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1.
公开(公告)号:US20070299390A1
公开(公告)日:2007-12-27
申请号:US11848432
申请日:2007-08-31
申请人: Brian Bellhouse , David Sarphie , John Greenford
发明人: Brian Bellhouse , David Sarphie , John Greenford
CPC分类号: A61M5/3015 , A61M5/2053 , A61M2205/42 , C12M35/00 , C12M35/04 , C12N15/895
摘要: A needleless syringe having a membrane (28) which is ruptured by gas pressure to generate a supersonic gas flow in which particles containing a therapeutic agent are injected.
摘要翻译: 一种无针注射器,其具有通过气体压力破裂的膜(28),以产生其中注入含有治疗剂的颗粒的超音速气流。
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公开(公告)号:US20080262417A1
公开(公告)日:2008-10-23
申请号:US12163798
申请日:2008-06-27
CPC分类号: G11B20/00 , A61M5/2046 , A61M5/3015
摘要: The invention provides a device which seeks to ensure that substantially all the particles delivered avoid interaction with the so-called “starting process”. There is provided a needleless injection device comprising a driver chamber (51) arranged, in use, to contain a charge of pressurised gas, a duct section (52) connected to the driver chamber (51) to receive gas therefrom and a closure means (53) for preventing the flow of gas from the driver chamber (51) to the duct section (52) until the closure means (53) is opened. Further, a dose of particles (58) is positioned within the device in the region of the closure means (53). The device is so constructed and arranged that upon opening of the closure means (53), a primary shock wave is produced to travel along the duct (52) in a downstream direction so that a substantially quasi-steady gas flow is established in the duct (52) upstream of the primary shock wave, with the dose of particles (58) being substantially wholly entrained in the substantially quasi-steady flow to be accelerated thereby and expelled from the device.
摘要翻译: 本发明提供了一种设备,其试图确保基本上所有的颗粒传递避免与所谓的“启动过程”相互作用。 提供了一种无针注射装置,其包括在使用中布置用于容纳加压气体的驱动器室(51),连接到驱动器室(51)以从其接收气体的管道部分(52)和封闭装置 53),用于防止气体从驱动室(51)流到管道部分(52),直到关闭装置(53)打开。 此外,在封闭装置(53)的区域中,剂量的颗粒(58)被定位在装置内。 该装置被构造和布置成使得在打开封闭装置(53)时,产生主冲击波沿下游方向沿管道(52)行进,使得在管道中建立基本上准稳定的气流 (52)在主冲击波的上游,其中颗粒(58)的剂量基本上完全夹带在基本上准稳定的流中,从而被加速并从装置中排出。
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公开(公告)号:US07060048B1
公开(公告)日:2006-06-13
申请号:US09548984
申请日:2000-04-14
申请人: Avtar S. Nat , Stuart P. Hendry , Colin Sheldrake
发明人: Avtar S. Nat , Stuart P. Hendry , Colin Sheldrake
IPC分类号: A61M5/30
CPC分类号: A61M5/3015 , A61M5/3134 , A61M2005/2073 , A61M2005/3104
摘要: A needleless syringe device for accelerating particles into a target tissue of a vertebrate subject is provided. The syringe features an elongate, tubular duct having a lumen for delivering the particles towards the target tissue. The duct may have a constant cross-sectional area. The device further features a receptacle holding the particles and a gas discharge chamber upstream of the receptacle. On actuation the gas discharge chamber discharges pressurised gas having a maximum total pressure of about 10 bar or less. Methods of using the device for delivering particles to a target tissue are also provided.
摘要翻译: 提供了一种用于将颗粒加速到脊椎动物对象的目标组织中的无针注射器装置。 注射器具有细长的管状管道,其具有用于将颗粒递送到靶组织的内腔。 管道可以具有恒定的横截面面积。 该装置还具有容纳颗粒的容器和容器上游的气体排出室。 在致动时,气体放电室排出具有约10巴或更小的最大总压力的加压气体。 还提供了使用该装置将颗粒输送到靶组织的方法。
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