公开(公告)号：US07514463B2

公开(公告)日：2009-04-07

申请号：US10922747

申请日：2004-08-20

申请人： Gunda I. Georg ,  Joseph S. Tash ,  Ramappa Chakrasali ,  Sudhakar Rao Jakkaraj

发明人： Gunda I. Georg ,  Joseph S. Tash ,  Ramappa Chakrasali ,  Sudhakar Rao Jakkaraj

IPC分类号： A61K31/416 ,  C07D231/56

CPC分类号： C07D231/56 ,  C07D471/04

摘要： Novel compounds useful for inhibiting spermatogenesis and cancer treatment, and in particular as inhibitors of heat shock proteins and/or elongation factor 1 alpha.

摘要翻译： 用于抑制精子发生和癌症治疗的新型化合物，特别是作为热休克蛋白和/或延伸因子1α的抑制剂。

公开(公告)号：US20230136602A1

公开(公告)日：2023-05-04

申请号：US17938851

申请日：2022-10-07

申请人： The Board of Regents for Oklahoma State University ,  University of Kansas

发明人： WENDY L. PICKING ,  WILLIAM D. PICKING

IPC分类号： A61K39/112 ,  A61K39/00

摘要： Antigenic molecules and compositions described herein protect against infection by typhoidal and non-typhoidal Salmonella serovars. Methods of immunization comprise the use of the antigenic molecules.

公开(公告)号：US20230041941A1

公开(公告)日：2023-02-09

申请号：US17790599

申请日：2020-12-31

申请人： University of Kansas

发明人： Saeed FAROKHI ,  Ray TAGHAVI ,  Zhi WANG ,  Huixuan WU ,  Zhongquan ZHENG

IPC分类号： F02K1/46 ,  F01N1/14 ,  F02K1/34

摘要： A method of reducing noise from a high-speed, including supersonic, jet, the method includes providing the high-speed or supersonic jet in a longitudinal flow direction; and inducing a rotation of a swirl layer of the high-speed or supersonic jet around a longitudinal direction of the jet and on the jet boundary so as to promote mixing of the high-speed or supersonic jet with surrounding air.

公开(公告)号：US20220396772A1

公开(公告)日：2022-12-15

申请号：US17582704

申请日：2022-01-24

申请人： University of Kansas

发明人： Hiroshi Nishimune ,  Richard Barohn ,  Buddhadeb Dawn ,  Yomna Badawi ,  James W. Mitchell ,  Rupal Soder

IPC分类号： C12N5/0775 ,  A61K35/51

摘要： Embodiments of the present disclosure relate generally to the production of therapeutic mesenchymal stem cells (MSCs). More particularly, the present disclosure relates to the use of cell culture compositions and methods for generating MSCs that secrete neurotrophic factors and synaptic organizing agents for the treatment of neurodegenerative diseases such as Amyotrophic Lateral Sclerosis (ALS). As such, the present disclosure addresses the need for establishing a reliable source of therapeutic stem cells useful for the treatment of neurodegenerative diseases.

公开(公告)号：US11492382B2

公开(公告)日：2022-11-08

申请号：US16640662

申请日：2018-08-21

申请人： University of Kansas

发明人： Candan Tamerler-Behar ,  Emily Caitlyn Wisdom ,  Kyle Boone

IPC分类号： C07K14/47 ,  C12N15/62

摘要： Provided in this disclosure are chimeric peptides that include a spacer domain, the spacer domain itself, substrates (e.g., implants) coated with the chimeric peptides, and methods for making and using the coated substrates.

公开(公告)号：US20220350009A1

公开(公告)日：2022-11-03

申请号：US17761326

申请日：2020-09-18

申请人： University of Kansas ,  Government of the United States, as represented by the Secretary of the Air Force

发明人： Cenk Sahin ,  Patrick M. McCormick ,  Justin G. Metcalf ,  John Jakabosky ,  Shannon David Biunt ,  Erik S. Perrins

IPC分类号： G01S13/32 ,  G01S7/00

摘要： Systems, methods, and computer-readable storage media for generating and utilizing radar signals with embedded data are disclosed. Data is encoded onto a CPM waveform, which is then combined with a base radar waveform to produce a radar-embedded communication (REC) waveform. Both the CPM waveform and the base radar waveform may have a continuous phase and constant envelope, resulting in the REC waveform having a continuous phase and constant envelope. The changing (e.g., on a pulse-to-pulse basis) nature of the REC waveform causes RSM of clutter which may result in residual clutter after clutter cancellation, decreasing target detection performance of the radar system. In an aspect, various parameters may be utilized to dynamically adjust the performance of the radar system for a particular operating scenario, such as to enhance radar signal processing or enhance data communication capabilities.

