公开(公告)号：US11285119B2

公开(公告)日：2022-03-29

申请号：US16342516

申请日：2017-08-25

申请人： NEOPHARM CO., LTD.

发明人： Ji Yeon Park ,  Minhee Kim ,  Bu-Mahn Park ,  Kyung Sook Yoo ,  Sung Woo Kim ,  Hye Seong Shin

IPC分类号： A61K31/16 ,  A61K8/42 ,  A61K31/164 ,  A61K31/198 ,  A61Q19/00 ,  A61Q19/08 ,  A61P17/00 ,  A61K9/00

摘要： An anti-inflammatory composition is disclosed. The anti-inflammatory composition is be useful for a pharmaceutical composition or a cosmetic composition by not only having excellent stability on the skin and therefore being harmless to the human body, but also by controlling the expression of an inflammatory skin disease-related mediating factor and thereby exhibiting an excellent anti-inflammatory effect.

公开(公告)号：US11161822B2

公开(公告)日：2021-11-02

申请号：US16877593

申请日：2020-05-19

申请人： NeoPharm Co., Ltd.

发明人： Kyung Sook Yoo ,  Bu-Mahn Park ,  Min Hee Kim ,  Yu Ra Jung ,  Hye Seong Shin

IPC分类号： C07D233/64 ,  C07C235/80 ,  C07D209/20 ,  C07C279/14

摘要： Provided are a novel amide compound and a use thereof. According to the present invention, there may be provided a use of a novel amide compound which is harmless to the human body with excellent skin stability and decreases activity of peroxisome proliferator activated receptor gamma (PPAR-γ) to fundamentally inhibit sebum overproduction, thereby providing the skin with an effective effect, and a cosmetic composition including the same.

公开(公告)号：US20210283031A1

公开(公告)日：2021-09-16

申请号：US17198703

申请日：2021-03-11

申请人： Neopharm Co., Ltd.

发明人： Yoon Kim ,  Kyung Sook Yoo ,  Bu-Mahn Park ,  Yu Ra Jung ,  Hye Seong Shin

IPC分类号： A61K8/42 ,  A61K8/02 ,  A61Q17/04 ,  A61Q19/00 ,  A61Q19/10

摘要： Provided is a cosmetic composition for protection of the skin against reactive oxygen species, ultraviolet rays, or blue light, which includes an amide-based compound. The cosmetic composition according to the present invention can effectively inhibit cell damage caused by the reactive oxygen species, the ultraviolet rays, or the blue light and protect the skin without irritating the skin, and can simultaneously aid in recovering the damaged skin.

公开(公告)号：US20150072935A1

公开(公告)日：2015-03-12

申请号：US14470025

申请日：2014-11-05

申请人： NEOPHARM CO., LTD.

发明人： Bong-Woo KIM ,  Jeong Eun JEON ,  Se Kyoo JEONG ,  Yoon KIM

IPC分类号： C07K7/06

CPC分类号： C07K7/06 ,  A61K9/0014 ,  A61K38/00

摘要： Provided are a composition and an external application for promoting muscle differentiation or improving muscle mass containing an amino acid derivative promoting muscle cell differentiation, a composition and an external application for alleviating muscle function deterioration caused by muscle damage and recovering damaged muscle containing the same, or a pharmaceutical composition and an external application for treating or improving a muscle deterioration disease containing the same.

摘要翻译： 本发明提供一种用于促进肌肉分化或改善肌肉质量的组合物和外部应用，其包含促进肌肉细胞分化的氨基酸衍生物，用于缓解由肌肉损伤引起的肌肉功能退化并恢复含有该肌肉功能的损伤的肌肉的组合物和外部应用，或 用于治疗或改善含有该组合物的肌肉退化疾病的药物组合物和外用途。

公开(公告)号：US20140112933A1

公开(公告)日：2014-04-24

申请号：US14009048

申请日：2011-04-05

申请人： Eunkyung Lee ,  Hyunjung Kang ,  Minhee Kim ,  Eun hye Park

发明人： Eunkyung Lee ,  Hyunjung Kang ,  Minhee Kim ,  Eun hye Park

IPC分类号： C07K16/26

CPC分类号： C07K16/26 ,  A61K2039/505 ,  A61K2039/545 ,  C07K16/22 ,  C07K2317/76

摘要： The present invention relates to antibodies against angiopoietins 1 and 2, and derivatives of these antibodies. More specifically, the present invention relates to therapeutic use of the antibodies and fragment thereof which specifically bind to angiopoietins 1 and 2.

摘要翻译： 本发明涉及针对血管生成素1和2的抗体以及这些抗体的衍生物。 更具体地，本发明涉及特异性结合血管生成素1和2的抗体及其片段的治疗用途。

公开(公告)号：US20130190397A1

公开(公告)日：2013-07-25

申请号：US13779080

申请日：2013-02-27

申请人： Neopharm Co., Ltd.

