such heterobifunctional compounds.
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公开(公告)号：US12102485B2
公开(公告)日：2024-10-01
申请号：US17714060
申请日：2022-04-05
CPC分类号： A61B8/5284 , A61B8/065 , A61B8/5223 , G16H10/60 , G16H15/00 , G16H50/20
摘要： Introduced here approaches to developing, training, and implementing algorithms to cardiac dysfunction through automated analysis of physiological data. As an example, a model may be developed and then trained to quantify left and right ventricular dysfunction using electrocardiogram waveform data that is associated with a population of individuals who are diverse in terms of age, gender, ethnicity, socioeconomic status, and the like. This approach to training allows the model to predict the presence of left and right ventricular dysfunction in a diverse population. Also introduced here is a regression framework for predicting numeric values of left ventricular ejection fraction.
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公开(公告)号：US12042534B2
公开(公告)日：2024-07-23
申请号：US16611813
申请日：2018-05-11
IPC分类号： A61K39/17 , A61K35/768 , A61K39/00 , A61K39/395 , A61P35/00 , C07K14/54 , C07K16/28 , C12N15/86
CPC分类号： A61K39/17 , A61K35/768 , A61K39/0005 , A61K39/3955 , A61P35/00 , C07K14/5434 , C07K16/28 , C12N15/86
摘要： Described herein are chimeric Newcastle disease viruses comprising a packaged genome comprising a transgene encoding interleukin-12. The chimeric Newcastle disease viruses and compositions thereof are useful in combination with an antagonist of programmed cell death protein 1 (“PD-1”) or a ligand thereof in the treatment of cancer. In particular, described herein are methods for treating cancer comprising administering the chimeric Newcastle disease viruses in combination with an antagonist of PD-1 or a ligand thereof, wherein the chimeric Newcastle disease virus comprises a packaged genome comprising a transgene encoding interleukin-12.
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公开(公告)号：US20240218029A1
公开(公告)日：2024-07-04
申请号：US18289181
申请日：2022-05-06
发明人： Robert C. Getts , Hugh A. Sampson , Maria Suprun
IPC分类号： C07K14/465 , A61K38/00 , C07K14/765 , C07K14/77 , C07K14/79 , C07K14/81 , C12N9/36 , G01N33/543 , G01N33/68
CPC分类号： C07K14/465 , C07K14/765 , C07K14/77 , C07K14/79 , C07K14/8135 , C12N9/2462 , G01N33/54353 , G01N33/6854 , A61K38/00 , G01N2800/24
摘要： The present disclosure provides egg peptide compositions and kits, and methods for diagnosis of egg allergy, methods for detecting the development of clinical tolerance to eggs, and methods for desensitizing an infant to egg allergens.
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公开(公告)号：US20240207329A1
公开(公告)日：2024-06-27
申请号：US18556218
申请日：2022-04-19
发明人： Louis J. Cohen , Sean Brady , Scott L. Freidman
IPC分类号： A61K35/74 , A61K31/164 , A61K38/45 , A61P35/00
CPC分类号： A61K35/74 , A61K31/164 , A61K38/45 , A61P35/00 , C12Y203/01
摘要： The presently claimed and described technology provides methods of treating adenocarcinoma in a subject by administering a genetically engineered cell expressing a human microbial N-acyl synthase (hm-NAS) gene, an hm-NAS gene, an N-acyl amide, or compositions thereof.
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9.发明公开公开(公告)号：US20240174983A1
公开(公告)日：2024-05-30
申请号：US18354452
申请日：2023-07-18
发明人： Andrew F. STEWART , Courtney ACKEIFI , Peng WANG , Bob DEVITA
IPC分类号： C12N5/071 , A61K31/437 , A61K38/22 , A61P3/10 , A61P5/48
CPC分类号： C12N5/0676 , A61K31/437 , A61K38/22 , A61P3/10 , A61P5/48 , C12N2501/335 , C12N2501/727
摘要： Disclosed herein are methods of increasing cell proliferation in a population of pancreatic beta cells. Also disclosed are methods of treating a subject for a condition associated with insufficient insulin secretion. Also disclosed is a composition comprising a DYRK1A inhibitor and a GLP1R agonist. The disclosure further describes a method of regenerating pancreatic beta cells in a transplant patient.
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10.发明公开公开(公告)号：US20240170146A1
公开(公告)日：2024-05-23
申请号：US18213070
申请日：2023-06-22
申请人： ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI , GEORGIA TECH RESEARCH CORPORATIONS , EMORY UNIVERSITY
发明人： Sankaraleengam Alagapan , Christopher Rozell , Helen Mayberg , Vineet Tiruvadi , Allison Waters , Patricio Riva-Posse , Stephen Heisig , Robert Butera , Ki Sueng Choi , Andrea Crowell
摘要： Methods and systems are described for providing deep brain stimulation (DBS) of the subcallosal cingulate region (SCC) to provide symptom relief in patients with treatment-resistant depression (TRD). The DBS devices may enable chronic electrophysiology recording to deliver SCC DBS therapy. One or more machine-learning models may identify SCC LFP changes that indicate the patient's current clinical state. The clinical state is distinct from acute transient stimulation effects, is sensitive to DBS stimulation adjustments, and accurately captures individual differences in recovery trajectory.
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