公开(公告)号：US09095532B2

公开(公告)日：2015-08-04

申请号：US13863817

申请日：2013-04-16

申请人： Unhwa Corporation

发明人： Mi Ok Jang ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： A61K36/25 ,  A61K8/97 ,  A61Q19/08 ,  A61Q19/00

CPC分类号： A61K8/97 ,  A61K2800/522 ,  A61Q19/004 ,  A61Q19/08

摘要： The present invention relates to an anti-aging or antioxidant composition which contains, as an active ingredient, a plant stem cell line derived from the cambium of Panax ginseng, including wild ginseng and ginseng, or an extract thereof, a lysate thereof and a culture thereof. The composition has minimized side effects compared to existing anti-aging agents and antioxidants, and thus is safe for the skin. Also, the composition of the present invention shows an antioxidant effect of inhibiting reactive oxygen species caused by exposure to UV radiation that is the major cause of skin aging, and it can effectively reduce or inhibit aging-related factors. Thus, the composition is useful for the prevention and inhibition of aging.

摘要翻译： 本发明涉及一种抗老化或抗氧化剂组合物，其含有源自人参人参和人参的形成层的植物干细胞系作为活性成分，或其提取物，其裂解物和培养物 其中。 与现有的抗老化剂和抗氧化剂相比，该组合物具有最小的副作用，因此对于皮肤是安全的。 此外，本发明的组合物显示出由于暴露于作为皮肤老化的主要原因的紫外线辐射引起的活性氧的抑制作用，并且可以有效地降低或抑制与老化有关的因素。 因此，该组合物可用于预防和抑制老化。

公开(公告)号：US20110033903A1

公开(公告)日：2011-02-10

申请号：US12889026

申请日：2010-09-23

申请人： Young Woo Jin

发明人： Young Woo Jin

IPC分类号： C12P17/02 ,  C12N5/04 ,  C12P1/00

CPC分类号： C12N5/04

摘要： This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from cambium to promote the stability of the plant-derived biologically active substances production by solving the problems of decrease in cell growth and the productivity during the long term culture.

摘要翻译： 本发明是通过均质细胞系发育来最小化细胞生长和产生变化的方法。 更具体地说，它是从形成层分离和增殖单细胞克隆的方法，通过解决长期培养中细胞生长减少和生产力的问题，促进植物来源的生物活性物质生产的稳定性。

公开(公告)号：US20140099285A1

公开(公告)日：2014-04-10

申请号：US13803963

申请日：2013-03-14

申请人： UNHWA CORPORATION

发明人： Sun Mi HONG ,  Eun Kyong LEE ,  Young Woo JIN

IPC分类号： A61K36/258 ,  C12N5/04

CPC分类号： A61K36/258 ,  A01H4/005 ,  A23L33/10 ,  A23L33/105 ,  A23V2002/00 ,  C12N5/04 ,  A23V2200/30 ,  A23V2250/2124

摘要： The present invention relates to a composition for preventing or treating acquired immunodeficiency syndrome (AIDS), comprising one or more of the following: a homogenous cell line, and a lysate, an extract and a culture thereof as an active ingredient. The homogenous cell line, the lysate, the extract and the culture thereof, which are derived from a natural product, minimize adverse side effects of prior therapeutic agents and safe for the human body. Further, they effectively increase the count of T cells such as CD4+ T cells and decrease the number of HIVs, thereby preventing opportunistic infection, dysneuria, and neoplaia caused by immune incompetence, and ultimately the risk of death. Therefore, they are useful in preventing and treating AIDS, and relieving symptoms of AIDS.

摘要翻译： 本发明涉及用于预防或治疗获得性免疫缺陷综合征（AIDS）的组合物，其包含以下一种或多种：均质细胞系，其裂解物，提取物和培养物作为活性成分。 衍生自天然产物的均质细胞系，裂解物，提取物和培养物使得现有治疗剂的不利副作用最小化并对人体安全。 此外，它们有效地增加了T细胞如CD4 + T细胞的数量，并减少了HIV的数量，从而防止了免疫功能不全引起的机会感染，排尿困难和赘生物，最终导致死亡风险。 因此，它们有助于预防和治疗艾滋病，缓解艾滋病的症状。

公开(公告)号：US20130137178A1

公开(公告)日：2013-05-30

申请号：US13551207

申请日：2012-07-17

申请人： Mi Ok Jang ,  Eun Kyong Lee ,  Young Woo Jin

发明人： Mi Ok Jang ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： C12N5/04

CPC分类号： C12N5/04

摘要： The present invention relates to a cell line derived from the cambium of an herbaceous plant having a storage root and a method for isolating the same. More specifically, relates to a cambium-derived homogeneous cell line having the ability to divide, which is obtained from the cambium-containing storage tissue of an herbaceous plant having a storage root without a separate dedifferentiation process, and to a method for isolating the same. The cell line derived from the cambium of an herbaceous plant having a storage root has an active division ability and is homogeneous. Also, it is stable during culture, because it has not undergone a dedifferentiation process. Thus, through the optimization of proliferation thereof, the cell line can be allowed to proliferate in a large amount within a short time.

