公开(公告)号：US20220122743A1

公开(公告)日：2022-04-21

申请号：US17323058

申请日：2021-05-18

申请人： MX3 Diagnostics, Inc.

发明人： Michael Erlichster ,  Gursharan Chana ,  Efstratios Skafidas

IPC分类号： G16H70/60 ,  G16H50/80 ,  G16H50/30

摘要： A method and system improving nucleic-acid testing-capacity for novel pathogens by applying family-level nucleic acid testing. The test system involves the use of an analyzer platform and single-use test cartridges which can identify the presence of one or multiple pathogens on the family-level. The test system is pro-actively stockpiled to ensure widespread availability for population screening in the event of a pandemic.

公开(公告)号：US20240151623A1

公开(公告)日：2024-05-09

申请号：US18326722

申请日：2023-05-31

申请人： MX3 Diagnostics, Inc.

发明人： Efstratios Skafidas ,  Hsien Ming ,  You Liang ,  Duc Huynh ,  Thanh Nguyen ,  Michael Erlichster

IPC分类号： G01N11/02 ,  G01N33/487 ,  G01N33/49 ,  G01N33/493

CPC分类号： G01N11/02 ,  G01N33/48707 ,  G01N33/49 ,  G01N33/493

摘要： A method of assessing a bodily fluid sample on a test strip may involve applying a periodic signal with a first electrode located at a first location in a microfluidic channel of the test strip, monitoring the applied periodic signal with a second electrode located at a second location in the microfluidic channel, and using a third electrode located at a third location in the microfluidic channel as a reference electrode. The method may also include: collecting the bodily fluid sample in the microfluidic channel; continuing to apply the periodic signal, monitor the periodic signal and use the third electrode as a reference electrode while collecting the bodily fluid sample; and determining that the bodily fluid sample is sufficient for analyzing, based at least in part on the applied and monitored periodic signal.

公开(公告)号：US20210007646A1

公开(公告)日：2021-01-14

申请号：US16924386

申请日：2020-07-09

申请人： MX3 Diagnostics, Inc.

发明人： Thanh Cong Nguyen ,  Efstratios Skafidas ,  Duc Hau Huynh ,  Michael Erlichster ,  Duc Phuong Nguyen ,  Hsien Ming ,  Gursharan Chana ,  Ting Ting Lee ,  Chathurika Darshani Abeyrathne ,  You Liang ,  Trevor John Kilpatrick ,  Michael Luther ,  Alan Dayvault Luther

IPC分类号： A61B5/145 ,  A61B10/00 ,  B01L3/00 ,  G01N27/327

摘要： A test strip for sampling a bodily fluid may include multiple layers of a substrate material, an adhesive between at least some of the multiple layers, and a microfluidic channel formed between at least some of the multiple layers. The test strip may further include multiple electrodes on one of the multiple layers, positioned and partially exposed within the microfluidic channel, an additional material positioned at or near an entrance to the microfluidic channel, to selectively limit the flow of at least one of bubbles or debris into the microfluidic channel, and at least one exit port in at least one of the multiple layers to allow for release of pressure from the test strip. In some embodiments, the test strip is a saliva analysis test strip. In some embodiments, the test strip includes multiple exit ports to prevent blockage of sample flow.

公开(公告)号：US11703436B2

公开(公告)日：2023-07-18

申请号：US17159770

申请日：2021-01-27

申请人： MX3 Diagnostics, Inc.

发明人： Efstratios Skafidas ,  Hsien Ming ,  You Liang ,  Duc Huynh ,  Thanh Nguyen ,  Michael Erlichster

IPC分类号： G01N11/02 ,  G01N33/493 ,  G01N33/487 ,  G01N33/49

CPC分类号： G01N11/02 ,  G01N33/48707 ,  G01N33/49 ,  G01N33/493

摘要： A method of assessing a bodily fluid sample on a test strip may involve applying a periodic signal with a first electrode located at a first location in a microfluidic channel of the test strip, monitoring the applied periodic signal with a second electrode located at a second location in the microfluidic channel, and using a third electrode located at a third location in the microfluidic channel as a reference electrode. The method may also include: collecting the bodily fluid sample in the microfluidic channel; continuing to apply the periodic signal, monitor the periodic signal and use the third electrode as a reference electrode while collecting the bodily fluid sample; and determining that the bodily fluid sample is sufficient for analyzing, based at least in part on the applied and monitored periodic signal.

