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公开(公告)号：US20170275248A1
公开(公告)日：2017-09-28
申请号：US15617839
申请日：2017-06-08
申请人： Thomas P. Daly
发明人： Thomas P. Daly
IPC分类号： C07C333/04 , A01N47/26 , C07C329/14
CPC分类号： C07C333/14 , A01N47/06 , A01N47/26 , C07C329/14 , C07D401/04 , C08L95/005 , Y02A30/333
摘要： Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
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公开(公告)号：US09676709B2
公开(公告)日：2017-06-13
申请号：US15410486
申请日：2017-01-19
申请人： Thomas P. Daly
发明人： Thomas P. Daly
IPC分类号： C07C333/04 , C07C329/14
CPC分类号： C07C333/04 , A01N47/26 , C07C219/04 , C07C229/08 , C07C229/12 , C07C229/14 , C07C329/14 , C07C333/14 , C07D401/04 , C08L95/005 , E21C50/00 , Y02A30/333
摘要： Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
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公开(公告)号：US5902881A
公开(公告)日：1999-05-11
申请号：US811233
申请日：1997-03-03
IPC分类号： C07H21/04 , C07C329/14 , C07H21/00 , C07H21/02
CPC分类号： C07H21/00 , C07C329/14
摘要： The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
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公开(公告)号：US20170129853A1
公开(公告)日：2017-05-11
申请号：US15410486
申请日：2017-01-19
申请人： Thomas P. Daly
发明人： Thomas P. Daly
IPC分类号： C07C333/04 , C07C329/14
CPC分类号： C07C333/04 , A01N47/26 , C07C219/04 , C07C229/08 , C07C229/12 , C07C229/14 , C07C329/14 , C07C333/14 , C07D401/04 , C08L95/005 , E21C50/00 , Y02A30/333
摘要： Amines and amine derivatives that improve the buffering range, and/or reduce the chelation and other negative interactions of the buffer and the system to be buffered. The reaction of amines or polyamines with various molecules to form polyamines with differing pKa's will extend the buffering range, derivatives that result in polyamines that have the same pKa yields a greater buffering capacity. Derivatives that result in zwitterionic buffers improve yield by allowing a greater range of stability.
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公开(公告)号：US06399831B1
公开(公告)日：2002-06-04
申请号：US09451913
申请日：1999-12-01
IPC分类号： C07C32100
CPC分类号： C07H21/00 , C07C329/14
摘要： The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
摘要翻译： 本发明涉及通过使含有磷（III）键的寡核苷酸类似物与具有制备硫化寡核苷酸类似物的二硫代碳酸二酯多硫化物反应来合成硫化寡核苷酸类似物的方法。 二酯多硫化物试剂可用于溶液和固相寡核苷酸类似物合成。
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公开(公告)号：US06384209B1
公开(公告)日：2002-05-07
申请号：US08979864
申请日：1997-11-26
申请人： Jin-Yan Tang , Zhaoda Zhang
发明人： Jin-Yan Tang , Zhaoda Zhang
IPC分类号： C07H2100
CPC分类号： C07C329/14
摘要： The invention relates to the chemical synthesis of oligonucleotides and to chemical entities useful in such synthesis. More particularly, the invention relates to sulfurization of the internucleoside linkages of oligonucleotides. The invention provides new sulfur transfer reagents and processes for their use in sulfurizing oligonucleotides. The sulfur transfer reagents according to the invention are inexpensive to make, stable in storage and highly efficient in sulfurization.
