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公开(公告)号:US20110300174A1
公开(公告)日:2011-12-08
申请号:US13151590
申请日:2011-06-02
申请人: Alan Daniel BROWN , Heather Lynn DAVIS , David P. GERVAIS , Lyn Howard JONES , James R. MERSON , David Cameron PRYDE , David R. STEAD , Michael J. MCCLUSKIE , Jennifer Marie THORN , Paul Robert MEHELIC , Parag Ashok KOLHE , Keshab BHATTACHARYA , Jari Ilmari FINNEMAN , Erin Kristen PARSONS , Nickolas ANASTASIOU
发明人: Alan Daniel BROWN , Heather Lynn DAVIS , David P. GERVAIS , Lyn Howard JONES , James R. MERSON , David Cameron PRYDE , David R. STEAD , Michael J. MCCLUSKIE , Jennifer Marie THORN , Paul Robert MEHELIC , Parag Ashok KOLHE , Keshab BHATTACHARYA , Jari Ilmari FINNEMAN , Erin Kristen PARSONS , Nickolas ANASTASIOU
IPC分类号: A61K39/385 , A61P25/34 , C07K14/34 , C07D401/04 , C07K17/06
CPC分类号: A61K39/385 , A61K31/465 , A61K39/39 , A61K47/6415 , A61K47/646 , A61K2039/55505 , A61K2039/55561 , A61K2039/6012 , A61K2039/6037 , A61K2039/627 , C07D401/04 , C07K14/34 , Y02A50/473
摘要: The present invention relates in part to nicotine-derived hapten-carrier conjugates of the formula (III): wherein m, n, W, -(spacer)-, X* and Y are as defined in the description. In certain embodiments, said nicotine-derived hapten-carrier conjugates can be used to prepare vaccines for the treatment and/or prevention of nicotine addiction.
摘要翻译: 本发明部分地涉及式(III)的尼古丁衍生的半抗原 - 载体共轭物:其中m,n,W, - (间隔基) - ,X *和Y如说明书中所定义。 在某些实施方案中,所述尼古丁衍生的半抗原 - 载体缀合物可用于制备用于治疗和/或预防尼古丁成瘾的疫苗。
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公开(公告)号:US09249233B2
公开(公告)日:2016-02-02
申请号:US14225258
申请日:2014-03-25
申请人: Pfizer Vaccines LLC
IPC分类号: A61K39/395 , C07K17/06 , A61K39/00 , C07K16/42 , A61K39/44 , A61K47/48 , A61K38/10 , A61K39/385 , C07K4/12 , C07K7/08
CPC分类号: C07K17/06 , A61K38/10 , A61K39/0005 , A61K39/385 , A61K39/44 , A61K47/48023 , A61K47/54 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/6037 , A61K2039/6075 , A61K2039/6081 , A61K2039/70 , A61K2300/00 , C07K4/12 , C07K7/08 , C07K16/4291 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2319/55 , Y10S424/805 , Y10S424/81 , Y10S530/806 , Y10S530/862 , Y10S530/866 , Y10S530/868
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier, compositions comprising the immunogens, and methods for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供包含抗原性IgE肽的新型免疫原,优选与免疫原性载体连接,包含免疫原的组合物,以及预防,治疗或减轻IgE介导的病症的方法。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US20150118256A1
公开(公告)日:2015-04-30
申请号:US14225258
申请日:2014-03-25
申请人: Pfizer Vaccines LLC
CPC分类号: C07K17/06 , A61K38/10 , A61K39/0005 , A61K39/385 , A61K39/44 , A61K47/48023 , A61K47/54 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/6037 , A61K2039/6075 , A61K2039/6081 , A61K2039/70 , A61K2300/00 , C07K4/12 , C07K7/08 , C07K16/4291 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2319/55 , Y10S424/805 , Y10S424/81 , Y10S530/806 , Y10S530/862 , Y10S530/866 , Y10S530/868
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier, compositions comprising the immunogens, and methods for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供包含抗原性IgE肽的新型免疫原,优选与免疫原性载体连接,包含免疫原的组合物,以及预防,治疗或减轻IgE介导的病症的方法。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US08298547B2
公开(公告)日:2012-10-30
申请号:US12634336
申请日:2009-12-09
申请人: Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
发明人: Alan Daniel Brown , Brian Robert Champion , Clare Christy , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
IPC分类号: A61K39/00
CPC分类号: A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供新型免疫原,其包含抗原性IgE肽,优选与免疫原性载体连接以预防,治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US09987341B2
公开(公告)日:2018-06-05
申请号:US15266812
申请日:2016-09-15
申请人: Pfizer Vaccines LLC
发明人: Brian Robert Champion, Jr. , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
IPC分类号: A61K39/00
CPC分类号: A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