摘要翻译： 本发明涉及源自具有贮藏根的草本植物的形成层的细胞系及其分离方法。 更具体地说，涉及具有分割能力的形成层的均质细胞系，其具有不具有分离去分化方法的具有储存根的草本植物的含有形成层的存储组织，以及其分离方法 。 源自具有储存根的草本植物的形成层的细胞系具有活性分裂能力并且是均匀的。 此外，它在培养期间是稳定的，因为它没有经历去分化过程。 因此，通过优化其增殖，可以在短时间内允许细胞系大量增殖。

公开(公告)号：US20100255585A1

公开(公告)日：2010-10-07

申请号：US12679263

申请日：2008-09-22

申请人： Young-Mi Yu ,  Eun Kyong Lee ,  Sun Mi Hong ,  Young Woo Jin

发明人： Young-Mi Yu ,  Eun Kyong Lee ,  Sun Mi Hong ,  Young Woo Jin

IPC分类号： C12N5/04 ,  C12N5/02

CPC分类号： C12N5/04

摘要： The present invention relates to a cell line derived from the quiescent center of a plant and a method for isolating the same, more specifically, relates to a quiescent center-derived homogeneous cell line of single-cell origin, which is obtained from the quiescent center of a plant without needing a separate de-differentiation process, and a method for isolating the same.

摘要翻译： 本发明涉及从植物的静止中心衍生的细胞系及其分离方法，更具体地涉及从静止中心获得的单细胞来源的静态中心衍生的均质细胞系 的植物，而不需要单独的去分化过程，以及用于分离其的方法。

公开(公告)号：US20080194025A1

公开(公告)日：2008-08-14

申请号：US12063929

申请日：2006-04-25

申请人： Young Woo Jin

发明人： Young Woo Jin

IPC分类号： C12N5/02

CPC分类号： C12N5/04

摘要： This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from the procambium or cambium to promote the stability of the plant-derived biologically active substances production by solving the problems of decrease in cell growth and the productivity during the long term culture. Key words: Procambium or cambium, single cell clone, cell aggregation, dedifferentiation, cryoperservation, variability.

摘要翻译： 本发明是通过均质细胞系发育来最小化细胞生长和产生变化的方法。 更具体地说，它是从原型或形成层分离和增殖单细胞克隆的方法，通过解决细胞生长减少和长期生产力的问题来促进植物来源的生物活性物质生产的稳定性 文化。 关键词：原核生物或形成层，单细胞克隆，细胞聚集，去分化，冷冻保护，变异性。

公开(公告)号：US08790927B2

公开(公告)日：2014-07-29

申请号：US13755517

申请日：2013-01-31

申请人： Unhwa Corporation

发明人： Joong Hyun Park ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Jung Chang Lee ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： C12N5/00 ,  C12N5/02

CPC分类号： A61K36/13

摘要： The present invention relates to a composition for preventing or treating cancer, which contains, as an active ingredient, a Taxus cambium- or procambium-derived cell line; a lysate thereof; an extract thereof; or a culture medium thereof. The cell line, the lysate, the extract, and the culture medium has minimized side effects compared to the conventional therapeutic drugs, is safe to the human body, is involved directly in the growth of cancer to induce cancer cell death, and shows anticancer activity of inhibiting angiogenesis occurring in carcinogenesis. Accordingly, the cell line, the lysate, the extract and the culture medium is useful for the prevention, treatment and alleviation of cancer.

