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    Propargylethoxyamino nucleotides
    1.
    发明申请
    Propargylethoxyamino nucleotides 失效
    丙炔乙氧基氨基核苷酸

    公开(公告)号：US20030148470A1

    公开(公告)日：2003-08-07

    申请号：US10192776

    申请日：2002-07-09

    申请人： PE Corporation (NY)

    发明人： Shaheer H. Khan ,  Steven M. Menchen ,  Barnett B. Rosenblum

    IPC分类号： C12Q001/68 ,  C12P019/34 ,  C07H021/04 ,  C07H019/067 ,  C07H019/04 ,  C07H019/16 ,  C07H019/06 ,  C07H019/073 ,  C07H019/09

    CPC分类号： C07H21/00 ,  C07H19/04 ,  C07H21/04 ,  C12Q1/686

    摘要： Propargylethoxyamino nucleosides are disclosed having the structure 1 wherein R1 and R2 are nullH, lower alkyl, or label; B is a 7-deazapurine, purine, or pyrimidine nucleoside base; W1 is nullH or nullOH; W2 is nullOH or a moiety which renders the nucleoside incapable of forming a phosphodiester bond at the 3null-position; and W3 is nullPO4, nullP2O7, nullP3O10, phosphate analog, or nullOH. Additionaly, a primer extension method is provided employing the above propargylethoxyamino nucleosides.

    摘要翻译： 公开了具有其中R 1和R 2为-H，低级烷基或标记的结构的丙炔乙氧基氨基核苷; B是7-脱氮嘌呤，嘌呤或嘧啶核苷碱基; W1是-H或-OH; W2是-OH或使核苷不能在3'-位形成磷酸二酯键的部分; W3是-PO 4，-P 2 O 7，-P 3 O 10，磷酸酯类似物或-OH。 另外，使用上述炔丙氧基氨基核苷提供引物延伸方法

    PCR sample handling device
    2.
    发明申请
    PCR sample handling device 有权

    公开(公告)号：US20030124714A1

    公开(公告)日：2003-07-03

    申请号：US10301870

    申请日：2002-11-22

    申请人： PE Corporation (NY)

    发明人： Gary L. Bordenkircher ,  Gary Lim ,  Jacob Koppel Freudenthal

    IPC分类号： C12M001/36

    CPC分类号： B01L7/52 ,  B01L3/50851 ,  B01L9/523 ,  B01L2200/025 ,  B01L2300/0609 ,  B01L2300/0816 ,  B01L2300/0864 ,  B01L2300/0887 ,  B01L2300/1805 ,  Y10S435/809 ,  Y10S435/81

    摘要： A device for handling PCR microcards, each having an array of sample chambers closed by a transparent material on one side thereof, in relation to a PCR instrument, the device including a carrier having an apertured region with an array of holes corresponding in number and relative location with the array of sample chambers in each of the microcards, and a provision for retaining a microcard on the carrier so that the transparent material faces the apertured region with the reagent sample chambers aligned, respectively, with the holes in the apertured region, and so that the side of the microcard opposite the transparent material is unobstructed at least throughout the array of sample chambers. The device cooperates with the PCR instrument to ensure accurate positioning of the carrier and the microcard retained thereon for real time PCR processing.

    ISOLATED HUMAN UDP-GLYCOSYLTRANSFERASE PROTEINS
    4.
    发明申请
    ISOLATED HUMAN UDP-GLYCOSYLTRANSFERASE PROTEINS 失效
    分离的人UDP-GLYCOSYLTRANSFERASE蛋白

    公开(公告)号：US20020182692A1

    公开(公告)日：2002-12-05

    申请号：US10060311

    申请日：2002-02-01

    申请人： PE CORPORATION (NY)

    发明人： Marion Webster ,  Ming-Hui Wei ,  Valentina Difrancesco ,  Ellen M. Beasley

    IPC分类号： C12P021/02 ,  C12N005/06 ,  C07K016/40 ,  C07H021/04 ,  C12N009/00 ,  C12N009/10

    CPC分类号： C12N9/1048

    摘要： The present invention provides amino acid sequences of peptides that are encoded by genes within the human genome, the drug-metabolizing enzyme peptides of the present invention. The present invention specifically provides isolated peptide and nucleic acid molecules, methods of identifying orthologs and paralogs of the drug-metabolizing enzyme peptides, and methods of identifying modulators of the drug-metabolizing enzyme peptides.

    摘要翻译： 本发明提供由人基因组内的基因编码的肽的氨基酸序列，本发明的药物代谢酶肽。 本发明特别提供分离的肽和核酸分子，鉴定药物代谢酶肽的直系同源物和旁系同源物的方法，以及鉴定药物代谢酶肽调节剂的方法。

    Capillary electrophoresis method and apparatus for reducing peak broadening associated with the establishment of an electtric field
    9.
    发明申请
    Capillary electrophoresis method and apparatus for reducing peak broadening associated with the establishment of an electtric field 有权
    用于减少与建立电场相关的峰值宽度的毛细管电泳方法和装置

    公开(公告)号：US20020100689A1

    公开(公告)日：2002-08-01

    申请号：US10075404

    申请日：2002-02-13

    申请人： PE Corporation (NY)

    发明人： Ben F. Johnson ,  Eric S. Nordman

    IPC分类号： G01N027/26 ,  G01N027/447

    CPC分类号： G01N27/44704 ,  G01N27/44708

    摘要： Methods for reducing peak broadening associated with the establishment of a run field in a capillary electrophoresis process, and apparatus useful for carrying out such methods, are described. Such methods include defining a maximum ramp rate to be used during an initial electric field ramp, defining a minimum period over which the run field is established, and/or maintaining a temperature of a separation medium to within certain ranges during the initial electric field ramp. In addition, methods for determining a ramp rate effective for reducing peak broadening are disclosed.

    摘要翻译： 描述了在毛细管电泳过程中与运行场的建立相关的峰拓宽减少的方法以及用于实施这些方法的装置。 这样的方法包括定义在初始电场斜坡期间要使用的最大斜坡速率，定义运行场建立的最小周期和/或在初始电场斜坡期间将分离介质的温度保持在特定范围内 。 此外，公开了用于确定有效减少峰值变宽的斜坡率的方法。