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公开(公告)号:US20220087590A1
公开(公告)日:2022-03-24
申请号:US17425459
申请日:2020-01-14
申请人: Takeshi TSUCHIYA , NATIONAL UNIVERSITY CORPORATION SHIGA UNIVERSITY OF MEDICAL SCIENCE , NIHON KOHDEN CORPORATION
摘要: A recording device includes: an acquisition unit (102) configured to acquire vital signs through a multi-electrode catheter (X) having a plurality of electrodes; a recording unit (104) configured to record a bipolar potential of a main channel which is defined by combining the plurality of electrodes, using the vital signs; an addition unit (32) configured to add a mark to each waveform plotted based on a potential of the bipolar potential, at a predetermined position on a time axis; and an adjusting unit (33) configured to adjust a position of the mark added to each waveform. The adjusting unit (33) is configured to adjust the position of the mark added to the bipolar potential of the main channel, based on bipolar potentials of reference channels including electrodes included in the main channel.
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公开(公告)号:US20240350668A1
公开(公告)日:2024-10-24
申请号:US18688563
申请日:2022-08-31
发明人: Keizo TOMONAGA , Akiko MAKINO , Madoka SAKAI , Ryo KOMORIZONO , Makoto URUSHITANI , Toshifumi MORIMURA , Sumio MINAMIYAMA
CPC分类号: A61K48/005 , A61P25/28 , C07K16/40 , C12N15/86 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C12N2760/00043
摘要: Disclosed are a bornavirus vector comprising a nucleic acid encoding an antibody or antibody fragment capable of binding to a mutant SOD1 protein, the antibody or antibody fragment comprising a heavy-chain variable region comprising a heavy-chain CDR1 consisting of an amino acid sequence GFSLNTSGMG (SEQ ID NO: 1), a heavy-chain CDR2 consisting of an amino acid sequence IWWDDDK (SEQ ID NO: 2), and a heavy-chain CDR3 consisting of an amino acid sequence ARLGYAMDY (SEQ ID NO: 3), the heavy-chain variable region optionally having 3 or fewer amino acid substitutions, and/or a light-chain variable region comprising a light-chain CDR1 consisting of an amino acid sequence ONVGTN (SEQ ID NO: 4), a light-chain CDR2 consisting of an amino acid sequence SAS, and a light-chain CDR3 consisting of an amino acid sequence QQYYIYPYT (SEQ ID NO: 5), the light-chain variable region optionally having 3 or fewer amino acid substitutions; a recombinant virus comprising RNA encoded by the bornavirus vector; a cell infected with the recombinant virus; and a pharmaceutical composition comprising the cell.
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公开(公告)号:US20230301697A1
公开(公告)日:2023-09-28
申请号:US18014889
申请日:2021-07-06
发明人: Shinji IMAI
IPC分类号: A61B17/88
CPC分类号: A61B17/88
摘要: Provided is a surgical instrument that can easily bring the coracoid process into proximity with the scapular neck. A surgical instrument 1 of the present invention includes a shaft 2 extending in the first direction, and an inclined part 3 extending from the tip of the shaft 2 in the second direction. The second direction, in which the inclined part 3 extends, is inclined at an angle of α in a range of 95° or more and 115° or less to the first direction, in which the shaft 2 extends, and the inclined part 3 includes on the outer edge thereof a notch 10 through which a screw is passed.
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公开(公告)号:US20220152357A1
公开(公告)日:2022-05-19
申请号:US17593619
申请日:2020-03-02
发明人: Tohru TANI , Atsushi YAMADA , Tatsuya SHIMA , Wataru YONEMICHI
摘要: A steerable catheter includes a flexible tube having a distal end and a proximal end. The tube includes a first tube section (sheath body section) the flexibility of which does not substantially change even upon receiving compression force in the axial direction; and a second tube section (deflection section) joined so as to be continuous with the distal end of the first tube section and constituted by a porous tube becoming hard upon being compressed according to the degree of the compression force acting in the axial direction and returning to being soft when the compression force is released. The tube includes operation means (wires) for releasably exerting a compression force compressing the second tube section in the axial direction and a deflection force deflecting the second tube section. According to some embodiments, both operability and insertability of the steerable catheter can be improved.
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公开(公告)号:US20210146096A1
公开(公告)日:2021-05-20
申请号:US17048061
申请日:2019-04-09
发明人: Atsushi YAMADA , Tohru TANI , Wataru YONEMICHI
摘要: A movable catheter is provided with a tube having a main lumen. The tube has a plurality of wire lumens and is provided with a wire. A substantial half on one end portion side thereof is inserted through the wire lumen, an intermediate part thereof is folded back in the distal end portion of the tube, and a substantial half on the other end portion side thereof is inserted through the wire lumen. The one end portion and the other end portion thereof are disposed on the proximal end side of the tube. Various embodiments enable the number of components to be reduced, and to reduce the number of manufacturing steps.
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公开(公告)号:US20200246776A1
公开(公告)日:2020-08-06
申请号:US16638586
申请日:2018-09-07
发明人: Junichi KASUYA , Ryo MATSUNAGA , Yoshiyuki UENO , Yuji UEDA , Kazuo TERAMOTO , Kazumasa OGASAWARA
IPC分类号: B01J20/26 , C07K14/495 , A61M1/36
摘要: An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 μmol and 2500 μmol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 μmol or less per 1 g.
