公开(公告)号：US20240123058A1

公开(公告)日：2024-04-18

申请号：US18276700

申请日：2022-01-29

申请人： XIAMEN UNIVERSITY ,  SUN YAT-SEN UNIVERSITY CANCER CENTER (SUN YAT-SEN UNIVERSITY CANCER CENTER HOSPITAL, SUN YAT-SEN ,  SUN YAT-SEN UNIVERSITY

发明人： Yixin CHEN ,  Xiao ZHANG ,  Junping HONG ,  Miao XU ,  Qian WU ,  Ling ZHONG ,  Ningshao XIA

IPC分类号： A61K39/245 ,  A61P35/00 ,  C07K16/08 ,  C12N7/00

CPC分类号： A61K39/245 ,  A61P35/00 ,  C07K16/085 ,  C12N7/00 ,  A61K2039/505 ,  C07K2317/24 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2319/30

摘要： Provided are an epitope peptide (or a variant thereof) that can be used for preventing or treating an EBV infection, a recombinant protein containing the epitope peptide (or variant thereof) and a carrier protein, and the use of the epitope peptide (or variant thereof) and the recombinant protein. Further provided are an antibody against the epitope peptide, and the use thereof in the detection, prevention and/or treatment of an EBV infection and/or diseases caused by the infection.

公开(公告)号：US10147228B2

公开(公告)日：2018-12-04

申请号：US15623363

申请日：2017-06-14

申请人： THE FIRST AFFILIATED HOSPITAL OF SUN YAT-SEN UNIVERSITY ,  SCHOOL OF DATA AND COMPUTER SCIENCE OF SUN YAT-SEN UNIVERSITY ,  NATIONAL SUPERCOMPUTER CENTRE IN GUANGZHOU OF SUN YAT-SEN UNIVERSITY

发明人： Liwei Yan ,  Shuang Zhu ,  Xiaolin Liu ,  Jian Qi ,  Qingtang Zhu ,  Yao Lu ,  Yongze Guo ,  Sha Yu ,  Yutong Lu ,  Xi Zhang ,  Yunfei Du ,  Tao Lin

IPC分类号： G06K9/00 ,  G06T17/00 ,  G06T7/10 ,  G01N1/30 ,  G06T15/04

摘要： The present invention relates to fields of clinical application of nerve defect repair and the medical three-dimensional (3D) printing technology, and provides an integrated visualization method for three-dimensional (3D) reconstruction of internal structure of human peripheral nerves. The method comprises the following steps: obtaining human peripheral nerves, preparing nerve specimens ex vivo by staining with an iodine preparation in combination with a freeze-drying method; scanning the pretreated peripheral nerves using Micro CT to acquire lossless two-dimensional images, and performing binarization processing to the two-dimensional images, then conducting image segmentation based on textural features to acquire images of nerve fascicles; finally, reconstructing the segmented images into a visualization model by using a supercomputer.

公开(公告)号：US12098167B2

公开(公告)日：2024-09-24

申请号：US17762308

申请日：2020-12-15

申请人： SUN YAT-SEN UNIVERSITY ,  SUN YAT-SEN UNIVERSITY CANCER CENTER (SYSUCC)

发明人： Musheng Zeng ,  Cong Sun ,  Yixin Zeng ,  Guokai Feng ,  Yinfeng Kang ,  Xinchun Chen ,  Xiao Zhang ,  Qianying Zhu ,  Jiangping Li ,  Xiangwei Kong

IPC分类号： C07K14/05 ,  A61K9/51 ,  A61K39/00 ,  A61K39/245 ,  A61P31/22

CPC分类号： C07K14/05 ,  A61K9/51 ,  A61K39/245 ,  A61P31/22 ,  A61K2039/55555

摘要： The present invention is related to a self-assembled nanoparticle containing a gB protein of an EB virus and a preparation method and use thereof. The self-assembled nanoparticle comprises a first polypeptide and a second polypeptide; the first polypeptide comprises the gB protein and a first vector subunit, the second polypeptide comprises a second vector subunit; the first vector subunit is I53-50A1, and the second vector subunit is I53-50B.4PT1. In the self-assembled nanoparticle, the gB protein of the EB virus is displayed on the surface of the nanoparticle for the first time. The particle size of the self-assembled nanoparticle is larger than that of the antigen gB, and the chemical stability of the self-assembled nanoparticle is higher than that of the antigen gB, and the binding capacity with the neutralizing antibody of the self-assembled nanoparticle are higher than that of the antigen gB.

