公开(公告)号：US20210339052A1

公开(公告)日：2021-11-04

申请号：US17197016

申请日：2021-03-09

申请人： Valam Corporation

发明人： Ralf Seip ,  Mark Carol ,  Ron Hadani ,  Yosef Krespi ,  Grant Adam Morris ,  Joshua Huff

IPC分类号： A61N7/00 ,  A61B90/00 ,  A61B17/32

摘要： There is presented a removable high-intensity focused ultrasound (HIFU) transducer and supporting system that allows for HIFU transducer assemblies and other therapeutic ultrasound assemblies to be attached to third party positioning, imaging, or guidance systems while maintaining the required focal-zone positioning ability and the required acoustic energy coupling to tissue, to mechanically or automatically ablate a target volume in unimpeded fashion. There is provided an acoustically transparent and pliable vessel that has an open top end and filled with acoustic coupling fluid, capable of holding the transducer assembly and distal end of the positioning system within it as it executes the HIFU treatment plan/process. The vessel is held in place using a transducer/positioning system and independent external fixturing mechanism.

公开(公告)号：US07435252B2

公开(公告)日：2008-10-14

申请号：US10929696

申请日：2004-08-30

申请人： Yosef Krespi ,  Ashutosh Kacker

发明人： Yosef Krespi ,  Ashutosh Kacker

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61B18/18 ,  A61B18/1815 ,  A61N5/0601 ,  A61N5/0624 ,  A61N2005/0606 ,  A61N2005/0607 ,  A61N2005/0644 ,  A61N2005/0654

摘要： Disclosed are methods and apparatus for safe, simple and effective broad-spectrum treatments of chronic rhinosinusitis and other common and less common infections of the sino-nasal tract which may implicate not only a wide range of bacterial species but also fungi and viruses. Electromagnetic radiative energy including visible, and optionally, thermal RF, microwave or other longer wavelengths, is applied to target internal surfaces of the sino-nasal tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. The treatment can be controlled to permit regrowth of healthy microflora. A handheld energy applicator has a light output head receivable into, or engageable with, the treatment subject's nostril which may be provided with extensions to reach the sinuses. Useful embodiments of the invention include pretreatment of target sino-nasal surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. For example methylene blue can be used with orange or red light. The combination treatment of photosensitizer and application of visual wavelength energy provides a flexible treatment regimen which enables low concentrations of stains to be employed, minimizing aesthetic problems.

摘要翻译： 公开了用于安全，简单和有效地广泛治疗慢性鼻鼻窦炎和其他常见且不太常见的中鼻道感染的方法和装置，其可能不仅涉及广泛的细菌种类，而且还涉及真菌和病毒。 将包括可见光和可选的RF，微波或其他较长波长的电磁辐射能量施加到中鼻道的目标内表面，以破坏或消除表面微生物而不使用抗生素。 可以控制治疗以允许健康微生物群落的再生长。 手持式能量施加器具有可以接收到治疗对象的鼻孔中或与受治疗者的鼻孔接合的光输出头，其可以设置有延伸部以达到鼻窦。 本发明的有用实施方案包括用光敏剂如氧化剂或互补染色剂预处理靶鼻鼻表面。 例如亚甲基蓝可以与橙色或红色的光一起使用。 光敏剂的组合治疗和视觉波长能量的应用提供了灵活的治疗方案，其使得能够使用低浓度的污渍，从而最小化审美问题。

公开(公告)号：US20220361870A1

公开(公告)日：2022-11-17

申请号：US17865202

申请日：2022-07-14

申请人： Valam Corporation

发明人： Yosef Krespi ,  Ron Hadani

IPC分类号： A61B17/04 ,  A61B17/29 ,  A61B17/06

摘要： There is provided a suture passer device used in procedures of robotic assisted minimally invasive suspension of the hyoid and tongue base in treatment of sleep apnea. The suture passer device is a dual use suture passer, having both suture insertor and extractor functionality on a single unitary instrument section of the device by means of insertion and extraction hooks positioned on an elongated needlelike body which is connected to a handle grip. The insertion and extraction hooks receive a suture via an opening in the body of the instrument, with the suture capable of removal and fastening to the extraction hook by robotic forceps. Procedures for using the device are disclosed which include a single point of entry on a patient and the device moved to first and second positions above and below the hyoid bone during robotic assisted surgery.