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公开(公告)号:US10166040B2
公开(公告)日:2019-01-01
申请号:US14400857
申请日:2013-05-14
发明人: Tohru Tani , Shigeyuki Naka , Hiroya Akabori
摘要: It is an object to provide a surgical tool for excising a hard solid organ such as cirrhotic liver or cutting the organ into a groove without causing bleeding. The inventors of the present invention have found that an organ resection tool including a brush-like structure capable of performing microwave irradiation and/or a brush-like structure capable of receiving a microwave can achieve the above-mentioned object, to thereby arrive at the present invention (organ resection tool including a brush structure capable of performing microwave irradiation). For example, an organ can be crushed or scraped away by manually abrading the organ with a brush of a solid organ resection tool including a brush structure capable of performing microwave irradiation according to the present invention. Further, the organ can be concurrently coagulated through the microwave irradiation to stop bleeding.
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公开(公告)号:US20140358165A1
公开(公告)日:2014-12-04
申请号:US14365620
申请日:2012-12-14
申请人: Tohru Tani , Shigeyuki Naka
发明人: Tohru Tani , Shigeyuki Naka
IPC分类号: A61B17/04
CPC分类号: A61B17/0469 , A61B18/1815 , A61B2018/00482 , A61B2018/00494 , A61B2018/00589 , A61B2018/00619 , A61B2018/0063 , A61B2018/1823 , A61B2018/1869
摘要: Provided is a surgical instrument that is substitutable for an operation of placing each stitch with a threaded needle or a stapler. It is confirmed that, in a tissue suturing device including a clamping section, and a protruding section including a central conductor and/or an external conductor for applying a microwave, the protruding section and the clamping section bring fragmentary portions of tissues to be sutured into contact or overlap with each other, and coagulate and/or fix contact or overlap portions with the microwave, to thereby stitch the tissues to be sutured.
摘要翻译: 提供了一种外科器械,其可替代用于使用螺纹针或吻合器放置每个线圈的操作。 确认在包括夹持部的组织缝合装置和包括用于施加微波的中心导体和/或外部导体的突出部中,突出部和夹持部将待缝合的组织的碎片部分 接触或重叠,并与微波凝固和/或固定接触或重叠部分,从而缝合要缝合的组织。
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公开(公告)号:US20100023001A1
公开(公告)日:2010-01-28
申请号:US12513559
申请日:2007-11-08
申请人: Makoto Hosaka , Tohru Tani , Yoshimasa Kurumi , Shigeyuki Naka
发明人: Makoto Hosaka , Tohru Tani , Yoshimasa Kurumi , Shigeyuki Naka
IPC分类号: A61B18/18 , A61B17/3201
CPC分类号: A61B18/18 , A61B18/1445 , A61B18/1815 , A61B2017/2932
摘要: Provided is an operating tool for organism, in particular, a microwave endoscope forceps. In terms of the operating tool for organism, provided is a multifunctional operating tool which has holding and scissors functions simultaneously, and may further perform coagulation (tissue fixation) by microwaves. The operating tool has no definite fulcrum, and has both the holding and scissors functions with a simple structure by deforming a long-track rod called beam. Two blades are insulated from each other so as to allow microwave current supply. With this structure, an operating tool having three functions, i.e., “a holding function”, “a coagulating function”, and “a cutting function” with a single tool may be developed.
摘要翻译: 本发明提供一种生物体的操作工具,特别是微波内窥镜镊子。 就生物的操作工具而言,提供了一种多功能操作工具,其具有同时保持和剪刀功能,并且可以进一步通过微波进行凝固(组织固定)。 操作工具没有明确的支点,通过使称为梁的长轨杆变形,具有简单结构的保持和剪刀功能。 两个叶片彼此绝缘,以便允许微波电流供应。 利用这种结构,可以开发具有单个工具的具有三个功能即“保持功能”,“凝结功能”和“切割功能”的操作工具。
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公开(公告)号:US11633716B2
公开(公告)日:2023-04-25
申请号:US16638586
申请日:2018-09-07
发明人: Junichi Kasuya , Ryo Matsunaga , Yoshiyuki Ueno , Yuji Ueda , Kazuo Teramoto , Kazumasa Ogasawara
IPC分类号: B01J20/26 , A61M1/36 , B01J20/28 , B01J20/32 , C07K14/495
摘要: An objective of the present disclosure is to provide an adsorption material that has a carrier material with retained physical strength, and efficiently adsorbs an immunosuppressive protein. The present disclosure provides an adsorption material for immunosuppressive protein. The adsorption material includes a water-insoluble carrier to which at least one nitrogen-containing compound selected from a polyamine represented by a predetermined formula and aliphatic amines represented by predetermined formulae is bound. A total content of amino groups on the water-insoluble carrier is more than 0 μmol and 2500 μmol or less per 1 g, and a content of primary amino groups on the water-insoluble carrier is 450 μmol or less per 1 g.
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