摘要翻译： 本发明涉及寡核苷酸的化学合成以及可用于这种合成的化学实体。 更具体地，本发明涉及寡核苷酸的核苷间键的硫化。 本发明提供新的硫转移试剂及其用于硫化寡核苷酸的方法。 根据本发明的硫转移试剂制备成本低，贮存稳定，硫化效率高。
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7.发明授权公开(公告)号：US11970441B2
公开(公告)日：2024-04-30
申请号：US16977107
申请日：2018-12-07
发明人： Hong Zhong , Xiaoping Huang , Shuai Wang , Zhanfang Cao
IPC分类号： C07C333/04 , B03D1/012 , C07C329/14
CPC分类号： C07C333/04 , B03D1/012 , C07C329/14 , B03D2201/02 , B03D2203/02
摘要： The invention belongs to the field of mineral flotation collector materials, and particularly discloses a method for preparing thionocarbamate. In the preparation process, xanthate and 2-haloethanol are esterified to obtain O-alkyl-S-hydroxyethyl xanthate, and then O-alkyl-S-hydroxyethyl xanthate and fatty amine are reacted to obtain a mixture of thionocarbamate and 2-mercaptoethanol. The mixture of thionocarbamate and 2-mercaptoethanol is washed with alkali, and the oil phase and water phase are separated. The oil phase and water phase are thionocarbamate and 2-hydroxyethylthiolate, respectively, and 2-mercaptoethanol is obtained by washing with an acid. 2-alkylthioethanol is obtained by reacting 2-hydroxyethanethiolate with alkyl halide, and then with carbon disulfide and alkali to prepare O-alkylthioethyl xanthate. Thionocarbamate, 2-mercaptoethanol and O-alkylthioethyl xanthate prepared by this method possess high yield and high purity. The process is green and environmentally friendly, and is beneficial to the industrialization of co-production.
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公开(公告)号：US20180222846A1
公开(公告)日：2018-08-09
申请号：US15948548
申请日：2018-04-09
申请人： Thomas P. Daly
发明人： Thomas P. Daly
IPC分类号： C07C217/08 , C07C329/14 , B03D1/00 , C11D1/42 , B01F17/00
CPC分类号： C07C217/08 , B01F17/0042 , B03D1/00 , B03D1/0043 , B03D1/011 , B03D1/012 , C07C329/14 , C07C2601/02 , C11D1/42
摘要： A family of amine mining collectors that uses alkoxylates allows for the easy adjustment of solubility and molecular weight useful because anionic and cationic mineral collectors require such varying degrees of solubility and molecular weight. The family of the present invention allows for the optimization of both parameters and an increase in collector efficiency.
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9.发明申请公开(公告)号：US20100240746A1
公开(公告)日：2010-09-23
申请号：US12666282
申请日：2008-07-03
申请人： Miyuki Tomioka , Ko Hasegawa
发明人： Miyuki Tomioka , Ko Hasegawa
IPC分类号： A61K31/265 , C07C329/14 , A61P31/12 , A61P35/00 , A61P29/00 , A61P25/00 , C12P15/00
CPC分类号： C07C329/14 , C07B2200/07 , C07C29/095 , C07C2603/68 , C12P11/00 , C12P15/00 , C12P41/004 , C07C35/37
摘要： Provided herein are optically active stereoisomers of tricylclodecan-9-yl xanthogenate, processes of preparation, and pharmaceutical compositions thereof. Also provided are methods of their use for treating, preventing, or ameliorating one or more symptoms of a disease caused by a virus.
摘要翻译： 本文提供了三氯代十二烷-9-基黄原酸酯的光学活性立体异构体，其制备方法及其药物组合物。 还提供了它们用于治疗，预防或改善由病毒引起的疾病的一种或多种症状的方法。
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公开(公告)号：US6040438A
公开(公告)日：2000-03-21
申请号：US104330
申请日：1998-06-25
IPC分类号： C07H21/04 , C07C329/14 , C07H21/00 , C07H21/02
CPC分类号： C07H21/00 , C07C329/14
摘要： The present invention is directed to a method of synthesizing sulfurized oligonucleotide analogs by reacting an oligonucleotide analog containing a phosphorous(III) linkage with a dithiocarbonic acid diester polysulfide having the formula ##STR1## to produce a sulfurized oligonucleotide analog. The diester polysulfide reagent is useful in solution and solid phase oligonucleotide analog synthesis.
摘要翻译： 本发明涉及通过使含有磷（III）键的寡核苷酸类似物与具有下式的二硫代碳酸二酯多硫化物反应产生硫化寡核苷酸类似物来合成硫化寡核苷酸类似物的方法。 二酯多硫化物试剂可用于溶液和固相寡核苷酸类似物合成。
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