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12 条记录 (耗时 0.026 秒)

    CANCER MARKERS
    1.
    发明申请
    CANCER MARKERS 审中-公开
    癌症标志

    公开(公告)号：US20140051587A1

    公开(公告)日：2014-02-20

    申请号：US14008182

    申请日：2012-03-30

    申请人： Attila Lorincz

    发明人： Attila Lorincz

    IPC分类号： C12Q1/68

    CPC分类号： C12Q1/6886 ,  C12Q2600/118 ,  C12Q2600/154

    摘要： Hence, the invention relates to a method for diagnosis and/or prognosis of cancer, comprising the steps of analyzing in a sample of a subject the DNA methylation status of a genomic region of at least one member of the group of, (i) SFN according to SEQ ID NO. 1, (ii) SLIT2 according to SEQ ID NO. 2, (iii) SERPINB5 according to SEQ ID NO. 3; and (iv) TWIST 1 according to SEQ ID NO 4; wherein, if (i) SFN shows a methylation cut off value of above 80% and/or, (ii) SLIT2 shows a methylation cut-off value of above 45% and/or, (iii) SERPBINB5 shows a methylation cut-off value of above 70%, and/or (iv) TWIST 1 shows a methylation level below 15% the sample is categorized as a sample from a patient with cancer and/of a poor prognosis.

    摘要翻译： 因此，本发明涉及一种用于癌症的诊断和/或预后的方法，包括以下步骤：在受试者的样品中分析以下组中至少一个成员的基因组区域的DNA甲基化状态：（i）SFN 根据SEQ ID NO。 1，（ii）根据SEQ ID NO。 2，（iii）SEQ ID NO：5的SERPINB5。 3; 和（iv）根据SEQ ID NO 4的TWIST 1; 其中，如果（i）SFN显示高于80％的甲基化切断值和/或（ii）SLIT2显示高于45％的甲基化截止值和/或（iii）SERPBINB5显示甲基化截止值 值高于70％，和/或（iv）TWIST 1显示甲基化水平低于15％，样品被分类为患有癌症和/或预后不良的患者的样品。

    AUDIO FORMAT
    4.
    发明申请
    AUDIO FORMAT 有权
    音频格式

    公开(公告)号：US20140169573A1

    公开(公告)日：2014-06-19

    申请号：US14106550

    申请日：2013-12-13

    申请人： Queen Mary and Westfield College, University of London

    发明人： Michael Terrel ,  Andrew Simpson ,  Marcus Pearce ,  Mark Sandler

    IPC分类号： H04R29/00

    CPC分类号： H04R3/04

    摘要： Mechanisms for obtaining an audio signal and information relating to the recording conditions of the audio signal are provided, the method comprising: obtaining an audio signal, wherein the audio signal is a voltage signal representation of sound, the voltage signal having been converted from a pressure signal; obtaining first information indicative of at least one objective feature and/or at least one perceptual feature associated with the conversion of the pressure signal into the audio signal in the form of a voltage signal representation; storing the audio signal, the first information, and second information identifying a relationship between the audio signal and the first information; determining an error adjustment for adjusting the audio signal based on the obtained information; applying the error adjustment to the audio signal to create an error-adjusted audio signal; and obtaining an audio signal and information relating to the recording conditions of the audio signal.

    摘要翻译： 提供了用于获得音频信号的机制和与音频信号的记录条件相关的信息，该方法包括：获得音频信号，其中音频信号是声音的电压信号表示，电压信号已从压力转换 信号; 获取表示至少一个目标特征的第一信息和/或与电压信号表示形式的将压力信号转换成音频信号相关联的至少一个感知特征; 存储音频信号，第一信息和标识音频信号与第一信息之间的关系的第二信息; 基于获得的信息确定用于调整音频信号的误差调整; 将误差调整应用于音频信号以产生经错误校正的音频信号; 并获得与音频信号的记录条件有关的音频信号和信息。

    Optical flow estimation method
    7.
    发明授权
    Optical flow estimation method 有权
    光流估计方法