公开(公告)号：US20240034755A1

公开(公告)日：2024-02-01

申请号：US17762308

申请日：2020-12-16

申请人： SUN YAT-SEN UNIVERSITY ,  SUN YAT-SEN UNIVERSITY CANCER CENTER (SYSUCC)

发明人： Musheng ZENG ,  Cong SUN ,  Yixin ZENG ,  Guokai FENG ,  Yinfeng KANG ,  Xinchun CHEN ,  Xiao ZHANG ,  Qianying ZHU ,  Jiangping LI ,  Xiangwei KONG

IPC分类号： C07K14/05 ,  A61K9/51 ,  A61K39/245 ,  A61P31/22

CPC分类号： C07K14/05 ,  A61K9/51 ,  A61K39/245 ,  A61P31/22 ,  A61K2039/55555

摘要： Disclosed are a self-assembled nanoparticle containing a gB protein of an EB virus and a preparation method and use thereof The self-assembled nanoparticle comprises a first polypeptide and a second polypeptide; the first polypeptide comprises the gB protein and a first vector subunit, the second polypeptide comprises a second vector subunit; the first vector subunit is I53-50A1, and the second vector subunit is I53-50B.4PT1. In the self-assembled nanoparticle provided herein, the gB protein of the EB virus is displayed on the surface of the nanoparticle for the first time. The particle size of the self-assembled nanoparticle is larger than that of the antigen gB, and the chemical stability of the self-assembled nanoparticle is higher than that of the antigen gB, and the binding capacity with the neutralizing antibody of the self-assembled nanoparticle are higher than that of the antigen gB.

公开(公告)号：US20230041271A1

公开(公告)日：2023-02-09

申请号：US17828609

申请日：2022-05-31

申请人： Shenzhen Campus of Sun Yat-sen University ,  SUN YAT-SEN UNIVERSITY

发明人： Qicai Xiao ,  Liqian Gao ,  Shizhe Zhou

IPC分类号： C07K7/06 ,  A61K47/54 ,  A61K47/62 ,  A61K49/00 ,  A61K31/704 ,  A61K31/4745

摘要： Disclosed are a type of mitochondria-targeted polypeptides, the preparation method and the uses thereof. The polypeptide is abbreviated as MTP. The synthesis method of the present disclosure is simple, and the mitochondria-targeted polypeptide prepared by the method can specifically target the mitochondria of cells and are basically non-toxic to cells. In addition, these synthesized polypeptides demonstrate good cell-membrane-penetrating properties, and can conveniently undergo further multi-functional derivation and modification, thereby providing a potential delivery tool for the preparation of a mitochondria-targeted medicament.

公开(公告)号：US20220298556A1

公开(公告)日：2022-09-22

申请号：US17830354

申请日：2022-06-02

申请人： SUN YAT-SEN UNIVERSITY ,  SUN YAT-SEN UNIVERSITY CANCER CENTER

发明人： Dongxin LIN ,  Jian ZHENG ,  Dongmei MAI ,  Liping TAN

IPC分类号： C12Q1/6827

摘要： The present invention relates to a piRNA-54265 detection kit used for early screening, diagnosis, efficacy monitoring and/or prognostic evaluation of colorectal cancer. The detection kit includes a primers combination, including a primer pair and a probe for specifically detecting piRNA-54265; the primer pair is a piRNA-54265 stem-loop PCR primer pair, or a piRNA-54265 PolyA tailed PCR primer pair; the primer pair includes a forward primer and a reverse primer.

公开(公告)号：US20200017906A1

公开(公告)日：2020-01-16

申请号：US16576746

申请日：2019-09-19

申请人： SUN YAT-SEN UNIVERSITY ,  SUN YAT-SEN UNIVERSITY CANCER CENTER

发明人： Dongxin LIN ,  Jian ZHENG ,  Dongmei MAI ,  Liping TAN

IPC分类号： C12Q1/6827

摘要： The present invention relates to a marker piRNA-54265 and a method in diagnosis, treatment, and prognostic evaluation of colorectal cancer. The marker piRNA-54265 is capable of being used for diagnosing and/or treating colorectal cancer, wherein the marker piRNA-54265 is selected from any of molecules as follows: (1) SEQ ID NO.29: tggaggtgatgaactgtctgagcctgacc; (2) SEQ ID NO.30: UGGAGGUGAUGAACUGUCUGAGCCUGACC; (3) SEQ ID NO.31: GGUCAGGCUCAGACAGUUCAUCACCUCCA; (4) a piR-54265 variant and a piR-54265 derivative modified from the molecule shown in (1), (2) or (3) with a same function; (5) a piR-54265 polynucleotide construct capable of down-regulating an amount of the piR-54265 in vivo after being introduced; and (6) an expression vector containing the polynucleotide construct of (5). The method is used for diagnosing/screening colorectal cancer, evaluating chemosensitivity of a colorectal cancer patient, evaluating a prognosis of a colorectal cancer patient or treating colorectal cancer.

