公开(公告)号：US20240327439A1

公开(公告)日：2024-10-03

申请号：US18575218

申请日：2022-06-28

申请人： Plex Pharmaceuticals, Inc.

发明人： Santosh C. SINHA ,  Sridhar Govinda PRASAD

IPC分类号： C07F9/38 ,  A61K31/222 ,  A61K31/661 ,  A61K31/662 ,  C07C205/45 ,  C07F9/12

CPC分类号： C07F9/38 ,  A61K31/222 ,  A61K31/661 ,  A61K31/662 ,  C07C205/45 ,  C07F9/12

摘要： Methods of treating presbyopia or cataract in a subject in need thereof are provided. The methods require administering to the subject an effective amount of a composition comprising a compound that inhibits the formation or dissolves high molecular weight aggregates of human α-A-crystallin. Compositions containing certain compounds are believed to be also effective in the treatment of transthyretin (TTR)-associated amyloidosis, Prion, Creutzfeldt-Jakob, Gerstmann-Sträussler-Scheinker disease and Ankyloblepharon-ectodermal dysplasia-cleft lip/palate syndrome.

公开(公告)号：US12065407B2

公开(公告)日：2024-08-20

申请号：US16640919

申请日：2018-08-21

申请人： PLEX PHARMACEUTICALS, INC.

发明人： Surya Kanta De ,  Sridhar G. Prasad ,  Marshall C. Peterman

IPC分类号： C07D213/30 ,  A61K31/4184 ,  A61K47/30 ,  C07C237/22 ,  C07D209/42 ,  C07D231/56 ,  C07D235/08 ,  C07D235/10 ,  C07D235/14 ,  C07D235/30 ,  A61K9/00

CPC分类号： C07D213/30 ,  A61K47/30 ,  C07C237/22 ,  C07D209/42 ,  C07D231/56 ,  C07D235/10 ,  C07D235/14 ,  C07D235/30 ,  A61K9/0043

摘要： Provided are novel compounds of Formulas (I) and (II), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful as dual FKBP12/FKABP inhibitors. Also provided are pharmaceutical compositions comprising the novel compounds of Formulas (I) and (II) and their use in treating Parkinson's disease.

公开(公告)号：US20210395203A1

公开(公告)日：2021-12-23

申请号：US17362688

申请日：2021-06-29

申请人： Plex Pharmaceuticals, Inc.

发明人： Surya Kanta DE ,  Sridhar G. PRASAD ,  Marshall C. PETERMAN

IPC分类号： C07D213/30 ,  A61K47/30 ,  C07C237/22 ,  C07D209/42 ,  C07D231/56 ,  C07D235/10 ,  C07D235/14 ,  C07D235/30

摘要： Provided are novel compounds of Formulas (I) and (II), pharmaceutically acceptable salts thereof, and pharmaceutical compositions thereof, which are useful as dual FKBP12/FKABP inhibitors. Also provided are pharmaceutical compositions comprising the novel compounds of Formulas (I) and (II) and their use in treating Parkinson's disease.

公开(公告)号：US20220241247A1

公开(公告)日：2022-08-04

申请号：US17615469

申请日：2020-06-01

申请人： PLEX PHARMACEUTICALS, INC.

发明人： Sridhar Govinda PRASAD ,  Marshall Clarke PETERMAN ,  Santosh SINHA

IPC分类号： A61K31/423 ,  A61K31/675 ,  A61P27/12 ,  A61K9/00

摘要： Methods of treating presbyopia or cataract in a subject in need thereof are provided. The methods require administering to the subject an effective amount of a composition comprising a compound that inhibits the formation of high molecular weight aggregates of human α-A-crystallin. A method of preventing and/or treating transthyretin (TTR)-associated amyloidosis using certain of these compounds is also provided.

公开(公告)号：US20240000812A1

公开(公告)日：2024-01-04

申请号：US18037021

申请日：2021-11-15

申请人： PLEX PHARMACEUTICALS, INC.

发明人： Santosh C. SINHA ,  Sridhar Govinda PRASAD ,  Marshall C. PETERMAN

IPC分类号： A61K31/662 ,  A61K31/46 ,  A61K31/198 ,  C07F9/38 ,  C07F9/12 ,  A61K31/661 ,  A61P27/10

CPC分类号： A61K31/662 ,  A61K31/46 ,  A61K31/198 ,  C07F9/3808 ,  C07F9/12 ,  A61K31/661 ,  A61P27/10

摘要： Provided are compounds useful for treating, preventing, reducing the occurrence of, slowing the progression of, or reducing, ameliorating, or alleviating the symptoms associated with a condition selected from the group consisting of: presbyopia, cataract, transthyretin (TTR)-associated amyloidosis, myopia, or other conditions or disorders associated with the eye, including COMT inhibitors and pro-drugs thereof, and methods of using these compounds.