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公开(公告)号:US09481875B2
公开(公告)日:2016-11-01
申请号:US14508977
申请日:2014-10-07
申请人: Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
发明人: Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
CPC分类号: A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要: The present invention relates to the provision of immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供免疫原,其包含与免疫原性载体连接的抗原性PCSK9肽,用于预防,治疗或缓解PCSK9介导的病症。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US08722053B2
公开(公告)日:2014-05-13
申请号:US13152032
申请日:2011-06-02
CPC分类号: C07K17/06 , A61K38/10 , A61K39/0005 , A61K39/385 , A61K39/44 , A61K47/48023 , A61K47/54 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/6037 , A61K2039/6075 , A61K2039/6081 , A61K2039/70 , A61K2300/00 , C07K4/12 , C07K7/08 , C07K16/4291 , C07K2317/52 , C07K2317/526 , C07K2317/528 , C07K2319/55 , Y10S424/805 , Y10S424/81 , Y10S530/806 , Y10S530/862 , Y10S530/866 , Y10S530/868
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier, compositions comprising the immunogens, and methods for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供包含抗原性IgE肽的新型免疫原,优选与免疫原性载体连接,包含免疫原的组合物,以及预防,治疗或减轻IgE介导的病症的方法。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US20110177109A1
公开(公告)日:2011-07-21
申请号:US12846719
申请日:2010-07-29
IPC分类号: A61K39/00 , C07K7/06 , A61P25/28 , C07K7/08 , C07K14/435
CPC分类号: A61K39/0005 , C07K14/4711
摘要: The present disclosure relates to novel immunogens and compositions comprising an antigenic tau peptide, preferably linked to an immunogenic carrier for use in the treatment of tau-related neurological disorders. The disclosure further relates to methods for production of these immunogens and compositions and their use in medicine.
摘要翻译: 本公开内容涉及包含抗原性tau肽的新型免疫原和组合物,优选与用于治疗tau相关神经障碍的免疫原性载体连接。 本公开还涉及生产这些免疫原和组合物及其在医学中的用途的方法。
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公开(公告)号:US09216229B2
公开(公告)日:2015-12-22
申请号:US13904432
申请日:2013-05-29
申请人: Alan Daniel Brown , Brian Robert Champion , Clare Lees , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
发明人: Alan Daniel Brown , Brian Robert Champion , Clare Lees , David Paul Gervais , Lyn Howard Jones , Anne Maria Kristina Kjerrstrom , David Cameron Pryde , Lee Richard Roberts , David Michael Wyatt
IPC分类号: A61K38/04 , A61K47/48 , A61K39/00 , A61K39/395
CPC分类号: A61K47/48338 , A61K39/00 , A61K39/395 , A61K47/643 , A61K47/646 , A61K2039/505 , A61K2039/6075 , A61K2039/627
摘要: The present invention relates to the provision of novel immunogens comprising an antigenic IgE peptide preferably linked to an immunogenic carrier for the prevention, treatment or alleviation of IgE-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供新型免疫原,其包含抗原性IgE肽,优选与免疫原性载体连接以预防,治疗或减轻IgE介导的病症。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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公开(公告)号:US08889144B2
公开(公告)日:2014-11-18
申请号:US12872645
申请日:2010-08-31
申请人: Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
发明人: Brian Robert Champion , Leonard Gabriel Contillo, Jr. , Michael Dale Eisenbraun , James Downey Fraser , Julie Jia Li Hawkins , James Richard Merson , Brian Gregory Pierce , Xiayang Qiu , Jakir Hussain Ullah , David Michael Wyatt
CPC分类号: A61K39/0005 , C12N9/6424 , C12Y304/21061
摘要: The present invention relates to the provision of immunogens comprising an antigenic PCSK9 peptide linked to an immunogenic carrier for the prevention, treatment or alleviation of PCSK9-mediated disorders. The invention further relates to methods for production of these medicaments, immunogenic compositions and pharmaceutical compositing thereof and their use in medicine.
摘要翻译: 本发明涉及提供免疫原,其包含与免疫原性载体连接的抗原性PCSK9肽,用于预防,治疗或缓解PCSK9介导的病症。 本发明还涉及这些药物的生产方法,免疫原性组合物及其药物合成及其在药物中的用途。
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