公开(公告)号：US20190148231A1

公开(公告)日：2019-05-16

申请号：US16092763

申请日：2016-05-31

申请人： SUN YAT-SEN UNIVERSITY ,  SUN YAT-SEN UNIVERSITY CARNEGIE MELLON UNIVERSITY SHUNDE INTERNATIONAL JOINT RESEARCH INSTITUTE

发明人： Shaojun LIU ,  Ke ZHANG ,  Deng PENG ,  Heshen WANG ,  Weijing MO ,  Xi LIU ,  Maosen HUANG

IPC分类号： H01L21/77 ,  H01L27/12 ,  H01L29/786

摘要： The invention discloses a MOS transistor for suppressing generation of a photo-induced leakage current in an active channel region, and an application thereof. A fabrication process comprises: forming a source and a drain at both ends of a substrate by ion implantation, fabricating a gate oxide layer in a middle of an upper surface of the substrate; depositing a polysilicon or a metal on the gate oxide layer to form a gate; depositing an isolation layer above the gate, the source, and the drain; etching contact holes above the source and the drain to extract the source and the drain; depositing the metal on the contact holes above the source and the drain; etching the metal on the drain to isolate the source from the drain; and enabling the metal on the source to directly extend to cover the active channel region, so as to block light rays. The MOS transistor proposed by the invention effectively blocks the light rays incident from above the MOS transistor, suppresses generation of the photo-induced leakage current, not only improves off-state characteristics of the transistor, but also improves a working performance of an active address driving circuit.

公开(公告)号：US20240058441A1

公开(公告)日：2024-02-22

申请号：US17766450

申请日：2021-05-18

申请人： SUN YAT-SEN UNIVERSITY ,  SUN YAT-SEN UNIVERSITY CANCER CENTER (SYSUCC)

发明人： Musheng Zeng ,  Jie Yang ,  Guokai Feng ,  Qiaoli Wang

IPC分类号： A61K39/395 ,  A61K38/46 ,  C07K16/40 ,  A61K31/5377 ,  A61P35/00 ,  C12N9/64

CPC分类号： A61K39/3955 ,  A61K38/46 ,  C07K16/40 ,  A61K31/5377 ,  A61P35/00 ,  C12N9/6424 ,  C12Y304/21 ,  C07K2319/33 ,  C07K2317/569

摘要： Disclosed are a fusion protein, and a preparation method and use thereof, which belong to the field of biomedicine technologies. The fusion protein comprises a polypeptide specifically bound to a KRas protein, a specific tumor-cell-penetrating peptide and a lysosome recognition peptide. The fusion protein with tumor targeting, penetrability and specific protein degradation is designed and constructed direct to an undruggable protein for the first time, thus providing a new idea for development of an anti-cancer targeted drug. Different from the prior art in which one molecule can only target one target protein, the fusion protein can simultaneously induce degradation of wild-type and mutant-type KRas proteins. Meanwhile, the fusion protein can improve the sensitivity of the KRas mutant-type tumor to the tumor-targeted drug by inducing degradation of KRas, thus expanding an application range of existing anti-cancer targeted drugs and having important significance in tumor clinic treatment.

公开(公告)号：US20230194554A1

公开(公告)日：2023-06-22

申请号：US18073905

申请日：2022-12-02

申请人： Sun Yat-sen University Cancer Center (The Affiliated Cancer Hospital of Sun Yat-sen University, The

发明人： Yumin HU ,  Yao YAO

IPC分类号： G01N33/68

CPC分类号： G01N33/6893

摘要： A medical diagnosis screens a biomarker for lung cancer detection by utilizing serum metabonomics. The medical diagnosis includes a biomarker for differential diagnosis between patients with lung cancer and healthy people, and between patients with lung cancer and patients with benign pulmonary nodules, and a biomarker for differential diagnosis between patients with lung cancer and healthy people, and between patients with lung cancer and patients with benign pulmonary nodules according to gender differences between a man and a woman. The biomarker is of great significance especially in the differential diagnosis of whether a patient with nodules in the lung has lung cancer.