    公开(公告)号：US07822231B2

    公开(公告)日：2010-10-26

    申请号：US10562604

    申请日：2004-07-01

    申请人： Miguel Coimbra ,  Michael Evan Davies

    发明人： Miguel Coimbra ,  Michael Evan Davies

    IPC分类号： G06T7/20 ,  G06K9/46

    CPC分类号： H04N19/521 ,  G06T7/269 ,  H04N19/48 ,  H04N19/51 ,  H04N19/513

    摘要： The optical flow in an image is estimated using only parameters extracted directly from a compressed video data stream, substantially eliminating the need to decode the video data stream for this purpose. Coefficients extracted from the compressed video data stream are used to establish a confidence map indicative of the edge strength within the image data and hence the accuracy of the associated motion field. A smooth motion field is generated from the motion vectors inherent in the compressed video data stream. The motion field is then used to update the confidence map between frames, providing an estimate of the optical flow.

    摘要翻译： 仅使用从压缩视频数据流直接提取的参数来估计图像中的光流，基本上无需为此目的解码视频数据流。 从压缩视频数据流提取的系数用于建立指示图像数据内的边缘强度的置信度图，并因此建立相关运动场的精度。 从压缩视频数据流中固有的运动矢量产生平滑运动场。 然后使用运动场来更新帧之间的置信度图，提供光流的估计。

    Antibody specifically binding synovial microvasculature of arthritis patients
    9.
    发明授权
    Antibody specifically binding synovial microvasculature of arthritis patients 有权
    抗体特异性结合关节炎患者的滑膜微血管

    公开(公告)号：US09416174B2

    公开(公告)日：2016-08-16

    申请号：US13877097

    申请日：2011-09-30

    申请人： Constantino Pitzalis

    发明人： Constantino Pitzalis

    IPC分类号： C07K16/00 ,  C07K16/46 ,  A61K39/395 ,  A61K39/44 ,  C07K16/18 ,  C07K16/28

    CPC分类号： C07K16/18 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/622

    摘要： The present invention provides an antigen binding polypeptide which specifically targets the synovial microvasculature of arthritis patients and comprises one or more complementarity determining regions (CDRs) selected from the group consisting of SEQ ID NOs 1 to 4. The present invention also relates to the use of such antigen binding polypeptides and conjugates thereof for use in the diagnosis and treatment of arthritis.

    摘要翻译： 本发明提供了特异性靶向关节炎患者的滑膜微血管的抗原结合多肽，并且包含一个或多个选自SEQ ID NO.1至4的互补决定区（CDR）。本发明还涉及使用 这种抗原结合多肽及其缀合物用于诊断和治疗关节炎。

    ANTIBODY SPECIFICALLY BINDING SYNOVIAL MICROVASCULATURE OF ARTHRITIS PATIENTS
    10.
    发明申请
    ANTIBODY SPECIFICALLY BINDING SYNOVIAL MICROVASCULATURE OF ARTHRITIS PATIENTS 有权
    抗体特异性结合性神经病变患者的微血管

    公开(公告)号：US20130266587A1

    公开(公告)日：2013-10-10

    申请号：US13877097

    申请日：2011-09-30

    申请人： Constantino Pitzalis

    发明人： Constantino Pitzalis

    IPC分类号： C07K16/18

    CPC分类号： C07K16/18 ,  C07K16/28 ,  C07K2317/21 ,  C07K2317/622

    摘要： The present invention provides an antigen binding polypeptide which specifically targets the synovial microvasculature of arthritis patients and comprises one or more complementarity determining regions (CDRs) selected from the group consisting of SEQ ID NOs 1 to 4. The present invention also relates to the use of such antigen binding polypeptides and conjugates thereof for use in the diagnosis and treatment of arthritis.

    摘要翻译： 本发明提供了特异性靶向关节炎患者的滑膜微血管的抗原结合多肽，并且包含一个或多个选自SEQ ID NO.1至4的互补决定区（CDR）。本发明还涉及使用 这种抗原结合多肽及其缀合物用于诊断和治疗关节炎。