公开(公告)号：US20240282401A1

公开(公告)日：2024-08-22

申请号：US18565837

申请日：2022-05-27

申请人： The University of Manchester

发明人： Fabian Gilberto CANTU REINHARD ,  Andrew ALMOND

IPC分类号： G16B5/00 ,  G16B20/50 ,  G16B40/20

CPC分类号： G16B5/00 ,  G16B20/50 ,  G16B40/20

摘要： The present invention relates to computer-implemented methods for predicting catalytic activity for a candidate mutant enzyme comprising estimating the electrostatic component of the activation barrier for each of a plurality of conformations of each candidate mutant enzyme, for predicting catalytic activity for a candidate mutant enzyme using a machine learning model trained using data obtained using such methods, for providing a site directed mutagenesis potential map for an enzyme using the described methods, and for identifying a candidate enzyme with improved catalytic activity using the described methods. Related systems and computer-readable media are also described.

公开(公告)号：US20230293576A1

公开(公告)日：2023-09-21

申请号：US17926847

申请日：2021-05-21

申请人： The University of Manchester

发明人： Samuel Thomas Jones

IPC分类号： A61K31/795 ,  A01N31/08 ,  A01P1/00 ,  A61P31/12 ,  C08F120/38 ,  C08F112/14

CPC分类号： A61K31/795 ,  A01N31/08 ,  A01P1/00 ,  A61P31/12 ,  C08F112/30 ,  C08F120/38 ,  C08F2438/01

摘要： The present invention relates to polymer compounds that have antiviral activity. The compounds have the structural Formula I defined herein. The present invention also relates to processes for the preparation of these compounds, to compositions comprising them, and to their use in the prevention or treatment of viral infections.

公开(公告)号：US20230236465A1

公开(公告)日：2023-07-27

申请号：US17999790

申请日：2021-05-26

申请人： The University of Manchester

发明人： Coskun Kocabas ,  Gokhan Bakan ,  Muhammed Said Ergoktas

IPC分类号： G02F1/1524 ,  G02B5/00 ,  G02F1/1523

CPC分类号： G02F1/1524 ,  G02B5/008 ,  G02F1/1525

摘要： This invention relates to devices that can controllably vary the properties of graphene with respect to different wavelengths of electromagnetic radiation and particularly its optical properties. The electronically variable optical surfaces of the invention comprise graphene layers with intercalated metal (e.g. lithium) ions. The cell comprises an Li-NMC anode as ion source, an ionic liquid electrolyte, and an multilayer graphene cathode.

公开(公告)号：US11559200B2

公开(公告)日：2023-01-24

申请号：US16629292

申请日：2018-07-09

申请人： The University of Manchester

发明人： Jeremiah Michael Francis Kelly

IPC分类号： G06K9/00 ,  A61B3/06 ,  G16H50/30 ,  G16H50/20 ,  A61B3/00 ,  A61B5/00

摘要： Embodiments of the present invention provide a computer-implemented method of determining a parameter indicative of dark adaptation of an eye, comprising receiving threshold data from a dark adaptometer indicative of a perception threshold of the eye, fitting first and second models to the threshold data, wherein the first model is associated with a first dark adaptation mechanism and the second model is associated with the first dark adaption mechanism and a second dark adaptation mechanism, determining a confidence associated with the fitting of each of the first and second models to the received threshold data, iteratively repeating the steps of receiving the threshold data and fitting the first and second models in dependence on the determined confidence, and outputting an indication of one or more parameters indicative of dark adaptation of an eye associated with one or both of the first and second models.

公开(公告)号：US20230017078A1

公开(公告)日：2023-01-19

申请号：US17904745

申请日：2021-02-25

申请人： The University of Manchester

发明人： Coskun Kocobas ,  Gokhan Bakan ,  Muhammed Said Ergoktas

IPC分类号： B32B15/18 ,  B32B15/14 ,  B32B27/16 ,  B32B27/32 ,  B32B15/02 ,  B32B7/14 ,  B32B9/04 ,  B32B9/00

摘要： This invention relates to devices integrally comprising fibres that have emissivities, particularly of infrared radiation, that can be controllably varied. The active emissive surface comprises graphene layers with intercalated ions.