公开(公告)号：US20210007804A1

公开(公告)日：2021-01-14

申请号：US16895951

申请日：2020-06-08

申请人： Valam Corporation

发明人： Yosef Krespi ,  Ron Hadani ,  Victor Kizhner ,  Karen Wilson

IPC分类号： A61B18/22

摘要： There is provided a process for treatment of rhinitis by diode laser ablation of the posterior nasal nerves. The laser diode delivery device with elongated optic tip is inserted through a patient's nostril and has the length, flexibility and a curvature to reach both above and under the patient's middle turbinate for treatment to both posterior nasal nerves. Skin and tissue temperature is raised to approximately 60-65° C. with the process. Optimal treatment wavelength was found to be approximately 940 nanometers.

公开(公告)号：US20090018485A1

公开(公告)日：2009-01-15

申请号：US12211295

申请日：2008-09-16

申请人： Yosef KRESPI ,  Ashutosh KACKER

发明人： Yosef KRESPI ,  Ashutosh KACKER

IPC分类号： A61N5/06

CPC分类号： A61N5/062 ,  A61B18/18 ,  A61B18/1815 ,  A61N5/0601 ,  A61N5/0624 ,  A61N2005/0606 ,  A61N2005/0607 ,  A61N2005/0644 ,  A61N2005/0654

摘要： Disclosed are methods and apparatus for safe, simple and effective broad-spectrum treatments of chronic rhinosinusitis and other common and less common infections of the sino-nasal tract which may implicate not only a wide range of bacterial species but also fungi and viruses. Electromagnetic radiative energy including visible, and optionally, thermal RF, microwave or other longer wavelengths, is applied to target internal surfaces of the sino-nasal tract to destroy or incapacitate superficial microorganisms without the use of antibiotics. The treatment can be controlled to permit regrowth of healthy microflora. A handheld energy applicator has a light output head receivable into, or engageable with, the treatment subject's nostril which may be provided with extensions to reach the sinuses. Useful embodiments of the invention include pretreatment of target sino-nasal surfaces with a photosensitizing agent such as an oxidizing agent or a complementary stain. For example methylene blue can be used with orange or red light. The combination treatment of photosensitizer and application of visual wavelength energy provides a flexible treatment regimen which enables low concentrations of stains to be employed, minimizing aesthetic problems.

摘要翻译： 公开了用于安全，简单和有效地广泛治疗慢性鼻鼻窦炎和其他常见且不太常见的中鼻道感染的方法和装置，其可能不仅涉及广泛的细菌种类，而且也可能涉及真菌和病毒。 将包括可见光和可选的RF，微波或其他较长波长的电磁辐射能量施加到中鼻道的目标内表面，以破坏或消除表面微生物而不使用抗生素。 可以控制治疗以允许健康微生物群落的再生长。 手持式能量施加器具有可以接收到治疗对象的鼻孔中或与受治疗者的鼻孔接合的光输出头，其可以设置有延伸部以达到鼻窦。 本发明的有用实施方案包括用光敏剂如氧化剂或互补染色剂预处理靶鼻鼻表面。 例如亚甲基蓝可以与橙色或红色的光一起使用。 光敏剂的组合治疗和视觉波长能量的应用提供了灵活的治疗方案，其使得能够使用低浓度的污渍，从而最小化审美问题。

公开(公告)号：US11464567B2

公开(公告)日：2022-10-11

申请号：US17081994

申请日：2020-10-27

申请人： Valam Corporation

发明人： Yosef Krespi ,  Ron Hadani

IPC分类号： A61B18/28 ,  A61B18/00 ,  A61B17/00

摘要： There is provided a process for treatment of rhinitis by diode laser ablation of the posterior nasal nerves. The laser diode delivery device with elongated optic tip is inserted through a patient's nostril and has the length, flexibility and a curvature to reach both above and under the patient's middle turbinate for treatment to both posterior nasal nerves. Skin and tissue temperature is raised to approximately 60-65° C. with the process. Optimal treatment wavelength was found to be approximately 380-450 nanometers with blue lasers.

