公开(公告)号：US07377900B2

公开(公告)日：2008-05-27

申请号：US10452061

申请日：2003-06-02

Applicant: Shuki Vitek ,  Doron Kopelman ,  Yoav Medan ,  Dov Maor

Inventor： Shuki Vitek ,  Doron Kopelman ,  Yoav Medan ,  Dov Maor

IPC: A61B8/00 ,  A61H1/00

CPC classification number: A61B17/2202 ,  A61B17/2251 ,  A61B2017/00274 ,  A61B2017/00477 ,  A61B2017/00867 ,  A61B2017/22028 ,  A61B2017/2253 ,  A61B2018/00547 ,  A61N7/022 ,  A61N2007/0078

Abstract: An apparatus for delivering acoustic energy to a target site adjacent a body passage includes first and second elongate members, each carrying one or more transducer elements on their distal ends. The first and/or second elongate members include connectors for securing the first and second elongate members together such that the transducer elements together define a transducer array. The first and second elongate members are introduced sequentially into a body passage until the transducer elements are disposed adjacent a target site. Acoustic energy is delivered from the transducer elements to the target site to treat tissue therein. In another embodiment, the apparatus includes a tubular member and an expandable structure carrying a plurality of transducer elements. The structure is expanded between a contracted configuration during delivery and an enlarged configuration when deployed for delivering acoustic energy to a target site adjacent the body passage.

Abstract translation: 用于将声能递送到身体通道附近的目标部位的装置包括第一和第二细长构件，每个细长构件在其远端上承载一个或多个换能器元件。 第一和/或第二细长构件包括用于将第一和第二细长构件固定在一起的连接器，使得换能器元件一起限定换能器阵列。 将第一和第二细长构件顺序地引入体通道中，直到换能器元件邻近目标位置设置。 声能从传感器元件输送到目标部位以在其中处理组织。 在另一个实施例中，该装置包括管状构件和承载多个换能器元件的可膨胀结构。 该结构在递送期间的收缩构造和在被部署以用于将声能递送到邻近身体通道的目标部位时的放大配置之间扩展。

公开(公告)号：US20070016039A1

公开(公告)日：2007-01-18

申请号：US11158657

申请日：2005-06-21

Applicant: Kobi Vortman ,  Shuki Vitek ,  David Freundlich

Inventor： Kobi Vortman ,  Shuki Vitek ,  David Freundlich

IPC: A61B8/00

CPC classification number: A61N7/02 ,  A61B8/467 ,  A61B8/481 ,  A61B90/37 ,  A61B2017/22008 ,  A61B2090/374 ,  A61B2090/376 ,  A61B2090/378

Abstract: A system for treating tissue within a body is configured to deliver a first level of ultrasound energy to a target tissue region for a first duration resulting in the generation of microbubbles in the target tissue region, determine one or more characteristics of the target tissue region in the presence of the microbubbles, and deliver a second level of ultrasound energy to the target tissue region for a second duration, wherein one or both of the second energy level and the second duration are based, at least in part, on the determined one or more characteristics of the target tissue region.

Abstract translation: 用于治疗身体内的组织的系统被配置为将第一级超声能量传递到目标组织区域持续第一持续时间，从而在目标组织区域中产生微泡，确定靶组织区域中的一个或多个特征 微泡的存在，并且在第二持续时间内向目标组织区域递送第二水平的超声能量，其中第二能量水平和第二持续时间中的一个或两个至少部分地基于所确定的一个或 目标组织区域的更多特征。

公开(公告)号：US20060058678A1

公开(公告)日：2006-03-16

申请号：US10927772

申请日：2004-08-26

Applicant: Shuki Vitek ,  Kobi Vortman

Inventor： Shuki Vitek ,  Kobi Vortman

IPC: A61B8/14

CPC classification number: A61B8/4281 ,  A61B8/0808 ,  A61B8/0825 ,  A61B8/4483 ,  A61B8/4494 ,  A61N7/02 ,  A61N2007/0078 ,  B06B1/0633

Abstract: A focused ultrasound system includes an ultrasound transducer device forming an opening, and having a plurality of transducer elements positioned at least partially around the opening. A focused ultrasound system includes a structure having a first end for allowing an object to be inserted and a second end for allowing the object to exit, and a plurality of transducer elements coupled to the structure, the transducer elements located relative to each other in a formation that at least partially define an opening, wherein the transducer elements are configured to emit acoustic energy that converges at a focal zone.

