Hydroxypropyl methyl cellulose acetate succinate and method for producing the same

    公开(公告)号:US11753483B2

    公开(公告)日:2023-09-12

    申请号:US17083615

    申请日:2020-10-29

    摘要: There is provided a method for producing hydroxypropyl methyl cellulose acetate succinate (HPMCAS), including an esterification step of reacting hydroxypropyl methyl cellulose with an acetylating agent and a succinoylating agent in the presence of an aliphatic carboxylic acid in a kneader reactor equipped with two or more stirring blades rotating around their own axes and orbitally revolving, to obtain a reaction product solution containing HPMCAS; a precipitation step of precipitating the HPMCAS by mixing the reaction product solution with water to obtain a suspension of the precipitated HPMCAS; and a washing and recovery step of washing the HPMCAS in the suspension and recovering the washed HPMCAS. Further, there is provided HPMCAS having yellowness at 20° C. of 15.0 or less, as determined in a 2% by mass solution of the HPMCAS in a mixed solvent of dichloromethane, methanol and water in a mass ratio of 44:44:10.

    CONED AUGER
    2.
    发明公开
    CONED AUGER 审中-公开

    公开(公告)号:US20230256402A1

    公开(公告)日:2023-08-17

    申请号:US17673060

    申请日:2022-02-16

    摘要: Coned augers for bulk mixers are described. The coned augers comprise first end and second end an auger post having a first end opposite a second end; fighting extending along and about the auger post, the pitch oriented to move bulk material generally from the first end toward the second end during operation of the auger; a coned section along the auger post, the coned section comprising a first cone protruding about the periphery of the auger post, the first cone having a tapered end opposite a wide end. Mixers comprising the coned augers are also described.