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    CATALYTIC METHOD FOR PRODUCING PHENOLPHTHALEIN COMPOUNDS
    1.
    发明申请
    CATALYTIC METHOD FOR PRODUCING PHENOLPHTHALEIN COMPOUNDS 有权
    用于生产苯酚酞化合物的催化方法

    公开(公告)号：US20100081828A1

    公开(公告)日：2010-04-01

    申请号：US12239908

    申请日：2008-09-29

    申请人： Venkata Rama Narayanan Ganapathy BHOTLA ,  Shivappa Basappa HALLIGUDI ,  Gurram KISHAN ,  Salkod Parameshwar MALLIKA ,  Bhaskar VELDURTHY

    发明人： Venkata Rama Narayanan Ganapathy BHOTLA ,  Shivappa Basappa HALLIGUDI ,  Gurram KISHAN ,  Salkod Parameshwar MALLIKA ,  Bhaskar VELDURTHY

    IPC分类号： C07D209/48 ,  C07D307/20

    CPC分类号： C07D307/885

    摘要： A method of producing a phenolphthalein comprises reacting a phenolic compound of the formula: wherein R1 is a hydrogen or a C1-C12 hydrocarbyl group, with a phthalic anhydride compound of the formula: wherein R2 is a hydrogen, a C1-C12 hydrocarbyl group, or a halogen, in the presence of a heterogeneous catalyst and a promoter to form a reaction mixture comprising a phenolphthalein compound of the formula: wherein each R1 is independently a hydrogen or a C1-C12 hydrocarbyl group, and R2 is a hydrogen, a C1-C12 hydrocarbyl group, or a halogen; wherein the heterogeneous catalyst comprises a metal oxide composition in combination with a porous support, wherein the metal is molybdenum, tungsten, or a combination comprising at least one of the foregoing metals.

    摘要翻译： 一种生产酚酞的方法包括使下式的酚化合物：其中R1是氢或C1-C12烃基，与下式的邻苯二甲酸酐化合物反应：其中R2是氢，C1-C12烃基， 或卤素，在非均相催化剂和促进剂的存在下，形成包含下式的酚酞化合物的反应混合物：其中每个R 1独立地是氢或C 1 -C 12烃基，并且R 2是氢，C 1 -C12烃基或卤素; 其中所述非均相催化剂包括与多孔载体组合的金属氧化物组合物，其中所述金属是钼，钨或包含至少一种前述金属的组合。

    Method for the preparation of Leuco Crystal Violet Lactone
    2.
    发明授权
    Method for the preparation of Leuco Crystal Violet Lactone 失效
    制备Leuco Crystal Violet内酯的方法

    公开(公告)号：US4455435A

    公开(公告)日：1984-06-19

    申请号：US005254

    申请日：1979-01-22

    申请人： John P. Dundon ,  Erwin Klingsberg

    发明人： John P. Dundon ,  Erwin Klingsberg

    IPC分类号： C07D307/885 ,  C07D307/78 ,  C09B11/10

    CPC分类号： C07D307/885

    摘要： Leuco Crystal Violet Lactone is prepared by condensing one molar proportion of each of N,N-dimethylaniline, p-dimethylaminobenzaldehyde, and m-dimethylaminobenzoic acid with 0-1 molar proportion of urea and 1-4 molar proportions of a strong acidic condensing agent.

    摘要翻译： 通过将1摩尔份的N，N-二甲基苯胺，对二甲基氨基苯甲醛和间二甲基氨基苯甲酸与0-1摩尔比例的尿素和1-4摩尔比例的强酸性缩合剂一起冷凝来制备无色结晶紫内酯。

    Preparation of phenolphthalein using cation exchange resins and aryl phosphites
    3.
    发明授权
    Preparation of phenolphthalein using cation exchange resins and aryl phosphites 失效
    使用阳离子交换树脂和亚磷酸芳基酯制备酚酞

    公开(公告)号：US4252725A

    公开(公告)日：1981-02-24

    申请号：US19058

    申请日：1979-03-09

    申请人： Hershel B. Prindle ,  George E. Ham

    发明人： Hershel B. Prindle ,  George E. Ham

    IPC分类号： C07D307/885 ,  C07D307/88

    CPC分类号： C07D307/885

    摘要： A process for the preparation of phenol-phthalein wherein phenol and phthalic anhydride are reacted in the presence of a crosslinked sulfonic cation exchange resin in the acid form and wherein the water content of the reaction mixture is reduced by the use of aryl phosphites.The sulfonic cation exchange resin can be in the macroporous form or in the gel form. The range of useful crosslinking is 4-40 percent for the macroporous resin and 2-16 percent for the gel resin.