公开(公告)号：US11419998B2

公开(公告)日：2022-08-23

申请号：US16022683

申请日：2018-06-28

申请人： Valam Corporation

发明人： Yosef Krespi ,  Robert Koorn

IPC分类号： A61M16/06 ,  A61M16/08 ,  A61M16/04 ,  A61M16/01 ,  A61B34/30 ,  A61M16/00 ,  A61B90/00 ,  A61B90/30

摘要： There is provided an LMA mask integrated for robotic surgery with ventilation or anesthesia tubes and for receiving the robot head with medical instruments through the mask. The inflatable cuff of the mask surrounds the robot head and ventilation so that the items necessary for surgical procedures are contained within a compact defined area. Increased maneuverability and visibility for the medical professional. Integration of the mask with processes for ventilation or anesthesia by accessories is also provided.

公开(公告)号：US09402686B2

公开(公告)日：2016-08-02

申请号：US12716561

申请日：2010-03-03

申请人： Yosef Krespi ,  Victor Z. Kizhner

发明人： Yosef Krespi ,  Victor Z. Kizhner

IPC分类号： A61B18/22 ,  A61M25/00 ,  A61N5/06 ,  A61B17/24 ,  A61M25/01 ,  A61M25/10

CPC分类号： A61B18/22 ,  A61B17/24 ,  A61M25/00 ,  A61M25/01 ,  A61M25/10 ,  A61M2025/105 ,  A61N5/0624 ,  A61N2005/0607

摘要： A method for sinus surgery includes piercing first and second access openings into the anatomy of a human subject to access an inaccessible sinus site for cooperatively manipulating respective first and second surgical instruments inserted through the openings. One instrument, for example an endoscope, can permit viewing of the sinus site while the other instrument is manipulated to effect a treatment at the sinus site. The maxillary and other sinuses can be accessed and anti-inflammatory and other treatments can be applied. Systems and instruments for performing such sinus surgery methods are also disclosed.

摘要翻译： 一种用于鼻窦手术的方法包括将第一和第二进入孔穿入人体受试者的解剖结构，以进入不可接近的窦部位，以协同操作通过开口插入的相应的第一和第二手术器械。 一个仪器，例如内窥镜，可以允许观察窦位，而另一个仪器被操纵以在窦位处进行治疗。 可以接触上颌骨和其他鼻窦，并可应用抗炎和其他治疗。 还公开了用于执行这种鼻窦手术方法的系统和仪器。

公开(公告)号：US08109981B2

公开(公告)日：2012-02-07

申请号：US11152946

申请日：2005-06-14

申请人： Michael Gertner ,  Erica Rogers

发明人： Michael Gertner ,  Erica Rogers

IPC分类号： A61N5/06

CPC分类号： A61N5/0603 ,  A61N5/0616 ,  A61N5/0624 ,  A61N2005/0605 ,  A61N2005/0606 ,  A61N2005/0607 ,  A61N2005/0608 ,  A61N2005/0609 ,  A61N2005/0611 ,  A61N2005/0644 ,  A61N2005/0645 ,  A61N2005/0651 ,  A61N2005/0661

摘要： An optical therapy device for providing therapeutic light to a person's nasal cavity includes a body and at least one UV light source in or on the body. A distal end of the body is configured to be inserted into the person's nasal cavity. The body can be configured to be hand-held. The optical therapy device is configured such that the UV light source emits a dose of UV light toward tissue in the patient's nasal cavity.

摘要翻译： 用于向人的鼻腔提供治疗光的光学治疗装置包括主体和身体中或身体上的至少一个UV光源。 身体的远端构造成插入人的鼻腔。 身体可以配置为手持式。 光学治疗装置被配置为使得UV光源向患者鼻腔中的组织发射一定剂量的UV光。

公开(公告)号：US20220362591A1

公开(公告)日：2022-11-17

申请号：US17870761

申请日：2022-07-21

申请人： Valam Corporation

发明人： Yosef P. Krespi ,  Ron Hadani ,  Alexander K. Arrow

IPC分类号： A62B23/06

摘要： A nasal device for filtering air breathed into a user's nose is disclosed herein. In an embodiment, a nasal device includes a body sized and shaped to be secured to at least one of a user's nostrils, and a filter positioned on the body so as to be located over at least one of the user's nasal passages when the body is secured to the user's at least one nostril, wherein the filter filters air breathed into the user's at least one nasal passage when the body is secured to the user's at least one nostril.