Abstract translation: 聚焦超声系统包括形成开口的超声换能器装置，并且具有至少部分地围绕开口定位的多个换能器元件。 聚焦超声系统包括具有用于允许物体被插入的第一端和用于允许物体离开的第二端的结构，以及耦合到该结构的多个换能器元件，换能器元件相对于彼此定位 至少部分地限定开口的形成，其中所述换能器元件被配置为发射在焦点区域会聚的声能。

公开(公告)号：US20060058671A1

公开(公告)日：2006-03-16

申请号：US10916998

申请日：2004-08-11

Applicant: Shuki Vitek ,  Kobi Vortman

Inventor： Shuki Vitek ,  Kobi Vortman

IPC: A61B8/06

CPC classification number: A61N7/02 ,  A61B90/04 ,  A61B2017/00084

Abstract: A method of treating tissue within a body includes directing an ultrasound transducer having a plurality of transducer elements towards target body tissue, and delivering ultrasound energy towards the target tissue from the transducer elements such that an energy intensity at the target tissue is at or above a prescribed treatment level, while an energy intensity at tissue to be protected in the ultrasound energy path of the transducer elements is at or below a prescribed safety level.

Abstract translation: 治疗身体内的组织的方法包括将具有多个换能器元件的超声换能器引导到靶体组织，以及从换能器元件向目标组织递送超声能量，使得目标组织处的能量强度等于或高于 而在换能器元件的超声能量路径中待保护的组织的能量强度处于或低于规定的安全水平。

公开(公告)号：US20040236253A1

公开(公告)日：2004-11-25

申请号：US10443549

申请日：2003-05-22

Applicant: Insightec-Image Guided Treatment Ltd.

Inventor： Kobi Vortman ,  Shuki Vitek ,  Avner Ezion

IPC: A61N007/00

CPC classification number: G10K11/346 ,  A61N7/02 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/0091 ,  A61N2007/0095

Abstract: A focused ultrasound system includes a transducer array, a controller for providing drive signals to the transducer array, and a switch. The transducer array includes a plurality of nullnnull transducer elements, and the controller includes a plurality of nullmnull output channels providing sets of drive signals having respective phase shift values, nullmnull being less than nulln.null The switch is coupled to the output channels of the controller and to the transducer elements, and is configured for connecting the output channels to respective transducer elements. The controller may assign the transducer elements to respective output channels based upon a size and/or shape of a desired focal zone within the target region, to steer or otherwise move a location of the focal zone, and/or to compensate for tissue aberrations caused by tissue between the transducer array and the focal zone, geometric tolerances and/or impedance variations of the transducer elements.

Abstract translation: 聚焦超声系统包括换能器阵列，用于向换能器阵列提供驱动信号的控制器和开关。 换能器阵列包括多个“n”个换能器元件，并且控制器包括多个“m”个输出通道，其提供具有各自相移值的驱动信号组，“m”小于“n”。 开关耦合到控制器和换能器元件的输出通道，并且被配置为将输出通道连接到相应的换能器元件。 控制器可以基于目标区域内的期望焦点区域的尺寸和/或形状来将换能器元件分配到相应的输出通道，以引导或以其他方式移动聚焦区域的位置，和/或补偿由此产生的组织像差 通过换能器阵列和焦点区域之间的组织，换能器元件的几何公差和/或阻抗变化。

