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163 条记录 (耗时 0.024 秒)

    TCR-INDEPENDENT MOLECULAR IDENTIFICATION OF MUTATION-RELATED AND TUMOR-SPECIFIC T CELLS
    4.
    发明申请
    TCR-INDEPENDENT MOLECULAR IDENTIFICATION OF MUTATION-RELATED AND TUMOR-SPECIFIC T CELLS 有权

    公开(公告)号：US20220357324A1

    公开(公告)日：2022-11-10

    申请号：US17754452

    申请日：2020-10-15

    申请人： MEDIZINISCHE HOCHSCHULE HANNOVER

    发明人： Norman WOLLER

    IPC分类号： G01N33/569 ,  G01N33/574

    摘要： The present invention relates to the field of tumor immunology. It provides a method for identifying mutation-related human CD8+ T cells, in particular, tumor-specific T cells of a human subject, comprising analyzing CD8+ T cells of the subject by analysing the expression of at least one marker selected from a first group consisting of CD82, CD194, CD244, CD28, CD62L and CD55, and preferably, a marker selected from a second group comprising CD11a or CD18 or CD43. A preferred marker for mutation-related CD8+ T cells is CD82, which may be analysed in combination, e.g., with CD11a. Without the need to identify any epitope to which T cells reacts, this method can advantageously be used to isolate the entire individual pool of mutation-related T cells, and, optionally, to identify the sequence of a mutation-related TCR, which allows for generation of transgenic T cells expressing the TCR. Compositions substantially comprising tumor-specific CD82hiCD8+ T cells and/or CD194hi, CD244−, CD28+, CD62L+ and/or CD55+ CD82hi CD8+ T cells can be used for treatment of a cancer patient, e.g., by adoptive T cell transfer. The method of the invention can also be used for diagnostic purposes to identify human mutation-related T cells or diagnosing a tumor disease or for testing responses of a cancer patient to an immune stimulatory therapy, preferably, a therapy with a checkpoint inhibitor.

    LNCRNAS FOR THERAPY AND DIAGNOSIS OF CARDIAC HYPERTROPHY
    6.
    发明申请
    LNCRNAS FOR THERAPY AND DIAGNOSIS OF CARDIAC HYPERTROPHY 有权

    公开(公告)号：US20220315924A1

    公开(公告)日：2022-10-06

    申请号：US17658957

    申请日：2022-04-12

    申请人： Medizinische Hochschule Hannover

    发明人： Thomas THUM ,  Kumarswamy REGALLA ,  Janika VIERECK

    IPC分类号： C12N15/113 ,  A61K48/00 ,  A61P9/00 ,  C12Q1/6883

    摘要： The present invention relates to a pharmaceutical composition comprising (i) a compound promoting the expression and/or the activity of one or more long non-coding RNAs (lncRNAs) selected from SEQ ID NOs 12, 8 to 11 and 13; and/or (ii) a compound inhibiting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 1 to 7, 27 and 28. The present invention also relates to a compound (i) promoting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 12, 8 to 11 and 13; and/or (ii) inhibiting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 1 to 7, 27 and 28 for use in treating or preventing cardiac hypertrophy.

    METHOD FOR COATING A MEDICAL DEVICE AND COATED MEDICAL DEVICE
    9.
    发明申请
    METHOD FOR COATING A MEDICAL DEVICE AND COATED MEDICAL DEVICE 有权

    公开(公告)号：US20220211906A1

    公开(公告)日：2022-07-07

    申请号：US17610611

    申请日：2020-05-20

    申请人： MEDIZINISCHE HOCHSCHULE HANNOVER

    发明人： Meike STIESCH ,  Sascha Nico STUMPP ,  Michael EISENBURGER ,  Muhammad Imran RAHIM

    IPC分类号： A61L27/34 ,  A61L27/36 ,  A61L27/54

    摘要： The present invention relates in a first aspect to a method for coating a medical device suitable for implantation into an individual or for application on skin or mucosal tissue of an individual. Said method comprises the steps of applying to at least a portion of the surface of said device a coating layer whereby said coating layer comprises commensal microorganisms, like commensal bacteria, to form a biofilm on the at least portion of the surface of said medical device, further comprising the step of drying the biofilm coated on the surface of said medical device whereby the commensal microorganisms are eventually killed in case they were not applied as killed microorganisms in the step above, for obtaining a medical device having at least a portion of its surface coated with non-living commensal microorganisms In a further aspect, the coated medical devices obtainable by the method according to the present invention are provided. The coated medical devices according to the present invention are particularly useful in applications being mucosal tissue or a skin of an individual, like for use as an implant for dental use in the oral cavity. Finally, the present invention relates to the use of commensal bacteria like Streptococcus oralis for coating a medical device suitable for use as an implant into an individual or for application on skin or mucosal tissue of an individual.

    LncRNAs for therapy and diagnosis of cardiac hypertrophy
    10.
    发明授权
    LncRNAs for therapy and diagnosis of cardiac hypertrophy 有权

    公开(公告)号：US11371043B2

    公开(公告)日：2022-06-28

    申请号：US16017375

    申请日：2018-06-25

    申请人： Medizinische Hochschule Hannover

    发明人： Thomas Thum ,  Kumarswamy Regalla ,  Janika Viereck

    IPC分类号： C12N15/113 ,  A61P9/00 ,  A61K48/00 ,  C12Q1/6883

    摘要： The present invention relates to a pharmaceutical composition comprising (i) a compound promoting the expression and/or the activity of one or more long non-coding RNAs (lncRNAs) selected from SEQ ID NOs 12, 8 to 11 and 13; and/or (ii)a compound inhibiting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 1 to 7, 27 and 28. The present invention also relates to a compound (i) promoting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 12, 8 to 11 and 13; and/or (ii) inhibiting the expression and/or the activity of one or more lncRNAs selected from SEQ ID NOs 1 to 7, 27 and 28 for use in treating or preventing cardiac hypertrophy.