公开(公告)号：US11701036B2

公开(公告)日：2023-07-18

申请号：US16924386

申请日：2020-07-09

申请人： MX3 Diagnostics, Inc.

发明人： Thanh Cong Nguyen ,  Efstratios Skafidas ,  Duc Hau Huynh ,  Michael Erlichster ,  Duc Phuong Nguyen ,  Hsien Ming ,  Gursharan Chana ,  Ting Ting Lee ,  Chathurika Darshani Abeyrathne ,  You Liang ,  Trevor John Kilpatrick ,  Michael Luther ,  Alan Dayvault Luther

IPC分类号： A61B5/145 ,  A61B10/00 ,  B01L3/00 ,  G01N27/327

CPC分类号： A61B5/14546 ,  A61B10/0051 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/567 ,  G01N27/3272 ,  A61B2562/0295 ,  B01L2300/123 ,  B01L2400/06

摘要： A test strip for sampling a bodily fluid may include multiple layers of a substrate material, an adhesive between at least some of the multiple layers, and a microfluidic channel formed between at least some of the multiple layers. The test strip may further include multiple electrodes on one of the multiple layers, positioned and partially exposed within the microfluidic channel, an additional material positioned at or near an entrance to the microfluidic channel, to selectively limit the flow of at least one of bubbles or debris into the microfluidic channel, and at least one exit port in at least one of the multiple layers to allow for release of pressure from the test strip. In some embodiments, the test strip is a saliva analysis test strip. In some embodiments, the test strip includes multiple exit ports to prevent blockage of sample flow.

公开(公告)号：US12019045B2

公开(公告)日：2024-06-25

申请号：US16598000

申请日：2019-10-10

申请人： MX3 Diagnostics, Inc.

发明人： Chathurika Darshani Abeyrathne ,  You Liang ,  Efstratios Skafidas

IPC分类号： G01N27/333 ,  G01N27/327 ,  G01N33/543

CPC分类号： G01N27/3335 ,  G01N27/3275 ,  G01N33/54366

摘要： An ion sensor includes a substrate, at least one ion selective electrode deposited on the substrate, and a reference electrode deposited on the substrate. The sensor may further include an insulating layer placed over the ion selective electrode and the reference electrode and having openings for the ion selective electrode and the reference electrode, a microfluidic layer placed over at least part of the insulating layer, and a cover layer placed over the microfluidic layer. The reference electrode includes reference electrode material deposited on the substrate and a combination of a polymer and a chloride-containing salt deposited on the reference electrode material.

公开(公告)号：US20240138723A1

公开(公告)日：2024-05-02

申请号：US18326472

申请日：2023-05-31

申请人： MX3 Diagnostics, Inc.

发明人： Thanh Cong Nguyen ,  Efstratios Skafidas ,  Duc Hau Huynh ,  Michael Erlichster ,  Duc Phuong Nguyen ,  Hsien Ming ,  Gursharan Chana ,  Ting Ting Lee ,  Chathurika Darshani Abeyrathne ,  You Liang ,  Trevor John Kilpatrick ,  Michael Luther ,  Alan Dayvault Luther

IPC分类号： A61B5/145 ,  A61B10/00 ,  B01L3/00 ,  G01N27/327

CPC分类号： A61B5/14546 ,  A61B10/0051 ,  B01L3/502715 ,  B01L3/502723 ,  B01L3/567 ,  G01N27/3272 ,  A61B2562/0295 ,  B01L2300/123 ,  B01L2400/06