发明人： Byoeung-Deog PARK ,  Jong-Hwan BAE ,  Se-Kyoo JEONG ,  Hyoung-Sub GWAK

IPC分类号： C07C233/11 ,  C07C231/02

CPC分类号： C07C233/11 ,  A61K31/27 ,  C07B2200/07 ,  C07C231/02 ,  C07C233/47

摘要： Disclosed is a compound having an acceleration effect on the secretion of human β-defensin, LL-37, which is a human-derived anti-microbial peptide, a method for preparing same, and a composition for accelerating the secretion of anti-microbial peptide having same as an active ingredient, and the compound and the composition using same of the present invention enhance the anti-microbial effect and the immunity control effect that the anti-microbial peptide has in the body by accelerating the secretion of the anti-microbial peptide in the body.

摘要翻译： 本发明公开了一种对人β-防御素的分泌具有加速作用的化合物，作为人衍生的抗微生物肽的LL-37，其制备方法以及用于促进抗微生物肽分泌的组合物 与活性成分相同，并且使用本发明的化合物和组合物通过加速抗微生物肽的分泌来增强抗微生物肽在体内具有的抗微生物作用和免疫控制作用 在身上。

公开(公告)号：US20110183983A1

公开(公告)日：2011-07-28

申请号：US12920243

申请日：2009-08-28

申请人： Tae-Seong Kim ,  Eunkyung Lee ,  Doyoung Kim ,  Bu-mahn Park ,  Jiyeon Park ,  JungJe Joo

发明人： Tae-Seong Kim ,  Eunkyung Lee ,  Doyoung Kim ,  Bu-mahn Park ,  Jiyeon Park ,  JungJe Joo

IPC分类号： A61K31/53 ,  C07D487/04 ,  C07D471/04 ,  C07D253/10 ,  A61K31/5025 ,  A61K31/437 ,  A61P35/00 ,  A61P17/06

CPC分类号： C07D471/04 ,  C07D487/04

摘要： Provided are novel heterocyclic compounds useful as anti-cancer drugs by suppressing protein kinase activities of growth factor receptors such as c-Met, pharmaceutical compositions containing the same, and methods for using the compound.

摘要翻译： 提供了通过抑制生长因子受体如c-Met的蛋白激酶活性，含有它们的药物组合物和使用该化合物的方法，可用作抗癌药物的新型杂环化合物。

公开(公告)号：US11471391B2

公开(公告)日：2022-10-18

申请号：US16877578

申请日：2020-05-19

申请人： NeoPharm Co., Ltd.

发明人： Kyung Sook Yoo ,  Bu-Mahn Park ,  Min Hee Kim ,  Yu Ra Jung ,  Hye Seong Shin

IPC分类号： A61K8/42 ,  A61K8/02 ,  A61K8/04 ,  A61Q19/00

摘要： Provided are a cosmetic composition for inhibiting sebum hypersecretion and a method of inhibiting sebum hypersecretion using the same. According to the present invention, there may be provided the cosmetic composition of inhibiting and adjusting sebum secretion which is harmless to the human body with excellent skin safety and decreases activity of peroxisome proliferator activated receptor gamma (PPAR-γ) to fundamentally decrease sebum overproduction, thereby providing the skin with an effective effect, and a method of using the same.

公开(公告)号：US10016351B2

公开(公告)日：2018-07-10

申请号：US15519822

申请日：2015-11-11

申请人： NEOPHARM CO., LTD.

发明人： Se Kyoo Jeong ,  Jong Hwan Bae ,  Bu Mahn Park ,  Dae Hwan Kim

IPC分类号： A61K8/68 ,  A61Q7/00 ,  A61Q5/02 ,  A61K8/49 ,  A61C7/00

CPC分类号： A61K8/68 ,  A61C7/00 ,  A61K8/4953 ,  A61Q5/02 ,  A61Q7/00

摘要： The present invention relates to a composition for promoting hair growth or preventing hair loss and, specifically, to a composition, which has excellent stability for skin and no side effects, promotes hair growth, prevents hair loss through the delay of hair loss, and has an excellent hair growth effect.

公开(公告)号：US09867776B2

公开(公告)日：2018-01-16

申请号：US14902102

申请日：2014-07-01

申请人： NEOPHARM CO., LTD.

发明人： Se Kyoo Jeong ,  Ji Yeon Park ,  Min Seok Kim ,  Jong Mi Lim

IPC分类号： A61K47/28 ,  A61K9/00 ,  A61K9/107 ,  A61K31/573 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/5415 ,  A61K31/542 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18

CPC分类号： A61K9/0014 ,  A61K9/107 ,  A61K31/192 ,  A61K31/196 ,  A61K31/405 ,  A61K31/5415 ,  A61K31/542 ,  A61K31/573 ,  A61K47/10 ,  A61K47/12 ,  A61K47/18 ,  A61K47/28

摘要： Provided is a transdermal drug delivery system, which is a delivery system for transdermal absorption, having a multi-lamellar emulsion structure, including: lipids including long-chain amides, sterols, fatty acid and fatty alcohol; an emulsifier; oil; and at least one drug for transdermal administration. The transdermal drug delivery system in a multi-lamellar emulsion structure, according to the present invention, has a lamellar structure in which a layered structure visible in stratum corneum intercellular lipids of the human body is repeated, and thus has an excellent skin barrier effect and enables a drug to be effectively partitioned through skin lipids, thereby obtaining an excellent drug delivery effect.