摘要翻译： 本发明涉及一种用于预防或治疗癌症的组合物，其含有作为有效成分的红豆杉形成层或原生动物来源的细胞系; 其裂解物; 其提取物; 或其培养基。 细胞系，裂解物，提取物和培养基与常规治疗药物相比具有最小化的副作用，对人体是安全的，直接参与癌症的生长以诱导癌细胞死亡，并且显示抗癌活性 抑制致癌作用中发生的血管生成。 因此，细胞系，裂解物，提取物和培养基可用于预防，治疗和缓解癌症。

公开(公告)号：US08247230B2

公开(公告)日：2012-08-21

申请号：US12679269

申请日：2008-09-22

申请人： Mi Ok Jang ,  Eun Kyong Lee ,  Young Woo Jin

发明人： Mi Ok Jang ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： C12N5/00 ,  C12N5/02

CPC分类号： C12N5/04

摘要： The present invention relates to a cell line derived from the cambium of an herbaceous plant having a storage root and a method for isolating the same. More specifically, relates to a cambium-derived homogeneous cell line having the ability to divide, which is obtained from the cambium-containing storage tissue of an herbaceous plant having a storage root without a separate dedifferentiation process, and to a method for isolating the same. The cell line derived from the cambium of an herbaceous plant having a storage root has active division ability and is homogeneous. Also, it is stable during culture, because it has not undergone a dedifferentiation process. Thus, through the optimization of proliferation thereof, the cell line can be allowed to proliferate in a large amount within a short time. Accordingly, the cell line derived from the cambium of an herbaceous plant having a storage root makes it possible to produce large amounts of useful plants which are difficult to cultivate outdoor due to various problems associated with the period of cultivation, the selection of cultivation land, cultivation cost and the like.

摘要翻译： 本发明涉及源自具有贮藏根的草本植物的形成层的细胞系及其分离方法。 更具体地说，涉及具有分割能力的形成层的均质细胞系，其是从没有分离去分化方法的具有储存根的草本植物的含有形成层的储存组织获得的，以及其分离方法 。 源自具有储存根的草本植物的形成层的细胞系具有活性分裂能力并且是均匀的。 此外，它在培养期间是稳定的，因为它没有经历去分化过程。 因此，通过优化其增殖，可以在短时间内允许细胞系大量增殖。 因此，从具有储藏根的草本植物的形成层衍生的细胞系，由于与栽培期间，种植面积的选择有关的各种问题，可能产生大量难以栽培的有用植物， 栽培成本等。

公开(公告)号：US08053238B2

公开(公告)日：2011-11-08

申请号：US12117783

申请日：2008-05-09

申请人： Young Woo Jin ,  Eun Kyong Lee

发明人： Young Woo Jin ,  Eun Kyong Lee

IPC分类号： C12N5/00 ,  C12N5/02

CPC分类号： C12N5/04

摘要： This invention is a method of minimizing the variation of cell growth and production through homogeneous cell line development. To be more specific, it is the method of isolating and proliferating single cell clone from the procambium to promote the stability of the plant-derived biologically active substances production by solving the problems of decrease in cell growth and the productivity during the long term culture.

摘要翻译： 本发明是通过均质细胞系发育来最小化细胞生长和产生变化的方法。 更具体地说，是通过解决长期培养中细胞生长减少和生产力的问题，从原型中分离和增殖单细胞克隆的方法来促进植物来源的生物活性物质生产的稳定性。

公开(公告)号：US20100272692A1

公开(公告)日：2010-10-28

申请号：US12682574

申请日：2008-10-10

申请人： Joong Hyun Park ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Jung Chang Lee ,  Eun Kyong Lee ,  Young Woo Jin

发明人： Joong Hyun Park ,  Min Jung Lim ,  Il Seok Oh ,  Dae Hee Lee ,  Jung Chang Lee ,  Eun Kyong Lee ,  Young Woo Jin

IPC分类号： A61K35/00 ,  A61K36/13 ,  A61P35/00

CPC分类号： A61K36/13

摘要： The present invention relates to a composition for preventing or treating cancer, which contains, as an active ingredient, a Taxus cambium- or procambium-derived cell line; a lysate thereof; an extract thereof; or a culture medium thereof. The cell line, the lysate, the extract, and the culture medium has minimized side effects compared to the conventional therapeutic drugs, is safe to the human body, is involved directly in the growth of cancer to induce cancer cell death, and shows anticancer activity of inhibiting angiogenesis occurring in carcinogenesis. Accordingly, the cell line, the lysate, the extract and the culture medium is useful for the prevention, treatment and alleviation of cancer.

摘要翻译： 本发明涉及一种用于预防或治疗癌症的组合物，其含有作为有效成分的红豆杉形成层或原生动物来源的细胞系; 其裂解物; 其提取物; 或其培养基。 细胞系，裂解物，提取物和培养基与常规治疗药物相比具有最小化的副作用，对人体是安全的，直接参与癌症的生长以诱导癌细胞死亡，并且显示抗癌活性 抑制致癌作用中发生的血管生成。 因此，细胞系，裂解物，提取物和培养基可用于预防，治疗和缓解癌症。