    摘要翻译： 一种制备酚酞的方法，其中苯酚和邻苯二甲酸酐在酸形式的交联磺酸阳离子交换树脂的存在下反应，并且其中通过使用亚磷酸芳基酯还原反应混合物的水含量。 磺酸阳离子交换树脂可以是大孔形式或凝胶形式。 有用的交联范围对于大孔树脂为4-40％，对于凝胶树脂为2-16％。

    Process for the manufacture of triarylcarbinol lactones
    5.
    发明授权
    Process for the manufacture of triarylcarbinol lactones 失效
    三叉珠菌素制剂的制备方法

    公开(公告)号：US3845077A

    公开(公告)日：1974-10-29

    申请号：US16744071

    申请日：1971-07-29

    申请人： ICI LTD

    发明人： HUGHES N

    IPC分类号： C07D307/885 ,  C07D5/38

    CPC分类号： C07D307/885

    摘要： 1. A PROCESS FOR THE MANUFACTURE OF TRIARYLCARBINOL LACTONE HAVING THE FORMULA:

    R-N(-R1)-(1,4-PHENYLENE(A))-C
    -(1,4-PHENYLENE(B)-N(-R2)-R3

    WHEREIN R, R1, R2 AND R3 EACH INDEPENDENTLY REPRRESRESENTS METHYL OR ETHYL, Z REPRESENTS HYDROGEN, DIMETHYLAMINO OR DIETHYLAMINO AND RINGS A AND B MAY OPTIONALLY BE SUBSTITUTED BY HALOGEN OR LOWER ALKYL, SAID PROCESS COMPRISING THE STEP OF OXIDISING A LEUCO COMPOUND HAVING THE FORMULA:

    R-N(-R1)-(1,4-PHENYLENE(A))-CH(-(2-(HOOC-)-1,4-PHENYLENE)-

    Z)-(1,4-PHENYLENE(B))-N(-R2)-R3

    WITH AN INORGANIC PERSULPHATE SELECTED FROM THE GROUP CONSISTING OF AMMONIA PERSULPHATE, SODIUM PERSULPHATE, POTASSIUM PERSULPHATE AND METHYLAMMONIUM PERSULPHATE.

    Preparation of radioactive mono and di-iodosulfobromophthalein
    6.
    发明授权
    Preparation of radioactive mono and di-iodosulfobromophthalein 失效
    放射性单体和二碘代吗啡黄酮的制备

    公开(公告)号：US3743713A

    公开(公告)日：1973-07-03

    申请号：US3743713D

    申请日：1971-06-22

    申请人： DAINABOT RADIOISOTOPE LABOR LT

    发明人： KATO S ,  KURATA K

    IPC分类号： C07D307/885 ,  C09B11/08 ,  A61K27/04

    CPC分类号： C07D307/885 ,  C09B11/08

    摘要： A METHOD OF PREPARING RADIOACTIVE MONO AND DI-IODOSULFOBROMOPHTHALEIN FOR CLINICAL PURPOSES AND WHEREIN THE RATIO OF DI TO MONOIOSOSUFOBROMOPHTHALEIN CAN BE CONTROLLED IS DISCLOSED. NO SEPARATION AND PURIFICATION OF THE COMPOUNDS IS REQUIRED FOR THEIR USE IN CLINICAL DIAGNOSTIC PROCEDURES. THE COMPOUNDS, PARTICULARLY THE MONOIODO COMPOUND, OFFER A NUMBER OF ADVANTAGES IN COMPARISON TO SULFOBROMOPHTHALEIN WHEN USED FOR BIOLOGICAL INVESTIGATION.

    Prosper monnet
    9.
    发明授权
    Prosper monnet 失效

    公开(公告)号：US499927A

    公开(公告)日：1893-06-20

    申请号：US499927D

    CPC分类号： C07D307/885

    Preparation process of phthalide compound
    10.
    发明授权
    Preparation process of phthalide compound 失效
    苯酞化合物的制备方法

    公开(公告)号：US5973168A

    公开(公告)日：1999-10-26

    申请号：US94559

    申请日：1998-06-15

    申请人： Takeshi Nishimura ,  Masaru Wada ,  Yoshinobu Kanemura ,  Satoshi Nakao ,  Mansuke Matsumoto

    发明人： Takeshi Nishimura ,  Masaru Wada ,  Yoshinobu Kanemura ,  Satoshi Nakao ,  Mansuke Matsumoto

    IPC分类号： C07D307/885

    CPC分类号： C07D307/885

    摘要： A process for preparing a phthalide compound represented by the formula (1): ##STR1## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are individually an alkyl group, and R.sup.1 and R.sup.2, R.sup.3 and R.sup.4, and R.sup.5 and R.sup.6 can respectively bond to each other to form a heterocyclic ring together with a nitrogen atom, comprising oxidizing a triphenylmethane compound represented by the formula (2) ##STR2## wherein R.sup.1, R.sup.2, R.sup.3, R.sup.4, R.sup.5 and R.sup.6 are the same as above, is oxidized in the presence of activated carbon in an aqueous solvent by an oxidizing agent.The process can provide a fast reaction that produces a high purity product with high yield.

    摘要翻译： 一种制备由式（1）表示的苯酞化合物的方法：其中R1，R2，R3，R4，R5和R6分别是烷基，R1和R2，R3和R4以及R5和R6可以分别键合到 彼此一起与氮原子一起形成杂环，包括氧化由式（2）表示的三苯基甲烷化合物，其中R 1，R 2，R 3，R 4，R 5和R 6与上述相同，在活化的 碳在水性溶剂中的氧化剂。 该方法可以提供产生高产率的高纯度产物的快速反应。