摘要： A test strip for sampling a bodily fluid may include multiple layers of a substrate material, an adhesive between at least some of the multiple layers, and a microfluidic channel formed between at least some of the multiple layers. The test strip may further include multiple electrodes on one of the multiple layers, positioned and partially exposed within the microfluidic channel, an additional material positioned at or near an entrance to the microfluidic channel, to selectively limit the flow of at least one of bubbles or debris into the microfluidic channel, and at least one exit port in at least one of the multiple layers to allow for release of pressure from the test strip. In some embodiments, the test strip is a saliva analysis test strip. In some embodiments, the test strip includes multiple exit ports to prevent blockage of sample flow.

公开(公告)号：US20210239586A1

公开(公告)日：2021-08-05

申请号：US17159770

申请日：2021-01-27

申请人： MX3 Diagnostics, Inc.

发明人： Efstratios Skafidas ,  Hsien Ming ,  You Liang ,  Duc Huynh ,  Thanh Nguyen ,  Michael Erlichster

IPC分类号： G01N11/02 ,  G01N33/49 ,  G01N33/487 ,  G01N33/493

摘要： A method of assessing a bodily fluid sample on a test strip may involve applying a periodic signal with a first electrode located at a first location in a microfluidic channel of the test strip, monitoring the applied periodic signal with a second electrode located at a second location in the microfluidic channel, and using a third electrode located at a third location in the microfluidic channel as a reference electrode. The method may also include: collecting the bodily fluid sample in the microfluidic channel; continuing to apply the periodic signal, monitor the periodic signal and use the third electrode as a reference electrode while collecting the bodily fluid sample; and determining that the bodily fluid sample is sufficient for analyzing, based at least in part on the applied and monitored periodic signal.

公开(公告)号：US20210005322A1

公开(公告)日：2021-01-07

申请号：US16918150

申请日：2020-07-01

申请人： MX3 Diagnostics, Inc.

发明人： Duc Hau Huynh ,  Michael Erlichster ,  Thanh Cong Nguyen ,  Duc Phuong Nguyen ,  Efstratios Skafidas ,  Hsien Ming ,  Gursharan Chana ,  Ting Ting Lee ,  Chathurika Darshani Abeyrathne ,  You Liang ,  Trevor John Kilpatrick ,  Michael Luther ,  Alan Dayvault Luther

IPC分类号： G16H50/30 ,  G16H10/60 ,  G16H10/40 ,  G16H50/70 ,  G01N33/50 ,  B01L3/00

摘要： A method of measuring an analyte in a bodily fluid sample and combining measurement data from multiple users may involve initiating a wireless connection between a handheld analyzer and a smart computing device on which an analyte analysis application has been downloaded and inserting a test strip into the handheld analyzer. The method may further involve collecting a sample of a bodily fluid on the test strip, measuring, with the handheld analyzer, a concentration of at least one analyte in the sample, wirelessly communicating the measured concentration from the handheld analyzer to the smart computing device, and displaying the measured concentration on the smart computing device. Finally, the method may involve transmitting the measured concentration to a database and organizing data including the measured concentration and at least one additional measured analyte concentration from at least one additional user on the database.

公开(公告)号：US12123865B2

公开(公告)日：2024-10-22

申请号：US17149181

申请日：2021-01-14

申请人： MX3 Diagnostics, Inc.

发明人： Michael Erlichster ,  Efstratios Skafidas ,  Chathurika Darshani Abeyrathne ,  Ting Ting Lee ,  Gursharan Chana

IPC分类号： G01N33/487 ,  G01N27/327 ,  G01N27/416

CPC分类号： G01N33/487 ,  G01N27/327 ,  G01N27/4166

摘要： A method and system improving the accuracy and/or interpretability of measurements in a body fluid, such as saliva, sweat or urine involves measurement of multiple parameters in a sample with biosensors. One or more biosensors may reflect the concentration of a target biomarker, and one or more biosensors may describe a parameter of the fluid known to impact the function of the first biosensor the way the measurement of the first biosensor should be interpreted.