公开(公告)号：US20220349025A1

公开(公告)日：2022-11-03

申请号：US17243032

申请日：2021-04-28

申请人： University of Kansas

发明人： Mark Brandon Shiflett ,  David Richard Corbin ,  Ankit Verma

IPC分类号： C22B21/00 ,  C01F7/20 ,  C01G49/02 ,  C22B3/12

摘要： Methods for recovering a metal from a metal-containing material are provided. In embodiments, such a method comprises exposing a metal-containing material to a leaching solution comprising a solvent and a binoxalate, a tetraoxalate, or a combination thereof, under conditions to provide a leachate comprising a soluble metal oxalate; inducing precipitation of a metal-containing precipitate comprising the metal of the soluble metal oxalate from the leachate; and recovering the metal-containing precipitate.

公开(公告)号：US11466198B2

公开(公告)日：2022-10-11

申请号：US16694004

申请日：2019-11-25

申请人： CONOCOPHILLIPS COMPANY ,  University of Kansas

发明人： Ahmad Moradi-Araghi ,  Min Cheng ,  Riley B. Needham ,  James H. Hedges ,  Ramesh S. Sarathi ,  Faye L. Scully ,  Terry M. Christian ,  Huili Guan ,  Cory Berkland ,  Jenn-Tai Liang

IPC分类号： C09K8/588 ,  E21B33/138 ,  E21B43/16

摘要： The invention is directed to stable and labile crosslinked water swellable polymeric microparticles that can be further gelled, methods for making same, and their various uses in the hygiene and medical arts, gel electrophoresis, packaging, agriculture, the cable industry, information technology, in the food industry, papermaking, use as flocculation aids, and the like. More particularly, the invention relates to a composition comprising expandable polymeric microparticles having labile crosslinkers and stable crosslinkers, said microparticle mixed with a fluid and an unreacted tertiary crosslinker comprising PEI or other polyamine based tertiary crosslinker that is capable of further crosslinking the microparticle on degradation of the labile crosslinker and swelling of the particle, so as to form a stable gel. A particularly important use is as an injection fluid in petroleum production, where the expandable polymeric microparticles are injected into a well and when the heat and/or pH of the well cause degradation of the labile crosslinker and when the microparticle expands, the tertiary crosslinker crosslinks the polymer to form a stable gel, thus diverting water to lower permeability regions and improving oil recovery.

公开(公告)号：US11460356B2

公开(公告)日：2022-10-04

申请号：US16895965

申请日：2020-06-08

申请人： THE UNIVERSITY OF KANSAS

发明人： Cory Berkland ,  Jonathan Whitlow ,  Jean Salash

IPC分类号： G01L1/12 ,  C09D11/037 ,  C09D11/102 ,  H01F7/20 ,  B33Y10/00 ,  B33Y70/00 ,  B33Y80/00 ,  B29K509/08 ,  H01F1/032 ,  B29C64/118 ,  B29K83/00 ,  B29K105/16

摘要： Disclosed are functional materials for use in additive manufacturing (AM). The functional material can comprise an elastomeric composition (e.g., a silicone composite) for use in, for example, direct ink writing. The elastomeric composition can include and elastomeric resin, and a magnetic nanorod filler dispersed within the elastomeric resin. Nanorod characteristics (e.g., length, diameter, aspect ratio) can be selected to create 3D-printed constructs with desired mechanical properties along different axes. Furthermore, since nickel nanorods are ferromagnetic, the spatial distribution and orientation of nanorods within the continuous phase can be controlled with an external magnetic field. This level of control over the nanostructure of the material system offers another degree of freedom in the design of functional parts and components with anisotropic properties. Magnetic fields can be used to remotely sense compression of the constructs, or alternatively, control the stiffness of these materials.

公开(公告)号：US20220306735A1

公开(公告)日：2022-09-29

申请号：US17638139

申请日：2020-08-27

申请人： University of Kansas ,  The U.S.A. as rep by the Sec., Dept. of Health and Human SVCS.

发明人： Brandon DEKOSKY ,  Peter D. KWONG ,  Wei JIN ,  Young Do KWON ,  Baoshan ZHANG

IPC分类号： C07K16/28 ,  C07K16/10

摘要： The present disclosure relates generally to antibodies and Fc fusion proteins comprising Fc variants, and uses thereof. The Fc variants disclosed herein exhibit elevated affinity towards FcRn at pH 6.0, and/or rapidly disassociate from FcRn at pH 7.4 compared to a parent Fc domain