公开(公告)号：US11254799B2

公开(公告)日：2022-02-22

申请号：US14376049

申请日：2013-01-31

申请人： The University of Manchester

发明人： Ian Kinloch ,  Robert Young ,  Lei Gong

IPC分类号： C08J3/20 ,  C08K3/04 ,  C08K3/30 ,  C08L101/00 ,  C09C1/44 ,  C09C1/00

摘要： The present invention relates to novel nanocomposite materials, methods of making nanocomposites and uses of nanocomposite materials. In particular, the invention relates to composite materials which contain two-dimensional materials (e.g. graphene) in multi-layer form i.e. in a form which has a number of atomic layers. The properties of a composite material containing two-dimensional material is in multi-layer from are shown to be superior to those which contain the two-dimensional material in monolayer form.

公开(公告)号：US11192908B2

公开(公告)日：2021-12-07

申请号：US16542727

申请日：2019-08-16

申请人： Nanoco 2D Materials Limited ,  The University Of Manchester

发明人： Steven Daniels ,  Nigel Pickett ,  Nicky Savjani ,  Virgil Gavriliuc

IPC分类号： C07F11/00 ,  C09K11/06

摘要： Methods for the synthesis of a polyoxometalate compounds include heating a metal precursor in the presence of an organic salt. The polyoxometalate compounds produced herein display high photoluminescence quantum yields and photoluminescence maximums in the blue and/or violet regions of the electromagnetic spectrum.

公开(公告)号：US20210151025A1

公开(公告)日：2021-05-20

申请号：US16625465

申请日：2018-06-22

申请人： The University of Manchester

发明人： William James Parnell ,  William David Rowley ,  Ian David Abrahams ,  William John Lamb ,  Stephanie Ruth Voisey ,  Nicolas Etaix

IPC分类号： G10K11/172

摘要： An apparatus for modifying acoustic transmission comprises an array of structures arranged along a transmission path and each structure having a major axis and a minor axis, the structures being arranged such that a minor axis of each void or structure is aligned with the transmission path.

公开(公告)号：US10959973B2

公开(公告)日：2021-03-30

申请号：US16061606

申请日：2016-12-14

申请人： The University of Manchester

发明人： Philip Morgan ,  Carole Maldonado-Codina ,  Michael Read ,  Curtis Dobson

IPC分类号： A61K31/23 ,  A61K9/00 ,  A61K47/44 ,  A61K36/736 ,  A61K8/92 ,  A61K9/06 ,  A61K36/185 ,  A61Q19/00 ,  A61K8/9789 ,  A61P27/02

摘要： A method for delivering a benefit agent to the surface of the eye, the method comprising applying an ocular benefit composition to a lid margin of the eye wherein the ocular benefit composition comprises at least 5 wt % of one or more lipid and/or lipid derived compounds.

公开(公告)号：US20210049787A1

公开(公告)日：2021-02-18

申请号：US17050815

申请日：2019-04-25

申请人： THE UNIVERSITY OF MANCHESTER

发明人： Robert James LUCAS ,  Annette Elizabeth ALLEN

IPC分类号： G06T7/90 ,  H04N9/67 ,  H04N9/64 ,  H05B47/155

摘要： Embodiments of the present invention provide a computer-implemented method (200) of processing colour image data which comprises determining (220, 230) output colour information values based on first and second tristimulus colour spaces indicative of first and second cone spectral sensitivity functions, wherein the determining (220, 230) comprises determining a first one of the output colour information values based on a first tristimulus colour space and determining a second one of the output colour information values based on a second tristimulus colour space to be within a predetermined range of the first one of the output colour information values, and outputting (240) the output colour information values.