公开(公告)号：US07699780B2

公开(公告)日：2010-04-20

申请号：US10916998

申请日：2004-08-11

Applicant: Shuki Vitek ,  Kobi Vortman

Inventor： Shuki Vitek ,  Kobi Vortman

IPC: A61B8/00 ,  A61N7/00 ,  A61B5/00

CPC classification number: A61N7/02 ,  A61B90/04 ,  A61B2017/00084

Abstract: A method of treating tissue within a body includes directing an ultrasound transducer having a plurality of transducer elements towards target body tissue, and delivering ultrasound energy towards the target tissue from the transducer elements such that an energy intensity at the target tissue is at or above a prescribed treatment level, while an energy intensity at tissue to be protected in the ultrasound energy path of the transducer elements is at or below a prescribed safety level.

Abstract translation: 治疗身体内的组织的方法包括将具有多个换能器元件的超声换能器引导到靶体组织，以及从换能器元件向目标组织递送超声能量，使得目标组织处的能量强度等于或高于 而在换能器元件的超声能量路径中待保护的组织的能量强度处于或低于规定的安全水平。

公开(公告)号：US07611462B2

公开(公告)日：2009-11-03

申请号：US10443549

申请日：2003-05-22

Applicant: Kobi Vortman ,  Shuki Vitek ,  Avner Ezion

Inventor： Kobi Vortman ,  Shuki Vitek ,  Avner Ezion

IPC: A61B8/00

CPC classification number: G10K11/346 ,  A61N7/02 ,  A61N2007/0065 ,  A61N2007/0078 ,  A61N2007/0091 ,  A61N2007/0095

Abstract: A focused ultrasound system includes a transducer array, a controller for providing drive signals to the transducer array, and a switch. The transducer array includes a plurality of “n” transducer elements, and the controller includes a plurality of “m” output channels providing sets of drive signals having respective phase shift values, “m” being less than “n.” The switch is coupled to the output channels of the controller and to the transducer elements, and is configured for connecting the output channels to respective transducer elements. The controller may assign the transducer elements to respective output channels based upon a size and/or shape of a desired focal zone within the target region, to steer or otherwise move a location of the focal zone, and/or to compensate for tissue aberrations caused by tissue between the transducer array and the focal zone, geometric tolerances and/or impedance variations of the transducer elements.

Abstract translation: 聚焦超声系统包括换能器阵列，用于向换能器阵列提供驱动信号的控制器和开关。 换能器阵列包括多个“n”个换能器元件，并且控制器包括多个“m”个输出通道，其提供具有各自相移值的驱动信号组，“m”小于“n”。 开关耦合到控制器和换能器元件的输出通道，并且被配置为将输出通道连接到相应的换能器元件。 控制器可以基于目标区域内的期望焦点区域的尺寸和/或形状来将换能器元件分配到相应的输出通道，以引导或以其他方式移动聚焦区域的位置，和/或补偿由此产生的组织像差 通过换能器阵列和焦点区域之间的组织，换能器元件的几何公差和/或阻抗变化。

公开(公告)号：US20070197918A1

公开(公告)日：2007-08-23

申请号：US11736109

申请日：2007-04-17

Applicant: Shuki Vitek ,  Doron Kopelman ,  Yoav Medan ,  Dov Maor

Inventor： Shuki Vitek ,  Doron Kopelman ,  Yoav Medan ,  Dov Maor

IPC: A61B8/14

CPC classification number: A61B17/2202 ,  A61B17/2251 ,  A61B2017/00274 ,  A61B2017/00477 ,  A61B2017/00867 ,  A61B2017/22028 ,  A61B2017/2253 ,  A61B2018/00547 ,  A61N7/022 ,  A61N2007/0078

Abstract: An apparatus for delivering acoustic energy to a target site adjacent a body passage includes first and second elongate members, each carrying one or more transducer elements on their distal ends. The first and/or second elongate members include connectors for securing the first and second elongate members together such that the transducer elements together define a transducer array. The first and second elongate members are introduced sequentially into a body passage until the transducer elements are disposed adjacent a target site. Acoustic energy is delivered from the transducer elements to the target site to treat tissue therein. In another embodiment, the apparatus includes a tubular member and an expandable structure carrying a plurality of transducer elements. The structure is expanded between a contracted configuration during delivery and an enlarged configuration when deployed for delivering acoustic energy to a target site adjacent the body passage.

Abstract translation: 用于将声能递送到身体通道附近的目标部位的装置包括第一和第二细长构件，每个细长构件在其远端上承载一个或多个换能器元件。 第一和/或第二细长构件包括用于将第一和第二细长构件固定在一起的连接器，使得换能器元件一起限定换能器阵列。 将第一和第二细长构件顺序地引入体通道中，直到换能器元件邻近目标位置设置。 声能从传感器元件输送到目标部位以在其中处理组织。 在另一个实施例中，该装置包括管状构件和承载多个换能器元件的可膨胀结构。 该结构在递送期间的收缩构造和在被部署以用于将声能递送到邻近身体通道的目标部位时的放大配置之间扩展。

公开(公告)号：US20040006272A1

公开(公告)日：2004-01-08

申请号：US10190787

申请日：2002-07-08

Applicant: InSightec - Image Guided Treatment, Ltd.

Inventor： Kobi Vortman ,  Shuki Vitek

IPC: A61B008/00

CPC classification number: A61B8/5276 ,  A61B8/0816 ,  A61B8/14 ,  G01S7/52049 ,  G01S15/8915 ,  G01S15/8927 ,  G01S15/8952

Abstract: A method of imaging a site of interest in a body using an ultrasound probe comprising a plurality of ultrasound transducer elements comprises obtaining an ultrasound image of a pass zone between the ultrasound probe and the site of interest. The image includes the site of interest and a plurality of tissue regions in a pass zone between the site of interest and the ultrasound probe. Boundaries of a selected tissue region in the pass zone are determined from the image. Focusing delay times are then computed for each ultrasound transducer element based in part on the speed of sound in the selected tissue region other than an average speed of sound in body tissue, and the boundaries of the selected tissue region. Preferably, a speed about the speed of sound in the selected tissue region is used and more preferably the speed of sound in the selected tissue region is used. Refraction may be considered, as well. Ultrasound imaging of the site of interest is then conducted employing the computed delay times. Fat and bone tissue regions are typically selected if present. Other tissue regions may be selected, as well. The boundaries of the tissue region or regions may be determined by segmentation. Tissue inhomogeneity is thereby compensated for, improving image contrast resolution. Ultrasound imaging systems and software are also disclosed. A new ultrasound probe comprising high and low frequency transducer elements is also disclosed.

Abstract translation: 使用包括多个超声换能器元件的超声波探头在身体中成像感兴趣的位置的方法包括获得超声波探头与感兴趣部位之间的通过区域的超声波图像。 图像包括感兴趣的位置和感兴趣部位与超声波探头之间的通过区域中的多个组织区域。 从图像中确定通过区域中所选择的组织区域的边界。 然后，部分地基于除了身体组织中的平均声速和所选择的组织区域的边界之外的所选择的组织区域中的声速来计算每个超声换能器元件的聚焦延迟时间。 优选地，使用围绕所选择的组织区域中的声速的速度，并且更优选地使用所选择的组织区域中的声音速度。 也可以考虑折射。 然后使用计算的延迟时间进行感兴趣位点的超声成像。 通常选择脂肪和骨组织区域（如果存在）。 也可以选择其他组织区域。 可以通过分割来确定组织区域或区域的边界。 从而补偿组织不均匀性，改善图像对比度分辨率。 还公开了超声成像系统和软件。 还公开了一种包括高频和低频换能器元件的新型超声波探头。